Difference between revisions of "Team:AFCM-Egypt"

 
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     <meta name="author" content="Web Domus Italia">
 
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                        <a>TEAM <span class="caret"></span></a>
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                <video autoplay controls loop style="width:85%;height:85%">
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                    <source src="https://static.igem.org/mediawiki/2017/8/88/Final_vid.mp4" type="video/mp4">
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                 <!--<h1 class="header-title">
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                     <p><img style="float: right;" src="https://static.igem.org/mediawiki/2017/d/d4/CRISPR_PNG.png" alt="" width="679" height="988" /></p>
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                     TEAM AFCM
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<h3 dir="ltr" style="text-align: left;"><span style="font-size: 20pt; color: #ffffff;">Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma</span><br /><br /><br />                  
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                </h1>
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  <h3 class="text-center" style="text-align: center;"><br /><br /><span style="font-size: 14pt; color: #ffffff;">Abstract</span></h3>
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                     <p style="text-align: left;"><span style="font-size: 14pt; color: #ffffff;">&nbsp;</span></p>
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                     since ****
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                  <span style="font-size: 14pt; color: #ffffff;">Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide &amp; ranked first among cancers in males and next to breast cancer among females in</span><span style="font-size: 14pt; color: #ffffff;"> Egypt based upon results of National Cancer Registry Program of Egypt. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain&nbsp; circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies&nbsp; &nbsp;miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.&nbsp; &nbsp;This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is&nbsp; &nbsp; accomplished by utilizing a&nbsp; &nbsp;synthetic circuit to give rise to a springboard in our battle against cancer.</span><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /></h3>
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             <h3 class='text-center' style='margin-bottom:30px'>Abstract</h3>
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             <div class='col-md-3'></div>
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                <h3>Knock-in of Circular RNA gene in Hepatocellular Carcinoma cells via CRISPR/Cas9</h4>
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                    AFCM-Egypt</h2>
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<p style='text-align: justify;font-size:18px'>
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                    <h3 class='text-center'>
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Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers
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                        A Culture of Discipline and Innovation</h3>
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in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-.
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                        <a href="http://www.afcm.ac.eg/" class="btn btn-primary btn-outline with-arrow" target="_blank"> click here <i class="fa fa-arrow-right"></i></a></div>
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"Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique
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            <div class='col-md-3'><img src="https://static.igem.org/mediawiki/2017/7/7b/AFCM_LOGO_PNG.png" alt="logo" style='width: 50%;float: right'></div>
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that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma.
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−
This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.
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This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
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            <h3 class='text-center'>OUR SPONSORS</h3>
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<h2 class='text-center' style='margin-bottom:30px'>AFCM-Egypt</h3>
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<h3 class='text-center'> We strive to excel</h4>
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<a class='btn btn-sub text-center' href='http://www.afcm.ac.eg' target='_blank'>click here</a>
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<img src="https://static.igem.org/mediawiki/2017/b/b4/8-AFCM-Egypt-sponsers-Zewail_logo.png" alt="add" class="add-item">
+
−
</div> <!-- /.item -->
+
−
<div class="item">
+
−
<img src="https://static.igem.org/mediawiki/2017/6/60/9-AFCM-Egypt-sponsers-Benchling.png" alt="add" class="add-item">
+
−
</div> <!-- /.item -->
+
−
</div> <!-- /.owl-carousel -->
+
−
</section>
+
  
