Difference between revisions of "Team:AFCM-Egypt"

 
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     <meta name="author" content="Web Domus Italia">
 
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                    <li>
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                        <a>TEAM <span class="caret"></span></a>
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                        <ul>
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                            <li><a href="meet the team.html">Meet The Team</a></li>
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                            <li><a href="collaborations.html">Collaborations</a></li>
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                    <li class="dropdown">
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                        <a>PROJECT <span class="caret"></span></a>
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                            <li><a href="Result.html">Result</a></li>
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                            <li><a href="proof of concept.html">Proof of concept</a></li>
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                    <li class="dropdown">
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                        <a>PARTS <span class="caret"></span></a>
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                        <ul>
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<li><a href="design.html">Design</a></li>
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<a>HUMAN PRACTICE <span class="caret"></span></a>
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                    <li><a href="attributions.html">ATTRIBUTIONS</a></li>
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                    <li><a href="medal criteria.html">MEDAL CRITERIA</a></li>
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                <video autoplay controls loop style="width:85%;height:85%">
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                    <source src="https://static.igem.org/mediawiki/2017/8/88/Final_vid.mp4" type="video/mp4">
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            <!-- /.container -->
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                     <!--<h1 class="header-title">
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                 <div class="col-md-6 text-center" style="float: none;height: auto ; width: 90%; margin: auto; background-color: rgba(0, 0, 0, 0.4);">
TEAM AFCM
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                     <p><img style="float: right;" src="https://static.igem.org/mediawiki/2017/d/d4/CRISPR_PNG.png" alt="" width="679" height="988" /></p>
</h1>  
+
<h3 dir="ltr" style="text-align: left;"><span style="font-size: 20pt; color: #ffffff;">Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma</span><br /><br /><br />               
<p class="header-subtitle">
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  <h3 class="text-center" style="text-align: center;"><br /><br /><span style="font-size: 14pt; color: #ffffff;">Abstract</span></h3>
since ****
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                    <p style="text-align: left;"><span style="font-size: 14pt; color: #ffffff;">&nbsp;</span></p>
</p>-->
+
                  <span style="font-size: 14pt; color: #ffffff;">Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide &amp; ranked first among cancers in males and next to breast cancer among females in</span><span style="font-size: 14pt; color: #ffffff;"> Egypt based upon results of National Cancer Registry Program of Egypt. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain&nbsp; circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies&nbsp; &nbsp;miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.&nbsp; &nbsp;This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is&nbsp; &nbsp; accomplished by utilizing a&nbsp; &nbsp;synthetic circuit to give rise to a springboard in our battle against cancer.</span><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /></h3>
 
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         </div>
<!---intro--->
 
 
 
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     </section>
 
     </section>
     <!-- /#header -->
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     <div class="twitter-feed purple" style="margin-bottom:50vh;background-color: rgba(0, 0, 0, 0.4);">
<div class="twitter-feed purple" style="margin-bottom:50vh;background-color: rgba(0, 0, 0, 0.4);">
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         <div class="container section-wrapper">
 
         <div class="container section-wrapper">
             <h3 class='text-center' style='margin-bottom:30px'>Abstract</h3>
+
             <div class='col-md-3'></div>
                <h3>Knock-in of Circular RNA gene in Hepatocellular Carcinoma cells via CRISPR/Cas9</h4>
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            <div class='col-md-6 text-center'>
           
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                <h2 class='text-center' style='margin-bottom:30px'>
            <div>
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                    AFCM-Egypt</h2>
<p style='text-align: justify;font-size:18px'>
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                    <h3 class='text-center'>
Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers
+
                        A Culture of Discipline and Innovation</h3>
in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-.
+
                        <a href="http://www.afcm.ac.eg/" class="btn btn-primary btn-outline with-arrow" target="_blank"> click here <i class="fa fa-arrow-right"></i></a></div>
"Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique
+
            <div class='col-md-3'><img src="https://static.igem.org/mediawiki/2017/7/7b/AFCM_LOGO_PNG.png" alt="logo" style='width: 50%;float: right'></div>
that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma.
+
This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.
+
This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
+
</p>
+
</div>
+
 
