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| | </li> | | </li> |
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| − | <li id="drop5" class="navy-link"><a href="#">MODELLING</a> | + | <li id="drop5" class="navy-link"><a href="#">MODELLING</a> |
| | <ul class="navy-hidden"> | | <ul class="navy-hidden"> |
| | <li><a href="https://2017.igem.org/Team:UCL/Model" class="dropped">Overview</a></li> | | <li><a href="https://2017.igem.org/Team:UCL/Model" class="dropped">Overview</a></li> |
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| | <li><a href="https://2017.igem.org/Team:UCL/Model4" class="dropped">LEGIT</a></li> | | <li><a href="https://2017.igem.org/Team:UCL/Model4" class="dropped">LEGIT</a></li> |
| | <li><a href="https://2017.igem.org/Team:UCL/Model3" class="dropped">MOM</a></li> | | <li><a href="https://2017.igem.org/Team:UCL/Model3" class="dropped">MOM</a></li> |
| | + | <li><a href="https://2017.igem.org/Team:UCL/Methods" class="dropped">Methods</a></li> |
| | <li><a href="https://2017.igem.org/Team:UCL/Glossary" class="dropped">Glossary</a></li> | | <li><a href="https://2017.igem.org/Team:UCL/Glossary" class="dropped">Glossary</a></li> |
| | </ul> | | </ul> |
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| | </ul></li> | | </ul></li> |
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| − | <li id="drop4" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Notebook">LAB BOOK</a></li> | + | <li id="drop4" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Notebook">LAB BOOK</a> |
| − | | + | <ul class="navy-hidden"> |
| − | </ul> | + | <li><a href="https://2017.igem.org/Team:UCL/Safety" class="dropped">Safety</a></li> |
| | + | </ul></li> |
| | </div> | | </div> |
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| | <nav id="side-index" class="col-sm-2"> | | <nav id="side-index" class="col-sm-2"> |
| | <ul class="nav nav-stacked" data-spy="affix" data-offset-top="205"> | | <ul class="nav nav-stacked" data-spy="affix" data-offset-top="205"> |
| − | <li id="step1" class="navy-link side-link"><a href="#ProjectDesign">Project Design</a></li> | + | <li id="step1" class="navy-link side-link"><a href="#safety">Safety</a></li> |
| − | <li id=" step2" class="navy-link side-link"><a href="# LabSafety">Lab Safety</a></li> | + | <li id="step2" class="navy-link side-link"><a href="#project">Project Design</a></li> |
| | + | <li id=" step3" class="navy-link side-link"><a href="# lab">Lab Safety</a></li> |
| | + | |
| | </ul> | | </ul> |
| | </nav> | | </nav> |
| | | | |
| − | <!-- Content -->
| + | |
| | <div style="float: right !important" class="col-sm-10"> | | <div style="float: right !important" class="col-sm-10"> |
| | | | |
| − | <!-- Intro -->
| + | |
| − | <div id="who" class="row">
| + | <div class="row"> |
| − | | + | |
| − | <!-- Product-->
| + | |
| − | <div id="product" class="row"> | + | |
| | <div class="text-section col-sm-10" style="border:none"> | | <div class="text-section col-sm-10" style="border:none"> |
| | | | |
| − | <h1 class="title" style="font-size: 50px!important">Safety </h1>
| + | <div style="margin-top:20px"><h1 class="title" style="font-size: 50px!important; color: #E55190; margin-left:0">Safety</h1></div> |
| − | <h1 class="subtitle">Currently under development </h1>
| + | |
| | <div class="row" style="border:none; max-width: 100%"> | | <div class="row" style="border:none; max-width: 100%"> |
| | | | |
| − | <div class="text-section" style="border: none" id="safety-considerations-in-our-project-design"> | + | <div class="text-section" style="border: none" id="safety"> |
| − | <h1 class="title">Safety Considerations of our Project Design</h1>
| + | <h1 class="title" style="font-size: 50px">Safety </h1> |
| − | <p class="text-content-new" style="border: none; margin-left:20px!important">Placeholder text: The ting goes skrrrahh! Pap, pap, ka-ka-ka! Skidiki-pap-pap! And a pu-pu-drrrr-boom! Skya! Du-du-ku-ku-pun-pun! Poom, poom. You dun know. -Big Shaq</p>
