Team:Fudan/HCC
When the aroma of wine fills the bistro and bard's harp rings jubilant; Or when starlight shines above the earth, declaring the busy day coming to an end; Storybooks are going to be opened; words will come to live again. All sufferings turned to gold, and all whishes became accomplishments. It was a piece of history that us human struggling with cancer. "SwordS", as they called the name.
Hepatocellular carcinoma, HCC is a kind of malignant tumor occurred in liver that has a universal feature—the presence of structural and numeric chromosomal abnormalities indicative of genomic instability. In most cases, it develops from small-cell, high-grade dysplastic nodules in cirrhotic livers. On histologic examination, HCCs range from well-differentiated lesions that reproduce hepatocytes arranged in cords, trabeculae or glandular patterns to poorly differentiated lesions, often composed of large, multinucleate anaplastic giant cells. It may be unifocal, multifocal or diffusely infiltrative in pathologic samples. HCC has a strong propensity for vascular invasion and recapitulates normal liver architecture to varying degrees. In summary, HCC is a serious malignant tumor with high heterogeneity. (Adapt from Robbins Basic Pathology 9th)
During 2012, 782,500 (male 554,400; female 228,100) new cases of liver cancer and 745,500 (male 521,100, second leading cause of cancer death among males; female 224,500) deaths in total occurred around the world. Meanwhile, China alone accounted for around 50% of the total number of cases and deaths 1. China’s liver cancer cases are still rising sharply. Later statistics reported that new cases and death cases climb to 466,100 and 422, 100 around China during 20152. According to World Health Organization (WHO), the primary liver cancers can be classified into primary hepatocellular carcinoma (HCC), cholangiocarcinoma (ICC), and combined hepatocellular and cholangiocarcinoma (cHCC-CC)3, among which HCC is the most common occurring, making up 80% of cases4. As the sixth most frequent and the third most lethal tumor5, HCC brings great harm to the Chinese health. How to improve HCC treatment and raise patient survival rate has become an urgent social problem nowadays.
During 2012, 782,500 (male 554,400; female 228,100) new cases of liver cancer and 745,500 (male 521,100, second leading cause of cancer death among males; female 224,500) deaths in total occurred around the world. Meanwhile, China alone accounted for around 50% of the total number of cases and deaths 1. China’s liver cancer cases are still rising sharply. Later statistics reported that new cases and death cases climb to 466,100 and 422, 100 around China during 20152. According to World Health Organization (WHO), the primary liver cancers can be classified into primary hepatocellular carcinoma (HCC), cholangiocarcinoma (ICC), and combined hepatocellular and cholangiocarcinoma (cHCC-CC)3, among which HCC is the most common occurring, making up 80% of cases4. As the sixth most frequent and the third most lethal tumor5, HCC brings great harm to the Chinese health. How to improve HCC treatment and raise patient survival rate has become an urgent social problem nowadays.
Behind the cold data is an icy fact: every single one counts for the death toll is a living world for someone else, leaving behind widows, widowers and orphans. As a creature with humanity and compassion, we feel the pain deeply; these torture our souls constantly. The torpor is still wandering the mist, while those who suffered had come to their conscious and step forward, directly into the unknown wilderness.