         </div>
 
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<div class="twitter-feed purple" style="margin-bottom:50vh;background-color: rgba(0, 0, 0, 0.4);">
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            <h3 class='text-center'>OUR SPONSORS</h3>
<div class='col-md-6 text-center'>
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<h2 class='text-center' style='margin-bottom:30px'>AFCM-Egypt</h3>
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                <button class="afcmcontrols" id="afcmcontrols-left">&#10094;</button>
<h3 class='text-center'> We strive to excel</h4>
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<a class='btn btn-sub text-center' href='http://www.afcm.ac.eg' target='_blank'>click here</a>
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                        Copyright &copy; 2017 AFCM Egypt
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<script type="text/javascript">
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!function(a,b,c,d){function e(b,c){this.settings=null,this.options=a.extend({},e.Defaults,c),this.$element=a(b),this.drag=a.extend({},m),this.state=a.extend({},n),this.e=a.extend({},o),this._plugins={},this._supress={},this._current=null,this._speed=null,this._coordinates=[],this._breakpoint=null,this._width=null,this._items=[],this._clones=[],this._mergers=[],this._invalidated={},this._pipe=[],a.each(e.Plugins,a.proxy(function(a,b){this._plugins[a[0].toLowerCase()+a.slice(1)]=new b(this)},this)),a.each(e.Pipe,a.proxy(function(b,c){this._pipe.push({filter:c.filter,run:a.proxy(c.run,this)})},this)),this.setup(),this.initialize()}function f(a){if(a.touches!==d)return{x:a.touches[0].pageX,y:a.touches[0].pageY};if(a.touches===d){if(a.pageX!==d)return{x:a.pageX,y:a.pageY};if(a.pageX===d)return{x:a.clientX,y:a.clientY}}}function g(a){var b,d,e=c.createElement("div"),f=a;for(b in f)if(d=f[b],"undefined"!=typeof e.style[d])return e=null,[d,b];return[!1]}function h(){return g(["transition","WebkitTransition","MozTransition","OTransition"])[1]}function i(){return g(["transform","WebkitTransform","MozTransform","OTransform","msTransform"])[0]}function j(){return g(["perspective","webkitPerspective","MozPerspective","OPerspective","MsPerspective"])[0]}function k(){return"ontouchstart"in b||!!navigator.msMaxTouchPoints}function l(){return b.navigator.msPointerEnabled}var m,n,o;m={start:0,startX:0,startY:0,current:0,currentX:0,currentY:0,offsetX:0,offsetY:0,distance:null,startTime:0,endTime:0,updatedX:0,targetEl:null},n={isTouch:!1,isScrolling:!1,isSwiping:!1,direction:!1,inMotion:!1},o={_onDragStart:null,_onDragMove:null,_onDragEnd:null,_transitionEnd:null,_resizer:null,_responsiveCall:null,_goToLoop:null,_checkVisibile:null},e.Defaults={items:3,loop:!1,center:!1,mouseDrag:!0,touchDrag:!0,pullDrag:!0,freeDrag:!1,margin:0,stagePadding:0,merge:!1,mergeFit:!0,autoWidth:!1,startPosition:0,rtl:!1,smartSpeed:250,fluidSpeed:!1,dragEndSpeed:!1,responsive:{},responsiveRefreshRate:200,responsiveBaseElement:b,responsiveClass:!1,fallbackEasing:"swing",info:!1,nestedItemSelector:!1,itemElement:"div",stageElement:"div",themeClass:"owl-theme",baseClass:"owl-carousel",itemClass:"owl-item",centerClass:"center",activeClass:"active"},e.Width={Default:"default",Inner:"inner",Outer:"outer"},e.Plugins={},e.Pipe=[{filter:["width","items","settings"],run:function(a){a.current=this._items&&this._items[this.relative(this._current)]}},{filter:["items","settings"],run:function(){var a=this._clones,b=this.$stage.children(".cloned");(b.length!==a.length||!this.settings.loop&&a.length>0)&&(this.$stage.children(".cloned").remove(),this._clones=[])}},{filter:["items","settings"],run:function(){var a,b,c=this._clones,d=this._items,e=this.settings.loop?c.length-Math.max(2*this.settings.items,4):0;for(a=0,b=Math.abs(e/2);b>a;a++)e>0?(this.$stage.children().eq(d.length+c.length-1).remove(),c.pop(),this.$stage.children().eq(0).remove(),c.pop()):(c.push(c.length/2),this.$stage.append(d[c[c.length-1]].clone().addClass("cloned")),c.push(d.length-1-(c.length-1)/2),this.$stage.prepend(d[c[c.length-1]].clone().addClass("cloned")))}},{filter:["width","items","settings"],run:function(){var a,b,c,d=this.settings.rtl?1:-1,e=(this.width()/this.settings.items).toFixed(3),f=0;for(this._coordinates=[],b=0,c=this._clones.length+this._items.length;c>b;b++)a=this._mergers[this.relative(b)],a=this.settings.mergeFit&&Math.min(a,this.settings.items)||a,f+=(this.settings.autoWidth?this._items[this.relative(b)].width()+this.settings.margin:e*a)*d,this._coordinates.push(f)}},{filter:["width","items","settings"],run:function(){var b,c,d=(this.width()/this.settings.items).toFixed(3),e={width:Math.abs(this._coordinates[this._coordinates.length-1])+2*this.settings.stagePadding,"padding-left":this.settings.stagePadding||"","padding-right":this.settings.stagePadding||""};if(this.$stage.css(e),e={width:this.settings.autoWidth?"auto":d-this.settings.margin},e[this.settings.rtl?"margin-left":"margin-right"]=this.settings.margin,!this.settings.autoWidth&&a.grep(this._mergers,function(a){return a>1}).length>0)for(b=0,c=this._coordinates.length;c>b;b++)e.width=Math.abs(this._coordinates[b])-Math.abs(this._coordinates[b-1]||0)-this.settings.margin,this.$stage.children().eq(b).css(e);else this.$stage.children().css(e)}},{filter:["width","items","settings"],run:function(a){a.current&&this.reset(this.