Difference between revisions of "Team:Sydney Australia/Patent Law"

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        <select>
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            <option value="choose">Choose Patent</option>
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            <option value="1">Lee et al. (2003)</option>
 +
            <option value="2">Lee et al. (2004)</option>
 +
            <option value="3">3rd patent</option>
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    <h1> GENERAL HEADER ON OUR PATENTS</h1>
 +
    <h4>Although our team attempted to be thorough, we recognise that not all patents can be checked. However, we targeted patents with the greatest relevance to avoid legal suits that may arise. Regardless, our work is for ‘research purposes’ in which an exception exists for patents under WHAT?? Testing of claims from patents are not illegal so long as we do not directly market this product which our team is not pursuing at this stage. 
 +
    </h4>
 +
<p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
 +
normal"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">DIMARCHI
 +
ET AL.<o:p></o:p></span></b></p>
 +
 +
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Single Chain Insulin with high
 +
bioactivity<o:p></o:p></span></p>
 +
 +
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Patent No: US 9458,220 B2<o:p></o:p></span></p>
 +
 +
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">October <span class="GramE">4<sup>th</sup></span>
 +
2016<o:p></o:p></span></p>
 +
 +
<p class="MsoNormal"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
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<table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="100%" style="width:100.0%;border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
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<tbody><tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;height:16.25pt">
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  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;mso-border-alt:
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  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
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  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">CLAIM<br style="mso-special-character:
 +
  line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--></span><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand"><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.66%;border:solid windowtext 1.0pt;border-left:
 +
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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  padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><br>
 +
  COMPARISON WITH OUR SEQUENCE<br style="mso-special-character:line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--></span><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand"><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border:solid windowtext 1.0pt;border-left:
 +
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">Y/N</span><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand"><o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:1;height:70.1pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:70.1pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">A single chain insulin agonist analogue with stricture of B-LM-A
 +
  <span class="GramE">wherein</span>&nbsp;B represents an insulin B chain
 +
  comprising the sequence R<sub>22</sub>X<sub>25</sub>LCGX<sub>29</sub></span><sub><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica;color:black">…</span></sub><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
 +
  Times;color:black"> <sub>&nbsp;</sub>and A represents an insulin A chain
 +
  comprising the sequence<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">GIVX<sub>4</sub>X<sub>5</sub>CCX<sub>8</sub></span><sub><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica;color:black">…</span></sub><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
 +
  Times;color:black">-R<sub>13</sub> <br style="mso-special-character:line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.66%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:70.1pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">Both insulin A and B chains involve R groups which stand for
 +
  modifications <span class="SpellE">eg</span>. carboxylation. As our <span class="GramE">insulin</span> B chain does not contain any modifications (except
 +
  an additional glycine at the A chain), our construct is outside the patent<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:70.1pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:2;height:36.55pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:36.55pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span class="GramE"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
 +
  Times;color:black">Furthermore</span></span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"> the linking moiety linking the <span class="SpellE">carboxy</span>
 +
  terminus of the B chain to the amino terminus of the A chain; further wherein
 +
  the linking moiety is an 8 amino acid sequence comprising of the sequence X<sub>51</sub>X<sub>52</sub>GSSSX<sub>57</sub>X<sub>58</sub>
 +
  wherein <br style="mso-special-character:line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--><o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">X<sub>51</sub> = group consisting of glycine, alanine, valine,
 +
  leucine, isoleucine, isoleucine and ornithine <br style="mso-special-character:
 +
  line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--><o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">X<sub>52</sub> = any amino acid other than tyrosine <br style="mso-special-character:line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--><o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">X<sub>57</sub> and X<sub>58</sub> are independently selected
