Difference between revisions of "Team:Amsterdam"

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           HP Silver
 
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          We are running out of oil and the climate is changing drastically due to the emission of polluting gases such as CO2.
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          We are running out of oil and the climate is changing drastically due to the emission of polluting gases such as CO2.
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          But what if CO2 were a resource, rather than a wasteful pollutant; and might even replace oil?
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          But what if CO2 were a resource, rather than a wasteful pollutant; and might even replace oil?
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          Traditionally people have tried to achieve this by producing fuels and sugars with plants, and by fermenting these sugars with bacteria to produce other chemicals.
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          Traditionally people have tried to achieve this by producing fuels and sugars with plants, and by fermenting these sugars with bacteria to produce other chemicals.
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          But there is a better way, where no arable land is needed and which is faster and more efficient. This is the way our team has chosen to go, using cyanobacteria to take up CO2 and directly convert it into the valuable chemical
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          But there is a better way, where no arable land is needed and which is faster and more efficient. This is the way our team has chosen to go, using cyanobacteria to take up CO2 and directly convert it into the valuable chemical
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          <span style="color: rgba(88, 190, 190, 1)">
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          FUMARATE
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            FUMARATE
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          We are 6 students from Amsterdam with a passion for creating a more sustainable future.
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          We are 6 students from Amsterdam with a passion for creating a more sustainable future.
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          We joined iGEM because we did not just wanted to ‘do science’ but we wanted to reach out to society, learn about communicating our research, and work on a shared vision in a small dynamic team.
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          We joined iGEM because we did not just wanted to ‘do science’ but we wanted to reach out to society, learn about communicating our research, and work on a shared vision in a small dynamic team.
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          Guided by our fantastic supervisors, and owing to the generosity of our sponsors, we have managed to successfully conclude this challenging and incredibly rewarding project.
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          Guided by our fantastic supervisors, and owing to the generosity of our sponsors, we have managed to successfully conclude this challenging and incredibly rewarding project.
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          We want to especially thank the Molecular Microbial Physiology group at the University of Amsterdam who have welcomed us in their lab for the past 7 months.
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          We want to especially thank the Molecular Microbial Physiology group at the University of Amsterdam who have welcomed us in their lab for the past 7 months.
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<p class="summary-text">We are running out of oil and the climate is changing drastically due to the emission of polluting gases such as CO<sub>2</sub>. But what if CO<sub>2</sub> were a resource, rather than a wasteful pollutant; and might even replace oil? We aspire to create a bio-based economy – one that meets its energy and production demands by leveraging biotechnology [1]. We can genetically engineer bacteria to produce a compound we need. This is what we call a bacterial ‘cell factory’.
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<p class="summary-text">We are running out of oil and the climate is changing drastically due to the emission of polluting gases such as CO<sub>2</sub>. But what if CO<sub>2</sub> were a resource, rather than a wasteful pollutant; and might even replace oil? We aspire to create a bio-based economy – one that meets its energy and production demands by leveraging biotechnology [1]. We can genetically engineer bacteria to produce a compound we need. This is what we call a bacterial ‘cell factory’.  
 
Meet <a class="in-text-link" href="#" style="font-size: 24px">CYANOFACTORY</a>, a cyanobacterium that stably and efficiently produces fumarate.</p>
 
Meet <a class="in-text-link" href="#" style="font-size: 24px">CYANOFACTORY</a>, a cyanobacterium that stably and efficiently produces fumarate.</p>
 
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<h1>Glyoxylate Shunt</h1>
 
<h1>Glyoxylate Shunt</h1>
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<p>We will incorporate two enzymes (the glyoxylate shunt) in the Synechocystis genome, creating a shortcut in the TCA-cycle. Our modeling results show that if this shunt is only expressed at night, and the pentose phosphate pathway is blocked by knocking out the zwf gene, more fumarate will be produced. This means we will create a unique combination of growth- coupled and inducible production.
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<p>We will incorporate two enzymes (the glyoxylate shunt) in the Synechocystis genome, creating a shortcut in the TCA-cycle. Our modeling results show that if this shunt is only expressed at night, and the pentose phosphate pathway is blocked by knocking out the zwf gene, more fumarate will be produced. This means we will create a unique combination of growth- coupled and inducible production.  
 
<br><a class="in-text-link" href="#">>>read more</a></p>
 
<br><a class="in-text-link" href="#">>>read more</a></p>
 
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Revision as of 00:23, 2 November 2017

Home

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Team zwart

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Achievements

Achievements

We are running out of oil and the climate is changing drastically due to the emission of polluting gases such as CO2.

But what if CO2 were a resource, rather than a wasteful pollutant; and might even replace oil?

Traditionally people have tried to achieve this by producing fuels and sugars with plants, and by fermenting these sugars with bacteria to produce other chemicals.

But there is a better way, where no arable land is needed and which is faster and more efficient. This is the way our team has chosen to go, using cyanobacteria to take up CO2 and directly convert it into the valuable chemical FUMARATE

PROJECT

Fumarate is used to make certain plastics, food additives, and medicine and is currently made from petroleum. The global market size of fumarate is estimated to be $760 million by 2020!

We are 6 students from Amsterdam with a passion for creating a more sustainable future.

We joined iGEM because we did not just wanted to ‘do science’ but we wanted to reach out to society, learn about communicating our research, and work on a shared vision in a small dynamic team.

Guided by our fantastic supervisors, and owing to the generosity of our sponsors, we have managed to successfully conclude this challenging and incredibly rewarding project.

We want to especially thank the Molecular Microbial Physiology group at the University of Amsterdam who have welcomed us in their lab for the past 7 months.

Aimms1 Sciencepark Auf Dsm Gss Idt Matrix Merck Rivm Phenomenex Snapgene Sils United consumers Vu Vu fs Vu cs