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| − | $("select").change(function(){
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| − | <body>
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| − | <div class="row">
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| − | <select>
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| − | <option value="choose">Choose a patent</option>
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| − | <option value="1">Dimarchi et al. 2003</option>
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| − | <option value="2">Lee et al. 2003</option>
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| − | <option value="3">Lee et al. 2004</option>
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| − | <option value="4">Kjeldsen et al. 2004</option>
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| − | <option value="5">Weiss et al. 2009</option>
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| − | <option value="6">Stowell et al. 2012</option>
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| − | </select>
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| − | </div>
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| − | <div class="choose box">PATENT STUFF</div>
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| − | <div class="patent_1 box">
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p
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| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
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| − | normal"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">DIMARCHI
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| − | ET AL.<o:p></o:p></span></b></p>
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| − |
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Single Chain Insulin with high
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| − | bioactivity<o:p></o:p></span></p>
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| − |
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Patent No: <b style="mso-bidi-font-weight:
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| − | normal">US 9458,220 B2<o:p></o:p></b></span></p>
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| − |
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">October <span class="GramE">4<sup>th</sup></span>
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| − | 2016<o:p></o:p></span></p>
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| − |
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| − | <p class="MsoNormal"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − |
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| − | <table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="100%" style="width:100.0%;border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
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| − | mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt">
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| − | <tbody><tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;height:16.25pt">
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| − | <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;mso-border-alt:
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| − | solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">CLAIM<br style="mso-special-character:
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| − | line-break">
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| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
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| − | <!--[endif]--></span><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand"><o:p></o:p></span></p>
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| − | </td>
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| − | <td width="42%" style="width:42.66%;border:solid windowtext 1.0pt;border-left:
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| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><br>
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| − | COMPARISON WITH OUR SEQUENCE<br style="mso-special-character:line-break">
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| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
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| − | <!--[endif]--></span><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand"><o:p></o:p></span></p>
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| − | </td>
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| − | <td width="7%" style="width:7.42%;border:solid windowtext 1.0pt;border-left:
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| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">Y/N</span><span lang="EN-AU" style="font-size:11.0pt;font-family:Quicksand"><o:p></o:p></span></p>
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| − | </td>
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| − | </tr>
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| − | <tr style="mso-yfti-irow:1;height:70.1pt">
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| − | <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | padding:0cm 5.4pt 0cm 5.4pt;height:70.1pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black">A single chain insulin agonist analogue with stricture of B-LM-A
| |
| − | <span class="GramE">wherein</span> B represents an insulin B chain
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| − | comprising the sequence R<sub>22</sub>X<sub>25</sub>LCGX<sub>29</sub></span><sub><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
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| − | Helvetica;mso-bidi-font-family:Helvetica;color:black">…</span></sub><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
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| − | Times;color:black"> <sub> </sub>and A represents an insulin A chain
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| − | comprising the sequence<o:p></o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black">GIVX<sub>4</sub>X<sub>5</sub>CCX<sub>8</sub></span><sub><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
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| − | Helvetica;mso-bidi-font-family:Helvetica;color:black">…</span></sub><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
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| − | Times;color:black">-R<sub>13</sub> <br style="mso-special-character:line-break">
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| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
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| − | <!--[endif]--><o:p></o:p></span></p>
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| − | </td>
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| − | <td width="42%" style="width:42.66%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
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| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:70.1pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black">Both insulin A and B chains involve R groups which stand for
| |
| − | modifications <span class="SpellE">eg</span>. carboxylation. As our <span class="GramE">insulin</span> B chain does not contain any modifications (except
| |
| − | an additional glycine at the A chain), our construct is outside the patent<o:p></o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | </td>
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| − | <td width="7%" style="width:7.42%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
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| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:70.1pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black">N<o:p></o:p></span></p>
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| − | </td>
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| − | </tr>
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| − | <tr style="mso-yfti-irow:2;height:36.55pt">
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| − | <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
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| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | padding:0cm 5.4pt 0cm 5.4pt;height:36.55pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span class="GramE"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
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| − | Times;color:black">Furthermore</span></span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"> the linking moiety linking the <span class="SpellE">carboxy</span>
| |
| − | terminus of the B chain to the amino terminus of the A chain; further wherein
| |
| − | the linking moiety is an 8 amino acid sequence comprising of the sequence X<sub>51</sub>X<sub>52</sub>GSSSX<sub>57</sub>X<sub>58</sub>
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| − | wherein <br style="mso-special-character:line-break">
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| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
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| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black">X<sub>51</sub> = group consisting of glycine, alanine, valine,
| |
| − | leucine, isoleucine, isoleucine and ornithine <br style="mso-special-character:
| |
| − | line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black">X<sub>52</sub> = any amino acid other than tyrosine <br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black">X<sub>57</sub> and X<sub>58</sub> are independently selected
| |
| − | form the ground consisting of arginine, lysine and ornithine<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | </td>
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| − | <td width="42%" style="width:42.66%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
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| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:36.55pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><i><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></i></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black;mso-bidi-font-style:italic">Our amino acid sequence is squarely
| |
| − | outside the scope of 8 amino acids<i>.</i></span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black">Even if we did fall within the claim; we do not contain the <span class="GramE">8 amino</span> acid sequence using both potential orientations<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black">X<sub>51</sub> is glutamine or arginine in our sequence<o:p></o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black">B-chain </span><span lang="EN-AU" style="font-size:14.0pt;
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| − | font-family:Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
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| − | Helvetica;color:black">–</span><span lang="EN-AU" style="font-size:14.0pt;
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| − | font-family:Quicksand;mso-bidi-font-family:Times;color:black"> QR . . . RR </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica;color:black">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
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| − | Times;color:black"> A-chain</span><span lang="EN-AU" style="font-size:14.0pt;
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| − | font-family:Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
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| − | Helvetica;color:black"><o:p></o:p></span></p>
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| − | </td>
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| − | <td width="7%" style="width:7.42%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
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| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:36.55pt">
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black;mso-bidi-font-style:italic"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black;mso-bidi-font-style:italic"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black;mso-bidi-font-style:italic"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black;mso-bidi-font-style:italic"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black;mso-bidi-font-style:italic"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black;mso-bidi-font-style:italic">N<o:p></o:p></span></p>
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| − | </td>
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| − | </tr>
| |
| − | <tr style="mso-yfti-irow:3;height:52.55pt">
| |
| − | <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
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| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | padding:0cm 5.4pt 0cm 5.4pt;height:52.55pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black">The LM also requires the sequence of GAGSSSRR or a sequence that
| |
| − | differs from GAGSSRR by 1 or 2 amino acids<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black"><o:p> </o:p></span></p>
| |
| − | </td>
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| − | <td width="42%" style="width:42.66%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
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| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:52.55pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black">Our sequence is 12 amino acids long and differs by more than 4
| |
| − | amino acids.<o:p></o:p></span></p>
| |
| − | </td>
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| − | <td width="7%" style="width:7.42%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
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| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:52.55pt">
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| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
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| − | color:black">N<o:p></o:p></span></p>
| |
| − | </td>
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| − | </tr>
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| − | <tr style="mso-yfti-irow:4;mso-yfti-lastrow:yes;height:16.25pt">
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| − | <td width="49%" style="width:49.92%;border:solid windowtext 1.0pt;border-top:
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| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black">LM represents linking moiety linking the carboxyl terminus of
| |
| − | the B chain to the amino terminus of <span class="GramE">the a</span> chain,
| |
| − | wherein said linking moiety is an <span style="mso-bidi-font-weight:bold">8 amino
| |
| − | acid sequence</span> consisting of X<sub>51</sub>X<sub>52</sub>X<sub>53</sub>X<sub>54</sub>...
| |