$stage.children().index(a.current))}},{filter:["position"],run:function(){this.animate(this.coordinates(this._current))}},{filter:["width","position","items","settings"],run:function(){var a,b,c,d,e=this.settings.rtl?1:-1,f=2*this.settings.stagePadding,g=this.coordinates(this.current())+f,h=g+this.width()*e,i=[];for(c=0,d=this._coordinates.length;d>c;c++)a=this._coordinates[c-1]||0,b=Math.abs(this._coordinates[c])+f*e,(this.op(a,"<=",g)&&this.op(a,">",h)||this.op(b,"<",g)&&this.op(b,">",h))&&i.push(c);this.$stage.children("."+this.settings.activeClass).removeClass(this.settings.activeClass),this.$stage.children(":eq("+i.join("), :eq(")+")").addClass(this.settings.activeClass),this.settings.center&&(this.$stage.children("."+this.settings.centerClass).removeClass(this.settings.centerClass),this.$stage.children().eq(this.current()).addClass(this.settings.centerClass))}}],e.prototype.initialize=function(){if(this.trigger("initialize"),this.$element.addClass(this.settings.baseClass).addClass(this.settings.themeClass).toggleClass("owl-rtl",this.settings.rtl),this.browserSupport(),this.settings.autoWidth&&this.state.imagesLoaded!==!0){var b,c,e;if(b=this.$element.find("img"),c=this.settings.nestedItemSelector?"."+this.settings.nestedItemSelector:d,e=this.$element.children(c).width(),b.length&&0>=e)return this.preloadAutoWidthImages(b),!1}this.$element.addClass("owl-loading"),this.$stage=a("<"+this.settings.stageElement+' class="owl-stage"/>').wrap('<div class="owl-stage-outer">'),this.$element.append(this.$stage.parent()),this.replace(this.$element.children().not(this.$stage.parent())),this._width=this.$element.width(),this.refresh(),this.$element.removeClass("owl-loading").addClass("owl-loaded"),this.eventsCall(),this.internalEvents(),this.addTriggerableEvents(),this.trigger("initialized")},e.prototype.setup=function(){var b=this.viewport(),c=this.options.responsive,d=-1,e=null;c?(a.each(c,function(a){b>=a&&a>d&&(d=Number(a))}),e=a.extend({},this.options,c[d]),delete e.responsive,e.responsiveClass&&this.$element.attr("class",function(a,b){return b.replace(/\b owl-responsive-\S+/g,"")}).addClass("owl-responsive-"+d)):e=a.extend({},this.options),(null===this.settings||this._breakpoint!==d)&&(this.trigger("change",{property:{name:"settings",value:e}}),this._breakpoint=d,this.settings=e,this.invalidate("settings"),this.trigger("changed",{property:{name:"settings",value:this.settings}}))},e.prototype.optionsLogic=function(){this.$element.toggleClass("owl-center",this.settings.center),this.settings.loop&&this._items.length<this.settings.items&&(this.settings.loop=!1),this.settings.autoWidth&&(this.settings.stagePadding=!1,this.settings.merge=!1)},e.prototype.prepare=function(b){var c=this.trigger("prepare",{content:b});return c.data||(c.data=a("<"+this.settings.itemElement+"/>").addClass(this.settings.itemClass).append(b)),this.trigger("prepared",{content:c.data}),c.data},e.prototype.update=function(){for(var b=0,c=this._pipe.length,d=a.proxy(function(a){return this[a]},this._invalidated),e={};c>b;)(this._invalidated.all||a.grep(this._pipe[b].filter,d).length>0)&&this._pipe[b].run(e),b++;this._invalidated={}},e.prototype.width=function(a){switch(a=a||e.Width.Default){case e.Width.Inner:case e.Width.Outer:return this._width;default:return this._width-2*this.settings.stagePadding+this.settings.margin}},e.prototype.refresh=function(){if(0===this._items.length)return!1;(new Date).getTime();this.trigger("refresh"),this.setup(),this.optionsLogic(),this.$stage.addClass("owl-refresh"),this.update(),this.$stage.removeClass("owl-refresh"),this.state.orientation=b.orientation,this.watchVisibility(),this.trigger("refreshed")},e.prototype.eventsCall=function(){this.e._onDragStart=a.proxy(function(a){this.onDragStart(a)},this),this.e._onDragMove=a.proxy(function(a){this.onDragMove(a)},this),this.e._onDragEnd=a.proxy(function(a){this.onDragEnd(a)},this),this.e._onResize=a.proxy(function(a){this.onResize(a)},this),this.e._transitionEnd=a.proxy(function(a){this.transitionEnd(a)},this),this.e._preventClick=a.proxy(function(a){this.preventClick(a)},this)},e.prototype.onThrottledResize=function(){b.clearTimeout(this.resizeTimer),this.resizeTimer=b.setTimeout(this.e._onResize,this.settings.responsiveRefreshRate)},e.prototype.onResize=function(){return this._items.length?this._width===this.$element.width()?!1:this.trigger("resize").isDefaultPrevented()?!1:(this._width=this.$element.width(),this.invalidate("width"),this.refresh(),void this.trigger("resized")):!1},e.prototype.eventsRouter=function(a){var b=a.type;"mousedown"===b||"touchstart"===b?this.onDragStart(a):"mousemove"===b||"touchmove"===b?this.onDragMove(a):"mouseup"===b||"touchend"===b?this.onDragEnd(a):"touchcancel"===b&&this.onDragEnd(a)},e.prototype.internalEvents=function(){var c=(k(),l());this.settings.mouseDrag?(this.$stage.on("mousedown",a.proxy(function(a){this.eventsRouter(a)},this)),this.$stage.on("dragstart",function(){return!1}),this.$stage.get(0).onselectstart=function(){return!1}):this.$element.addClass("owl-text-select-on"),this.settings.touchDrag&&!c&&this.$stage.on("touchstart touchcancel",a.proxy(function(a){this.eventsRouter(a)},this)),this.transitionEndVendor&&this.on(this.$stage.get(0),this.transitionEndVendor,this.e._transitionEnd,!1),this.settings.responsive!