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| − | <p> | + | <p>Cancer mortality rate is very high. The biggest characteristic of cancer cells is rapid cell division, resulting in the hypoxia microenvironment of solid tumor. Our project is to construct three plasmids, which are transported to the solid tumor using the probiotics Nissle 1917 as gene delivery carrier. When the extracellular environment lacks of oxygen, a plasmid in Nissle 1917 can express invasin and Hyl proteins, making the Nisssle 1917 invade into tumor cells, and avoid cell lysosomes endocytosis. After the Nissle 1917 enter solid tumor cells, another plasmid will expresse Bmp2 protein, inducing cell apoptosis. The specialty of our project is that if the Nissle 1917 enter the nontumorous cells by mistake, the third plasmid will start suicide program, which will not pose a threat to normal cells, achieving the safety of gene therapy.</p> |
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Revision as of 00:36, 30 June 2017
JNFLS
Welcome to iGEM 2017!
Your team has been approved and you are ready to start the iGEM season!
Before you start:
Please read the following pages:
Project Abstract
Cancer mortality rate is very high. The biggest characteristic of cancer cells is rapid cell division, resulting in the hypoxia microenvironment of solid tumor. Our project is to construct three plasmids, which are transported to the solid tumor using the probiotics Nissle 1917 as gene delivery carrier. When the extracellular environment lacks of oxygen, a plasmid in Nissle 1917 can express invasin and Hyl proteins, making the Nisssle 1917 invade into tumor cells, and avoid cell lysosomes endocytosis. After the Nissle 1917 enter solid tumor cells, another plasmid will expresse Bmp2 protein, inducing cell apoptosis. The specialty of our project is that if the Nissle 1917 enter the nontumorous cells by mistake, the third plasmid will start suicide program, which will not pose a threat to normal cells, achieving the safety of gene therapy.
Wiki template information
We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the Pages for awards link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!
Editing your wiki
On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world!
Use WikiTools - Edit in the black menu bar to edit this page
Tips
This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started:
- State your accomplishments! Tell people what you have achieved from the start.
- Be clear about what you are doing and how you plan to do this.
- You have a global audience! Consider the different backgrounds that your users come from.
- Make sure information is easy to find; nothing should be more than 3 clicks away.
- Avoid using very small fonts and low contrast colors; information should be easy to read.
- Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the iGEM 2017 calendar
- Have lots of fun!
Inspiration
You can also view other team wikis for inspiration! Here are some examples:
Uploading pictures and files
You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name.
When you upload, set the "Destination Filename" to T--YourOfficialTeamName--NameOfFile.jpg. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)
UPLOAD FILES