 +
  form the ground consisting of arginine, lysine and ornithine<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.66%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:36.55pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><i><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></i></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black;mso-bidi-font-style:italic">Our amino acid sequence is squarely
 +
  outside the scope of 8 amino acids<i>.</i></span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">Even if we did fall within the claim; we do not contain the <span class="GramE">8 amino</span> acid sequence using both potential orientations<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">X<sub>51</sub> is glutamine or arginine in our sequence<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">B-chain </span><span lang="EN-AU" style="font-size:14.0pt;
 +
  font-family:Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
 +
  Helvetica;color:black">–</span><span lang="EN-AU" style="font-size:14.0pt;
 +
  font-family:Quicksand;mso-bidi-font-family:Times;color:black"> QR . . . RR </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica;color:black">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
 +
  Times;color:black"> A-chain</span><span lang="EN-AU" style="font-size:14.0pt;
 +
  font-family:Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
 +
  Helvetica;color:black"><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:36.55pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black;mso-bidi-font-style:italic"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black;mso-bidi-font-style:italic"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black;mso-bidi-font-style:italic"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black;mso-bidi-font-style:italic"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black;mso-bidi-font-style:italic"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black;mso-bidi-font-style:italic">N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:3;height:52.55pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:52.55pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">The LM also requires the sequence of GAGSSSRR or a sequence that
 +
  differs from GAGSSRR by 1 or 2 amino acids<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.66%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:52.55pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">Our sequence is 12 amino acids long and differs by more than 4
 +
  amino acids.<o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:52.55pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:4;mso-yfti-lastrow:yes;height:16.25pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">LM represents linking moiety linking the carboxyl terminus of
 +
  the B chain to the amino terminus of <span class="GramE">the a</span> chain,
 +
  wherein said linking moiety is an <span style="mso-bidi-font-weight:bold">8 amino
 +
  acid sequence</span> consisting of X<sub>51</sub>X<sub>52</sub>X<sub>53</sub>X<sub>54</sub>...
 +
  wherein X<sub>51</sub></span><span lang="EN-AU" style="font-size:14.0pt;
 +
  font-family:Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
 +
  Helvetica;color:black"> </span><span lang="EN-AU" style="font-size:14.0pt;
 +
  font-family:Quicksand;mso-bidi-font-family:Times;color:black">is selected
 +
  from the group consisting of glycine, alanine, valine, leucine, isoleucine
 +
  and proline</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;
 +
  mso-fareast-font-family:Helvetica;mso-bidi-font-family:Helvetica;color:black">…</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
 +
  Times;color:black"><o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.66%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">Similarly, the patent claim is over an <span class="GramE">8 amino</span>
 +
  acid sequence. Applying the same principle our;<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">X<sub>51</sub> is glutamine or arginine (depending on
 +
  orientation) and outside the scope<o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
 +
  mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
 +
  color:black">N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
</tbody></table>
 +
</div>   
 +
<div class="patent_1 box">
 +
<p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
 +
normal"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">LEE ET
 +
AL. <o:p></o:p></span></b></p>
 +
 +
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">Single Chain Insulin Analog and
 +
a polynucleotide sequence encoding the <span class="SpellE">analog</span> <o:p></o:p></span></p>
 +
 +
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">Patent No: US 6,630,348 B1<o:p></o:p></span></p>
 +
 +
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">October <span class="GramE">7<sup>th</sup></span>
 +
2003<o:p></o:p></span></p>
 +
 +
<p class="MsoNormal"><span lang="EN-AU" style="font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
 +
<table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="99%" style="width:99.54%;border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
 +
mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt">
 +
<tbody><tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes">
 +
  <td width="50%" style="width:50.16%;border:solid windowtext 1.0pt;mso-border-alt:
 +
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">CLAIM<br style="mso-special-character:
 +
  line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.84%;border:solid windowtext 1.0pt;border-left:
 +
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><br>
 +
  COMPARISON WITH OUR SEQUENCE<br style="mso-special-character:line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.0%;border:solid windowtext 1.0pt;border-left:
 +
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">Y/N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:1">
