Difference between revisions of "Team:UCLouvain/Team"

 
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<div class="big-title montserrat-text uppercase">TEAM</div>
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<div class="big-title montserrat-text uppercase">about us</div>
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<div class="small-title montserrat-text uppercase">100% of WORK&FUN</div>
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<div class="small-title montserrat-text uppercase"><Marine style="margin-left:32px;font-family:'Brush Script MT';font-size:32px;text-transform:none;font-weight:bold;">BactaSun - Work, Learn and Have Fun!</Marine></div>
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<span>Our PIs</span>
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<span>1. Auxotrophic</span>
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<span>about us</span>
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<p class="montserrat-text uppercase"><Marine style="margin-left:32px;font-family:'Brush Script MT';font-size:32px;text-transform:none;font-weight:bold;">We Are Awesome</Marine></p>
 
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<p>Using the iGEM’s biobricks, we construct a plasmid containing a gene coding for a RFP. Arabinose activates this gene, thanks to its pBAD promoter.</p>
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<p>It is very simple to describe … “Work, Learn and have Fun” is our motto. This represents quite well our crazy team. Since the beginning we are creating a great atmosphere between us. Our agenda is full of iGEM activities!! Road trip to Wageningen for the iGEM Benelux meeting, team working each week to meet us and share about the project, presentation of our adventure during a conference, etc…  Though we come from various faculties, we see skills differences as a real added value and all of us have something to say around the table. Responsibilities have been allocated according to our expertise and preferences but jokes duty is exclusively for Marine.</p>
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<p>On the other hand, we knocked out (KO) a gene required for tyrosine synthesis in E. coli, TyrA. A medium containing photo-caged tyrosine (Ortho Nitro Benzyl-Tyrosine) is used to grow the bacteria: this special tyrosine is sensitive to UV’s, and will be only available for our KO E. coli once uncaged.</p>
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<p>So, we do not need to say a lot but only: “It is a great experience with great people”.</p>
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<a href="#" class="btn blue" style="float:right;"><span>learn more</span></a>
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<span>2. Com R/S</span>
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<span>What We Do</span>
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<p class="montserrat-text uppercase"><Marine style="margin-left:32px;font-family:'Brush Script MT';font-size:32px;text-transform:none;font-weight:bold;">Solar Biobadges</Marine></p>
 
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<p>Our objective is to design a biobadge detecting excessive UV exposure and therefore warning us to seek sun protection should it become necessary. This badge would work as a capsule holding <i>E. coli</i> cells, changing colours as the UV intensity increases. Therefore, we investigated two approaches using photocaged tyrosine (o-nitrobenzyl tyrosine). In both cases, UV-rays will release the tyrosine and enhance a reporter signal. (1) Starting with a tyrosine auxotroph <i>E. coli</i> strain, a reporter RFP will be synthetized once tyrosine is liberated from its cage. (2) Using a photocaged peptide and a specific transcription factor called ComR, we also aim at UV-controlling the expression of the reporter gene. The capsule would also work as a safe and reliable containment, destroying the engineered microorganisms once the biobadge is discarded.</p>
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<p>ComS is a small peptide imported into the cytoplasm by the cell. Interacting with ComR, it will form a complex, that acts as a gene activator.</p>
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<p>ComS contains some tyrosine. Thanks to a collaboration with…, we synthetize ComS using the photo-caged Tyrosine instead of Tyrosine. This new ComS can’t interact with ComR, unless its Tyrosine have been uncaged by UV’s.</p>
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<p>The complex of ComR/ComS will simply activate a RFP gene, creating as previously a system responding to UV’s.</p>
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<a href="#" class="btn blue" style="float:right;"><span>learn more</span></a>
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<div class="container">
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<div class="section-title">
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<span>the dream team</span>
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<br>
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<br>
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<p><Marine style="margin-left:32px;font-family:'Brush Script MT';font-size:32px;text-transform:none;font-weight:bold;">Because each project needs a great team!</Marine></p>
 
