Difference between revisions of "Team:UCopenhagen/Collaborations"

 
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                         <h1>C O L L A B O R A T I O N S</h1>
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                    <p class="lead"> Collaboration is a powerful driver of progress in science. To stand on the shoulders of giants is increasingly unrealistic in a globalised world where scientists work in ever more specialised areas and without geographic or language barriers.<br><br>
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For science to continue to benefit from globalisation, we must advance the axiom and seek to build a human pyramid from the shoulders before and around us. Collaboration and open source data are at the heart of iGEM and so too the heart of Incell. <br><br>
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Below we describe our most significant collaborations within the iGEM community. The symbiosis we strive for in our project has shone brightly through the partnerships established with teams around the world. Our story — and the stories of our friends — have been mutually shaped by the diversity of our shared experiences, knowledge and perspectives.
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<figcaption><b>Image 1 </b>Nordic iGEM teams during the final party of the Nordic iGEM Conference 2017.</figcaption>
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<h2 class="section-heading">DTU Biobuilders’ BioBrick Weekend (February, 2017)</h2>
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                    <h2 class="section-heading">Introduction </h2>
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<li>DTU-Denmark (Denmark)</li>
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                    <p class="lead">Our team believes that establishing a stable platform for scientists to create naïve orthogonal living compartments, would allow for an unpredictable advancement in the field of synthetic biology. Our project will not attempt to create an endosymbiont, but instead investigate the mechanisms in free-living cells in a bottom-up approach to endosymbiosis. 
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<li>SDU-Denmark (Denmark)</li>
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The endosymbiotic theory, formulated in the early years of the previous century, outlines that the organelles of the eukaryotic cell, such as the mitochondria, have their origin in free-living prokaryotes engulfed by bigger cells. These incorporated cells then co-evolved with their host conferring to it novel emergent properties which ultimately helped fuel the development of more complex multicellular biological systems such as plants and animals (Archibald, 2015). </p>
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<li>NTNU Trondheim (Norway) </li>
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<li>Chalmers-Gothenburg (Sweden) </li>
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<br><br>
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<p class="lead">An inspiring and practical three-day introduction to iGEM hosted by our friends and closest neighbours. Workshops covered the structure of the competition, hands-on laboratory experience in BioBrick assembly and debate of the ethical considerations surrounding synthetic biology.
  
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<figcaption><b>Image 2 </b>Incell at DTU Biobuilders’ BioBrick Weekend (February, 2017).</figcaption>
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<p>We have identified three mechanisms we believe to be mandatory for the development of a stable endosymbiotic relationship, which we will be trying to replicate in free-living cells. First of all, in order for the relationship to be stable, the two organisms must  be mutually dependent on each other; there must be a mutually beneficial interaction between host and symbiont. Secondly, there has to be some sort of control and synchronization of symbiont replication. If the symbiont were to be replicating freely we could end up with way too many or not enough symbionts in the host.  Finally, a common feature of the endosymbiotic organelles we have looked at, is the transfer of genes from the symbiont to the host. Because of this transfer, the gene and protein expression is taking place in the nucleus and the proteins and metabolites are transported to the organelle. This import of proteins is interesting not just for understanding endosymbiosis, but also for the potential applications in synthetic biology.</p>
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<h2 class="section-heading">Nordic iGEM Conference (June, 2017)</h2>
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<li>DTU-Denmark (Denmark)</li>
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<li>SDU-Denmark (Denmark)</li>
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<li>Stockholm (Sweden) </li>
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<li>Lund (Sweden)</li>
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<li>Uppsala University (Sweden)</li>
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<li>Chalmers-Gothenburg (Sweden) </li>
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<li>Aalto-Helsinki (Finland)</li>
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<p class="lead">In the tradition of the previous year’s winners hosting the following year’s conference, we had the pleasure to host teams from the Nordic region in Copenhagen. Teams had the opportunity to present their projects and receive questions and feedback from peers and judges. It was beneficial and a huge confidence boost for teams to be able to play with presentation strategy and get a feel for which parts of project stories gained traction and areas in need of development. All in a safe space in front of an audience of equals.
  
