Difference between revisions of "Team:UCLouvain"

 
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{{UCLouvain}}
 
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<span class="montserrat-text uppercase service-title">Global issue</span>
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<p style="padding-right: 30px;">Over the last years, our exposition to UV rays has <b>increased</b> and scientists noticed an <b>upward trend</b> in the risks of developing skin cancers.</p></a>
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<span class="montserrat-text uppercase service-title">Protection exists</span>
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<p style="padding-right: 30px;"> Although we can protect ourselves against this health hazard, <b> we cannot feel the UV rays </b> and when sunburns appear, it is already too late. </p></a>
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<span class="montserrat-text uppercase service-title">Badge design</span>
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<p style="padding-right: 30px;"> Hence, <b>we have designed a wearable UV-sensitive badge</b> to help warning people on their level of exposure anytime and anywhere. The badge turns red when exposed to a certain level of sunlight. </p></a>
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<span class="montserrat-text uppercase service-title">Culture design</span>
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<p style="padding-right: 30px;">This badge contains a <b>liquid cell culture</b>. The bacterial cells are engineered o produce a red fluorescent protein, which is only developed when. They only produce it when the badge is exposed to UV rays, thanks to a <b>photocaged amino acid</b>.</p></a>
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<a href="https://2017.igem.org/Team:UCLouvain"><img
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src="https://static.igem.org/mediawiki/2017/0/0d/Logo_2017.png"
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style="height: 150px; margin-top: 12.5px; float: left;"></a> <br>
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<div class="container"> <a href="https://2017.igem.org/Team:UCLouvain">Home</a>
 
<div class="dropdown"> <button class="dropbtn">Our Project</button>
 
<div class="dropdown-content"> <a
 
href="https://2017.igem.org/Team:UCLouvain/OurProject/Overview">Overview</a>
 
<a href="https://2017.igem.org/Team:UCLouvain/OurProject/ApproachI">Approach
 
1</a> <a
 
href="https://2017.igem.org/Team:UCLouvain/OurProject/ApproachII">Approach
 
2</a> </div>
 
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href="https://2017.igem.org/Team:UCLouvain/InTheLab/Overview">Overview</a>
 
<a href="https://2017.igem.org/Team:UCLouvain/InTheLab/Protocols">Prototcols</a>
 
<a href="https://2017.igem.org/Team:UCLouvain/InTheLab/Parts">Parts</a> </div>
 
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<a href="https://2017.igem.org/Team:UCLouvain/HumanPractices">Human
 
Practices</a>
 
<div class="dropdown"> <button class="dropbtn">About Us</button>
 
<div class="dropdown-content"> <a
 
href="https://2017.igem.org/Team:UCLouvain/AboutUs/Team">Team</a> <a
 
href="https://2017.igem.org/Team:UCLouvain/AboutUs/Aknowledgement">Aknowledgement</a>
 
<a href="https://2017.igem.org/Team:UCLouvain/AboutUs/OurUniversity">Our
 
University</a> </div>
 
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<h1>UCLouvain team @ iGEM 2017</h1>
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<img src="https://static.igem.org/mediawiki/2017/a/a7/UCLOUVAIN_badge_exterieur.jpeg" alt="Our Badge">
<h2>BactaSun: on the road for summer!</h2>
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<figcaption> <right> <font size = "2"><i><b> NB : bacteria free prototype</b></i></font></figcaption>
<img
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src="https://static.igem.org/mediawiki/2017/d/d9/UCLouvain_iGEM_Team_2017.jpeg"
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<span style="text-align: justify;">
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">Nowadays,
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exposition to harmful UV rays has led to an ever growing number of skin
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cancer cases, among other sun-related diseases. While efficient
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sunscreens do exist, we do not always think it necessary or forget to
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reapply it as often as we should. With our project called BactaSun, we
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propose to design a biobadge which would detect excessive UV exposure
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and therefore warn us to seek sun protection should it become necessary.</p>
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">This
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badge would work as a capsule holding an E. Coli strain, changing
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colors as the UV dose and intensity increases. The capsule would also
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work as a safe and reliable containment, destroying the engineered
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microorganisms once the biobadge is discarded.</p>
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">Starting
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with a tyrosine auxotroph E. coli, a gene coding for a colored protein
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which contains tyrosine will be constitutively expressed. Only
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photocaged tyrosine will be available in the media, and linked to a
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specific tRNA. The reporter protein will be synthetise but in the wrong
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conformation due to the cage presence. Once the bacterium is exposed to
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direct sunlight, the cage will be cleaved, inducing the good
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conformation of the protein and its coloration.</p>
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">Besides
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the biotechnological side of this project, the design of the badge
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capsule itself is going to represent a great challenge. We will need to
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find a specific plastic which lets the UV pass trough and design a way
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to kill the microorganisms once the badge has been used.</p>
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">Our
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team has also started an effort to educate the public on
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biotechnologies and synthetic biology. We are motivated to raise
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interest among scientist and others around iGEM and project like ours.
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The academic year 2016-2017 at UCL will unfold under the theme
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"Scientific Adventures". Under these circumstances, we already have
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been asked to lead panels and participate in debates and discussions.
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We hope to associate the UCLouvain iGEM project with many more
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initiative of this kind in the future.</p>
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Latest revision as of 15:54, 1 November 2017

iGEM UCLouvain Team iGEM UCLouvain Team

we are
iGEM UCLouvain Team
the project BactaSun

Although melanoma accounts for less than 1% of skin cancer cases, they are responsible for the vast majority of skin cancer deaths. More than 80% of melanomas are caused by the exposure to ultraviolet (UV) radiation from the sun.

Our project: BactaSun, a bio-badge changing color when exposed to sunlight.

read more
you think we're cool? so are our sponsors!
  • UCL
  • Fédération Wallonie Bruxelles
  • Fondation Louvain
  • Imperial College
  • Agilent Technologies
  • AGL
  • ISV
  • UCL faculté des Sciences