−
</body>
+
    <script>
−
<script type="text/javascript" src="https://2017.igem.org/Template:AFCM-Egypt/owl.carouseljs/Javascript?
+
$(document).ready(function() {
−
action=raw&ctype=text/javascript"></script>
+
$('#myBtn').click(function(){
−
<script type="text/javascript" src="https://2017.igem.org/Template:AFCM-Egypt/bootstrapjs/Javascript?
+
document.body.scrollTop = 0;
−
action=raw&ctype=text/javascript"></script>
+
             document.documentElement.scrollTop = 0;
−
<script>
+
})
−
! function (a, b, c, d) {
+
window.onscroll = function () { scrollFunction() };
−
    function e(b, c) {
+
         function scrollFunction() {
−
        this.settings = null, this.options = a.extend({}, e.Defaults, c), this.$element = a(b), this.drag = a.extend({}, m), this.state = a.extend({}, n), this.e = a.extend({}, o), this._plugins = {}, this._supress = {}, this._current = null, this._speed = null, this._coordinates = [], this._breakpoint = null, this._width = null, this._items = [], this._clones = [], this._mergers = [], this._invalidated = {}, this._pipe = [], a.each(e.Plugins, a.proxy(function (a, b) {
+
            if (document.body.scrollTop > 20 || document.documentElement.scrollTop > 20) {
−
             this._plugins[a[0].toLowerCase() + a.slice(1)] = new b(this)
+
                document.getElementById("myBtn").style.display = "block";
−
        }, this)), a.each(e.Pipe, a.proxy(function (b, c) {
+
             } else {
−
            this._pipe.push({
+
                 document.getElementById("myBtn").style.display = "none";
−
                filter: c.filter,
+
−
                run: a.proxy(c.run, this)
+
−
            })
+
−
         }, this)), this.setup(), this.initialize()
+
−
    }
+
−
 
+
−
    function f(a) {
+
−
        if (a.touches !== d) return {
+
−
            x: a.touches[0].pageX,
+
−
            y: a.touches[0].pageY
+
−
        };
+
−
        if (a.touches === d) {
+
−
            if (a.pageX !== d) return {
+
−
                x: a.pageX,
+
−
                y: a.pageY
+
−
             };
+
−
            if (a.pageX === d) return {
+
−
                 x: a.clientX,
+
−
                y: a.clientY
+
 
             }
 
             }
 
         }
 
         }
−
    }
+
       
−
 
+
document.getElementById('navbar-toggle').onclick = function () {
−
    function g(a) {
+
    var active = document.querySelector(".navbar-collapse");
−
        var b, d, e = c.createElement("div"),
+
    active.classList.toggle("in");
−
            f = a;
+
}
−
        for (b in f)
+
var slides = document.querySelectorAll('#afcmslides .afcmslide');
−
            if (d = f[b], "undefined" != typeof e.style[d]) return e = null, [d, b];
+
         var currentSlide = 0;
−
        return [!1]
+
var slideInterval ;
−
    }
+
         var controls = document.querySelectorAll('.afcmcontrols');
−
 
+
−
    function h() {
+
−
         return g(["transition", "WebkitTransition", "MozTransition", "OTransition"])[1]
+
−
    }
+
−
 
+
−
    function i() {
+
−
        return g(["transform", "WebkitTransform", "MozTransform", "OTransform", "msTransform"])[0]
+
−
    }
+
−
 
+
−
    function j() {
+
−
         return g(["perspective", "webkitPerspective", "MozPerspective", "OPerspective", "MsPerspective"])[0]
+
−
    }
+
−
 
+
−
    function k() {
+
−
        return "ontouchstart" in b || !!navigator.msMaxTouchPoints
+
−
    }
+
  
