Difference between revisions of "Team:UPMC PARIS"

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<h1> The BioMaker Factory, Synthetic biology for access to care </h1>
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<h1> The BioMaker Factory, Synthetic biology for access to health care </h1>
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The biomarker factory project began from the alarming observation that over 150 000 people around the word die from venomous snakebites. Yet, there already exists safe and effective treatments which lead to a complete recovery. Unfortunately, those accidents mainly occur in developing countries in which the population cannot easily afford such expensive treatments.  
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<span style="display:inline-block; width: 20px;"></span> Realizing that the lack of access to health care is a major problem in developing countries, we decided to create an automated user-friendly mobile factory able to produce therapeutic molecules for multiple diseases. A heterologous recombinant protein expression system will make E. coli bacteria produce antigen-binding (Fab) fragments of antibodies under an optogenetic regulation thus the production. Our smart box will automatically manage the expression of active biological substances as well as their purification thanks to a computer that will control every step through a software specially designed for our box.
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Therefore, through our first project called “Antivenom box”, we wanted to facilitate the antivenom access to the people in need that are often far from any hospital or facility providing these treatments.
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“The BioMaker Factory” will be available to humanitarian organizations and local facilities to tackle the lack of access to health care in areas in need.  
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However, it became obvious to us that the lack of antivenom in these countries was in fact part of a much bigger problem: the lack of access to health care. Thus, we decided to adapt our project according to this issue and renamed it “The Biomarker Factory”.
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The BioMaker Factory is a miniaturized mobile factory able to produce therapeutic molecules for multiple diseases. To do so, we have used a heterologous recombinant protein expression system, which synthesizes the active ingredients within a completely automated smart box that can manage the expression of the active ingredients as well as their purification.
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Thanks to the BioBricks system and the work currently done by researchers and industries to develop bioproduction, we are now confident that “The BioMaker Factory” will offer a wide range of applications.
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Hence, our project can be split in two facets:
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On one hand, it’s an efficient and innovative biological system that can make E. coli bacteria express Fab antibodies. This expression would be accurately regulated by the light through an optogenetic system.
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On another hand, it’s a complex engineering system. Indeed, our smart box will contain a bioreactor and all the needed elements to purify the Fab antibodies. Everything will be under computer control thanks to a software specially designed for our box.
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Our  final purpose for “The Biomaker Factory” is to be as simple as possible to operate so it can easily and safely be used by everyone, maybe even by kids! Thus, we consider to make it available to humanitarian organizations and local facilities to tackle the lack of health care in areas in need.
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Thanks to the Biobrick system and the work currently done by searchers and industries to develop the bioproduction, we are confident that “The Biomaker Factory” will offer a large range of applications. By easing the access to synthetic biology, it could stimulate everyone’s creativity and may even lead to new discoveries!
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Revision as of 00:54, 2 September 2017

Impact UPMC

The BioMaker Factory, Synthetic biology for access to health care


Realizing that the lack of access to health care is a major problem in developing countries, we decided to create an automated user-friendly mobile factory able to produce therapeutic molecules for multiple diseases. A heterologous recombinant protein expression system will make E. coli bacteria produce antigen-binding (Fab) fragments of antibodies under an optogenetic regulation thus the production. Our smart box will automatically manage the expression of active biological substances as well as their purification thanks to a computer that will control every step through a software specially designed for our box.

“The BioMaker Factory” will be available to humanitarian organizations and local facilities to tackle the lack of access to health care in areas in need.


Thanks to the BioBricks system and the work currently done by researchers and industries to develop bioproduction, we are now confident that “The BioMaker Factory” will offer a wide range of applications.

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