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One of the limitations we identified early on in our project was the lack of concise and clear information about microfluidics for researchers in Synthetic Biology. Using the iGEM poll we were able to confirm this suspicion and understand what the synbio community wanted us to design for them.
 
One of the limitations we identified early on in our project was the lack of concise and clear information about microfluidics for researchers in Synthetic Biology. Using the iGEM poll we were able to confirm this suspicion and understand what the synbio community wanted us to design for them.
 
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<h2> <u>Introduction to Microfluidics</u> </h2>
 
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<h3>What is Microfluidics?</h3>
 
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Microfluidics is the manipulation of microlitre volumes of liquid in order to perform scientific experiments. This is performed on devices called microfluidic chips that can be made of polycarbonate, glass or silicone.
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Microfluidics is the manipulation of microlitre volumes of liquid in order to perform scientific experiments. This is performed on devices called microfluidic chips that can be made of polycarbonate, glass or silicone.  
 
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Revision as of 07:30, 28 October 2017

BostonU_HW

Introduction to Microfluidics

Get Ready to Learn about Microfludics!

One of the limitations we identified early on in our project was the lack of concise and clear information about microfluidics for researchers in Synthetic Biology. Using the iGEM poll we were able to confirm this suspicion and understand what the synbio community wanted us to design for them.

As a result, the first stage of MARS is increasing the understanding of microfluidics. Under this section we have included a brief introduction to microfluidics as a whole and an explanation of how our continuous flow devices function. A primitive guide has also been included so researchers can identify and understand the function of each element on their chips. This guide can also be used in conjunction with the software tool 3Duf in order to design your own chip, or to adapt and iterate on our designs in the MARS Repository.

Introduction to Microfluidics

What is Microfluidics?

Microfluidics is the manipulation of microlitre volumes of liquid in order to perform scientific experiments. This is performed on devices called microfluidic chips that can be made of polycarbonate, glass or silicone.

What is a Microfluidic Chip?

A continuous flow microfluidic chip typically consists of three layers: a flow layer and control layer with a flexible layer of PDMS between them. There are many other types of microfluidics such as digital or paper which operate using different mechanisms, however we will focus on continuous flow chips as this is the type utilised by MARS.
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Control Layer

This is the section that will talk about Control layer.

PDMS Layer

This is the section that will talk about PDMS layer.

Flow Layer

These features are called “primitives”. The Control layer allows us to move the elastic PDMS layer in the middle to further manipulate the flow layer, typically by opening or closing valves. To further understand how primitives work click on the following link: Primitive Table



How does this apply to Synthetic Biology?

Microfluidic chips can be designed to perform various procedures used in synthetic biology. However, microfluidics is often an overlooked tool because designing and using chips requires specialized knowledge.

Primitive Table

Primitive Design Mill
Channel
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DESIGN Channel DESIGN Channel
Mixer
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DESIGN Channel DESIGN Channel
3-D Valve
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DESIGN Channel DESIGN Channel
Chamber
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DESIGN Channel DESIGN Channel
Metering
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DESIGN Channel DESIGN Channel

Check out MARS Tutorial Videos

Summary

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Video 1

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Video 2

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Video 3

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Video 4

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