Difference between revisions of "Team:UCLouvain"

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{{UCLouvain}}
 
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<a href="https://2017.igem.org/Team:UCLouvain/OurProject/Overview" style="color:#60606e;"><i class="icon ion-arrow-graph-up-right"></i>
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<span class="montserrat-text uppercase service-title">Global issue</span>
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<p style="padding-right: 30px;">Over the last years, our exposition to UV rays has <b>increased</b> and scientists noticed an <b>upward trend</b> in the risks of developing skin cancers.</p></a>
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<span class="montserrat-text uppercase service-title">Protection exists</span>
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<p style="padding-right: 30px;"> Although we can protect ourselves against this health hazard, <b> we cannot feel the UV rays </b> and when sunburns appear, it is already too late. </p></a>
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<span class="montserrat-text uppercase service-title">Badge design</span>
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<p style="padding-right: 30px;"> Hence, <b>we have designed a wearable UV-sensitive badge</b> to help warning people on their level of exposure anytime and anywhere. The badge turns red when exposed to a certain level of sunlight. </p></a>
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<span class="montserrat-text uppercase service-title">Culture design</span>
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<p style="padding-right: 30px;">This badge contains a <b>liquid cell culture</b>. The bacterial cells are engineered o produce a red fluorescent protein, which is only developed when. They only produce it when the badge is exposed to UV rays, thanks to a <b>photocaged amino acid</b>.</p></a>
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<div class="container"> <a href="https://2017.igem.org/Team:UCLouvain">Home</a>
 
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href="https://2017.igem.org/Team:UCLouvain/OurProject/Overview">Overview</a>
 
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<a href="https://2017.igem.org/Team:UCLouvain/OurProject/ApproachI">Approach
 
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1</a> <a
 
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<a href="https://2017.igem.org/Team:UCLouvain/InTheLab/Protocols">Prototcols</a>
 
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<a href="https://2017.igem.org/Team:UCLouvain/InTheLab/Parts">Parts</a> </div>
 
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<a href="https://2017.igem.org/Team:UCLouvain/HumanPractices">Human
 
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Practices</a>
 
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<a href="https://2017.igem.org/Team:UCLouvain/AboutUs/OurUniversity">Our
 
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<h1>UCLouvain team @ iGEM 2017</h1>
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<img src="https://static.igem.org/mediawiki/2017/a/a7/UCLOUVAIN_badge_exterieur.jpeg" alt="Our Badge">
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<h2>BactaSun: on the road for summer!</h2>
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<figcaption> <right> <font size = "2"><i><b> NB : bacteria free prototype</b></i></font></figcaption>
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<span style="text-align: justify;">
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">Nowadays,
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exposition to harmful UV rays has led to an ever growing number of skin
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cancer cases, among other sun-related diseases. While efficient
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sunscreens do exist, we do not always think it necessary or forget to
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reapply it as often as we should. With our project called BactaSun, we
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propose to design a biobadge which would detect excessive UV exposure
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and therefore warn us to seek sun protection should it become necessary.</p>
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">This
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badge would work as a capsule holding an E. Coli strain, changing
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colors as the UV dose and intensity increases. The capsule would also
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work as a safe and reliable containment, destroying the engineered
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microorganisms once the biobadge is discarded.</p>
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">Starting
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with a tyrosine auxotroph E. coli, a gene coding for a colored protein
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which contains tyrosine will be constitutively expressed. Only
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photocaged tyrosine will be available in the media, and linked to a
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specific tRNA. The reporter protein will be synthetise but in the wrong
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conformation due to the cage presence. Once the bacterium is exposed to
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direct sunlight, the cage will be cleaved, inducing the good
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conformation of the protein and its coloration.</p>
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">Besides
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the biotechnological side of this project, the design of the badge
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capsule itself is going to represent a great challenge. We will need to
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find a specific plastic which lets the UV pass trough and design a way
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to kill the microorganisms once the badge has been used.</p>
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<p style="font-size: 14px; line-height: 24px; margin-bottom: 15px;">Our
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team has also started an effort to educate the public on
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biotechnologies and synthetic biology. We are motivated to raise
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interest among scientist and others around iGEM and project like ours.
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The academic year 2016-2017 at UCL will unfold under the theme
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"Scientific Adventures". Under these circumstances, we already have
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been asked to lead panels and participate in debates and discussions.
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We hope to associate the UCLouvain iGEM project with many more
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initiative of this kind in the future.</p>
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{{UCLouvainFooter}}

Latest revision as of 15:54, 1 November 2017

iGEM UCLouvain Team iGEM UCLouvain Team

we are
iGEM UCLouvain Team
the project BactaSun

Although melanoma accounts for less than 1% of skin cancer cases, they are responsible for the vast majority of skin cancer deaths. More than 80% of melanomas are caused by the exposure to ultraviolet (UV) radiation from the sun.

Our project: BactaSun, a bio-badge changing color when exposed to sunlight.

read more
Global issue

Over the last years, our exposition to UV rays has increased and scientists noticed an upward trend in the risks of developing skin cancers.
Protection exists

Although we can protect ourselves against this health hazard, we cannot feel the UV rays and when sunburns appear, it is already too late.

Badge design

Hence, we have designed a wearable UV-sensitive badge to help warning people on their level of exposure anytime and anywhere. The badge turns red when exposed to a certain level of sunlight.

Culture design

This badge contains a liquid cell culture. The bacterial cells are engineered o produce a red fluorescent protein, which is only developed when. They only produce it when the badge is exposed to UV rays, thanks to a photocaged amino acid.






Our Badge
NB : bacteria free prototype
you think we're cool? so are our sponsors!
  • UCL
  • Fédération Wallonie Bruxelles
  • Fondation Louvain
  • Imperial College
  • Agilent Technologies
  • AGL
  • ISV
  • UCL faculté des Sciences