Blocking the Urate Storm in the Blood
SCU-WestChina 2017 Project
Hyperuricemia and refractory gout are caused by the high urate concentration in the blood. Considering there are still debates on whether the drug should be used in the asymptomatic hyperuricemia patients and the drug resistance of the refractory gout patients, new approaches are eagerly needed. We constructed the urate metabolic pathway in the probiotic E. coli Nissle 1917 and applied it in the gut to reduce the urate concentration in the blood indirectly. In addition, we built a dialysis-like device combined with modified bacteria to utilize the urate directly in the blood. Our solutions provide a suitable, long-term and non-drug treatment for the asymptomatic hyperuricemia patients and an ultimate treatment for the refractory gout patients.
Human Practice
Uric acid is the end product of purine metabolism in human. Increased production or decreased excretion of uric acid can lead to its accumulation in the body, causing hyperuricemia. If sodium urate crystals deposit from super-saturated extracellular fluids to joints, synovium or other tissues and organs, it will cause a syndrome clinically known as "gout". Controversy still exists on whether to use medications on asymptomatic hyperuricemia, refractory gout can be still hard to treat even with the new drug. And those are the reasons why we start our project. More
Based on the background, our project will put forward a new method to control hyperuricemia and treat refractory gout from the following two aspects: 1. Control of ordinary hyperuricemia (in the intestinal tract); 2. Treatment of refractory gout when Pegloticase treatment is of no avail (with methods of dialysis) More
We used the insulator to measure the expression of eGFP driven by 10 Anderson's promoters for the first time. We updated the information of the constitutive promoter family with quantitative protein data. The data is used for our project modeling to construct the pathway. More
We collected the information from various tubes. As a medical school team, we got the first-hand feedback from clinical doctors to make our project really meaningful. And it's our duty to spread the medical knowledge to the public to practice the saying: "Health related, life entrusted." More
"Wit beyond measure is a man’s greatest treasure." — Luna Lovegood, Harry Potter and the Order of the Phoenix More
How close can the numbers be when fluorescence is measured all around the world?