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<p>Based on these considerations, we decided to work on three distinct, but intertwined, projects pertaining to endosymbiosis, namely Interdependence, Number Control, and Protein import. We believe that by combining these three projects, a key step towards the understanding of endosymbiosis and its employment in synthetic biology will be obtained. </p>
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<figcaption><b>Image 3 </b>Will Wright at Nordic iGEM Conference (June, 2017).</figcaption>
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<h2 class="section-heading">Incell podcast series (August–November, 2017)</h2>
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<li>Toronto (Canada)</li>
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<li>REC-CHENNAI (India)</li>
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<p class="lead">We have been and continue to be, very motivated in taking Incell beyond the lab. The Incell podcast series has enabled us to draw upon diverse scientific, non-scientific, cultural and environmental perspectives from around the world. Incell is an abstract, foundational science project and we felt it important for development to be in the spirit of the humanity we hope to serve. Collaborating with other teams from Canada and India enhanced our content, multiplied our audience and maximised the public outreach and human value of our work.
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<figcaption><b>Image 4 </b>Two first releases of Incell's podcast. </figcaption>
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                    <<p>By understanding the basic principles behind the creation of stable endosymbiotic events we hope that in the future it will be possible to use artificial endosymbiosis as a new technology in synthetic biology, and we believe that value can be created in the foundational track of the iGEM competition. History has shown that great scientific advances has followed the implementation of new revolutionary technologies (Gershon 2003). </p>
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<p>We envision that artificial endosymbiosis could be applied in a broad range of fields, including agriculture, medicine and production of valuable compounds. A deeper understanding of the relationships intertwining endosymbionts and their hosts could unravel new knowledge applicable for the treatment of mitochondrial diseases, while a living compartment able to fixate nitrogen from the air could decrease the fertilizer use in agricultural production. </p>
+
<p class="lead">A brilliant day of workshops offering advice and inspiration for producing an effective and beautiful wiki. SDU are established leaders in producing exceptional iGEM wikis and their counsel proved indispensable when designing and creating our own. We added further value to the event — producing and sharing a video blog of the experience and take home messages with our social media network.
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<p>However, the applications are only limited by the imagination of future users. Indeed, the game-changing role of endosymbiosis has not gone unseen to the eyes of the modern bioengineers, who predict that the establishment of a novel interaction has the potential to radically alter the host cell physiology without directly affecting the host genome (Scientific America Vol 105 pp. 36-45).</p>
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<p>Before the potential application of artificial endosymbiosis, there are many things to consider. While the current regulations regarding GMO limits what is possible to apply in agriculture and medicine, regulations regarding synthetically modified organisms (SMOs) have not yet been systematically put into place. How will a new field of SMO be regulated, and how will it influence possible applications of artificial endosymbiosis?</p>
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<p>In addition to our scientific investigation we are enthused to trigger debate about synthetic biology. We intend to podcast intriguing conversations with experts, thereby hoping to reach the general public and impel the discussion about the ethics and future prospects in combining biology and engineering.</p>
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Latest revision as of 23:25, 1 November 2017

C O L L A B O R A T I O N S

Collaboration is a powerful driver of progress in science. To stand on the shoulders of giants is increasingly unrealistic in a globalised world where scientists work in ever more specialised areas and without geographic or language barriers.

For science to continue to benefit from globalisation, we must advance the axiom and seek to build a human pyramid from the shoulders before and around us. Collaboration and open source data are at the heart of iGEM and so too the heart of Incell.

Below we describe our most significant collaborations within the iGEM community. The symbiosis we strive for in our project has shone brightly through the partnerships established with teams around the world. Our story — and the stories of our friends — have been mutually shaped by the diversity of our shared experiences, knowledge and perspectives.

Image 1 Nordic iGEM teams during the final party of the Nordic iGEM Conference 2017.

DTU Biobuilders’ BioBrick Weekend (February, 2017)

  • DTU-Denmark (Denmark)
  • SDU-Denmark (Denmark)
  • NTNU Trondheim (Norway)
  • Chalmers-Gothenburg (Sweden)



An inspiring and practical three-day introduction to iGEM hosted by our friends and closest neighbours. Workshops covered the structure of the competition, hands-on laboratory experience in BioBrick assembly and debate of the ethical considerations surrounding synthetic biology.




Image 2 Incell at DTU Biobuilders’ BioBrick Weekend (February, 2017).

Nordic iGEM Conference (June, 2017)

  • DTU-Denmark (Denmark)
  • SDU-Denmark (Denmark)
  • Stockholm (Sweden)
  • Lund (Sweden)
  • Uppsala University (Sweden)
  • Chalmers-Gothenburg (Sweden)
  • Aalto-Helsinki (Finland)


In the tradition of the previous year’s winners hosting the following year’s conference, we had the pleasure to host teams from the Nordic region in Copenhagen. Teams had the opportunity to present their projects and receive questions and feedback from peers and judges. It was beneficial and a huge confidence boost for teams to be able to play with presentation strategy and get a feel for which parts of project stories gained traction and areas in need of development. All in a safe space in front of an audience of equals.





Image 3 Will Wright at Nordic iGEM Conference (June, 2017).

Incell podcast series (August–November, 2017)

  • Toronto (Canada)
  • REC-CHENNAI (India)


We have been and continue to be, very motivated in taking Incell beyond the lab. The Incell podcast series has enabled us to draw upon diverse scientific, non-scientific, cultural and environmental perspectives from around the world. Incell is an abstract, foundational science project and we felt it important for development to be in the spirit of the humanity we hope to serve. Collaborating with other teams from Canada and India enhanced our content, multiplied our audience and maximised the public outreach and human value of our work.



Image 4 Two first releases of Incell's podcast.

SDU Wiki writing workshop (August, 2017)

  • DTU-Denmark (Denmark)
  • SDU-Denmark (Denmark)


A brilliant day of workshops offering advice and inspiration for producing an effective and beautiful wiki. SDU are established leaders in producing exceptional iGEM wikis and their counsel proved indispensable when designing and creating our own. We added further value to the event — producing and sharing a video blog of the experience and take home messages with our social media network.



Image 5 DTU BioBuilders, SDU iGEM and Incell

Find Incell here: