(29 intermediate revisions by 4 users not shown) | |||
Line 40: | Line 40: | ||
<div class="nav-collapse collapse"> | <div class="nav-collapse collapse"> | ||
<ul class="nav"> | <ul class="nav"> | ||
− | + | <li><a href="https://2017.igem.org/Team:Georgia_State" class="active">Home</a></li> | |
+ | <li class="dropdown-submenu"> | ||
+ | <a class="dropdown-toggle" data-toggle="dropdown">Team | ||
+ | <ul class="dropdown-menu"> | ||
<li><a href="https://2017.igem.org/Team:Georgia_State/Team">Team</a></li> | <li><a href="https://2017.igem.org/Team:Georgia_State/Team">Team</a></li> | ||
− | <li | + | <li><a href="https://2017.igem.org/Team:Georgia_State/Attributions">Attributions</a></li> |
− | + | </ul> | |
− | + | </li> | |
− | + | ||
− | + | <li class="dropdown-submenu"> | |
− | + | <a class="dropdown-toggle" data-toggle="dropdown">Project | |
− | + | <ul class="dropdown-menu"> | |
− | + | ||
− | + | <li><a href=" https://2017.igem.org/Team:Georgia_State/Description">Description</a></li> | |
− | + | <li><a href="https://2017.igem.org/Team:Georgia_State/Results">Results</a></li> | |
− | + | <li><a href="https://2017.igem.org/Team:Georgia_State/Collaborations">Collaborations</a></li> | |
− | + | ||
− | + | </ul> | |
− | + | </li> | |
− | + | ||
− | + | <li class="dropdown-submenu"> | |
− | + | <a class="dropdown-toggle" data-toggle="dropdown">Parts | |
− | + | <ul class="dropdown-menu"> | |
− | + | <li><a href="https://2017.igem.org/Team:Georgia_State/Parts">Parts</a></li> | |
− | + | <li><a href="https://2017.igem.org/Team:Georgia_State/Design">Design</a></li> | |
− | + | <li><a href="https://2017.igem.org/Team:Georgia_State/Contribution">Contribution</a></li> | |
− | + | <li><a href="https://2017.igem.org/Team:Georgia_State/Improve">Improvement</a></li> | |
− | + | </ul> | |
− | + | </li> | |
− | + | <li><a href="https://2017.igem.org/Team:Georgia_State/Safety">Safety</a></li> | |
− | + | ||
− | + | <li class="dropdown-submenu"> | |
− | + | <a class="dropdown-toggle" data-toggle="dropdown">Notebook | |
− | + | <ul class="dropdown-menu"> | |
+ | <li><a href="https://2017.igem.org/Team:Georgia_State/Notebook">Notebook</a></li> | ||
+ | <li><a href="https://2017.igem.org/Team:Georgia_State/Experiments">Experiments</a></li> | ||
+ | </ul> | ||
+ | </a> | ||
+ | </li> | ||
+ | |||
+ | , <li class="dropdown-submenu"> | ||
+ | <a class="dropdown-toggle" data-toggle="dropdown">Human Practices | ||
+ | <ul class="dropdown-menu"> | ||
+ | <li><a href="https://2017.igem.org/Team:Georgia_State/Engagement">Public Engagement</a></li> | ||
+ | <li><a href="https://2017.igem.org/Team:Georgia_State/HP/Silver">Silver</a></li> | ||
+ | <li><a href="https://2017.igem.org/Team:Georgia_State/HP/Gold_Integrated">Integrated and Gold</a> | ||
+ | <ul><a href="https://2017.igem.org/Team:Georgia_State/HP/ASL">ASL Gallery</a></ul> | ||
+ | </li> | ||
+ | </ul> | ||
+ | </a> | ||
+ | </li> | ||
+ | |||
+ | <li><a href="https://igem.org/2017_Judging_Form?team=Georgia_State">Judging</a></li> | ||
+ | </div> | ||
<!--/.nav-collapse --> | <!--/.nav-collapse --> | ||
</div> | </div> | ||
Line 76: | Line 99: | ||
<label> | <label> | ||
<select class="selectnav"onChange="window.location.href=this.value"> | <select class="selectnav"onChange="window.location.href=this.value"> | ||
− | <option value=" | + | <option value="/Team:Georgia_State">Home</option> |
− | <option value=" | + | <option value="/Team:Georgia_State/Team">Team</option> |
− | <option value=" | + | <option value="/Team:Georgia_State/Attributions">Attributions</option> |
− | <option value=" | + | <option value="/Team:Georgia_State/Results">Results</option> |
− | <option value=" | + | <option value="/Team:Georgia_State/Collaborations">Collaborations</option> |
− | <option value=" | + | <option value="/Team:Georgia_State/Parts">Parts</option> |
− | <option value=" | + | <option value="/Team:Georgia_State/Description">Description</option> |
− | <option value=" | + | <option value="/Team:Georgia_State/Design">Design</option> |
+ | <option value="/Team:Georgia_State/Contribution">Contribution</option> | ||
+ | <option value="/Team:Georgia_State/Improvement">Improve</option> | ||
+ | <option value="/Team:Georgia_State/Safety">Safety</option> | ||
+ | <option value="/Team:Georgia_State/Notebook">Notebook</option> | ||
+ | <option value="/Team:Georgia_State/Experiments">Experiments</option> | ||
+ | <option value="/Team:Georgia_State/Engagement">Public Engagement</option> | ||
+ | <option value="/Team:Georgia_State/HP/Silver">Silver</option> | ||