==!1&&this.on(b,"resize",a.proxy(this.onThrottledResize,this))},e.prototype.onDragStart=function(d){var e,g,h,i;if(e=d.originalEvent||d||b.event,3===e.which||this.state.isTouch)return!1;if("mousedown"===e.type&&this.$stage.addClass("owl-grab"),this.trigger("drag"),this.drag.startTime=(new Date).getTime(),this.speed(0),this.state.isTouch=!0,this.state.isScrolling=!1,this.state.isSwiping=!1,this.drag.distance=0,g=f(e).x,h=f(e).y,this.drag.offsetX=this.$stage.position().left,this.drag.offsetY=this.$stage.position().top,this.settings.rtl&&(this.drag.offsetX=this.$stage.position().left+this.$stage.width()-this.width()+this.settings.margin),this.state.inMotion&&this.support3d)i=this.getTransformProperty(),this.drag.offsetX=i,this.animate(i),this.state.inMotion=!0;else if(this.state.inMotion&&!this.support3d)return this.state.inMotion=!1,!1;this.drag.startX=g-this.drag.offsetX,this.drag.startY=h-this.drag.offsetY,this.drag.start=g-this.drag.startX,this.drag.targetEl=e.target||e.srcElement,this.drag.updatedX=this.drag.start,("IMG"===this.drag.targetEl.tagName||"A"===this.drag.targetEl.tagName)&&(this.drag.targetEl.draggable=!1),a(c).on("mousemove.owl.dragEvents mouseup.owl.dragEvents touchmove.owl.dragEvents touchend.owl.dragEvents",a.proxy(function(a){this.eventsRouter(a)},this))},e.prototype.onDragMove=function(a){var c,e,g,h,i,j;this.state.isTouch&&(this.state.isScrolling||(c=a.originalEvent||a||b.event,e=f(c).x,g=f(c).y,this.drag.currentX=e-this.drag.startX,this.drag.currentY=g-this.drag.startY,this.drag.distance=this.drag.currentX-this.drag.offsetX,this.drag.distance<0?this.state.direction=this.settings.rtl?"right":"left":this.drag.distance>0&&(this.state.direction=this.settings.rtl?"left":"right"),this.settings.loop?this.op(this.drag.currentX,">",this.coordinates(this.minimum()))&&"right"===this.state.direction?this.drag.currentX-=(this.settings.center&&this.coordinates(0))-this.coordinates(this._items.length):this.op(this.drag.currentX,"<",this.coordinates(this.maximum()))&&"left"===this.state.direction&&(this.drag.currentX+=(this.settings.center&&this.coordinates(0))-this.coordinates(this._items.length)):(h=this.coordinates(this.settings.rtl?this.maximum():this.minimum()),i=this.coordinates(this.settings.rtl?this.minimum():this.maximum()),j=this.settings.pullDrag?this.drag.distance/5:0,this.drag.currentX=Math.max(Math.min(this.drag.currentX,h+j),i+j)),(this.drag.distance>8||this.drag.distance<-8)&&(c.preventDefault!==d?c.preventDefault():c.returnValue=!1,this.state.isSwiping=!0),this.drag.updatedX=this.drag.currentX,(this.drag.currentY>16||this.drag.currentY<-16)&&this.state.isSwiping===!1&&(this.state.isScrolling=!0,this.drag.updatedX=this.drag.start),this.animate(this.drag.updatedX)))},e.prototype.onDragEnd=function(b){var d,e,f;if(this.state.isTouch){if("mouseup"===b.type&&this.$stage.removeClass("owl-grab"),this.trigger("dragged"),this.drag.targetEl.removeAttribute("draggable"),this.state.isTouch=!1,this.state.isScrolling=!1,this.state.isSwiping=!1,0===this.drag.distance&&this.state.inMotion!==!0)return this.state.inMotion=!1,!1;this.drag.endTime=(new Date).getTime(),d=this.drag.endTime-this.drag.startTime,e=Math.abs(this.drag.distance),(e>3||d>300)&&this.removeClick(this.drag.targetEl),f=this.closest(this.drag.updatedX),this.speed(this.settings.dragEndSpeed||this.settings.smartSpeed),this.current(f),this.invalidate("position"),this.update(),this.settings.pullDrag||this.drag.updatedX!==this.coordinates(f)||this.transitionEnd(),this.drag.distance=0,a(c).off(".owl.dragEvents")}},e.prototype.removeClick=function(c){this.drag.targetEl=c,a(c).on("click.preventClick",this.e._preventClick),b.setTimeout(function(){a(c).off("click.preventClick")},300)},e.prototype.preventClick=function(b){b.preventDefault?b.preventDefault():b.returnValue=!1,b.stopPropagation&&b.stopPropagation(),a(b.target).off("click.preventClick")},e.prototype.getTransformProperty=function(){var a,c;return a=b.getComputedStyle(this.$stage.get(0),null).getPropertyValue(this.vendorName+"transform"),a=a.replace(/matrix(3d)?\(|\)/g,"").split(","),c=16===a.length,c!==!0?a[4]:a[12]},e.prototype.closest=function(b){var c=-1,d=30,e=this.width(),f=this.coordinates();return this.settings.freeDrag||a.each(f,a.proxy(function(a,g){return b>g-d&&g+d>b?c=a:this.op(b,"<",g)&&this.op(b,">",f[a+1]||g-e)&&(c="left"===this.state.direction?a+1:a),-1===c},this)),this.settings.loop||(this.op(b,">",f[this.minimum()])?c=b=this.minimum():this.op(b,"<",f[this.maximum()])&&(c=b=this.maximum())),c},e.prototype.animate=function(b){this.trigger("translate"),this.state.inMotion=this.speed()>0,this.support3d?this.$stage.css({transform:"translate3d("+b+"px,0px, 0px)",transition:this.speed()/1e3+"s"}):this.state.isTouch?this.$stage.css({left:b+"px"}):this.$stage.animate({left:b},this.speed()/1e3,this.settings.fallbackEasing,a.proxy(function(){this.state.inMotion&&this.transitionEnd()},this))},e.prototype.current=function(a){if(a===d)return this._current;if(0===this._items.length)return d;if(a=this.normalize(a),this._current!==a){var b=this.trigger("change",{property:{name:"position",value:a}});b.data!==d&&(a=this.normalize(b.data)),this._current=a,this.invalidate("position"),this.trigger("changed",{property:{name:"position",value:this._current}})}return this._current},e.prototype.invalidate=function(a){this._invalidated[a]=!0},e.prototype.reset=function(a){a=this.normalize(a),a!