 +
  <td width="50%" style="width:50.16%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">A single chain insulin
 +
  analogue compound of formula (I) having the properties of greater insulin
 +
  receptor binding activity than proinsulin and less insulin receptor binding
 +
  activity than insulin:<br style="mso-special-character:line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--><o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B chain -<span style="mso-spacerun:yes">&nbsp; </span>X </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
 +
  14.0pt;font-family:Quicksand"> A chain wherein:</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica"><o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.84%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">General B </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> X </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
 +
  14.0pt;font-family:Quicksand"> A chain single chain formula</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica"><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.0%;border-top:none;border-left:none;border-bottom:
 +
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top-alt:
 +
  solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
 +
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand">Y<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:2">
 +
  <td width="50%" style="width:50.16%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B and A chain are human
 +
  insulin chains, respectively and,<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.84%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Our B and A chain are human insulin
 +
  chains although our A chain includes a modification (additional glycine)<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.0%;border-top:none;border-left:none;border-bottom:
 +
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top-alt:
 +
  solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
 +
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:3;mso-yfti-lastrow:yes;height:79.2pt">
 +
  <td width="50%" style="width:50.16%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:79.2pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">X is a joining peptide of
 +
  about 5 to 18 amino acids comprising the following sequence: <span class="SpellE">Gly</span>-<span class="SpellE">Gly</span>-<span class="SpellE">Gly</span>-Pro-<span class="SpellE">Gly</span>- Lys-<span class="SpellE">Arg</span><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.84%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:79.2pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Where the term </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica">‘</span><i style="mso-bidi-font-style:
 +
  normal"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">comprising</span></i><i style="mso-bidi-font-style:normal"><span lang="EN-AU" style="font-size:14.0pt;
 +
  font-family:Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
 +
  Helvetica">’ </span></i><span lang="EN-AU" style="font-size:14.0pt;font-family:
 +
  Quicksand">is included, the patent requires</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica"> </span><span lang="EN-AU" style="font-size:
 +
  14.0pt;font-family:Quicksand">that the specific sequence named MUST be part
 +
  of the linker region.<i style="mso-bidi-font-style:normal"><o:p></o:p></i></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Although our sequence is 12
 +
  amino acids long, it does not contain the </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica">‘</span><span lang="EN-AU" style="font-size:
 +
  14.0pt;font-family:Quicksand">GGGPGLR</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica">’</span><span lang="EN-AU" style="font-size:
 +
  14.0pt;font-family:Quicksand"> identified in the patent</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica"><o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.0%;border-top:none;border-left:none;border-bottom:
 +
  solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top-alt:
 +
  solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
 +
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:79.2pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
</tbody></table>
 +
</div>
 +
    <div class="patent_2 box">
 +
<p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
 +
normal"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">LEE ET
 +
AL.<o:p></o:p></span></b></p>
 +
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">Single Chain Insulin <span class="SpellE">Analogs</span><o:p></o:p></span></p>
 +
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand">Patent No: <b style="mso-bidi-font-weight:
 +
normal">EP 1 193 272 B1<o:p></o:p></b></span></p>
 +
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand">October <span class="GramE">30<sup>th</sup></span>
 +
2004<o:p></o:p></span></p>
 +
<p class="MsoNormal"><span lang="EN-AU" style="font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
<table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="100%" style="width:100.0%;border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
 +
mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt">
 +
<tbody><tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;height:12.75pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;mso-border-alt:
 +
  solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">CLAIM<br style="mso-special-character:
 +
  line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.64%;border:solid windowtext 1.0pt;border-left:
 +
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><br>
 +
  COMPARISON WITH OUR SEQUENCE<br style="mso-special-character:line-break">
 +
  <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
 +
  <!--[endif]--><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border:solid windowtext 1.0pt;border-left:
 +