−
    function l() {
+
        var next = document.getElementById('afcmcontrols-left');
−
         return b.navigator.msPointerEnabled
+
         var previous = document.getElementById('afcmcontrols-right');
−
    }
+
         for (var i = 0; i < slides.length; i++) {
−
    var m, n, o;
+
             slides[i].style.position = 'absolute';
−
    m = {
+
−
        start: 0,
+
−
        startX: 0,
+
−
        startY: 0,
+
−
        current: 0,
+
−
        currentX: 0,
+
−
        currentY: 0,
+
−
        offsetX: 0,
+
−
        offsetY: 0,
+
−
        distance: null,
+
−
        startTime: 0,
+
−
        endTime: 0,
+
−
        updatedX: 0,
+
−
        targetEl: null
+
−
    }, n = {
+
−
        isTouch: !1,
+
−
        isScrolling: !1,
+
−
        isSwiping: !1,
+
−
        direction: !1,
+
−
        inMotion: !1
+
−
    }, o = {
+
−
        _onDragStart: null,
+
−
        _onDragMove: null,
+
−
        _onDragEnd: null,
+
−
        _transitionEnd: null,
+
−
        _resizer: null,
+
−
        _responsiveCall: null,
+
−
        _goToLoop: null,
+
−
        _checkVisibile: null
+
−
    }, e.Defaults = {
+
−
        items: 3,
+
−
        loop: !1,
+
−
        center: !1,
+
−
        mouseDrag: !0,
+
−
        touchDrag: !0,
+
−
        pullDrag: !0,
+
−
        freeDrag: !1,
+
−
        margin: 0,
+
−
        stagePadding: 0,
+
−
        merge: !1,
+
−
        mergeFit: !0,
+
−
        autoWidth: !1,
+
−
        startPosition: 0,
+
−
        rtl: !1,
+
−
        smartSpeed: 250,
+
−
        fluidSpeed: !1,
+
−
        dragEndSpeed: !1,
+
−
        responsive: {},
+
−
        responsiveRefreshRate: 200,
+
−
        responsiveBaseElement: b,
+
−
        responsiveClass: !1,
+
−
        fallbackEasing: "swing",
+
−
        info: !1,
+
−
        nestedItemSelector: !1,
+
−
        itemElement: "div",
+
−
        stageElement: "div",
+
−
        themeClass: "owl-theme",
+
−
         baseClass: "owl-carousel",
+
−
        itemClass: "owl-item",
+
−
        centerClass: "center",
+
−
        activeClass: "active"
+
−
    }, e.Width = {
+
−
        Default: "default",
+
−
        Inner: "inner",
+
−
        Outer: "outer"
+
−
    }, e.Plugins = {}, e.Pipe = [{
+
−
        filter: ["width", "items", "settings"],
+
−
        run: function (a) {
+
−
             a.current = this._items && this._items[this.relative(this._current)]
+
 
         }
 
         }
−
    }, {
+
         for (var i = 0; i < controls.length; i++) {
−
         filter: ["items", "settings"],
+
             controls[i].style.display = 'inline-block';
−
        run: function () {
+
−
            var a = this._clones,
+
−
                b = this.$stage.children(".cloned");
+
−
             (b.length !== a.length || !this.settings.loop && a.length > 0) && (this.$stage.children(".cloned").remove(), this._clones = [])
+
 
         }
 
         }
−
    }, {
+
         function nextSlide() {
−
        filter: ["items", "settings"],
+
             goToSlide(currentSlide + 1);
−
         run: function () {
+
−
             var a, b, c = this._clones,
+
−
                d = this._items,
+
−
                e = this.settings.loop ? c.length - Math.max(2 * this.settings.items, 4) : 0;
+
−
            for (a = 0, b = Math.abs(e / 2) ; b > a; a++) e > 0 ? (this.$stage.children().eq(d.length + c.length - 1).remove(), c.pop(), this.$stage.children().eq(0).remove(), c.pop()) : (c.push(c.length / 2), this.$stage.append(d[c[c.length - 1]].clone().addClass("cloned")), c.push(d.length - 1 - (c.length - 1) / 2), this.$stage.prepend(d[c[c.length - 1]].clone().addClass("cloned")))
+
 
         }
 
         }
−
    }, {
+
         function previousSlide() {
−
        filter: ["width", "items", "settings"],
+
             goToSlide(currentSlide - 1);
−
         run: function () {
+
−
             var a, b, c, d = this.settings.rtl ? 1 : -1,
+
−
                e = (this.width() / this.settings.items).toFixed(3),
+
−
                f = 0;
+
−
            for (this._coordinates = [], b = 0, c = this._clones.length + this._items.length; c > b; b++) a = this._mergers[this.relative(b)], a = this.settings.mergeFit && Math.min(a, this.settings.items) || a, f += (this.settings.autoWidth ? this._items[this.relative(b)].width() + this.settings.margin : e * a) * d, this._coordinates.push(f)
+
 
