Difference between revisions of "Team:Stuttgart/Model"

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     <h1>LIGHT UP THE PIPE</h1>
 
     <h1>LIGHT UP THE PIPE</h1>
  
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     <p>The clogging of drains and pipe systems by hair and fat is a serious problem in industry and private households. Currently many blockages are dissolved by toxic and reactive chemicals like hydroxide and chlorine compounds, leading to accelerate corrosion in the pipe system and ecological damage. Our aim is to engage this problem in a more sustainable and eco-friendly way by developing a biological cleaner based on a holistic approach using E.coli. Our microbial system is targeted on producing and secreting enzymes, such as keratinases, lipases and esterases to break down hair, fat and other pollutants. By optimizing the secretion of the selected enzymes, we are avoiding enzyme purification which can save valuable money and time. Additionally, we want to produce a scent from the existing waste as an indicator of successful degradation. Involving mathematical modeling of enzymatic kinetics and degradation processes will support the experimental work.
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     <p>Our modelling process considers three successional blocks: The first one describes the synthesis and  excretion of the desired enzymes, this is followed by the hair and lipid degradation block and the last one depicts the synthesis of the rose scent. The modelling and simulation team aims to describe the whole system with an equational system which characterizes the intracellular and extracellular concentration time courses of all enzymes, the degradation time courses as well as the produced rose scent. In order to find the best enzyme composition for the maximal hair and lipid breakdown in a specific time period the 2nd modelling block is used to perform an optimization by the method of least square. Finally, we want to examine the system’s sensitivity to fluctuations in temperature and pH value.
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        Finally this approach will LIGHT UP THE PIPE again!
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     <img src="https://static.igem.org/mediawiki/2017/7/7f/Team_iGEM_Stuttgart_GRUPPENFOTO.png" />
 
     <img src="https://static.igem.org/mediawiki/2017/7/7f/Team_iGEM_Stuttgart_GRUPPENFOTO.png" />

Revision as of 15:18, 21 September 2017

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LIGHT UP THE PIPE

Our modelling process considers three successional blocks: The first one describes the synthesis and excretion of the desired enzymes, this is followed by the hair and lipid degradation block and the last one depicts the synthesis of the rose scent. The modelling and simulation team aims to describe the whole system with an equational system which characterizes the intracellular and extracellular concentration time courses of all enzymes, the degradation time courses as well as the produced rose scent. In order to find the best enzyme composition for the maximal hair and lipid breakdown in a specific time period the 2nd modelling block is used to perform an optimization by the method of least square. Finally, we want to examine the system’s sensitivity to fluctuations in temperature and pH value.