Difference between revisions of "Team:Fudan/Basic Part"
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<div class="block main-text sub-title dark-blue"> | <div class="block main-text sub-title dark-blue"> | ||
<h class="sup-title dark-blue">Basic Part – surEGFP</br></h> | <h class="sup-title dark-blue">Basic Part – surEGFP</br></h> | ||
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<div class="block main-text main-text"> | <div class="block main-text main-text"> | ||
<h class="highlight-title dark-blue"></br></br>For this year’s iGEM competition, our favorite basic part is surEGFP (BBa_K2446051) </h> | <h class="highlight-title dark-blue"></br></br>For this year’s iGEM competition, our favorite basic part is surEGFP (BBa_K2446051) </h> | ||
| − | <p></br>This part is a surface-expressed EGFP which can be used to set up heterogeneous antigen density expression cell model. Our team is very excited to be the first to bring the idea of antigen density heterogeneity to the iGEM competition, and propose a tri-response immunotherapy, SwordS. | + | <p></br>This part is a surface-expressed EGFP which can be used to set up heterogeneous antigen density expression cell model. Our team is very excited to be the first to bring the idea of antigen density heterogeneity to the iGEM competition, and propose a tri-response immunotherapy, SwordS. |
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CD8α peptide guides surEGFP to be located to cell membrane. transmembrane region of CD86 supports surEGFP to fix on membrane. | CD8α peptide guides surEGFP to be located to cell membrane. transmembrane region of CD86 supports surEGFP to fix on membrane. | ||
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| + | <div class="block main-text main-text"> | ||
| + | <h class="highlight-title dark-blue" id="Antigen"></br></br>See More</h> | ||
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Integrated information about surEGFP posted on Demonstrate page: Antigen density heterogeneity cell model. Or you can alternatively check the <a href="http://parts.igem.org/wiki/index.php?title=Part:BBa_K2446051">(surEGFP BBa_K2446051)</a> on the Registry of Standard Biological Parts website. | Integrated information about surEGFP posted on Demonstrate page: Antigen density heterogeneity cell model. Or you can alternatively check the <a href="http://parts.igem.org/wiki/index.php?title=Part:BBa_K2446051">(surEGFP BBa_K2446051)</a> on the Registry of Standard Biological Parts website. | ||
Revision as of 00:37, 1 November 2017
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This part is a surface-expressed EGFP which can be used to set up heterogeneous antigen density expression cell model. Our team is very excited to be the first to bring the idea of antigen density heterogeneity to the iGEM competition, and propose a tri-response immunotherapy, SwordS.
Surface-expressed EGFP (surEGFP) is built by fusing CD8α signal peptid and EGFP to the transmembrane region of CD86 (NM_175862) from N terminal to C terminal. CD8α peptide guides surEGFP to be located to cell membrane. transmembrane region of CD86 supports surEGFP to fix on membrane.
Integrated information about surEGFP posted on Demonstrate page: Antigen density heterogeneity cell model. Or you can alternatively check the (surEGFP BBa_K2446051) on the Registry of Standard Biological Parts website.
We listed other basic part we constructed this year here.
