Difference between revisions of "Team:SiCAU-China"

 
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<title>SiCAU-iGEM</title>
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          SCU-WestChina 2017 Project: Blocking Urate Storm in the Blood
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            Hyperuricemia and refractory gout are caused by the high urate concentration in the blood.
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            Considering there are still debates on whether the drug should be used in the asymptomatic hyperuricemia patients
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            and the drug resistance of the refractory gout patients,
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            new approaches are eagerly needed. We constructed the urate metabolic pathway in the probiotic E. coli Nissle 1917
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            and applied it in the gut to reduce the urate concentration in the blood indirectly.
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            In addition, we built a dialysis-like device combined with modified bacteria to utilize the urate directly in the blood.
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            Our solutions provide a suitable, long-term and non-drug treatment
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            for the asymptomatic hyperuricemia patients and an ultimate treatment for the refractory gout patients.
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<div class="mao"><a href="#"><img src="https://static.igem.org/mediawiki/2017/b/bc/T-SICAU-sidebar_mao.jpg" />  <div class="t"><b>top</b></div></a></div>
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<img src="https://static.igem.org/mediawiki/2017/thumb/5/5b/T-SICAU-magnifier.jpg/180px-T-SICAU-magnifier.jpg.png" alt="project" class="up-nav-icon" />project</div></a>
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<a href="https://2017.igem.org/Team:SiCAU-China/Description">Description</a>
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  <a href="https://2017.igem.org/Team:SiCAU-China/Results">Results</a>
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                  <a href="https://2017.igem.org/Team:SiCAU-China/Contribution">Contribution</a> 
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        Model</div></a>
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<img src="https://static.igem.org/mediawiki/2017/thumb/7/77/T-SICAU-hat.jpg/105px-T-SICAU-hat.jpg.png" alt="practice" class="up-nav-icon" />
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    Human Practices</div></a>
  
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        <a href="https://2017.igem.org/Team:SiCAU-China/Notebook">Notebook</a>
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          Collaborations</div></a>
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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Positive feedback system can be found in everywhere, which exists widely in creatures ranging from Lac operon of prokaryotes to human beings.  It has been used to construct various attractive circuits such bistable state, oscillators and other inconceivable systems. In our project this year, the significant performance of sensitivity would be developed in the positive feedback loop established by LuxR/LuxI quorum sensing system. But this loop can be opened up because of its background expression. The AiiA, which can hydrolyze the AHL, together with the Lac operon, will control the background expression. Furthermore, the input defined by user will have a negative correlation to the opening time. Hence, there is a need to establish a model to describe this relation and even realize quantitative determination.
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<h1> description </h1>
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Antibiotic is one of the most popular drug in the world, it can be used in medical treatment, agriculture, food processing, research and so on. But overusing antibiotics may bring antibiotics residue to environment, which will cause potential damage to human and impact the ecotope. Nowadays there are some physical and chemical methods to detect antibiotics residue, but they often need high cost and complicated process. So this year our team focus on Biosensor, said to be a easier way to detect than traditional methods at a lower price, to realize the trace detection.
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The positive feedback loop has been widely applied in synthetic biology, such as logic gates, oscillators, bistable circuit. Besides, the positive feedback loop is also an ultra-sensitive circuit, just like Polymerase Chain Reaction (PCR), even be used in quantitative expression detected. So we engineered a biosensor, which will be established a positive feedback loop using luxI/luxR system in E.coli, to achieve trace detection. Similar to the detect theory of real-time quantitative PCR, there will be a relation between the content of input signal and the time to open the loop. We will use this system to do some antibiotics leftover detections.
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Latest revision as of 19:47, 1 November 2017

SiCAU-iGEM

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      Positive feedback system can be found in everywhere, which exists widely in creatures ranging from Lac operon of prokaryotes to human beings. It has been used to construct various attractive circuits such bistable state, oscillators and other inconceivable systems. In our project this year, the significant performance of sensitivity would be developed in the positive feedback loop established by LuxR/LuxI quorum sensing system. But this loop can be opened up because of its background expression. The AiiA, which can hydrolyze the AHL, together with the Lac operon, will control the background expression. Furthermore, the input defined by user will have a negative correlation to the opening time. Hence, there is a need to establish a model to describe this relation and even realize quantitative determination.





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