Team:CU-Boulder

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Project Description

Bacterial Micro-compartments (BMCs) exist naturally in cells as protein “cages” which encapsulate different chemical reactions within bacteria. BMCs have many potential research and medical applications including concentrating reactions within cells and novel drug delivery. In order to apply BMCs in a functional way, they need to be opened and closed on command. To achieve this, we have integrated a non-canonical “light activated” photo switching amino acid, name AzoPhe, into the ethanolamine utilization (Eut) BMC. AzoPhe contains a photo switching molecule called azobenzene that when exposed to certain wavelengths of light will change its physical conformation. Depending on its cis and trans conformation, Azobenzene may be able to offer steric hindrance in core locations of the Eut BMC. Through modeling and site directed mutagenesis, potential sites for azobenzene can be tested to open and close the Eut compartment. We are continuing our previous research to improve the stability of the compartments and adjust fluorescent cargo so that it does not interfere with the AzoPhe activation.

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