Team:Aalto-Helsinki/Model Results
Results and Discussion
Based on molecular dynamics simulations of DCD-1L at different salt concentrations and temperatures, we evaluated occurring changes in protein secondary structure through secondary structure assignment using DSSP and observed Ramachandran plot representations. Additionally we characterized the structure of the simulated peptide by scrutinizing the radius of gyration, solvent accessible surface area and hydrogen bonding.
Characterization of the amino acid sequence
Despite the great diversity of antimicrobial peptides, they exhibit many commonly shared characteristics. Such characteristics include the presence of multiple basic amino acids and amphipathic structures consisting of clusters of hydrophobic and hydrophilic amino acids. Commonly, AMPs have a positive net charge which has been shown to contribute to their initial binding to the often negatively charged bacterial cell membrane. The amphipathic structures found in AMPs have been found to enhance interactions with the phospholipids of the bacterial cell membrane, especially at the water-lipid interface.
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Contrary to popular belief, Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur, from a Lorem Ipsum passage, and going through the cites of the word in classical literature, discovered the undoubtable source. Lorem Ipsum comes from sections 1.10.32 and 1.10.33 of "de Finibus Bonorum et Malorum" (The Extremes of Good and Evil) by Cicero, written in 45 BC. This book is a treatise on the theory of ethics, very popular during the Renaissance. The first line of Lorem Ipsum, "Lorem ipsum dolor sit amet..", comes from a line in section 1.10.32.
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References
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[5] Writers, YEAR. Name of article / book. Publication. Accessible at: [url here].