| + | <p class="text-content-new"> Laboratories are equipped with many chemicals and electrical equipment that could be hazardous. Therefore, it is imperative students and professionals understand and detect safety hazards. iGEM has stressed the importance of lab safety right from the beginning of the competition. Our team strived to eliminate and raise awareness about safety hazards throughout our journey in this competition. </p> |
| − | </div>
| + | <div class="text-section" style="margin-bottom: none; border-left: none; border-right: none" id="project"> |
| − | </div> | + | |
| | + | <h1 class="title">Safety Considerations of our Project Design</h1> |
| | + | <div class="text-content-new"> |
| | + | |
| | + | |
| | + | <ul class=“text-content-new” style="padding: 5%">Mammalian |
| | + | <li style=“margin-left: 40px”> We considered that there could be many hazards with genetically modifying a patient’s own cells</li> |
| | + | <li style=“margin-left: 40px”> We analysed the light activated ‘dead-switch’ device that chews up exogenous DNA from the cells. This device is activated after the cells create a self-sustaining tissue, to ensure the newly generated tissue does not lead to complications after transplantation</li> |
| | + | <li style=“margin-left: 40px”> Once we produce the 3D printed tissue, we need to make sure the genetically engineered cells are unresponsive to the specific light wavelengths we used to activate them (to prevent further spontaneous cell activation (e.g. by sunlight) )</li> |
| | + | </ul> |
| | | | |
| − | <div class="text-section" style="border: none" id="Lab-Safety">
| |
| − | <h1 class="title">Lab Safety</h1>
| |
| − | <img src="https://static.igem.org/mediawiki/2017/0/07/HowDoesItWork.png" id="special-image-here-2" style="width:700px; height:400px; margin-left: 10%">
| |
| − | <p class="text-content-new">Placeholder text: The ting goes skrrrahh! Pap, pap, ka-ka-ka! Skidiki-pap-pap! And a pu-pu-drrrr-boom! Skya! Du-du-ku-ku-pun-pun! Poom, poom. You dun know. -Big Shaq</p>
| |
| − | </div>
| |
| | | | |
| − | <div class="text-section" style="border: none" id="bioterrorism">
| + | <ul class=“text-content-new” style="padding: 5%">Barchitecture |
| − | <h1 class="title">Biotrerrorism</h1>
| + | <li style=“margin-left: 40px”>Bio-hazardous and risk of biocontamination</li> |
| − | <div class="text-section col-sm-10" style="border: none">
| + | <li style=“margin-left: 40px”>Incorporating bacteria into architecture and public spaces could lead to health and safety issues. Therefore, we decided that in order to incorporate our technology in communities safely we would need to ensure our bacterial cells were dead once our structures were generated</li> |
| − | <p class="text-content-new">Placeholder text: The ting goes skrrrahh! Pap, pap, ka-ka-ka! Skidiki-pap-pap! And a pu-pu-drrrr-boom! Skya! Du-du-ku-ku-pun-pun! Poom, poom. You dun know. -Big Shaq</p>
| + | </ul> |
| − | </div>
| + | |
| | | | |
| − | </div>
| |
| − | </div>
| |
| − | </div>
| |
| | | | |
| | + | <ul class=“text-content-new” style="padding: 5%">LIT bulb |
| | + | <li style=“margin-left: 40px”> We considered the risks associated with our LIT bulb breaking, and releasing bacteria to the environment. Thoughts we evaluated included: how much bacteria could kill a person? Would people be willing to use potentially hazardous lightbulbs in their communities?</li> |
| | + | <li style=“margin-left: 40px”> We read about how we could tackle safety issues associated with our bacterial-powered lightbulb. We decided to engineer a bacterial strain that could only grow under highly defined environmental conditions (e.g. high Hydrogen Peroxide levels). Therefore, if our bacteria was ever released in the environment it would die before it could contaminate its surroundings</li> |
| | + | </ul> |
| | | | |
| − | <div class="text-section col-sm-10" style="border:none"> | + | |
| − | <div class="text-section" style="border: none" >
| + | <div class="text-section" style="border: none " id="lab"> |