| − | wherein X<sub>51</sub></span><span lang="EN-AU" style="font-size:14.0pt;
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| − | font-family:Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
| |
| − | Helvetica;color:black"> </span><span lang="EN-AU" style="font-size:14.0pt;
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| − | font-family:Quicksand;mso-bidi-font-family:Times;color:black">is selected
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| − | from the group consisting of glycine, alanine, valine, leucine, isoleucine
| |
| − | and proline</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Helvetica;
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| − | mso-fareast-font-family:Helvetica;mso-bidi-font-family:Helvetica;color:black">…</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:
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| − | Times;color:black"><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="42%" style="width:42.66%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
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| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black">Similarly, the patent claim is over an <span class="GramE">8 amino</span>
| |
| − | acid sequence. Applying the same principle our;<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
| |
| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black">X<sub>51</sub> is glutamine or arginine (depending on
| |
| − | orientation) and outside the scope<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="7%" style="width:7.42%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
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| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:16.25pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center;mso-pagination:none;
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| − | mso-layout-grid-align:none;text-autospace:none"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-bidi-font-family:Times;
| |
| − | color:black">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | </tbody></table>
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| − |
| |
| − |
| |
| − | </div>
| |
| − | <div class="patent_2 box">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
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| − |
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| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
| |
| − | normal"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">LEE ET
| |
| − | AL.<o:p></o:p></span></b></p>
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| − |
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Single Chain Insulin Analog and
| |
| − | a polynucleotide sequence encoding the <span class="SpellE">analog</span><o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Patent No: <b style="mso-bidi-font-weight:
| |
| − | normal">US 6,630,348 B1<o:p></o:p></b></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">October <span class="GramE">7<sup>th</sup></span>
| |
| − | 2003<o:p></o:p></span></p>
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| − |
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
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| − |
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| − | <table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="100%" style="width:100.0%;border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
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| − | mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt">
| |
| − | <tbody><tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;height:53.95pt">
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| − | <td width="50%" style="width:50.6%;border:solid windowtext 1.0pt;mso-border-alt:
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| − | solid windowtext .5pt;background:#A1C4C8;padding:0cm 5.4pt 0cm 5.4pt;
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| − | height:53.95pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
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| − | font-family:Quicksand"><o:p> </o:p></span></b></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
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| − | font-family:Quicksand">CLAIM<br style="mso-special-character:line-break">
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| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></b></p>
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| − | </td>
| |
| − | <td width="43%" style="width:43.1%;border:solid windowtext 1.0pt;border-left:
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| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | background:#A1C4C8;padding:0cm 5.4pt 0cm 5.4pt;height:53.95pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand"><br>
| |
| − | COMPARISON WITH OUR SEQUENCE<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></b></p>
| |
| − | </td>
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| − | <td width="6%" style="width:6.3%;border:solid windowtext 1.0pt;border-left:
| |
| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | background:#A1C4C8;padding:0cm 5.4pt 0cm 5.4pt;height:53.95pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand">Y/N<o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:1">
| |
| − | <td width="50%" style="width:50.6%;border:solid windowtext 1.0pt;border-top:
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| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | padding:0cm 5.4pt 0cm 5.4pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">A single chain insulin analogue
| |
| − | compound of formula (I) having the properties of greater insulin receptor
| |
| − | binding activity than proinsulin and less insulin receptor binding activity
| |
| − | than insulin:<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>B chain -<span style="mso-spacerun:yes"> </span>X </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand"> A chain wherein:</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica"><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="43%" style="width:43.1%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">General B </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> X </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand"> A chain single chain formula</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica"><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.3%;border-top:none;border-left:none;border-bottom:
| |
| − | solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top-alt:
| |
| − | solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
| |
| − | solid windowtext .5pt;background:#E2EFD9;mso-background-themecolor:accent6;
| |
| − | mso-background-themetint:51;padding:0cm 5.4pt 0cm 5.4pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Y<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:2">
| |
| − | <td width="50%" style="width:50.6%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B and A chain are human
| |
| − | insulin chains, respectively and,<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="43%" style="width:43.1%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Our B and A chain are human
| |
| − | insulin chains although our A chain includes a modification (additional
| |
| − | glycine)<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.3%;border-top:none;border-left:none;border-bottom:
| |
| − | solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top-alt:
| |
| − | solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
| |
| − | solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:3;mso-yfti-lastrow:yes;height:79.2pt">
| |
| − | <td width="50%" style="width:50.6%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:79.2pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">X is a joining peptide of
| |
| − | about 5 to 18 amino acids comprising the following sequence: <span class="SpellE">Gly</span>-<span class="SpellE">Gly</span>-<span class="SpellE">Gly</span>-Pro-<span class="SpellE">Gly</span>- Lys-<span class="SpellE">Arg</span><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="43%" style="width:43.1%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:79.2pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Where the term </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">‘</span><i style="mso-bidi-font-style:
| |
| − | normal"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">comprising</span></i><i style="mso-bidi-font-style:normal"><span lang="EN-AU" style="font-size:14.0pt;
| |
| − | font-family:Helvetica;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
| |
| − | Helvetica">’ </span></i><span lang="EN-AU" style="font-size:14.0pt;font-family:
| |
| − | Quicksand">is included, the patent requires</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica"> </span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand">that the specific sequence named MUST be part
| |
| − | of the linker region.<i style="mso-bidi-font-style:normal"><o:p></o:p></i></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Although our sequence is 12
| |
| − | amino acids long, it does not contain the </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica">‘</span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand">GGGPGLR</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica">’</span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand"> identified in the patent</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica"><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.3%;border-top:none;border-left:none;border-bottom:
| |
| − | solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;mso-border-top-alt:
| |
| − | solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:
| |
| − | solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:79.2pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | </tbody></table></div>
| |
| − | <div class="patent_3 box">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
| |
| − | normal"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">LEE ET
| |
| − | AL.<o:p></o:p></span></b></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Single Chain Insulin <span class="SpellE">Analogs</span><o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Patent No: <b style="mso-bidi-font-weight:
| |
| − | normal">EP 1 193 272 B1<o:p></o:p></b></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">October <span class="GramE">30<sup>th</sup></span>
| |
| − | 2004<o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − |
| |
| − | <table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="100%" style="width:100.0%;border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
| |
| − | mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt">
| |
| − | <tbody><tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;height:12.75pt">
| |
| − | <td width="48%" style="width:48.28%;border:solid windowtext 1.0pt;mso-border-alt:
| |
| − | solid windowtext .5pt;background:#BBB8EB;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand"><o:p> </o:p></span></b></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand">CLAIM<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.5%;border:solid windowtext 1.0pt;border-left:
| |
| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | background:#BBB8EB;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand"><br>
| |
| − | COMPARISON WITH OUR SEQUENCE<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.22%;border:solid windowtext 1.0pt;border-left:
| |
| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | background:#BBB8EB;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand">Y/N<o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:1;height:12.75pt">
| |
| − | <td width="48%" style="width:48.28%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">A single chain insulin
| |
| − | analogue compound of formula (I) having the properties of greater insulin
| |
| − | receptor binding activity than <span class="SpellE">prosinsulin</span> and less
| |
| − | insulin receptor binding activity than insulin:<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B Chain </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> U<sub>I</sub> </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> Z<sub>n</sub> </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> Y </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand"> Z<sub>I</sub> </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand"> U<sub>n </sub></span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand"> A chain</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica"><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.5%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.22%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#E2EFD9;mso-background-themecolor:
| |
| − | accent6;mso-background-themetint:51;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:2;height:14.15pt">
| |
| − | <td width="48%" style="width:48.28%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:14.15pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B and A chain are human
| |
| − | insulin chains respectively and<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.5%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:14.15pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">We have a modified A chain<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.22%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:14.15pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:3;height:18.35pt">
| |
| − | <td width="48%" style="width:48.28%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:18.35pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">U is an arginine or lysine
| |
| − | residue<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.5%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:18.35pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Our </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica">‘</span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand">U</span><span lang="EN-AU" style="font-size:14.0pt;
| |
| − | font-family:Quicksand;mso-fareast-font-family:Helvetica;mso-bidi-font-family:
| |
| − | Helvetica">’</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">
| |
| − | is glutamine<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.22%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:18.35pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:4;height:27.45pt">
| |
| − | <td width="48%" style="width:48.28%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:27.45pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Z is a glycine<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.5%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:27.45pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Z Is Glycine<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.22%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#E2EFD9;mso-background-themecolor:
