Difference between revisions of "Team:WHU-China"
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| − | < | + | <p>Halogenated phenols are a group of organic molecules, characterized by benzene rings with |
| − | hydroxyl groups and halogen atoms. In general, halogenated phenols tend to be more toxic and less biodegradable than their nonhalogenated counterparts, to note that phenols, cresols, and catechols do not bioaccumulate to any great extent. Used in large quantities for diverse purposes and moderately soluble in water, fugitive phenolics are inevitable and these can be moved around readily by water. It’s been reported that halogenated phenols have accumulated in various anoxic subsurface environments as a consequence of improper disposal. What’s even worse, increasing levels of halogenated phenol detected in humans and wildlife are of particular concern. With an original dehalogenase named RdhANP from Nitratireductor pacificus | + | hydroxyl groups and halogen atoms. In general, halogenated phenols tend to be more toxic and less biodegradable than their nonhalogenated counterparts, to note that phenols, cresols, and catechols do not bioaccumulate to any great extent. Used in large quantities for diverse purposes and moderately soluble in water, fugitive phenolics are inevitable and these can be moved around readily by water. It’s been reported that halogenated phenols have accumulated in various anoxic subsurface environments as a consequence of improper disposal. What’s even worse, increasing levels of halogenated phenol detected in humans and wildlife are of particular concern. With an original dehalogenase named RdhANP from Nitratireductor pacificus, we aim to engineer selected microbes to build a dehalogenater, to remove halogen atoms from halogenated phenols, thus reducing their toxicity and facilitate their subsequent treatment. Compared with other enzymes in the dehalogenase subfamily, which are usually membrane-associated and oxygen-sensitive, RdhANP is a soluble, oxygen-tolerant reductive dehalogenase depending on cobalamin (B12) and electron donors (i.e NADPH) for its catalytic activity. After successful heterologous expression of RdhANP, we’d design our dehalogenator to function efficiently in suitable devices.</p> |
| − | , we aim to engineer selected microbes to build a dehalogenater, to remove halogen atoms from halogenated phenols, thus reducing their toxicity and facilitate their subsequent treatment. Compared with other enzymes in the dehalogenase subfamily, which are usually membrane-associated and oxygen-sensitive, RdhANP is a soluble, oxygen-tolerant reductive dehalogenase depending on cobalamin (B12) and electron donors (i.e NADPH) for its catalytic activity. After successful heterologous expression of RdhANP, we’d design our dehalogenator to function efficiently in suitable devices. | + | |
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Revision as of 03:38, 29 May 2017
Halogenated phenols are a group of organic molecules, characterized by benzene rings with hydroxyl groups and halogen atoms. In general, halogenated phenols tend to be more toxic and less biodegradable than their nonhalogenated counterparts, to note that phenols, cresols, and catechols do not bioaccumulate to any great extent. Used in large quantities for diverse purposes and moderately soluble in water, fugitive phenolics are inevitable and these can be moved around readily by water. It’s been reported that halogenated phenols have accumulated in various anoxic subsurface environments as a consequence of improper disposal. What’s even worse, increasing levels of halogenated phenol detected in humans and wildlife are of particular concern. With an original dehalogenase named RdhANP from Nitratireductor pacificus, we aim to engineer selected microbes to build a dehalogenater, to remove halogen atoms from halogenated phenols, thus reducing their toxicity and facilitate their subsequent treatment. Compared with other enzymes in the dehalogenase subfamily, which are usually membrane-associated and oxygen-sensitive, RdhANP is a soluble, oxygen-tolerant reductive dehalogenase depending on cobalamin (B12) and electron donors (i.e NADPH) for its catalytic activity. After successful heterologous expression of RdhANP, we’d design our dehalogenator to function efficiently in suitable devices.
Welcome to iGEM 2017!
Your team has been approved and you are ready to start the iGEM season!
Before you start:
Please read the following pages:
Styling your wiki
You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.
While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.
Wiki template information
We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!
Editing your wiki
On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
Use WikiTools - Edit in the black menu bar to edit this page
Tips
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
- State your accomplishments! Tell people what you have achieved from the start.
- Be clear about what you are doing and how you plan to do this.
- You have a global audience! Consider the different backgrounds that your users come from.
- Make sure information is easy to find; nothing should be more than 3 clicks away.
- Avoid using very small fonts and low contrast colors; information should be easy to read.
- Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2017 calendar
- Have lots of fun!
Inspiration
You can also view other team wikis for inspiration! Here are some examples:
Uploading pictures and files
You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to T--YourOfficialTeamName--NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)
UPLOAD FILES