  none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">Y/N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:1;height:12.75pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">A single chain insulin
 +
  analogue compound of formula (I) having the properties of greater insulin
 +
  receptor binding activity than <span class="SpellE">prosinsulin</span> and less
 +
  insulin receptor binding activity than insulin:<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B Chain </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> U<sub>I</sub> </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> Z<sub>n</sub> </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
 +
  Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> Y </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
 +
  14.0pt;font-family:Quicksand"> Z<sub>I</sub> </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
 +
  14.0pt;font-family:Quicksand"> U<sub>n </sub></span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
 +
  14.0pt;font-family:Quicksand"> A chain</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica"><o:p></o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.64%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:2;height:14.15pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:14.15pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B and A chain are human
 +
  insulin chains respectively and<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.64%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.15pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">We have a modified A chain<o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.15pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:3;height:18.35pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:18.35pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">U is an arginine or lysine
 +
  residue<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.64%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:18.35pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Our </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:Helvetica;
 +
  mso-bidi-font-family:Helvetica">‘</span><span lang="EN-AU" style="font-size:
 +
  14.0pt;font-family:Quicksand">U</span><span lang="EN-AU" style="font-size:14.0pt;
 +
  font-family:Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
 +
  Helvetica">’</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">
 +
  is glutamine<o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:18.35pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:4;height:27.45pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:27.45pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Z is a glycine<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.64%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:27.45pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Z Is Glycine<o:p></o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:27.45pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Y<o:p></o:p></span></p>
 +
  </td>
 +
</tr>
 +
<tr style="mso-yfti-irow:5;height:12.75pt">
 +
  <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
 +
  none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
 +
  padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">I <span class="GramE">is</span>
 +
  an integer of 2 </span><span lang="EN-AU" style="font-size:14.0pt;font-family:
 +
  Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:Helvetica">–
 +
  n<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N is an integer of 0 or 2 and<o:p></o:p></span></p>
 +
  </td>
 +
  <td width="42%" style="width:42.64%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">The maximum size of the linker
 +
  sequence when considering this is 9 amino acids. Since our sequence is 12
 +
  amino acids they are outside the scope<o:p></o:p></span></p>
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
 +
  </td>
 +
  <td width="7%" style="width:7.42%;border-top:none;border-left:none;
 +
  border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
 +
  mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
 +
  mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
 +
  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
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  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Y is glycine-<b style="mso-bidi-font-weight:normal">proline-</b>glycine, or alanine-<b style="mso-bidi-font-weight:normal">proline</b>-glycine-aspartic acid</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
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  Helvetica;mso-bidi-font-family:Helvetica">–valine, or tyrosine-</span><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:14.0pt;
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  font-family:Quicksand">proline</span></b><span lang="EN-AU" style="font-size:
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  14.0pt;font-family:Quicksand">-glycine-aspartic acid-valine, or histidine-<b style="mso-bidi-font-weight:normal">proline</b>-glycine-aspartic acid-valine.<o:p></o:p></span></p>
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  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
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  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
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  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p>&nbsp;</o:p></span></p>
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  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Our sequence has no proline<o:p></o:p></span></p>
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  <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
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    <div class="patent_3 box">3rd patent shite</div>
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    INSERT YOUR PATENT HERE
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Revision as of 10:47, 25 October 2017