| |
| − | accent6;mso-background-themetint:51;padding:0cm 5.4pt 0cm 5.4pt;height:27.45pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Y<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:5;height:12.75pt">
| |
| − | <td width="48%" style="width:48.28%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">I <span class="GramE">is</span>
| |
| − | an integer of 2 </span><span lang="EN-AU" style="font-size:14.0pt;font-family:
| |
| − | Quicksand;mso-fareast-font-family:Helvetica;mso-bidi-font-family:Helvetica">–
| |
| − | n<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N is an integer of 0 or 2 and<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.5%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">The maximum size of the linker
| |
| − | sequence when considering this is 9 amino acids. Since our sequence is 12
| |
| − | amino acids they are outside the scope<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.22%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:6;mso-yfti-lastrow:yes;height:58.85pt">
| |
| − | <td width="48%" style="width:48.28%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:58.85pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Y is glycine-<b style="mso-bidi-font-weight:normal">proline-</b>glycine, or alanine-<b style="mso-bidi-font-weight:normal">proline</b>-glycine-aspartic acid</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">–valine, or tyrosine-</span><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:14.0pt;
| |
| − | font-family:Quicksand">proline</span></b><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand">-glycine-aspartic acid-valine, or histidine-<b style="mso-bidi-font-weight:normal">proline</b>-glycine-aspartic acid-valine.<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.5%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:58.85pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Our sequence has no proline<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.22%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:58.85pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | </tbody></table></div>
| |
| − | <div class="patent_4 box">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
| |
| − | normal"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">KJELDSEN
| |
| − | ET AL.<o:p></o:p></span></b></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Single Chain insulin<o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Patent No:<b style="mso-bidi-font-weight:
| |
| − | normal"> EP 1692168 B1<o:p></o:p></b></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">December 3<sup>rd</sup>, 2004<o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − |
| |
| − | <table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="100%" style="width:100.0%;border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
| |
| − | mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt">
| |
| − | <tbody><tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;height:12.75pt">
| |
| − | <td width="48%" style="width:48.82%;border:solid windowtext 1.0pt;mso-border-alt:
| |
| − | solid windowtext .5pt;background:#FFF2CC;mso-background-themecolor:accent4;
| |
| − | mso-background-themetint:51;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand"><o:p> </o:p></span></b></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand">CLAIM<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.02%;border:solid windowtext 1.0pt;border-left:
| |
| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | background:#FFF2CC;mso-background-themecolor:accent4;mso-background-themetint:
| |
| − | 51;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand"><br>
| |
| − | COMPARISON WITH OUR SEQUENCE<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.16%;border:solid windowtext 1.0pt;border-left:
| |
| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | background:#FFF2CC;mso-background-themecolor:accent4;mso-background-themetint:
| |
| − | 51;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand">Y/N<o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:1;height:12.75pt">
| |
| − | <td width="48%" style="width:48.82%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | Single-chain insulin for treatment of type 1 diabetes and type 2 diabetes
| |
| − | having the formula<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span class="GramE"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B(</span></span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">1-26)- X<sub>1</sub>
| |
| − | - X<sub>2</sub> - X<sub>3</sub>- X<sub>4</sub>- A (1-21),<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br style="mso-special-character:
| |
| − | line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.02%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B - linker - A formula<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.16%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#E2EFD9;mso-background-themecolor:
| |
| − | accent6;mso-background-themetint:51;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Y<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:2;height:12.75pt">
| |
| − | <td width="48%" style="width:48.82%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | <span class="GramE">B(</span>1-26) is a peptide chain <b style="mso-bidi-font-weight:
| |
| − | normal">consisting of the first 26 amino acid residues of the B chain of
| |
| − | human insulin</b> counted from the N-terminal end of the B chain or an
| |
| − | analogue of the B-chain with one addition or one deletion of one of the amino
| |
| − | acid residues in the B-chain or derivative of the B-chain being chemically
| |
| − | modified by introducing a group in the side chain in one or more positions of
| |
| − | the B-chain or by oxidation or reduction of the side chains of the amino
| |
| − | acids residues in the B-chain,<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.02%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | Our B chain consists of 28 AA. Although the patents contain different
| |
| − | versions <span class="SpellE">eg</span> </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:Helvetica;
| |
| − | mso-bidi-font-family:Helvetica">‘</span><span lang="EN-AU" style="font-size:
| |
| − | 14.0pt;font-family:Quicksand">an analogue of the B-chain with one addition or
| |
| − | deletion</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;
| |
| − | mso-fareast-font-family:Helvetica;mso-bidi-font-family:Helvetica">’</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> the total length of the
| |
| − | B-chain must STILL be 26AA.<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.16%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:3;height:12.75pt">
| |
| − | <td width="48%" style="width:48.82%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;color:black;mso-themecolor:
| |
| − | text1"><br>
| |
| − | and <span class="GramE">A(</span>1-21) is the natural insulin A chain or an
| |
| − | analogue thereof with one addition or one deletion of one of the amino acid
| |
| − | residues in the A-chain or derivative of the A-chain being chemically
| |
| − | modified by introducing a group in the side chain in one or more positions of
| |
| − | the A-chain or by oxidation or reduction of the side chains of the amino
| |
