Difference between revisions of "Team:KU Leuven"

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{{KU_Leuven}}
 
{{KU_Leuven}}
 
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<h1>The iGEM KULeuven 2017 Team presents:</h1><p><strong>HEKcite!</strong> Inspired by the human heart rhythm, we aim to create an electrophysiological oscillator from eukaryotic cells. Rhythmic contraction of heart cells is coordinated by a small group of cells called the sinus node that have an intrinsic frequency of de- and repolarization. This frequency of electrical oscillation is influenced by environmental parameters as well as certain molecular substrates. The oscillator that is proposed here consists of genetically modified excitable Human Embryonic Kidney (HEK) cells, altered to contain the intrinsic pacemaker ability found in sinus cells. As witnessed in heart cells, the rhythm would be dependent on substrate-activated ion channels in the membrane. As there is a great variety of ion channels available in nature, the oscillator could be modified to measure concentrations of many specific substrates. By integrating a certain ion channel into the oscillating system, specificity for a substrate can be chosen.Building an electrical oscillator from cells has several advantages. Extra- or intracellular changes that influence the conductance of ion channels in the membrane have an immediate impact on the frequency of oscillation. Once these cells are connected to each other (by for example gap-junctions), they generate an electrical signal that can easily be measured from a distance and non-invasively—similar to the way electrocardiography (ECG) and electroencephalography (EEG) measure electrical activity in the heart and brain respectively.
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A multi-purpose sensor suitable for this system could be developed for medical and biotechnological applications. One such application is the measurement of drugs that interact with ion channels, such as anti-epileptics or a certain class of immunosuppressants.</p>
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<h1> Welcome to iGEM 2017! </h1>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<h5>Before you start: </h5>
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<p> Please read the following pages:</p>
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<li>  <a href="https://2017.igem.org/Competition">Competition Hub</a> </li>
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<li> <a href="https://2017.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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<li> <a href="https://2017.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<h5> Wiki template information </h5>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2017.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<h5> Editing your wiki </h5>
 
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
 
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<p> <a href="https://2017.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
 
  
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 +
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 +
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 +
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 +
          transform-origin: 260.41667% 50%;
 +
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 +
.cont.s--el-active .el:nth-child(3):not(.s--active) {
 +
  -webkit-transform: scale(0.5) translate3d(210.41667%, 0, 0);
 +
          transform: scale(0.5) translate3d(210.41667%, 0, 0);
 +
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 +
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 +
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 +
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 +
  transition: transform 0.95s, opacity 0.95s, -webkit-transform 0.95s;
 +
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 +
.el:nth-child(3) .el__inner {
 +
  -webkit-transition-delay: 0.2s;
 +
          transition-delay: 0.2s;
 +
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 +
.el:nth-child(3) .el__bg {
 +
  -webkit-transform: translate3d(-38.4%, 0, 0);
 +
          transform: translate3d(-38.4%, 0, 0);
 +
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 +
.el:nth-child(3) .el__bg:before {
 +
  -webkit-transition-delay: 0.2s;
 +
          transition-delay: 0.2s;
 +
  background-image: url("https://static.igem.org/mediawiki/2017/archive/9/96/20171030191733%21New_Homepage.jpg");
 +
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 +
.el:nth-child(4) {
 +
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 +
  -webkit-transform-origin: 365.625% 50%;
 +
          transform-origin: 365.625% 50%;
 +
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 +
.cont.s--el-active .el:nth-child(4):not(.s--active) {
 +
  -webkit-transform: scale(0.5) translate3d(315.625%, 0, 0);
 +
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 +
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 +
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 +
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 +
.el:nth-child(4) .el__inner {
 +
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 +
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 +
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 +
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 +
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 +
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 +
.el:nth-child(4) .el__bg:before {
 +
  -webkit-transition-delay: 0.3s;
 +
          transition-delay: 0.3s;
 +
  background-image: url("https://static.igem.org/mediawiki/2017/archive/9/96/20171030191733%21New_Homepage.jpg");
 +
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 +
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 +
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 +
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 +
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 +
          transform-origin: 470.83333% 50%;
 +
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 +
.cont.s--el-active .el:nth-child(5):not(.s--active) {
 +
  -webkit-transform: scale(0.5) translate3d(420.83333%, 0, 0);
 +
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 +
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 +
  transition: transform 0.95s, opacity 0.95s, -webkit-transform 0.95s;
 +
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 +
.el:nth-child(5) .el__inner {
 +
  -webkit-transition-delay: 0.4s;
 +
          transition-delay: 0.4s;
 +
}
 +
.el:nth-child(5) .el__bg {
 +
  -webkit-transform: translate3d(-76.8%, 0, 0);
 +
          transform: translate3d(-76.8%, 0, 0);
 +
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 +
.el:nth-child(5) .el__bg:before {
 +
  -webkit-transition-delay: 0.4s;
 +
          transition-delay: 0.4s;
 +
  background-image: url("https://static.igem.org/mediawiki/2017/archive/9/96/20171030191733%21New_Homepage.jpg");
 +
}
 +
.el:hover .el__bg:after {
 +
  opacity: 0;
 +
}
 +
.el.s--active {
 +
  z-index: 1;
 +
  width: 100%;
 +
  -webkit-transform: translate3d(0, 0, 0);
 +
          transform: translate3d(0, 0, 0);
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 +
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 +
.el.s--active .el__bg {
 +
  -webkit-transform: translate3d(0, 0, 0);
 +
          transform: translate3d(0, 0, 0);
 +
  -webkit-transition: -webkit-transform 0.6s;
 +
  transition: -webkit-transform 0.6s;
 +
  transition: transform 0.6s;
 +
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 +
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 +
.el.s--active .el__bg:before {
 +
  -webkit-transition-delay: 0.6s;
 +
          transition-delay: 0.6s;
 +
  -webkit-transform: scale(1.1);
 +
          transform: scale(1.1);
 +
}
 +
img .rotate180 {
 +
    -webkit-transform: rotate(180deg);
 +
    -moz-transform: rotate(180deg);
 +
    -o-transform: rotate(180deg);
 +
    -ms-transform: rotate(180deg);
 +
    transform: rotate(180deg);
 +
}
 +
 +
.animated_svg1 {
 +
position: relative;
 +
display: block;
 +
width: 100%;
 +
height: 1000px;
 +
min-height: 100% !important;
 +
}
 +
.animated_svg1 > * {
 +
position: center;
 +
}
 +
.animated_svg2 {
 +
        position: relative;
 +
        display: block;
 +
        width: 100%;
 +
        height: auto;
 +
        text-align: center;
 +
    }
  
