Difference between revisions of "Team:SCU China"
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According to NIH reports, around 50-70 million U.S. adults are suffering from sleep insufficiency and poor-quality sleep. | According to NIH reports, around 50-70 million U.S. adults are suffering from sleep insufficiency and poor-quality sleep. | ||
The circadian rhythm in human is predominantly under the regulation of melatonin, a hormone produced by pineal gland | The circadian rhythm in human is predominantly under the regulation of melatonin, a hormone produced by pineal gland | ||
| − | periodically. This year we want to use engineered E.coli to mimic this process in human. We propose to <strong>construct a melatonin | + | periodically. This year we want to use engineered <i>E.coli</i> to mimic this process in human. We propose to <strong>construct a melatonin |
biosynthesis pathway in <i>E.coli</i> to produce melatonin</strong>, while simultaneously<strong> couple this process with periodically-optimized | biosynthesis pathway in <i>E.coli</i> to produce melatonin</strong>, while simultaneously<strong> couple this process with periodically-optimized | ||
repressilator</strong>, a synthetic genetic oscillator with higher precision, with the intention to <strong>render melatonin production | repressilator</strong>, a synthetic genetic oscillator with higher precision, with the intention to <strong>render melatonin production | ||
Revision as of 07:39, 29 October 2017
Rhythmic Production of Melatonin in E.coli
Nowadays, insomnia and circadian rhythm disorders are increasingly plaguing individuals' daily life. According to NIH reports, around 50-70 million U.S. adults are suffering from sleep insufficiency and poor-quality sleep. The circadian rhythm in human is predominantly under the regulation of melatonin, a hormone produced by pineal gland periodically. This year we want to use engineered E.coli to mimic this process in human. We propose to construct a melatonin biosynthesis pathway in E.coli to produce melatonin, while simultaneously couple this process with periodically-optimized repressilator, a synthetic genetic oscillator with higher precision, with the intention to render melatonin production resemble mammalian periodicity in E.coli.
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