| − | acids residues in the A-chain, wherein<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--></span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.02%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">In our sequence construct </span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">–</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> the A chain is 22 amino acids
| |
| − | long. Just like in the B-chain (it only covers a TOTAL of 21 AA). Even though
| |
| − | our A chain contains the addition of an amino acid (glycine), the length is
| |
| − | too long for the patent to operate over.<b style="mso-bidi-font-weight:normal"><o:p></o:p></b></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.16%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:4;height:12.75pt">
| |
| − | <td width="48%" style="width:48.82%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | X<sub>4 </sub>does not contain two adjacent basic amino acid residues and
| |
| − | wherein the single-chain insulin has an affinity to the human insulin
| |
| − | receptor of at least about 20% of that of human insulin if the single-chain
| |
| − | insulin molecule is not chemically modified by acylation.<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.02%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">We have 2 adjacent basic amino
| |
| − | acid residues and the affinity cannot be tested<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.16%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:5;height:15.55pt">
| |
| − | <td width="48%" style="width:48.82%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:15.55pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | wherein X<sub>1</sub> is <span class="SpellE">Thr</span>, Lys or <span class="SpellE">Arg</span><br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.02%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.55pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | X<sub>1</sub> is glutamine<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.16%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:15.55pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:6;height:12.75pt">
| |
| − | <td width="48%" style="width:48.82%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | X<sub>2</sub> is Pro, Lys or Asp,<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.02%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | X<sub>2 </sub>is arginine<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.16%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:7;height:12.75pt">
| |
| − | <td width="48%" style="width:48.82%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | X<sub>3</sub> is Lys, Pro or <span class="SpellE">Glu</span>,<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.02%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">X<sub>3</sub> is glycine<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.16%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:8;mso-yfti-lastrow:yes;height:12.75pt">
| |
| − | <td width="48%" style="width:48.82%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">X<sub>4</sub> is a
| |
| − | peptide sequence with the following formula <span class="SpellE">X<sub>a</sub>-X<sub>b</sub>-X<sub>c</sub>-X<sub>d</sub>-X<sub>e</sub>-X<sub>f</sub>X<sub>g</sub></span> (SEQ
| |
| − | ID NO:129) wherein<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpFirst" align="center" style="text-align:center"><span class="SpellE"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:
| |
| − | EN-GB">X<sub>a</sub></span></span><span style="font-size:14.0pt;font-family:
| |
| − | Quicksand;mso-ansi-language:EN-GB"> is selected from the group
| |
| − | consisting of L, R, T, A, H, Q, G, S and V;<o:p></o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:EN-GB"><o:p> </o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span class="SpellE"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:
| |
| − | EN-GB">X<sub>b</sub></span></span><span style="font-size:14.0pt;font-family:
| |
| − | Quicksand;mso-ansi-language:EN-GB"> is selected from the group
| |
| − | consisting of W, G, S, A, H, R, and T;<o:p></o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:EN-GB"><o:p> </o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span class="SpellE"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:
| |
| − | EN-GB">X<sub>c</sub></span></span><span style="font-size:14.0pt;font-family:
| |
| − | Quicksand;mso-ansi-language:EN-GB"> is selected from the group
| |
| − | consisting of L, Y, M, H, R, T, Q, K, V, S, A, G and P;<o:p></o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:EN-GB"><o:p> </o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span class="SpellE"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:
| |
| − | EN-GB">X<sub>d</sub></span></span><span style="font-size:14.0pt;font-family:
| |
| − | Quicksand;mso-ansi-language:EN-GB"> is selected from the group
| |
| − | consisting of R, A, Y, M, S, N, H, and G;<o:p></o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span class="SpellE"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:
| |
| − | EN-GB">X<sub>e</sub></span></span><span style="font-size:14.0pt;font-family:
| |
| − | Quicksand;mso-ansi-language:EN-GB"> is selected from the group
| |
| − | consisting of S, R, A, T, K, P, N, M, H, Q, V, and G;<o:p></o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:EN-GB"><o:p> </o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span class="SpellE"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:
| |
| − | EN-GB">X<sub>f</sub></span></span><span style="font-size:14.0pt;font-family:
| |
| − | Quicksand;mso-ansi-language:EN-GB"> is selected from the group
| |
| − | consisting of G and A; and<o:p></o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpMiddle" align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:EN-GB"><o:p> </o:p></span></p>
| |
| − | <p class="MsoListParagraphCxSpLast" align="center" style="text-align:center"><span class="SpellE"><span style="font-size:14.0pt;font-family:Quicksand;mso-ansi-language:
| |
| − | EN-GB">X<sub>g</sub></span></span><span style="font-size:14.0pt;font-family:
| |
| − | Quicksand;mso-ansi-language:EN-GB"> is selected from the group
| |
| − | consisting of K, R, P, H, F, T, I, Q, W, and A,<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.02%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">The total linker length that
| |
| − | can be formulated from <span class="SpellE">X<sub>a</sub></span><sub> </sub>– <span class="SpellE">X<sub>g</sub></span> is 7 amino acids with the three other
| |
| − | residues for X<sub>1</sub> – X<sub>3</sub>. This totals to a maximum linker
| |
| − | length of 10 amino acids. Our linker is <b style="mso-bidi-font-weight:normal">12
| |
| − | amino</b> acids long.<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.16%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | </tbody></table>
| |
| − | </div>
| |
| − | <div class="patent_5 box">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
| |
| − | normal"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">WEISS
| |
| − | ET AL.<o:p></o:p></span></b></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Fibrillation-resistant insulin
| |
| − | and insulin analogues <br>
| |
| − | Patent No: <b style="mso-bidi-font-weight:normal">EP 2074140 B1</b><o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">April 6th, 2009<o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − |
| |