 +
    .animated_svg2>* {
 +
        max-width: 800px;
 +
        display: inline-block;
 +
    }
 +
/* IF THE SCREEN IS LESS THAN 800PX */
 +
@media only screen and (max-width: 800px) {
 +
.home{
 +
display: block;
 +
}
 +
.cont{
 +
display: none;
 +
}
 +
.animated_svg1{
 +
display: none;
 +
}
 +
.animated_svg2{
 +
margin-top: 18px;
 +
}
 +
}
 +
/* IF THE SCREEN IS MORE THAN 800PX */
 +
@media only screen and (min-width: 801px) {
 +
.home{
 +
display: none;
 +
}
 +
.cont{
 +
display: block;
 +
}
 +
.animated_svg1{
 +
display: block;
 +
}
 +
}
 +
p {
 +
font-color:white;
 +
font-size: 120px;
  
−
<div class="column half_size" >
+
}
−
<h5>Tips</h5>
+
.imagecontainer{
−
<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
+
padding:0;
−
<ul>
+
}
−
<li>State your accomplishments! Tell people what you have achieved from the start. </li>
+
−
<li>Be clear about what you are doing and how you plan to do this.</li>
+
−
<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
+
−
<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
+
−
<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
+
−
<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2017.igem.org/Calendar">iGEM 2017 calendar</a> </li>
+
−
<li>Have lots of fun! </li>
+
−
</ul>
+
−
</div>
+
  
 +
 +
</style>
 +
<div class="igem_2017_content_wrapper">
  
−
<div class="column half_size" >
+
<div id="grad">
−
<h5>Inspiration</h5>
+
<div class="home">
−
<p> You can also view other team wikis for inspiration! Here are some examples:</p>
+
            <div class="bg">
−
<ul>
+
            </div>
−
<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
+
            <div id="scrolldown" class="arrow">
−
<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
+
                <img src="https://static.igem.org/mediawiki/2017/0/0f/KU_Leuven-scroll_arrow.png">
−
<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
+
            </div>
−
<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
+
        </div>
−
<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
+
−
<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
+
<div class="cont s--inactive">
−
</ul>
+
−
</div>
+
  <!-- cont inner start -->
−
 