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                                  <span>Patrice Soumillon</span>
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<img src="https://static.igem.org/mediawiki/2017/6/6d/UCLOUVAIN_TEAM-Alex.jpeg" alt="team image">
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<div class="team_member_name">Alexandre Jolly</div>
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                                  <span>Patrice Soumillon</span>
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<img src="https://static.igem.org/mediawiki/2017/5/5a/UCLOUVAIN_TEAM-Ben.jpeg
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                                  <span>Patrice Soumillon</span>
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<div class="team_member_name">Benjamin Ledoux</div>
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<div class="team_member_job">Bio-engineering student</div>
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  <p>Patrice Soumillion is teaching biochemistry and enzymology at the Université catholique de Louvain. He is a specialist in the functioning and evolution of enzymes. His research team is part of the group of biochemistry, biophysics and genetics of microorganisms at the Life Sciences Institute. With his help and expertise, he follows us all along our scientific adventure and he gives us valuable advice.</p>
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<div class="team_member_name">Caroline de Pret</div>
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<div class="team_member_job">Economic sciences student</div>
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                                            <span>Charles Hachez</span>
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<div class="team_member_name">Guillaume Cerckel</div>
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<div class="team_member_job">Biochemistry student</div>
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</div>
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</div>
  
−
<p>Charles Hachez is teaching at the Faculty of Sciences of the Université catholique de Louvain, Belgium. He is specifically interested in the molecular genetic structure ruling the development of glandular trichomes tractable in the leaf epidermis of Nicotiana tabacum. He will accompany our team during the Giant Jamboree in Boston. </p>
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<img src="https://static.igem.org/mediawiki/2017/5/54/UCLOUVAIN_TEAM-Marine.jpeg
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" alt="team image">
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<div class="team_member_name">Marine Lefèvre</div>
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<div class="team_member_job">Bio-engineering student</div>
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<div class="small-title montserrat-text uppercase">Bernard Hallet</div>
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<div class="team_member_info">
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<div class="team_member_name">Olivier Suys</div>
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<div class="team_member_job">Biochemistry student</div>
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</div>
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</div>
  
−
<p>Bernard Hallet is also a professor at the Faculty of Sciences of the Université catholique de Louvain, Belgium. He conducts research on the molecular system that mediate specialized DNA rearrangements in bacteria. As Prof. Hachez and Prof. Soumillion, he has been an important actor in our project. Thanks to his support and knowledge, we are succeeding to develop BactaSun</p>
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<div class="team_member_name">Pierre Van Meerbeeck</div>
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<div class="team_member_job">Bio-engineering student</div>
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<div class="team_member_info">
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<div class="team_member_name">Roxane Scleusner</div>
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<div class="team_member_job">Biochemistry student</div>
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<div class="team_member_name">Thomas Reginster</div>
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<div class="team_member_job">Bio-engineering student</div>
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<div class="team_member_info">
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<div class="team_member_name">Cyril Maréchal</div>
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<div class="team_member_job">Engineering student</div>
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<p></p>
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On top of that, we are all studying at the Université catholique de Louvain.
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<a href="https://2017.igem.org/Team:UCLouvain/OurUniversity" class="btn blue" style="float:right"><span>learn more</span></a>
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<span>The team instructors</span>
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                    <Span><g style="font-weight: bold;color: #60606e;">Patrice Soumillion</g></Span>
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                    <p>Patrice Soumillion is teaching biochemistry and enzymology at the Université catholique de Louvain. He is a specialist in the functioning and evolution of enzymes. His research team is part of the group of biochemistry, biophysics and genetics of microorganisms at the Life Sciences Institute. With his help and expertise, he follows us all along our scientific adventure and he gives us valuable advice.</p>
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                    <Span><g style="font-weight: bold;color: #60606e;">Charles Hachez</g></Span>
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                    <p> Charles Hachez is teaching at the Faculty of Sciences of the Université catholique de Louvain, Belgium. He is specifically interested in the molecular genetic structure ruling the development of glandular trichomes tractable in the leaf epidermis of <i>Nicotiana tabacum</i>. He will accompany our team during the Giant Jamboree in Boston. </p>
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                    <span><g style="font-weight: bold;color: #60606e;">Bernard Hallet</g></span>
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                    <p>Bernard Hallet is also a professor at the Faculty of Sciences of the Université catholique de Louvain, Belgium. He conducts research on the molecular system that mediate specialized DNA rearrangements in bacteria. As Prof. Hachez and Prof. Soumillion, he has been an important actor in our project. Thanks to his support and knowledge, we are succeeding in developing BactaSun</p>
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                    <img class="in_text_img" src="https://static.igem.org/mediawiki/2017/6/68/Bh.png"/>
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<a href="https://www.facebook.com/igemuclouvain/" class="btn blue" style="display:block; margin-left: auto; margin-right: auto;"><span>Follow us on Facebook!</span></a></div>
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Latest revision as of 00:04, 2 November 2017