+ | <option value="/Team:Georgia_State/HP/Gold_Integrated">Gold and Integrated</option> | ||
+ | <option value="/Team:Georgia_State/HP/ASL">ASL Gallery</option> | ||
<option value="https://igem.org/2017_Judging_Form?team=Georgia_State">Judging</option> | <option value="https://igem.org/2017_Judging_Form?team=Georgia_State">Judging</option> | ||
</select> | </select> | ||
Line 106: | Line 138: | ||
<div class="span5 offset1"> | <div class="span5 offset1"> | ||
<div class="block"> | <div class="block"> | ||
− | <h1> | + | <h1>A Novel Synthesis of Factor C</h1> |
− | <h2> | + | <h2>A Story of Blood and Venom</h2> |
</div> | </div> | ||
</div> | </div> | ||
Line 124: | Line 156: | ||
<div class="featured-blocks"> | <div class="featured-blocks"> | ||
<div class="row-fluid"> | <div class="row-fluid"> | ||
− | <div class=" | + | <div class="span6"> |
<div class="media"> | <div class="media"> | ||
<a class="pull-left" href="#"> | <a class="pull-left" href="#"> | ||
Line 133: | Line 165: | ||
<div class="ruler-bottom"></div> | <div class="ruler-bottom"></div> | ||
<p class="spacing-t"> | <p class="spacing-t"> | ||
− | Mambalgin is a potent analgesic protein found in the venom of the Black Mamba snake (Dendroaspis polylepis). This protein has been found to inhibit acid-sensing ion channels (ASICs) in the central and peripheral nervous systems of mice through | + | Mambalgin is a potent analgesic protein found in the venom of the Black Mamba snake (Dendroaspis polylepis). This protein has been found to inhibit acid-sensing ion channels (ASICs) in the central and peripheral nervous systems of mice through intraplantar and intrathecal injections. We are using the expression of mambalgin (the subject of last year's GSU team project) to assess our ability to produce, purify, and detect new recombinant fusion proteins with a glutathione-s-transferase tag. </p> |
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
<a href="https://2017.igem.org/Team:Georgia_State/Description" class="btn">more</a> | <a href="https://2017.igem.org/Team:Georgia_State/Description" class="btn">more</a> | ||
</div> | </div> | ||
</div> | </div> | ||
</div> | </div> | ||
− | <div class=" | + | <div class="span6"> |
<div class="media"> | <div class="media"> | ||
<a class="pull-left" href="#"> | <a class="pull-left" href="#"> | ||
Line 159: | Line 176: | ||
</a> | </a> | ||
<div class="media-body"> | <div class="media-body"> | ||
− | <h1 class="media-heading">Horseshoe Crab Factor | + | <h1 class="media-heading">Horseshoe Crab Factor C</h1> |
<div class="ruler-bottom"></div> | <div class="ruler-bottom"></div> | ||
− | <p class="spacing-t">We | + | <p class="spacing-t">Horseshoe crab blood is used in a test to detect bacterial contamination in medical solutions and devices. We propose to replace this test with a synthetic protein consisting of human chorionic gonadotropin fused to factor C, the protein that activates the coagulation response in horseshoe crab blood. Using this fusion protein and a simple pregnancy test strip we hope to create a system to detect gram negative |
bacteria without the harvesting of horseshoe crabs. | bacteria without the harvesting of horseshoe crabs. | ||
</p> | </p> |
Latest revision as of 02:39, 2 November 2017
Georgia State University
A Novel Synthesis of Factor C
A Story of Blood and Venom
We’re Doing It #TheStateWay
Located at the heart of Downtown Atlanta, Georgia, GSU is among the top 20 most innovative institutions in the USA.
Mambalgin
Mambalgin is a potent analgesic protein found in the venom of the Black Mamba snake (Dendroaspis polylepis). This protein has been found to inhibit acid-sensing ion channels (ASICs) in the central and peripheral nervous systems of mice through intraplantar and intrathecal injections. We are using the expression of mambalgin (the subject of last year's GSU team project) to assess our ability to produce, purify, and detect new recombinant fusion proteins with a glutathione-s-transferase tag.
moreHorseshoe Crab Factor C
Horseshoe crab blood is used in a test to detect bacterial contamination in medical solutions and devices. We propose to replace this test with a synthetic protein consisting of human chorionic gonadotropin fused to factor C, the protein that activates the coagulation response in horseshoe crab blood. Using this fusion protein and a simple pregnancy test strip we hope to create a system to detect gram negative bacteria without the harvesting of horseshoe crabs.
moreContact
Kell Hall Rm# 439, 24 Peachtree Center Ave SE, Atlanta, Georgia 30303