+
  <div class="cont__inner">
−
<div class="column half_size" >
+
    <!-- el start -->
−
<h5> Uploading pictures and files </h5>
+
    <div class="el">
−
<p> You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
+
      <div class="el__overflow">
−
When you upload, set the "Destination Filename" to <br><code>T--YourOfficialTeamName--NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)<br><br>
+
        <div class="el__inner">
 +
          <div class="el__bg"></div>
 +
          <div class="el__preview-cont">
 +
            <h2 class="el__heading"><font color="white">Project</font></h2>
 +
          </div>
 +
          <div class="el__content">
 +
          <div class="el__text">HEKcite</div>
 +
          <div class="container2">
 +
          <p style="color:white;font-size:25px; font-family:arial; position:absolute;text-align:justify">Inspired by the heart and its rhythm, our team sought to aid those who need continuous drug monitoring. To achieve this goal, we transformed ourselves into real dance instructors as we introduced a continuous rhythm in HEK cells. Our cells performed wonderfully so we are very proud to present you: <a href="https://2017.igem.org/Team:KU_Leuven/Description">HEKcite!</a></p>
 +
          </div>
 +
            <div class="el__close-btn"></div>
 +
          </div>
 +
        </div>
 +
      </div>
 +
      <div class="el__index">
 +
        <div class="el__index-back">1</div>
 +
        <div class="el__index-front">
 +
          <div class="el__index-overlay" data-index="1">1</div>
 +
        </div>
 +
      </div>
 +
    </div>
 +
    <!-- el end -->
 +
    <!-- el start -->
 +
    <div class="el">
 +
      <div class="el__overflow">
 +
        <div class="el__inner">
 +
          <div class="el__bg"></div>
 +
          <div class="el__preview-cont">
 +
            <h2 class="el__heading"><font color="white">Team</font></h2>
 +
          </div>
 +
          <div class="el__content">
 +
            <div class="el__text"></div>
 +
            <div class="container2">
 +
           
 +
          <p style="color:white;font-size:25px; font-family:arial; position:absolute;text-align:justify">The story of our team starts with four bioscience engineering students who were eager to expand their knowledge and learn vital practical skills. Almost one year later they were joined by nine motivated students and so the final 2017 KULeuven iGEM team was formed. A vast amount of meetings were followed by the actual lab work in the summer, but hard work was always varied with fantastic teambuilding activities. The great camaraderie is formed.
 +
                                            <a href="https://2017.igem.org/Team:KU_Leuven/Team">Meet our amazing team</a>
 +
         
 +
          <br>
 +
         
 +
          </p>
 +
                   
  
−
<a href="https://2017.igem.org/Special:Upload">
+
            </div>
−
UPLOAD FILES
+
            <div class="el__close-btn"></div>
−
</a>
+
          </div>
−
</p>
+
        </div>
 +
      </div>
 +
      <div class="el__index">
 +
        <div class="el__index-back">2</div>
 +
        <div class="el__index-front">
 +
          <div class="el__index-overlay" data-index="2">2</div>
 +
        </div>
 +
      </div>
 +
    </div>
 +
    <!-- el end -->
 +
    <!-- el start -->
 +
    <div class="el">
 +
      <div class="el__overflow">
 +
        <div class="el__inner">
 +
          <div class="el__bg"></div>
 +
          <div class="el__preview-cont">
 +
            <h2 class="el__heading"><font color="white">KU LEUVEN</font></h2>
 +
          </div>
 +
          <div class="el__content">
 +
            <div class="el__text"></div>
 +
            <div class="container2">
 +
          <p style="color:white;font-size:20px; font-family:arial; position:absolute;text-align:justify">Located just 30 kilometers from Brussels lies the educational beating heart of Belgium, the city of Leuven. It is home to the KULeuven, one of the oldest universities in Europe. Allow us to tell you some fun facts about Leuven.<br>
 +
          <br>
 +
Fact number 1: Did you know that Leuven is famously home to the biggest bar in the world?
 +
<br>
 +
<br>
 +
Fact number 2: Around one third of the population of Leuven is a student at the university or works there. During summer, the streets of Leuven do indeed look emptier.
 +
<br>
 +
<br>
 +
Fact number 3: Every year in October there is a major sports event where the different student societies battle it out on the racing track. The society that ran the most of laps after 24 hours wins this prestigious competition.
 +
<br>
 +
<br>
 +
Want to know more about our university, click <a href="https://www.kuleuven.be/english/">here</a>
 +
</p>
 +
          </div>
 +
         