==d&&(this._speed=0,this._current=a,this.suppress(["translate","translated"]),this.animate(this.coordinates(a)),this.release(["translate","translated"]))},e.prototype.normalize=function(b,c){var e=c?this._items.length:this._items.length+this._clones.length;return!a.isNumeric(b)||1>e?d:b=this._clones.length?(b%e+e)%e:Math.max(this.minimum(c),Math.min(this.maximum(c),b))},e.prototype.relative=function(a){return a=this.normalize(a),a-=this._clones.length/2,this.normalize(a,!0)},e.prototype.maximum=function(a){var b,c,d,e=0,f=this.settings;if(a)return this._items.length-1;if(!f.loop&&f.center)b=this._items.length-1;else if(f.loop||f.center)if(f.loop||f.center)b=this._items.length+f.items;else{if(!f.autoWidth&&!f.merge)throw"Can not detect maximum absolute position.";for(revert=f.rtl?1:-1,c=this.$stage.width()-this.$element.width();(d=this.coordinates(e))&&!(d*revert>=c);)b=++e}else b=this._items.length-f.items;return b},e.prototype.minimum=function(a){return a?0:this._clones.length/2},e.prototype.items=function(a){return a===d?this._items.slice():(a=this.normalize(a,!0),this._items[a])},e.prototype.mergers=function(a){return a===d?this._mergers.slice():(a=this.normalize(a,!0),this._mergers[a])},e.prototype.clones=function(b){var c=this._clones.length/2,e=c+this._items.length,f=function(a){return a%2===0?e+a/2:c-(a+1)/2};return b===d?a.map(this._clones,function(a,b){return f(b)}):a.map(this._clones,function(a,c){return a===b?f(c):null})},e.prototype.speed=function(a){return a!==d&&(this._speed=a),this._speed},e.prototype.coordinates=function(b){var c=null;return b===d?a.map(this._coordinates,a.proxy(function(a,b){return this.coordinates(b)},this)):(this.settings.center?(c=this._coordinates[b],c+=(this.width()-c+(this._coordinates[b-1]||0))/2*(this.settings.rtl?-1:1)):c=this._coordinates[b-1]||0,c)},e.prototype.duration=function(a,b,c){return Math.min(Math.max(Math.abs(b-a),1),6)*Math.abs(c||this.settings.smartSpeed)},e.prototype.to=function(c,d){if(this.settings.loop){var e=c-this.relative(this.current()),f=this.current(),g=this.current(),h=this.current()+e,i=0>g-h?!0:!1,j=this._clones.length+this._items.length;h<this.settings.items&&i===!1?(f=g+this._items.length,this.reset(f)):h>=j-this.settings.items&&i===!0&&(f=g-this._items.length,this.reset(f)),b.clearTimeout(this.e._goToLoop),this.e._goToLoop=b.setTimeout(a.proxy(function(){this.speed(this.duration(this.current(),f+e,d)),this.current(f+e),this.update()},this),30)}else this.speed(this.duration(this.current(),c,d)),this.current(c),this.update()},e.prototype.next=function(a){a=a||!1,this.to(this.relative(this.current())+1,a)},e.prototype.prev=function(a){a=a||!1,this.to(this.relative(this.current())-1,a)},e.prototype.transitionEnd=function(a){return a!==d&&(a.stopPropagation(),(a.target||a.srcElement||a.originalTarget)!==this.$stage.get(0))?!1:(this.state.inMotion=!1,void this.trigger("translated"))},e.prototype.viewport=function(){var d;if(this.options.responsiveBaseElement!==b)d=a(this.options.responsiveBaseElement).width();else if(b.innerWidth)d=b.innerWidth;else{if(!c.documentElement||!c.documentElement.clientWidth)throw"Can not detect viewport width.";d=c.documentElement.clientWidth}return d},e.prototype.replace=function(b){this.$stage.empty(),this._items=[],b&&(b=b instanceof jQuery?b:a(b)),this.settings.nestedItemSelector&&(b=b.find("."+this.settings.nestedItemSelector)),b.filter(function(){return 1===this.nodeType}).each(a.proxy(function(a,b){b=this.prepare(b),this.$stage.append(b),this._items.push(b),this._mergers.push(1*b.find("[data-merge]").andSelf("[data-merge]").attr("data-merge")||1)},this)),this.reset(a.isNumeric(this.settings.startPosition)?this.settings.startPosition:0),this.invalidate("items")},e.prototype.add=function(a,b){b=b===d?this._items.length:this.normalize(b,!0),this.trigger("add",{content:a,position:b}),0===this._items.length||b===this._items.length?(this.$stage.append(a),this._items.push(a),this._mergers.push(1*a.find("[data-merge]").andSelf("[data-merge]").attr("data-merge")||1)):(this._items[b].before(a),this._items.splice(b,0,a),this._mergers.splice(b,0,1*a.find("[data-merge]").andSelf("[data-merge]").attr("data-merge")||1)),this.invalidate("items"),this.trigger("added",{content:a,position:b})},e.prototype.remove=function(a){a=this.normalize(a,!0),a!==d&&(this.trigger("remove",{content:this._items[a],position:a}),this._items[a].remove(),this._items.splice(a,1),this._mergers.splice(a,1),this.invalidate("items"),this.trigger("removed",{content:null,position:a}))},e.prototype.addTriggerableEvents=function(){var b=a.proxy(function(b,c){return a.proxy(function(a){a.relatedTarget!==this&&(this.suppress([c]),b.apply(this,[].slice.call(arguments,1)),this.release([c]))},this)},this);a.each({next:this.next,prev:this.prev,to:this.to,destroy:this.destroy,refresh:this.refresh,replace:this.replace,add:this.add,remove:this.remove},a.proxy(function(a,c){this.$element.on(a+".owl.carousel",b(c,a+".owl.carousel"))},this))},e.prototype.watchVisibility=function(){function c(a){return a.offsetWidth>0&&a.offsetHeight>0}function d(){c(this.$element.get(0))&&(this.$element.removeClass("owl-hidden"),this.refresh(),b.clearInterval(this.e._checkVisibile))}c(this.$element.get(0))||(this.