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Revision as of 13:03, 30 October 2017

<!DOCTYPE html> Coli Sapiens

iGEM Tokyo Tech

Composite Parts



TokyoTech 2017 iGEM Team Composite Parts


Name Type Description Design Length(bp)
BBa_K2505001 Composite PBAD/araC-rbs-ahk4 Hazuki Hasegawa 4415
BBa_K2505004 Composite atIPT4-IVS-IRES-log1 Hazuki Hasegawa 2539
BBa_K2505005 Composite (tra box)7-CMVmin-atIPT4-IVS-IRES-log1-polyA Hazuki Hasegawa 3264
BBa_K2505007 Composite Pcps-rbs-mCherry Takuma Yasue 1428
BBa_K2505008 Composite Ptet-rbs-traI-tt Hazuki Hasegawa 1079
BBa_K2505009 Composite Ptra-rrbs-gfp-tt Hazuki Hasegawa 1034
BBa_K2505010 Composite Ptet-rbs-traI-tt Hazuki Hasegawa 856
BBa_K2505030 Composite Ptet-rbs-traI(34M)-tt Kazunori Motai 859
BBa_K2505031 Composite Ptet-rbs-traI(63M)-tt Kazunori Motai 856
BBa_K2505032 Composite Ptet-rbs-traI(WM)-tt Kazunori Motai 856
John

Project


Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.


Modeling


Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.



Notebook


Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.


Team


Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.


John

Sponsers


JASSO

Kuramae Kougyoukai

IDT

Hajime Fujita: All Rights Reserved