         }
 
         }
−
    }, {
+
         function goToSlide(n) {
−
         filter: ["width", "items", "settings"],
+
             if (playing) {
−
        run: function () {
+
                slides[currentSlide].className = 'afcmslide';
−
             var b, c, d = (this.width() / this.settings.items).toFixed(3),
+
                currentSlide = (n + slides.length) % slides.length;
−
                 e = {
+
                 $(slides[currentSlide]).css({ opacity: 0.0 }, "slow")
−
                    width: Math.abs(this._coordinates[this._coordinates.length - 1]) + 2 * this.settings.stagePadding,
+
                 .addClass('afcmshowing')
−
                    "padding-left": this.settings.stagePadding || "",
+
                 .animate({
−
                    "padding-right": this.settings.stagePadding || ""
+
                    opacity: 1.0
−
                 };
+
                }, "slow", function () {
−
            if (this.$stage.css(e), e = {
+
                     $(slides[currentSlide]).removeClass('active');
−
                 width: this.settings.autoWidth ? "auto" : d - this.settings.margin
+
                });
−
            }, e[this.settings.rtl ? "margin-left" : "margin-right"] = this.settings.margin, !this.settings.autoWidth && a.grep(this._mergers, function (a) {
+
             }
−
                     return a > 1
+
−
            }).length > 0)
+
−
                for (b = 0, c = this._coordinates.length; c > b; b++) e.width = Math.abs(this._coordinates[b]) - Math.abs(this._coordinates[b - 1] || 0) - this.settings.margin, this.$stage.children().eq(b).css(e);
+
−
             else this.$stage.children().css(e)
+
 
         }
 
         }
−
    }, {
+
         $('.afcmslide').click(function () {
−
         filter: ["width", "items", "settings"],
+
             if (playing) {
−
        run: function (a) {
+
                 pauseSlideshow();
−
            a.current && this.reset(this.$stage.children().index(a.current))
+
             } else {
−
        }
+
                playSlideshow();
−
    }, {
+
−
        filter: ["position"],
+
−
        run: function () {
+
−
             this.animate(this.coordinates(this._current))
+
−
        }
+
−
    }, {
+
−
        filter: ["width", "position", "items", "settings"],
+
−
        run: function () {
+
−
            var a, b, c, d, e = this.settings.rtl ? 1 : -1,
+
−
                 f = 2 * this.settings.stagePadding,
+
−
                g = this.coordinates(this.current()) + f,
+
−
                h = g + this.width() * e,
+
−
                i = [];
+
−
             for (c = 0, d = this._coordinates.length; d > c; c++) a = this._coordinates[c - 1] || 0, b = Math.abs(this._coordinates[c]) + f * e, (this.op(a, "<=", g) && this.op(a, ">", h) || this.op(b, "<", g) && this.op(b, ">", h)) && i.push(c);
+
−
            this.$stage.children("." + this.settings.activeClass).removeClass(this.settings.activeClass), this.$stage.children(":eq(" + i.join("), :eq(") + ")").addClass(this.settings.activeClass), this.settings.center && (this.$stage.children("." + this.settings.centerClass).removeClass(this.settings.centerClass), this.$stage.children().eq(this.current()).addClass(this.settings.centerClass))
+
−
        }
+
−
    }], e.prototype.initialize = function () {
+
−
        if (this.trigger("initialize"), this.$element.addClass(this.settings.baseClass).addClass(this.settings.themeClass).toggleClass("owl-rtl", this.settings.rtl), this.browserSupport(), this.settings.autoWidth && this.state.imagesLoaded !== !0) {
+
−
            var b, c, e;
+
−
            if (b = this.$element.find("img"), c = this.settings.nestedItemSelector ? "." + this.settings.nestedItemSelector : d, e = this.$element.children(c).width(), b.length && 0 >= e) return this.preloadAutoWidthImages(b), !1
+
−
        }
+
−
        this.$element.addClass("owl-loading"), this.$stage = a("<" + this.settings.stageElement + ' class="owl-stage"/>').wrap('<div class="owl-stage-outer">'), this.$element.append(this.$stage.parent()), this.replace(this.$element.children().not(this.$stage.parent())), this._width = this.$element.width(), this.refresh(), this.$element.removeClass("owl-loading").addClass("owl-loaded"), this.eventsCall(), this.internalEvents(), this.addTriggerableEvents(), this.trigger("initialized")
+
−
    }, e.prototype.setup = function () {
+
−
        var b = this.viewport(),
+
−
            c = this.options.responsive,
+
−
            d = -1,
+
−
            e = null;
+
−
        c ? (a.each(c, function (a) {
+
−
            b >= a && a > d && (d = Number(a))
+
−
        }), e = a.extend({}, this.options, c[d]), delete e.responsive, e.responsiveClass && this.$element.attr("class", function (a, b) {
+
−
            return b.replace(/\b owl-responsive-\S+/g, "")
+
−
        }).addClass("owl-responsive-" + d)) : e = a.extend({}, this.options), (null === this.settings || this._breakpoint !== d) && (this.trigger("change", {
+
−
            property: {
+
−
                name: "settings",
+
−
                value: e
+
 
