Difference between revisions of "Team:Freiburg/Introduction"

Line 33: Line 33:
 
         <div class="flex-container">
 
         <div class="flex-container">
 
<div class="item">
 
<div class="item">
−
<p style="font-size:20.5px!important;">CARTEL<sup>TM</sup> T cells act like ‘good’ mafia enforcers, as they eliminate the tumor cells which are undesired intruders into the mafia’s territory where they compete with the body’s healthy cells. In our CARTEL<sup>TM</sup> system the T cells specifically target tumors by their microenvironment, unlike the ‘bad’ mafia in current CAR T cell therapy where off-target effects occur like collateral damage caused by real world mafias. The CARTEL<sup>TM</sup> mafia is peaceful when no tumor is present, however, if the CARTEL<sup>TM</sup> finds cancer this gang of CAR T cells effectively eliminates the invasion.
+
<p style="font-size:20.5px!important;">T cells guard their territory, the body. They are peaceful, until they find signs of an intruder. These intruders are usually viruses or other pathogens, which are rigorously eliminated. In case of tumors, fighting off the invader is more difficult because cancerous cells are very similar to healthy tissue. The defense against tumors is therefore often linked to heavy collateral damage. For this purpose a special task force is necessary: CARTEL<sup>TM</sup> cells. Activated by changes to their territory - the tumor microenvironment - they can be sure not to harm any healthy cells - and work hard to eliminate all intruders - the tumor cells. They are trained to infiltrate the tumor and only attack aberrant tissue, which is recognized by special traits: 1st via the tumor microenvironment, sensed via specialized AND gate equipment and 2nd via tumor antigens that activate the chimeric antigen receptor. Thus, the cartel ensures not to harm any of the healthy cells they are sworn to protect.
 
</p>
 
</p>
 
</div>
 
</div>

Revision as of 17:30, 1 November 2017

Logo
Overview Motivation CAR T Cells Tumor Microenvironment AND Gate Outlook Achievements References
Members Attributions Partners Contact
Main Project Modeling Applied Design Proof of Concept BioBricks Basic Part BioBrick Improvement Interlab Study
Safety Cloning HIF1A Knockdown Cell Culture Lab Book
Human Practice Integrated Human Practice Collaborations

T cells guard their territory, the body. They are peaceful, until they find signs of an intruder. These intruders are usually viruses or other pathogens, which are rigorously eliminated. In case of tumors, fighting off the invader is more difficult because cancerous cells are very similar to healthy tissue. The defense against tumors is therefore often linked to heavy collateral damage. For this purpose a special task force is necessary: CARTELTM cells. Activated by changes to their territory - the tumor microenvironment - they can be sure not to harm any healthy cells - and work hard to eliminate all intruders - the tumor cells. They are trained to infiltrate the tumor and only attack aberrant tissue, which is recognized by special traits: 1st via the tumor microenvironment, sensed via specialized AND gate equipment and 2nd via tumor antigens that activate the chimeric antigen receptor. Thus, the cartel ensures not to harm any of the healthy cells they are sworn to protect.

Home

Motivation