| − | <table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="100%" style="width:100.0%;border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
| |
| − | mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt">
| |
| − | <tbody><tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;height:55.45pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;mso-border-alt:
| |
| − | solid windowtext .5pt;background:#A1C4C8;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:55.45pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand"><o:p> </o:p></span></b></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand">CLAIM<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border:solid windowtext 1.0pt;border-left:
| |
| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | background:#A1C4C8;padding:0cm 5.4pt 0cm 5.4pt;height:55.45pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand"><br>
| |
| − | COMPARISON WITH OUR SEQUENCE<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border:solid windowtext 1.0pt;border-left:
| |
| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | background:#A1C4C8;padding:0cm 5.4pt 0cm 5.4pt;height:55.45pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:normal"><span lang="EN-AU" style="font-size:15.0pt;
| |
| − | font-family:Quicksand">Y/N<o:p></o:p></span></b></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:1;height:86.8pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:86.8pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">An insulin analogue comprising
| |
| − | a single chain polypeptide containing an insulin A-chain polypeptide and an
| |
| − | insulin B-chain polypeptide connected by a truncated linker,<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:86.8pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Our linker is truncated from
| |
| − | the entire C-peptide to 12 amino acids and has the general formula of B-X-A
| |
| − | where our linker is<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">QRGGGSGGGQRR<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" rowspan="2" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#E2EFD9;mso-background-themecolor:
| |
| − | accent6;mso-background-themetint:51;padding:0cm 5.4pt 0cm 5.4pt;height:86.8pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Y<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:2;height:8.6pt">
| |
| − | <td width="93%" colspan="2" style="width:93.82%;border:solid windowtext 1.0pt;
| |
| − | border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:8.6pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">wherein the truncated linker
| |
| − | is a polypeptide selected from the group consisting of:<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:3;height:12.05pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.05pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">a polypeptide having the
| |
| − | sequence GGGPRR<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.05pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">No proline<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.05pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:4;height:12.75pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">a polypeptide having the
| |
| − | sequence GGPRR<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">No proline<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:5;height:5.05pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:5.05pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">a polypeptide having the
| |
| − | sequence GSEQRR<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:5.05pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">No glutamate<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:5.05pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:6;height:12.75pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">a polypeptide having the
| |
| − | sequence RREQR<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">No glutamate<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:7;height:12.75pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">a polypeptide having the
| |
| − | sequence RREALQKR<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">No glutamate<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:8;height:27.45pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:27.45pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">a polypeptide having the
| |
| − | sequence GAGPRR<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:27.45pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">No proline<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:27.45pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:9;height:12.75pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">a polypeptide having the
| |
| − | sequence GPRR<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">No proline<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:10;height:30.95pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:30.95pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">wherein the insulin B-chain
| |
| − | polypeptide optionally contains one or more of:<br style="mso-special-character:
| |
| − | line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">an aspartate substitution at
| |
| − | the position corresponding to position B10 of insulin,<br style="mso-special-character:
| |
| − | line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">a lysine or an aspartate
| |
| − | substitution at the position corresponding to position B28 of insulin, and<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">a proline substitution at the
| |
| − | position corresponding to position B29 of insulin<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.95pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Our B-chain is native human
| |
| − | insulin<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:30.95pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:11;mso-yfti-lastrow:yes;height:12.75pt">
| |
| − | <td width="47%" style="width:47.74%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><br>
| |
| − | and wherein the insulin A-chain polypeptide contains a histidine substitution
| |
| − | at the position corresponding to position A8 of insulin.<br style="mso-special-character:
| |
| − | line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="46%" style="width:46.08%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Our A-chain does not contain
| |
| − | the relevant substitution and only an additional glycine<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.18%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | </tbody></table> </div>
| |
| − | <div class="patent_6 box">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
| |
| − | normal"><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand">STOWELL
| |
| − | ET AL.</span></b><span lang="EN-AU" style="font-size:20.0pt;font-family:Quicksand"><o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Chemically and thermodynamically
| |
| − | stable insulin analogues and improved<o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">methods for their production<o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">Patent No: <b style="mso-bidi-font-weight:
| |
| − | normal">US 9006176 B2</b><o:p></o:p></span></p>
| |
| − |
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:16.0pt;font-family:Quicksand">October <span class="GramE">16<sup>th</sup></span>
| |
| − | 2012<o:p></o:p></span></p>
| |
| − |