             }
 
             }
−
        }), this._breakpoint = d, this.settings = e, this.invalidate("settings"), this.trigger("changed", {
 
−
            property: {
 
−
                name: "settings",
 
−
                value: this.settings
 
−
            }
 
−
        }))
 
−
    }, e.prototype.optionsLogic = function () {
 
−
        this.$element.toggleClass("owl-center", this.settings.center), this.settings.loop && this._items.length < this.settings.items && (this.settings.loop = !1), this.settings.autoWidth && (this.settings.stagePadding = !1, this.settings.merge = !1)
 
−
    }, e.prototype.prepare = function (b) {
 
−
        var c = this.trigger("prepare", {
 
−
            content: b
 
−
        });
 
−
        return c.data || (c.data = a("<" + this.settings.itemElement + "/>").addClass(this.settings.itemClass).append(b)), this.trigger("prepared", {
 
−
            content: c.data
 
−
        }), c.data
 
−
    }, e.prototype.update = function () {
 
−
        for (var b = 0, c = this._pipe.length, d = a.proxy(function (a) {
 
−
                return this[a]
 
−
        }, this._invalidated), e = {}; c > b;) (this._invalidated.all || a.grep(this._pipe[b].filter, d).length > 0) && this._pipe[b].run(e), b++;
 
−
        this._invalidated = {}
 
−
    }, e.prototype.width = function (a) {
 
−
        switch (a = a || e.Width.Default) {
 
−
            case e.Width.Inner:
 
−
            case e.Width.Outer:
 
−
                return this._width;
 
−
            default:
 
−
                return this._width - 2 * this.settings.stagePadding + this.settings.margin
 
−
        }
 
−
    }, e.prototype.refresh = function () {
 
−
        if (0 === this._items.length) return !1;
 
−
        (new Date).getTime();
 
−
        this.trigger("refresh"), this.setup(), this.optionsLogic(), this.$stage.addClass("owl-refresh"), this.update(), this.$stage.removeClass("owl-refresh"), this.state.orientation = b.orientation, this.watchVisibility(), this.trigger("refreshed")
 
−
    }, e.prototype.eventsCall = function () {
 
−
        this.e._onDragStart = a.proxy(function (a) {
 
−
            this.onDragStart(a)
 
−
        }, this), this.e._onDragMove = a.proxy(function (a) {
 
−
            this.onDragMove(a)
 
−
        }, this), this.e._onDragEnd = a.proxy(function (a) {
 
−
            this.onDragEnd(a)
 
−
        }, this), this.e._onResize = a.proxy(function (a) {
 
−
            this.onResize(a)
 
−
        }, this), this.e._transitionEnd = a.proxy(function (a) {
 
−
            this.transitionEnd(a)
 
−
        }, this), this.e._preventClick = a.proxy(function (a) {
 
−
            this.preventClick(a)
 
−
        }, this)
 
−
    }, e.prototype.onThrottledResize = function () {
 
−
        b.clearTimeout(this.resizeTimer), this.resizeTimer = b.setTimeout(this.e._onResize, this.settings.responsiveRefreshRate)
 
−
    }, e.prototype.onResize = function () {
 
−
        return this._items.length ? this._width === this.$element.width() ? !1 : this.trigger("resize").isDefaultPrevented() ? !1 : (this._width = this.$element.width(), this.invalidate("width"), this.refresh(), void this.trigger("resized")) : !1
 
−
    }, e.prototype.eventsRouter = function (a) {
 
−
        var b = a.type;
 
−
        "mousedown" === b || "touchstart" === b ? this.onDragStart(a) : "mousemove" === b || "touchmove" === b ? this.onDragMove(a) : "mouseup" === b || "touchend" === b ? this.onDragEnd(a) : "touchcancel" === b && this.onDragEnd(a)
 
−
    }, e.prototype.internalEvents = function () {
 
−
        var c = (k(), l());
 
−
        this.settings.mouseDrag ? (this.$stage.on("mousedown", a.proxy(function (a) {
 
−
            this.eventsRouter(a)
 
−
        }, this)), this.$stage.on("dragstart", function () {
 
−
            return !1
 
−
        }), this.$stage.get(0).onselectstart = function () {
 
−
            return !1
 
−
        }) : this.$element.addClass("owl-text-select-on"), this.settings.touchDrag && !c && this.$stage.on("touchstart touchcancel", a.proxy(function (a) {
 
−
            this.eventsRouter(a)
 
−
        }, this)), this.transitionEndVendor && this.on(this.$stage.get(0), this.transitionEndVendor, this.e._transitionEnd, !1), this.settings.responsive !== !1 && this.on(b, "resize", a.proxy(this.onThrottledResize, this))
 
−
    }, e.prototype.onDragStart = function (d) {
 
−
        var e, g, h, i;
 
−
        if (e = d.originalEvent || d || b.event, 3 === e.which || this.state.isTouch) return !1;
 
−
        if ("mousedown" === e.type && this.$stage.addClass("owl-grab"), this.trigger("drag"), this.drag.startTime = (new Date).getTime(), this.speed(0), this.state.isTouch = !0, this.state.isScrolling = !1, this.state.isSwiping = !1, this.drag.distance = 0, g = f(e).x, h = f(e).y, this.drag.offsetX = this.$stage.position().left, this.drag.offsetY = this.$stage.position().top, this.settings.rtl && (this.drag.offsetX = this.$stage.position().left + this.$stage.width() - this.width() + this.settings.margin), this.state.inMotion && this.support3d) i = this.getTransformProperty(), this.drag.offsetX = i, this.animate(i), this.state.inMotion = !0;
 
−
        else if (this.state.inMotion && !this.support3d) return this.state.inMotion = !1, !1;
 
−
        this.drag.startX = g - this.drag.offsetX, this.drag.startY = h - this.drag.offsetY, this.drag.start = g - this.drag.startX, this.drag.targetEl = e.target || e.srcElement, this.drag.updatedX = this.drag.start, ("IMG" === this.drag.targetEl.tagName || "A" === this.drag.targetEl.tagName) && (this.drag.targetEl.draggable = !1), a(c).on("mousemove.owl.dragEvents mouseup.owl.dragEvents touchmove.owl.dragEvents touchend.owl.dragEvents", a.proxy(function (a) {
 
−
            this.eventsRouter(a)
 
−
        }, this))
 
−
    }, e.prototype.onDragMove = function (a) {
 
−
        var c, e, g, h, i, j;
 
−
        this.state.isTouch && (this.state.isScrolling || (c = a.originalEvent || a || b.event, e = f(c).x, g = f(c).y, this.drag.currentX = e - this.drag.startX, this.drag.currentY = g - this.drag.startY, this.drag.distance = this.drag.currentX - this.drag.offsetX, this.drag.distance < 0 ? this.state.direction = this.settings.rtl ? "right" : "left" : this.drag.distance > 0 && (this.state.direction = this.settings.rtl ? "left" : "right"), this.settings.loop ? this.op(this.drag.currentX, ">", this.coordinates(this.minimum())) && "right" === this.state.direction ? this.drag.currentX -= (this.settings.center && this.coordinates(0)) - this.coordinates(this._items.length) : this.op(this.drag.currentX, "<", this.coordinates(this.maximum())) && "left" === this.state.direction && (this.drag.currentX += (this.settings.center && this.coordinates(0)) - this.coordinates(this._items.length)) : (h = this.coordinates(this.settings.rtl ? this.maximum() : this.minimum()), i = this.coordinates(this.settings.rtl ? this.minimum() : this.maximum()), j = this.settings.pullDrag ? this.drag.distance / 5 : 0, this.drag.currentX = Math.max(Math.min(this.drag.currentX, h + j), i + j)), (this.drag.distance > 8 || this.drag.distance < -8) && (c.preventDefault !== d ? c.preventDefault() : c.returnValue = !1, this.state.isSwiping = !0), this.drag.updatedX = this.drag.currentX, (this.drag.currentY > 16 || this.drag.currentY < -16) && this.state.isSwiping === !1 && (this.state.isScrolling = !0, this.drag.updatedX = this.drag.start), this.animate(this.drag.updatedX)))
 
