Difference between revisions of "Team:Warwick"

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      <h1>Blueprint 361</h1>
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      <p style="color:#99b3e6">Revolutionising Implants</p>
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    <div class="hwrap"><h2>The Project</h2></div>
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<h1> Welcome to iGEM 2017! </h1>
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<p>By providing a well-defined, biocompatible surface coating, the risk of bone and dental implant failure will be greatly reduced. In order to produce such coatings, light will have control over the spatial production of extra-cellular cellulose and formation of biofilm. The modified E.coli builds on work from previous iGEM teams, utilising a transmembrane protein complex: upon exposure to red light Cph8 prevents the phosphorylation of a promoter and begins the synthesis cascade. Using this technology, the team will be able to build a 3D printer where living bacteria act as the 'bio-ink'. They will then be able to produce biocompatible structures, featuring micrometre pores, which mimic the surface of broken bone for implants. Micropore structures have been shown to induce the body to produce new bone, helping the implant fuse efficiently and thus reduce overall failure rates.</p>
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<p>Our project will focus on light activated gene transcription and its application to 3-D printing. We propose developing a novel CRISPR promoter system incorporating unnatural amino acids which can be selectively returned to their native state upon exposure to light. This technology will not only allow for temporal control of gene expression but also expression in a spatially controlled manner. By changing the genes expressed to those needed for biopolymer synthesis, the team will be able to produce objects via a layer by layer printing technique. The biocompatible nature of the polymer produced, allows the final products to be used for tailored implant coatings or even as a scaffolding substrate for tissue and organ growth.</p>
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        <a href="https://2017.igem.org/Team:Warwick/Description">
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<h5>Before you start: </h5>
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<p> Please read the following pages:</p>
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    <div class="text"><h2 class="white">Description</h2></div>
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<li>  <a href="https://2017.igem.org/Competition">Competition Hub</a> </li>
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<li> <a href="https://2017.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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<li> <a href="https://2017.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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        <img class="img-responsive" src="https://static.igem.org/mediawiki/2017/0/06/T--Warwick--Front-outreach-Small.jpg"/>
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        <a href="https://2017.igem.org/Team:Warwick/Engagement">
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    <div class="text"><h2 class="white">Outreach</h2></div>
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<h5> Styling your wiki </h5>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>  
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        <a href="https://2017.igem.org/Team:Warwick/HP/Silver">
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    <div class="text"><h2 class="white">Human Practices</h2></div>
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<h5> Wiki template information </h5>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2017.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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        <img class="img-responsive" src="https://static.igem.org/mediawiki/2017/1/12/T--Warwick--Front-software.png"/>
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            <a href="https://2017.igem.org/Team:Warwick/Software">
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    <div class="text"><h2 class="white">Software</h2></div>
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<h5> Editing your wiki </h5>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p> <a href="https://2017.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
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          <a href="https://2017.igem.org/Team:Warwick/Team">
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    <div class="text"><h2 class="white">Team</h2></div>
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<h5>Tips</h5>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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  <a href="https://2017.igem.org/Team:Warwick/Attributions">
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away. </li>
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    <div class="text"><h2 class="white">Attributions</h2></div>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read. </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2017.igem.org/Calendar">iGEM 2017 calendar</a> </li>
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<li>Have lots of fun! </li>
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<h5>Inspiration</h5>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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<h5> Uploading pictures and files </h5>
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<p> You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <br><code>T--YourOfficialTeamName--NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)<br><br>
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UPLOAD FILES
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Latest revision as of 23:48, 1 November 2017

Blueprint 361

Revolutionising Implants

The Project

By providing a well-defined, biocompatible surface coating, the risk of bone and dental implant failure will be greatly reduced. In order to produce such coatings, light will have control over the spatial production of extra-cellular cellulose and formation of biofilm. The modified E.coli builds on work from previous iGEM teams, utilising a transmembrane protein complex: upon exposure to red light Cph8 prevents the phosphorylation of a promoter and begins the synthesis cascade. Using this technology, the team will be able to build a 3D printer where living bacteria act as the 'bio-ink'. They will then be able to produce biocompatible structures, featuring micrometre pores, which mimic the surface of broken bone for implants. Micropore structures have been shown to induce the body to produce new bone, helping the implant fuse efficiently and thus reduce overall failure rates.

Description

Outreach

Human Practices

Software

Team

Attributions

We thank our sponsors without whom none of this would have been possible: