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Revision as of 19:49, 28 July 2017

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Delaware

Harvard OPTI POLY
udel-igem {{Delaware}}

University of Delaware's First iGEM Team!

Project Description

Targeted Microbiome Manipulations

The gut microbiome is an exciting field of research that has increased exponentially across the past few years. Many studies have found a correlation between imbalances in the gut microbiome and disease states, such as Autism Spectrum Disorder (One such research project at the University of Delaware). To simply ask if altering the gut microbiome can alter or affect a disease state in any way, methods are required for targeted microbiome manipulations that allow researchers or clinicians to modulate the populations of specific microbes within a microbiome. The human gut microbiome is home to what is estimated to be near 1000 microbial species. The goal of our project is to take a genetic engineering approach in vitro to develop methods towards gut microbiome therapeutics that can be more targeted than broad spectrum antibiotics.

The goal of our project is to overexpress bacteriocin genes (toxins that bacteria produce that affect other bacteria) in E. coli in order to develop a dose dependent relationship with multiple bacteriocins and indicator strains known to be sensitive to these bacteriocins. The long term goal and rationale for our methodoly this year is to determine how to make E. coli overexpress bacteriocins in order to
1. kill specific indicator strains relevant to the human gut microbiome
2. answer questions similar to "how much of a specific bacteriocin is needed to reduce the abundance of a single microbe by 60%?"
Our intention is to develop these methods in E. coli and generate data that will be used in computational modeling and future experimental projects towards developing gut microbiome therapeutics.

General Wiki Information (kept for now for reference)

Before you start:

Please read the following pages:

Before you start:

Please read the following pages:

Styling your wiki

You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.

While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.

Wiki template information

We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!

Editing your wiki

On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!

Use WikiTools - Edit in the black menu bar to edit this page

Tips

This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:

  • State your accomplishments! Tell people what you have achieved from the start.
  • Be clear about what you are doing and how you plan to do this.
  • You have a global audience! Consider the different backgrounds that your users come from.
  • Make sure information is easy to find; nothing should be more than 3 clicks away.
  • Avoid using very small fonts and low contrast colors; information should be easy to read.
  • Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2017 calendar
  • Have lots of fun!
Inspiration

You can also view other team wikis for inspiration! Here are some examples:

Uploading pictures and files

You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to
T--YourOfficialTeamName--NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)

UPLOAD FILES

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<a href="https://madcal.wixsite.com/udel-igem" target="_self">University of Delaware </a>


<a href="https://madcal.wixsite.com/udel-igem" target="_self">iGem Team 2017</a>


           


           


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Project Description 

The gut microbiome is an exciting field of research that has increased exponentially across the past few years. Many studies have found a correlation between imbalances in the gut microbiome and disease states, such as Autism Spectrum Disorder (<a href="http://www1.udel.edu/udaily/2013/mar/engineering-autism-030413.html" target="_blank" rel="nofollow">One such research project at the University of Delaware</a>). To simply ask if altering the gut microbiome can alter or affect a disease state in any way, methods are required for targeted microbiome manipulations that allow researchers or clinicians to modulate the populations of specific microbes within a microbiome. The human gut microbiome is home to what is estimated to be near 1000 microbial species. The goal of our project is to take a genetic engineering approach in vitro to develop methods towards gut microbiome therapeutics that can be more targeted than broad spectrum antibiotics. 

The goal of our project is to overexpress bacteriocin genes (toxins that bacteria produce that affect other bacteria) in E. coli in order to develop a dose dependent relationship with multiple bacteriocins and indicator strains known to be sensitive to these bacteriocins. The long term goal and rationale for our methodoly this year is to determine how to make E. coli overexpress bacteriocins in order to 
1. kill specific indicator strains relevant to the human gut microbiome 
2. answer questions similar to "how much of a specific bacteriocin is needed to reduce the abundance of a single microbe by 60%?" 
Our intention is to develop these methods in E. coli and generate data that will be used in computational modeling and future experimental projects towards developing gut microbiome therapeutics.


 


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"Capturing the moments of today that will wow your heart tomorrow"


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Let's talk

500 Terry Francois St. 

San Francisco, CA 94158

Tel: 123-456-7890 

info@mysite.com

 


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