−
    }, e.prototype.onDragEnd = function (b) {
 
−
        var d, e, f;
 
−
        if (this.state.isTouch) {
 
−
            if ("mouseup" === b.type && this.$stage.removeClass("owl-grab"), this.trigger("dragged"), this.drag.targetEl.removeAttribute("draggable"), this.state.isTouch = !1, this.state.isScrolling = !1, this.state.isSwiping = !1, 0 === this.drag.distance && this.state.inMotion !== !0) return this.state.inMotion = !1, !1;
 
−
            this.drag.endTime = (new Date).getTime(), d = this.drag.endTime - this.drag.startTime, e = Math.abs(this.drag.distance), (e > 3 || d > 300) && this.removeClick(this.drag.targetEl), f = this.closest(this.drag.updatedX), this.speed(this.settings.dragEndSpeed || this.settings.smartSpeed), this.current(f), this.invalidate("position"), this.update(), this.settings.pullDrag || this.drag.updatedX !== this.coordinates(f) || this.transitionEnd(), this.drag.distance = 0, a(c).off(".owl.dragEvents")
 
−
        }
 
−
    }, e.prototype.removeClick = function (c) {
 
−
        this.drag.targetEl = c, a(c).on("click.preventClick", this.e._preventClick), b.setTimeout(function () {
 
−
            a(c).off("click.preventClick")
 
−
        }, 300)
 
−
    }, e.prototype.preventClick = function (b) {
 
−
        b.preventDefault ? b.preventDefault() : b.returnValue = !1, b.stopPropagation && b.stopPropagation(), a(b.target).off("click.preventClick")
 
−
    }, e.prototype.getTransformProperty = function () {
 
−
        var a, c;
 
−
        return a = b.getComputedStyle(this.$stage.get(0), null).getPropertyValue(this.vendorName + "transform"), a = a.replace(/matrix(3d)?\(|\)/g, "").split(","), c = 16 === a.length, c !== !0 ? a[4] : a[12]
 
−
    }, e.prototype.closest = function (b) {
 
−
        var c = -1,
 
−
            d = 30,
 
−
            e = this.width(),
 
−
            f = this.coordinates();
 
−
        return this.settings.freeDrag || a.each(f, a.proxy(function (a, g) {
 
−
            return b > g - d && g + d > b ? c = a : this.op(b, "<", g) && this.op(b, ">", f[a + 1] || g - e) && (c = "left" === this.state.direction ? a + 1 : a), -1 === c
 
−
        }, this)), this.settings.loop || (this.op(b, ">", f[this.minimum()]) ? c = b = this.minimum() : this.op(b, "<", f[this.maximum()]) && (c = b = this.maximum())), c
 
−
    }, e.prototype.animate = function (b) {
 
−
        this.trigger("translate"), this.state.inMotion = this.speed() > 0, this.support3d ? this.$stage.css({
 
−
            transform: "translate3d(" + b + "px,0px, 0px)",
 
−
            transition: this.speed() / 1e3 + "s"
 
−
        }) : this.state.isTouch ? this.$stage.css({
 
−
            left: b + "px"
 
−
        }) : this.$stage.animate({
 
−
            left: b
 
−
        }, this.speed() / 1e3, this.settings.fallbackEasing, a.proxy(function () {
 
−
            this.state.inMotion && this.transitionEnd()
 
−
        }, this))
 
−
    }, e.prototype.current = function (a) {
 
−
        if (a === d) return this._current;
 
−
        if (0 === this._items.length) return d;
 
−
        if (a = this.normalize(a), this._current !== a) {
 
−
            var b = this.trigger("change", {
 
−
                property: {
 
−
                    name: "position",
 
−
                    value: a
 
−
                }
 
−
            });
 