| − | <h1 class="title">The future of the LIT bulbs </h1>
| + | <h1 class="title" style="margin-left:-10%!important">Lab Safety</h1> |
| − | <div class="row" style="border: none; max-width: 100%!important">
| + | <ul class=“text-content-new” style="padding: 5%"> |
| − | <p class="text-content-new">We decided to envision the implementation of our product, the LIT bulb, using a “think global, act local” approach. We examined and quantified the economic, social and ecological advantages the application of the LIT bulb would have in the U.K. and extrapolated these results onto the world. We also worked on tweaking our original idea to include a further safety measure that could assuage public concerns about leakage of genetically modified organisms into the surroundings. Our long-term future thinking includes making LIT bulbs that can be used for lighting billboards, gardens and outdoor venues.</p>
| + | <li style=“margin-left: 40px”> We used Personal Protective Equipment (PPE), including lab coats, goggles and gloves, for all our experiments to prevent any physical contact or contamination with biological materials, including GMOs</li> |
| − | </div>
| + | <li style=“margin-left: 40px”> When carrying out chemical aggregation experiments, we used a fume hood cupboard to protect ourselves from volatile DMF fumes</li> |
| | + | <li style=“margin-left: 40px”>When performing the IrrE UV crosslinker test, as well as any UV gel visualisations, we used UV protection goggles and operated all equipment following the safety manuals</li> |
| | + | </ul> |
| | + | </div> |
| | + | |
| | + | </div> |
| | + | |
| | + | </div> |
| | </div> | | </div> |
| | </div> | | </div> |
| | | | |
| − | <div class="text-section col-sm-10" style="border:none">
| |
| − | <div class="text-section" style="border:none" id="safety">
| |
| − | <h1 class="title">Safety</h1>
| |
| − | <p class="text-content-new">According to the GPP (Green Public Procurement), a public street light can be defined as:</p>
| |
| − | <p class="text-content-new"><i>“Fixed lighting installation intended to provide good visibility to users of outdoor public traffic areas during the hours of darkness to support traffic safety, traffic flow and public security”. </i></p>
| |
| − | <p class="text-content-new">The aim is to install the LIT bulb in conventional LIT bulb all around London, our product will constantly be exposed to the general public. At LIT we put a lot of weight on the security and opinion of our customers. Hence, we have established internal policies to ensure a safe use of the LIT bulb and to diminish the negative view associated with GMOs.</p>
| |
| − | <p class="text-content-new">To tackle public concerns for using genetically engineered cells we will set up LIT bulbs in small communities and educate the public about the scientific steps involved in the production of bioluminescence from cells and showcase the fool proof safety measures involved in its workings.</p>
| |
| − | <p class="text-content-new">The 21st century is an era of high tech and incredible technological advance, where authorities and governments aim to implement new technologies in any areas of public life. Yet, whenever a new product is introduced to the market, the regulations in place have to be considered. We worked on tweaking our original idea to include a further safety measure that could assuage public concerns about leakage of genetically modified organisms into the surroundings. In case a LIT bulb broke (e.g. from a car accident) and the genetically engineered bacteria were released into the environment, the cells would die immediately and as such verify that they would not pose a threat of bio-contaminant .</p>
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| − | </div>
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| − | </div>
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| | </div> | | </div> |
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