$element.addClass("owl-hidden"),b.clearInterval(this.e._checkVisibile),this.e._checkVisibile=b.setInterval(a.proxy(d,this),500))},e.prototype.preloadAutoWidthImages=function(b){var c,d,e,f;c=0,d=this,b.each(function(g,h){e=a(h),f=new 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touchcancel"),a(c).off(".owl.dragEvents"),this.$stage.get(0).onselectstart=function(){},this.$stage.off("dragstart",function(){return!1})),this.$element.off(".owl"),this.$stage.children(".cloned").remove(),this.e=null,this.$element.removeData("owlCarousel"),this.$stage.children().contents().unwrap(),this.$stage.children().unwrap(),this.$stage.unwrap()},e.prototype.op=function(a,b,c){var d=this.settings.rtl;switch(b){case"<":return d?a>c:c>a;case">":return d?c>a:a>c;case">=":return d?c>=a:a>=c;case"<=":return d?a>=c:c>=a}},e.prototype.on=function(a,b,c,d){a.addEventListener?a.addEventListener(b,c,d):a.attachEvent&&a.attachEvent("on"+b,c)},e.prototype.off=function(a,b,c,d){a.removeEventListener?a.removeEventListener(b,c,d):a.detachEvent&&a.detachEvent("on"+b,c)},e.prototype.trigger=function(b,c,d){var e={item:{count:this._items.length,index:this.current()}},f=a.camelCase(a.grep(["on",b,d],function(a){return a}).join("-").toLowerCase()),g=a.Event([b,"owl",d||"carousel"].join(".").toLowerCase(),a.extend({relatedTarget:this},e,c));return this._supress[b]||(a.each(this._plugins,function(a,b){b.onTrigger&&b.onTrigger(g)}),this.$element.trigger(g),this.settings&&"function"==typeof this.settings[f]&&this.settings[f].apply(this,g)),g},e.prototype.suppress=function(b){a.each(b,a.proxy(function(a,b){this._supress[b]=!0},this))},e.prototype.release=function(b){a.each(b,a.proxy(function(a,b){delete this._supress[b]},this))},e.prototype.browserSupport=function(){if(this.support3d=j(),this.support3d){this.transformVendor=i();var a=["transitionend","webkitTransitionEnd","transitionend","oTransitionEnd"];this.transitionEndVendor=a[h()],this.vendorName=this.transformVendor.replace(/Transform/i,""),this.vendorName=""!==this.vendorName?"-"+this.vendorName.toLowerCase()+"-":""}this.state.orientation=b.orientation},a.fn.owlCarousel=function(b){return this.each(function(){a(this).data("owlCarousel")||a(this).data("owlCarousel",new e(this,b))})},a.fn.owlCarousel.Constructor=e}(window.Zepto||window.jQuery,window,document),function(a,b){var c=function(b){this._core=b,this._loaded=[],this._handlers={"initialized.owl.carousel change.owl.carousel":a.proxy(function(b){if(b.namespace&&this._core.settings&&this._core.settings.lazyLoad&&(b.property&&"position"==b.property.name||"initialized"==b.type))for(var c=this._core.settings,d=c.center&&Math.ceil(c.items/2)||c.items,e=c.center&&-1*d||0,f=(b.property&&b.property.value||this._core.current())+e,g=this._core.clones().length,h=a.proxy(function(a,b){this.load(b)},this);e++<d;)this.load(g/2+this._core.relative(f)),g&&a.each(this._core.clones(this._core.relative(f++)),h)},this)},this._core.options=a.extend({},c.Defaults,this._core.options),this._core.$element.on(this._handlers)};c.Defaults={lazyLoad:!1},c.prototype.load=function(c){var d=this._core.$stage.children().eq(c),e=d&&d.find(".owl-lazy");!e||a.inArray(d.get(0),this._loaded)>-1||(e.each(a.proxy(function(c,d){var e,f=a(d),g=b.devicePixelRatio>1&&f.attr("data-src-retina")||f.attr("data-src");this._core.trigger("load",{element:f,url:g},"lazy"),f.is("img")?f.one("load.owl.lazy",a.proxy(function(){f.css("opacity",1),this._core.trigger("loaded",{element:f,url:g},"lazy")},this)).attr("src",g):(e=new Image,e.onload=a.proxy(function(){f.css({"background-image":"url("+g+")",opacity:"1"}),this._core.trigger("loaded",{element:f,url:g},"lazy")},this),e.src=g)},this)),this._loaded.push(d.get(0)))},c.prototype.destroy=function(){var a,b;for(a in this.handlers)this._core.$element.off(a,this.handlers[a]);for(b in Object.getOwnPropertyNames(this))"function"!=typeof this[b]&&(this[b]=null)},a.fn.owlCarousel.Constructor.Plugins.Lazy=c}(window.Zepto||window.jQuery,window,document),function(a){var b=function(c){this._core=c,this._handlers={"initialized.owl.carousel":a.proxy(function(){this._core.settings.autoHeight&&this.update()},this),"changed.owl.carousel":a.proxy(function(a){this._core.settings.autoHeight&&"position"==a.property.name&&this.update()},this),"loaded.owl.lazy":a.proxy(function(a){this._core.settings.autoHeight&&a.element.closest("."+this._core.settings.itemClass)===this._core.$stage.children().eq(this._core.current())&&this.update()},this)},this._core.options=a.extend({},b.Defaults,this._core.options),this._core.$element.on(this._handlers)};b.Defaults={autoHeight:!1,autoHeightClass:"owl-height"},b.prototype.update=function(){this._core.$stage.parent().height(this._core.$stage.children().eq(this._core.current()).height()).addClass(this._core.settings.autoHeightClass)},b.prototype.destroy=function(){var a,b;for(a in this._handlers)this._core.$element.off(a,this._handlers[a]);for(b in Object.getOwnPropertyNames(this))"function"!=typeof this[b]&&(this[b]=null)},a.fn.owlCarousel.Constructor.Plugins.AutoHeight=b}(window.Zepto||window.jQuery,window,document),function(a,b,c){var d=function(b){this._core=b,this._videos={},this._playing=null,this._fullscreen=!1,this._handlers={"resize.owl.carousel":a.proxy(function(a){this._core.settings.video&&!this.isInFullScreen()&&a.preventDefault()},this),"refresh.owl.carousel changed.owl.carousel":a.proxy(function(){this._playing&&this.stop()},this),"prepared.owl.carousel":a.proxy(function(b){var c=a(b.content).find(".owl-video");c.length&&(c.css("display","none"),this.fetch(c,a(b.content)))},this)},this._core.options=a.extend({},d.Defaults,this._core.options),this._core.