Team:SCU-WestChina
Blocking the Urate Storm in the Blood
SCU-WestChina 2017 Project
Abstract
Hyperuricemia and refractory gout are caused by the high urate concentration in the blood. Considering there are still debates
on whether the drug should be used in the asymptomatic hyperuricemia patients and the drug resistance
of the refractory gout patients, new approaches are eagerly needed. We constructed the urate metabolic
pathway in the probiotic E. coli Nissle 1917 and applied it in the gut to reduce the urate concentration
in the blood indirectly. In addition, we built a dialysis-like device combined with modified bacteria
to utilize the urate directly in the blood. Our solutions provide a suitable, long-term and non-drug
treatment for the asymptomatic hyperuricemia patients and an ultimate treatment for the refractory gout
patients.
Background
Project
Modeling
Human Practice
Notebook
Team
InterLab
Uric acid is the end product of purine metabolism in human. Increased production or decreased excretion of uric acid can
lead to its accumulation in the body, causing hyperuricemia. If sodium urate crystals deposit from super-saturated
extracellular fluids to joints, synovium or other tissues and organs, it will cause a syndrome clinically
known as "gout". Controversy still exists on whether to use medications on asymptomatic hyperuricemia,
refractory gout can be still hard to treat even with the new drug. And those are the reasons why we start
our project.
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Based on the background, our project will put forward a new method to control hyperuricemia and treat refractory gout from
the following two aspects: 1. Control of ordinary hyperuricemia (in the intestinal tract); 2. Treatment
of refractory gout when Pegloticase treatment is of no avail (with methods of dialysis)
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We used the insulator to measure the expression of eGFP driven by 10 Anderson's promoters for the first time. We updated
the information of the constitutive promoter family with quantitative protein data. The data is used
for our project modeling to construct the pathway.
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We collected the information from various tubes. As a medical school team, we got the first-hand feedback from clinical doctors
to make our project really meaningful. And it's our duty to spread the medical knowledge to the public
to practice the saying: "Health related, life entrusted."
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"Wit beyond measure is a man’s greatest treasure." — Luna Lovegood, Harry Potter and the Order of the Phoenix
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How close can the numbers be when fluorescence is measured all around the world?
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