GENERAL HEADER ON OUR PATENTS

Although our team attempted to be thorough, we recognise that not all patents can be checked. However, we targeted patents with the greatest relevance to avoid legal suits that may arise. Regardless, our work is for ‘research purposes’ in which an exception exists for patents under WHAT?? Testing of claims from patents are not illegal so long as we do not directly market this product which our team is not pursuing at this stage.

DIMARCHI ET AL.

Single Chain Insulin with high bioactivity

Patent No: US 9458,220 B2

October 4th 2016

 

 

CLAIM


COMPARISON WITH OUR SEQUENCE

Y/N

 

A single chain insulin agonist analogue with stricture of B-LM-A wherein B represents an insulin B chain comprising the sequence R22X25LCGX29…  and A represents an insulin A chain comprising the sequence

GIVX4X5CCX8…-R13

 

Both insulin A and B chains involve R groups which stand for modifications eg. carboxylation. As our insulin B chain does not contain any modifications (except an additional glycine at the A chain), our construct is outside the patent

 

 

 

 

N

 

Furthermore the linking moiety linking the carboxy terminus of the B chain to the amino terminus of the A chain; further wherein the linking moiety is an 8 amino acid sequence comprising of the sequence X51X52GSSSX57X58 wherein

X51 = group consisting of glycine, alanine, valine, leucine, isoleucine, isoleucine and ornithine

X52 = any amino acid other than tyrosine

X57 and X58 are independently selected form the ground consisting of arginine, lysine and ornithine

 

 

Our amino acid sequence is squarely outside the scope of 8 amino acids.

 

Even if we did fall within the claim; we do not contain the 8 amino acid sequence using both potential orientations

 

X51 is glutamine or arginine in our sequence

 

 

B-chain – QR . . . RR – A-chain

 

 

 

 

 

N

 

The LM also requires the sequence of GAGSSSRR or a sequence that differs from GAGSSRR by 1 or 2 amino acids

 

Our sequence is 12 amino acids long and differs by more than 4 amino acids.

N

 

LM represents linking moiety linking the carboxyl terminus of the B chain to the amino terminus of the a chain, wherein said linking moiety is an 8 amino acid sequence consisting of X51X52X53X54... wherein X51 is selected from the group consisting of glycine, alanine, valine, leucine, isoleucine and proline…

 

Similarly, the patent claim is over an 8 amino acid sequence. Applying the same principle our;

 

X51 is glutamine or arginine (depending on orientation) and outside the scope

N

LEE ET AL.

Single Chain Insulin Analog and a polynucleotide sequence encoding the analog

Patent No: US 6,630,348 B1

October 7th 2003

 

 

CLAIM


COMPARISON WITH OUR SEQUENCE

Y/N

 

A single chain insulin analogue compound of formula (I) having the properties of greater insulin receptor binding activity than proinsulin and less insulin receptor binding activity than insulin:

B chain -  X – A chain wherein:

 

General B – X – A chain single chain formula

Y

 

B and A chain are human insulin chains, respectively and,

 

 

Our B and A chain are human insulin chains although our A chain includes a modification (additional glycine)

 

N

 

 

X is a joining peptide of about 5 to 18 amino acids comprising the following sequence: Gly-Gly-Gly-Pro-Gly- Lys-Arg

 

Where the term ‘comprising’ is included, the patent requires that the specific sequence named MUST be part of the linker region.

 

Although our sequence is 12 amino acids long, it does not contain the ‘GGGPGLR’ identified in the patent

 

N

LEE ET AL.

Single Chain Insulin Analogs

Patent No: EP 1 193 272 B1

October 30th 2004

 

 

CLAIM


COMPARISON WITH OUR SEQUENCE

Y/N

 

A single chain insulin analogue compound of formula (I) having the properties of greater insulin receptor binding activity than prosinsulin and less insulin receptor binding activity than insulin:

 

B Chain – UI – Zn – Y – ZI – Un – A chain

 

 

 

B and A chain are human insulin chains respectively and

 

 

We have a modified A chain

N

 

U is an arginine or lysine residue

 

Our ‘U’ is glutamine

N

 

Z is a glycine

 

 

Z Is Glycine

Y

 

 

I is an integer of 2 – n

N is an integer of 0 or 2 and

 

The maximum size of the linker sequence when considering this is 9 amino acids. Since our sequence is 12 amino acids they are outside the scope

 

N

 

Y is glycine-proline-glycine, or alanine-proline-glycine-aspartic acid–valine, or tyrosine-proline-glycine-aspartic acid-valine, or histidine-proline-glycine-aspartic acid-valine.

 

 

 

Our sequence has no proline

 

N
3rd patent shite
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