| |
| − | <table class="MsoTableGrid" border="1" cellspacing="0" cellpadding="0" width="100%" style="width:100.0%;border-collapse:collapse;border:none;mso-border-alt:solid windowtext .5pt;
| |
| − | mso-yfti-tbllook:1184;mso-padding-alt:0cm 5.4pt 0cm 5.4pt">
| |
| − | <tbody><tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;height:14.85pt">
| |
| − | <td width="48%" style="width:48.32%;border:solid windowtext 1.0pt;mso-border-alt:
| |
| − | solid windowtext .5pt;background:#BBB8EB;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:14.85pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">CLAIM<br style="mso-special-character:
| |
| − | line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.14%;border:solid windowtext 1.0pt;border-left:
| |
| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | background:#BBB8EB;padding:0cm 5.4pt 0cm 5.4pt;height:14.85pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand"><br>
| |
| − | COMPARISON WITH OUR SEQUENCE<br style="mso-special-character:line-break">
| |
| − | <!--[if !supportLineBreakNewLine]--><br style="mso-special-character:line-break">
| |
| − | <!--[endif]--><o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.54%;border:solid windowtext 1.0pt;border-left:
| |
| − | none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | background:#BBB8EB;padding:0cm 5.4pt 0cm 5.4pt;height:14.85pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:15.0pt;font-family:Quicksand">Y/N<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:1;height:12.75pt">
| |
| − | <td width="48%" style="width:48.32%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">A single chain insulin (SCI)
| |
| − | compound of formula a(I):<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B chain - C</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">’</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> – A Chain (Formula (I))<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">having the properties of
| |
| − | higher affinity for the insulin receptor and lower affinity for the IGF-1
| |
| − | receptor as compared to those of native proinsulin with chemical and
| |
| − | thermodynamic degradation profiles such that the SCI can be formulated and
| |
| − | stored for extended periods of time without refrigeration;<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.14%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Correct linker formulation of
| |
| − | B-linker-A<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.54%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#E2EFD9;mso-background-themecolor:
| |
| − | accent6;mso-background-themetint:51;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Y<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:2;height:12.75pt">
| |
| − | <td width="48%" style="width:48.32%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">W herein B chain and A chain
| |
| − | are modified human insulin chains; and<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.14%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.54%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#E2EFD9;mso-background-themecolor:
| |
| − | accent6;mso-background-themetint:51;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Y<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | </tr>
| |
| − | <tr style="mso-yfti-irow:3;height:12.75pt">
| |
| − | <td width="48%" style="width:48.32%;border:solid windowtext 1.0pt;border-top:
| |
| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
| |
| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">Wherein C</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand;mso-fareast-font-family:
| |
| − | Helvetica;mso-bidi-font-family:Helvetica">’</span><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"> covalently links the
| |
| − | C-terminus of the B chain to the N-terminus of the A chain, and is a peptide
| |
| − | of 5 amino acids comprising the following sequence: Y-P-G-D-X (SEQ ID NO: 1);
| |
| − | wherein X is any amino acid;<o:p></o:p></span></p>
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
| |
| − | </td>
| |
| − | <td width="45%" style="width:45.14%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">No proline (P) and no aspartic
| |
| − | acid (D)<o:p></o:p></span></p>
| |
| − | </td>
| |
| − | <td width="6%" style="width:6.54%;border-top:none;border-left:none;
| |
| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
| |
| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
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| − | </td>
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| − | </tr>
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| − | <tr style="mso-yfti-irow:4;mso-yfti-lastrow:yes;height:12.75pt">
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| − | <td width="48%" style="width:48.32%;border:solid windowtext 1.0pt;border-top:
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| − | none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt:solid windowtext .5pt;
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| − | padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">wherein the B chain is
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| − | modified from a native human insulin B chain (SEQ ID NO:11), and A chain is
| |
| − | modified from a native human insulin A chain (SEQ ID NO:10), wherein the
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| − | modifications comprise one or more mutations at<o:p></o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">(1) Gln5, Gln15, Asn18, or
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| − | Asn21 of SEQ ID NO:10, or<o:p></o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">(2) Asn3 or Gln5 of SEQ ID
| |
| − | NO:11; resulting in enhanced resistance to <span class="SpellE">deamidation</span>.<o:p></o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − | </td>
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| − | <td width="45%" style="width:45.14%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
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| − | mso-border-alt:solid windowtext .5pt;padding:0cm 5.4pt 0cm 5.4pt;height:12.75pt">
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand"><o:p> </o:p></span></p>
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| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">B is not modified and A chain
| |
| − | does not have similar modifications, rather an addition at residue 1 without
| |
| − | the purpose of resisting deamination.<o:p></o:p></span></p>
| |
| − | </td>
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| − | <td width="6%" style="width:6.54%;border-top:none;border-left:none;
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| − | border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;
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| − | mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowtext .5pt;
| |
| − | mso-border-alt:solid windowtext .5pt;background:#FFC8CD;padding:0cm 5.4pt 0cm 5.4pt;
| |
| − | height:12.75pt">
| |
| − | <p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-AU" style="font-size:14.0pt;font-family:Quicksand">N<o:p></o:p></span></p>
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| − | </td>
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| − | </tr>
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| − | </tbody></table> </div>
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