$element.on(this._handlers),this._core.$element.on("click.owl.video",".owl-video-play-icon",a.proxy(function(a){this.play(a)},this))};d.Defaults={video:!1,videoHeight:!1,videoWidth:!1},d.prototype.fetch=function(a,b){var c=a.attr("data-vimeo-id")?"vimeo":"youtube",d=a.attr("data-vimeo-id")||a.attr("data-youtube-id"),e=a.attr("data-width")||this._core.settings.videoWidth,f=a.attr("data-height")||this._core.settings.videoHeight,g=a.attr("href");if(!g)throw new Error("Missing video URL.");if(d=g.match(/(http:|https:|)\/\/(player.|www.)?(vimeo\.com|youtu(be\.com|\.be|be\.googleapis\.com))\/(video\/|embed\/|watch\?v=|v\/)?([A-Za-z0-9._%-]*)(\&\S+)?/),d[3].indexOf("youtu")>-1)c="youtube";else{if(!(d[3].indexOf("vimeo")>-1))throw new Error("Video URL not supported.");c="vimeo"}d=d[6],this._videos[g]={type:c,id:d,width:e,height:f},b.attr("data-video",g),this.thumbnail(a,this._videos[g])},d.prototype.thumbnail=function(b,c){var d,e,f,g=c.width&&c.height?'style="width:'+c.width+"px;height:"+c.height+'px;"':"",h=b.find("img"),i="src",j="",k=this._core.settings,l=function(a){e='<div class="owl-video-play-icon"></div>',d=k.lazyLoad?'<div class="owl-video-tn '+j+'" '+i+'="'+a+'"></div>':'<div class="owl-video-tn" style="opacity:1;background-image:url('+a+')"></div>',b.after(d),b.after(e)};return b.wrap('<div class="owl-video-wrapper"'+g+"></div>"),this._core.settings.lazyLoad&&(i="data-src",j="owl-lazy"),h.length?(l(h.attr(i)),h.remove(),!1):void("youtube"===c.type?(f="http://img.youtube.com/vi/"+c.id+"/hqdefault.jpg",l(f)):"vimeo"===c.type&&a.ajax({type:"GET",url:"http://vimeo.com/api/v2/video/"+c.id+".json",jsonp:"callback",dataType:"jsonp",success:function(a){f=a[0].thumbnail_large,l(f)}}))},d.prototype.stop=function(){this._core.trigger("stop",null,"video"),this._playing.find(".owl-video-frame").remove(),this._playing.removeClass("owl-video-playing"),this._playing=null},d.prototype.play=function(b){this._core.trigger("play",null,"video"),this._playing&&this.stop();var c,d,e=a(b.target||b.srcElement),f=e.closest("."+this._core.settings.itemClass),g=this._videos[f.attr("data-video")],h=g.width||"100%",i=g.height||this._core.$stage.height();"youtube"===g.type?c='<iframe width="'+h+'" 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b,c=a.proxy(this.clear,this),d=this.core.$stage.children().eq(this.previous),e=this.core.$stage.children().eq(this.next),f=this.core.settings.animateIn,g=this.core.settings.animateOut;this.core.current()!==this.previous&&(g&&(b=this.core.coordinates(this.previous)-this.core.coordinates(this.next),d.css({left:b+"px"}).addClass("animated owl-animated-out").addClass(g).one("webkitAnimationEnd mozAnimationEnd MSAnimationEnd oanimationend animationend",c)),f&&e.addClass("animated owl-animated-in").addClass(f).one("webkitAnimationEnd mozAnimationEnd MSAnimationEnd oanimationend animationend",c))}},e.prototype.clear=function(b){a(b.target).css({left:""}).removeClass("animated owl-animated-out owl-animated-in").removeClass(this.core.settings.animateIn).removeClass(this.core.settings.animateOut),this.core.transitionEnd()},e.prototype.destroy=function(){var a,b;for(a in this.handlers)this.core.$element.off(a,this.handlers[a]);for(b in Object.getOwnPropertyNames(this))"function"!=typeof this[b]&&(this[b]=null)},a.fn.owlCarousel.Constructor.Plugins.Animate=e}(window.Zepto||window.jQuery,window,document),function(a,b,c){var d=function(b){this.core=b,this.core.options=a.extend({},d.Defaults,this.core.options),this.handlers={"translated.owl.carousel refreshed.owl.carousel":a.proxy(function(){this.autoplay()
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    <script>
},this),"play.owl.autoplay":a.proxy(function(a,b,c){this.play(b,c)},this),"stop.owl.autoplay":a.proxy(function(){this.stop()},this),"mouseover.owl.autoplay":a.proxy(function(){this.core.settings.autoplayHoverPause&&this.pause()},this),"mouseleave.owl.autoplay":a.proxy(function(){this.core.settings.autoplayHoverPause&&this.autoplay()},this)},this.core.$element.on(this.handlers)};d.Defaults={autoplay:!1,autoplayTimeout:5e3,autoplayHoverPause:!1,autoplaySpeed:!1},d.prototype.autoplay=function(){this.core.settings.autoplay&&!this.core.state.videoPlay?(b.clearInterval(this.interval),this.interval=b.setInterval(a.proxy(function(){this.play()},this),this.core.settings.autoplayTimeout)):b.clearInterval(this.interval)},d.prototype.play=function(){return c.hidden===!0||this.core.state.isTouch||this.core.state.isScrolling||this.core.state.isSwiping||this.core.state.inMotion?void 0:this.core.settings.autoplay===!1?void b.clearInterval(this.interval):void this.core.next(this.core.settings.autoplaySpeed)},d.prototype.stop=function(){b.clearInterval(this.interval)},d.prototype.pause=function(){b.clearInterval(this.interval)},d.prototype.destroy=function(){var a,c;b.clearInterval(this.interval);for(a in this.handlers)this.core.$element.off(a,this.handlers[a]);for(c in Object.getOwnPropertyNames(this))"function"!=typeof this[c]&&(this[c]=null)},a.fn.owlCarousel.Constructor.Plugins.autoplay=d}(window.Zepto||window.jQuery,window,document),function(a){"use strict";var b=function(c){this._core=c,this._initialized=!1,this._pages=[],this._controls={},this._templates=[],this.