iGEM UCLouvain Team iGEM UCLouvain Team

about us

BactaSun - Work, Learn and Have Fun!
about us

We Are Awesome



It is very simple to describe … “Work, Learn and have Fun” is our motto. This represents quite well our crazy team. Since the beginning we are creating a great atmosphere between us. Our agenda is full of iGEM activities!! Road trip to Wageningen for the iGEM Benelux meeting, team working each week to meet us and share about the project, presentation of our adventure during a conference, etc… Though we come from various faculties, we see skills differences as a real added value and all of us have something to say around the table. Responsibilities have been allocated according to our expertise and preferences but jokes duty is exclusively for Marine.

So, we do not need to say a lot but only: “It is a great experience with great people”.

What We Do

Solar Biobadges



Our objective is to design a biobadge detecting excessive UV exposure and therefore warning us to seek sun protection should it become necessary. This badge would work as a capsule holding E. coli cells, changing colours as the UV intensity increases. Therefore, we investigated two approaches using photocaged tyrosine (o-nitrobenzyl tyrosine). In both cases, UV-rays will release the tyrosine and enhance a reporter signal. (1) Starting with a tyrosine auxotroph E. coli strain, a reporter RFP will be synthetized once tyrosine is liberated from its cage. (2) Using a photocaged peptide and a specific transcription factor called ComR, we also aim at UV-controlling the expression of the reporter gene. The capsule would also work as a safe and reliable containment, destroying the engineered microorganisms once the biobadge is discarded.

the dream team

Because each project needs a great team!

team image
Alexandre Jolly
Bio-engineering student
team image
Benjamin Ledoux
Bio-engineering student
team image
Caroline de Pret
Economic sciences student
team image
Guillaume Cerckel
Biochemistry student
team image
Marine Lefèvre
Bio-engineering student
team image
Olivier Suys
Biochemistry student
team image
Pierre Van Meerbeeck
Bio-engineering student
team image
Roxane Scleusner
Biochemistry student
team image
Thomas Reginster
Bio-engineering student
team image
Cyril Maréchal
Engineering student

On top of that, we are all studying at the Université catholique de Louvain.

learn more
The team instructors



Patrice Soumillion

Patrice Soumillion is teaching biochemistry and enzymology at the Université catholique de Louvain. He is a specialist in the functioning and evolution of enzymes. His research team is part of the group of biochemistry, biophysics and genetics of microorganisms at the Life Sciences Institute. With his help and expertise, he follows us all along our scientific adventure and he gives us valuable advice.

Charles Hachez

Charles Hachez is teaching at the Faculty of Sciences of the Université catholique de Louvain, Belgium. He is specifically interested in the molecular genetic structure ruling the development of glandular trichomes tractable in the leaf epidermis of Nicotiana tabacum. He will accompany our team during the Giant Jamboree in Boston.

Bernard Hallet

Bernard Hallet is also a professor at the Faculty of Sciences of the Université catholique de Louvain, Belgium. He conducts research on the molecular system that mediate specialized DNA rearrangements in bacteria. As Prof. Hachez and Prof. Soumillion, he has been an important actor in our project. Thanks to his support and knowledge, we are succeeding in developing BactaSun

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you think we're cool? so are our sponsors!
  • UCL
  • Fédération Wallonie Bruxelles
  • Fondation Louvain
  • Imperial College
  • Agilent Technologies
  • AGL
  • ISV
  • UCL faculté des Sciences