 +
           
 +
            <div class="el__close-btn"></div>
 +
          </div>
 +
        </div>
 +
      </div>
 +
      <div class="el__index">
 +
        <div class="el__index-back">3</div>
 +
        <div class="el__index-front">
 +
          <div class="el__index-overlay" data-index="3">3</div>
 +
        </div>
 +
      </div>
 +
    </div>
 +
    <!-- el end -->
 +
    <!-- el start -->
 +
    <div class="el">
 +
      <div class="el__overflow">
 +
        <div class="el__inner">
 +
          <div class="el__bg"></div>
 +
          <div class="el__preview-cont">
 +
            <h2 class="el__heading"><font color="white">Education</font></h2>
 +
          </div>
 +
          <div class="el__content">
 +
            <div class="el__text"></div>
 +
            <div class="container2">
 +
          <p style="color:white;font-size:25px; font-family:arial; position:absolute; text-align:justify;">Developing a card game that teaches you more about the immune system and its enemies, teaching children and young adults about biology and the importance of synthetic biology, doing fun experiments with children attending the children’s university event... Our team did all this and more to make sure that we left a positive impact on the next generation. Want to know more about our education project, click <a href="https://2017.igem.org/Team:KU_Leuven/HP/Education">here</a> </p>
 +
          </div>
 +
         
 +
 +
            <div class="el__close-btn"></div>
 +
          </div>
 +
        </div>
 +
      </div>
 +
      <div class="el__index">
 +
        <div class="el__index-back">4</div>
 +
        <div class="el__index-front">
 +
          <div class="el__index-overlay" data-index="4">4</div>
 +
        </div>
 +
      </div>
 +
    </div>
 +
    <!-- el end -->
 +
    <!-- el start -->
 +
    <div class="el">
 +
      <div class="el__overflow">
 +
        <div class="el__inner">
 +
          <div class="el__bg"></div>
 +
          <div class="el__preview-cont">
 +
            <h2 class="el__heading"><font color="white">Contact</font></h2>
 +
          </div>
 +
          <div class="el__content">
 +
            <div class="el__text"></div>
 +
            <div class="container2">
 +
          <p style="color:white;font-size:25px; font-family:arial; position:absolute;text-align:justify">You can contact the KU Leuven team through our <a href="https://www.facebook.com/KULeuveniGEM/">Facebook</a>page or via igem2017@kuleuven.be. So, send us some love, or if you have any questions feel free to ask them there!
 +
          </p>
 +
          </div>
 +
         
 +
            <div class="el__close-btn"></div>
 +
          </div>
 +
        </div>
 +
      </div>
 +
      <div class="el__index">
 +
        <div class="el__index-back">5</div>
 +
        <div class="el__index-front">
 +
          <div class="el__index-overlay" data-index="5">5</div>
 +
        </div>
 +
      </div>
 +
    </div>
 +
    <!-- el end -->
 +
  </div>
 +
</div>
 +
<div style="text-align:center">
 +
<div class="animated_svg1">
 +
<svg version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px"
 +
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 +
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<g id="Shape_7_copy">
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 +
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 +
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        <div id="overlay" class="overlay" style="border-top: 2px solid #c33">
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                        <a xlink:href="https://2017.igem.org/Team:KU_Leuven/HP/HP_Main">
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                </a>
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                <a href="http://kuleuven.be">
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                    </li>
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                </a>
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                <a href="#">
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Latest revision as of 17:11, 6 June 2018

Project

HEKcite

Inspired by the heart and its rhythm, our team sought to aid those who need continuous drug monitoring. To achieve this goal, we transformed ourselves into real dance instructors as we introduced a continuous rhythm in HEK cells. Our cells performed wonderfully so we are very proud to present you: HEKcite!

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Team

The story of our team starts with four bioscience engineering students who were eager to expand their knowledge and learn vital practical skills. Almost one year later they were joined by nine motivated students and so the final 2017 KULeuven iGEM team was formed. A vast amount of meetings were followed by the actual lab work in the summer, but hard work was always varied with fantastic teambuilding activities. The great camaraderie is formed. Meet our amazing team

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KU LEUVEN

Located just 30 kilometers from Brussels lies the educational beating heart of Belgium, the city of Leuven. It is home to the KULeuven, one of the oldest universities in Europe. Allow us to tell you some fun facts about Leuven.

Fact number 1: Did you know that Leuven is famously home to the biggest bar in the world?

Fact number 2: Around one third of the population of Leuven is a student at the university or works there. During summer, the streets of Leuven do indeed look emptier.

Fact number 3: Every year in October there is a major sports event where the different student societies battle it out on the racing track. The society that ran the most of laps after 24 hours wins this prestigious competition.

Want to know more about our university, click here

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Education

Developing a card game that teaches you more about the immune system and its enemies, teaching children and young adults about biology and the importance of synthetic biology, doing fun experiments with children attending the children’s university event... Our team did all this and more to make sure that we left a positive impact on the next generation. Want to know more about our education project, click here

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Contact

You can contact the KU Leuven team through our Facebookpage or via igem2017@kuleuven.be. So, send us some love, or if you have any questions feel free to ask them there!

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