$element=this._core.$element,this._overrides={next:this._core.next,prev:this._core.prev,to:this._core.to},this._handlers={"prepared.owl.carousel":a.proxy(function(b){this._core.settings.dotsData&&this._templates.push(a(b.content).find("[data-dot]").andSelf("[data-dot]").attr("data-dot"))},this),"add.owl.carousel":a.proxy(function(b){this._core.settings.dotsData&&this._templates.splice(b.position,0,a(b.content).find("[data-dot]").andSelf("[data-dot]").attr("data-dot"))},this),"remove.owl.carousel prepared.owl.carousel":a.proxy(function(a){this._core.settings.dotsData&&this._templates.splice(a.position,1)},this),"change.owl.carousel":a.proxy(function(a){if("position"==a.property.name&&!this._core.state.revert&&!this._core.settings.loop&&this._core.settings.navRewind){var b=this._core.current(),c=this._core.maximum(),d=this._core.minimum();a.data=a.property.value>c?b>=c?d:c:a.property.value<d?c:a.property.value}},this),"changed.owl.carousel":a.proxy(function(a){"position"==a.property.name&&this.draw()},this),"refreshed.owl.carousel":a.proxy(function(){this._initialized||(this.initialize(),this._initialized=!0),this._core.trigger("refresh",null,"navigation"),this.update(),this.draw(),this._core.trigger("refreshed",null,"navigation")},this)},this._core.options=a.extend({},b.Defaults,this._core.options),this.$element.on(this._handlers)};b.Defaults={nav:!1,navRewind:!0,navText:["prev","next"],navSpeed:!1,navElement:"div",navContainer:!1,navContainerClass:"owl-nav",navClass:["owl-prev","owl-next"],slideBy:1,dotClass:"owl-dot",dotsClass:"owl-dots",dots:!0,dotsEach:!1,dotData:!1,dotsSpeed:!1,dotsContainer:!1,controlsClass:"owl-controls"},b.prototype.initialize=function(){var b,c,d=this._core.settings;d.dotsData||(this._templates=[a("<div>").addClass(d.dotClass).append(a("<span>")).prop("outerHTML")]),d.navContainer&&d.dotsContainer||(this._controls.$container=a("<div>").addClass(d.controlsClass).appendTo(this.$element)),this._controls.$indicators=d.dotsContainer?a(d.dotsContainer):a("<div>").hide().addClass(d.dotsClass).appendTo(this._controls.$container),this._controls.$indicators.on("click","div",a.proxy(function(b){var c=a(b.target).parent().is(this._controls.$indicators)?a(b.target).index():a(b.target).parent().index();b.preventDefault(),this.to(c,d.dotsSpeed)},this)),b=d.navContainer?a(d.navContainer):a("<div>").addClass(d.navContainerClass).prependTo(this._controls.$container),this._controls.$next=a("<"+d.navElement+">"),this._controls.$previous=this._controls.$next.clone(),this._controls.$previous.addClass(d.navClass[0]).html(d.navText[0]).hide().prependTo(b).on("click",a.proxy(function(){this.prev(d.navSpeed)},this)),this._controls.$next.addClass(d.navClass[1]).html(d.navText[1]).hide().appendTo(b).on("click",a.proxy(function(){this.next(d.navSpeed)},this));for(c in this._overrides)this._core[c]=a.proxy(this[c],this)},b.prototype.destroy=function(){var a,b,c,d;for(a in this._handlers)this.$element.off(a,this._handlers[a]);for(b in this._controls)this._controls[b].remove();for(d in this.overides)this._core[d]=this._overrides[d];for(c in Object.getOwnPropertyNames(this))"function"!=typeof this[c]&&(this[c]=null)},b.prototype.update=function(){var a,b,c,d=this._core.settings,e=this._core.clones().length/2,f=e+this._core.items().length,g=d.center||d.autoWidth||d.dotData?1:d.dotsEach||d.items;if("page"!==d.slideBy&&(d.slideBy=Math.min(d.slideBy,d.items)),d.dots||"page"==d.slideBy)for(this._pages=[],a=e,b=0,c=0;f>a;a++)(b>=g||0===b)&&(this._pages.push({start:a-e,end:a-e+g-1}),b=0,++c),b+=this._core.mergers(this._core.relative(a))},b.prototype.draw=function(){var b,c,d="",e=this._core.settings,f=(this._core.$stage.children(),this._core.relative(this._core.current()));if(!e.nav||e.loop||e.navRewind||(this._controls.$previous.toggleClass("disabled",0>=f),this._controls.$next.toggleClass("disabled",f>=this._core.maximum())),this._controls.$previous.toggle(e.nav),this._controls.$next.toggle(e.nav),e.dots){if(b=this._pages.length-this._controls.$indicators.children().length,e.dotData&&0!==b){for(c=0;c<this._controls.$indicators.children().length;c++)d+=this._templates[this._core.relative(c)];this._controls.$indicators.html(d)}else b>0?(d=new Array(b+1).join(this._templates[0]),this._controls.$indicators.append(d)):0>b&&this._controls.$indicators.children().slice(b).remove();this._controls.$indicators.find(".active").removeClass("active"),this._controls.$indicators.children().eq(a.inArray(this.current(),this._pages)).addClass("active")}this._controls.$indicators.toggle(e.dots)},b.prototype.onTrigger=function(b){var 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Latest revision as of 20:11, 31 October 2017

A F C M

A F C M

Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma




Abstract

 

Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers in males and next to breast cancer among females in Egypt based upon results of National Cancer Registry Program of Egypt. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain  circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies   miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.   This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is    accomplished by utilizing a   synthetic circuit to give rise to a springboard in our battle against cancer.














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