−
            b.data !== d && (a = this.normalize(b.data)), this._current = a, this.invalidate("position"), this.trigger("changed", {
 
−
                property: {
 
−
                    name: "position",
 
−
                    value: this._current
 
−
                }
 
−
            })
 
−
        }
 
−
        return this._current
 
−
    }, e.prototype.invalidate = function (a) {
 
−
        this._invalidated[a] = !0
 
−
    }, e.prototype.reset = function (a) {
 
−
        a = this.normalize(a), a !== d && (this._speed = 0, this._current = a, this.suppress(["translate", "translated"]), this.animate(this.coordinates(a)), this.release(["translate", "translated"]))
 
−
    }, e.prototype.normalize = function (b, c) {
 
−
        var e = c ? this._items.length : this._items.length + this._clones.length;
 
−
        return !a.isNumeric(b) || 1 > e ? d : b = this._clones.length ? (b % e + e) % e : Math.max(this.minimum(c), Math.min(this.maximum(c), b))
 
−
    }, e.prototype.relative = function (a) {
 
−
        return a = this.normalize(a), a -= this._clones.length / 2, this.normalize(a, !0)
 
−
    }, e.prototype.maximum = function (a) {
 
−
        var b, c, d, e = 0,
 
−
            f = this.settings;
 
−
        if (a) return this._items.length - 1;
 
−
        if (!f.loop && f.center) b = this._items.length - 1;
 
−
        else if (f.loop || f.center)
 
−
            if (f.loop || f.center) b = this._items.length + f.items;
 
−
            else {
 
−
                if (!f.autoWidth && !f.merge) throw "Can not detect maximum absolute position.";
 
−
                for (revert = f.rtl ? 1 : -1, c = this.$stage.width() - this.$element.width() ;
 
−
                    (d = this.coordinates(e)) && !(d * revert >= c) ;) b = ++e
 
−
            } else b = this._items.length - f.items;
 
−
        return b
 
−
    }, e.prototype.minimum = function (a) {
 
−
        return a ? 0 : this._clones.length / 2
 
−
    }, e.prototype.items = function (a) {
 
−
        return a === d ? this._items.slice() : (a = this.normalize(a, !0), this._items[a])
 
−
    }, e.prototype.mergers = function (a) {
 
−
        return a === d ? this._mergers.slice() : (a = this.normalize(a, !0), this._mergers[a])
 
−
    }, e.prototype.clones = function (b) {
 
−
        var c = this._clones.length / 2,
 
−
            e = c + this._items.length,
 
−
            f = function (a) {
 
−
                return a % 2 === 0 ? e + a / 2 : c - (a + 1) / 2
 
−
            };
 
−
        return b === d ? a.map(this._clones, function (a, b) {
 
−
            return f(b)
 
−
        }) : a.map(this._clones, function (a, c) {
 
−
            return a === b ? f(c) : null
 
 
         })
 
         })
−
    }, e.prototype.speed = function (a) {
+
         function pauseSlideshow() {
−
         return a !== d && (this._speed = a), this._speed
+
             playing = false;
−
    }, e.prototype.coordinates = function (b) {
+
             clearInterval(slideInterval);
−
        var c = null;
+
−
        return b === d ? a.map(this._coordinates, a.proxy(function (a, b) {
+
−
             return this.coordinates(b)
+
−
        }, this)) : (this.settings.center ? (c = this._coordinates[b], c += (this.width() - c + (this._coordinates[b - 1] || 0)) / 2 * (this.settings.rtl ? -1 : 1)) : c = this._coordinates[b - 1] || 0, c)
+
−
    }, e.prototype.duration = function (a, b, c) {
+
−
        return Math.min(Math.max(Math.abs(b - a), 1), 6) * Math.abs(c || this.settings.smartSpeed)
+
−
    }, e.prototype.to = function (c, d) {
+
−
        if (this.settings.loop) {
+
−
            var e = c - this.relative(this.current()),
+
−
                f = this.current(),
+
−
                g = this.current(),
+
−
                h = this.current() + e,
+
−
                i = 0 > g - h ? !0 : !1,
+
−
                j = this._clones.length + this._items.length;
+
−
             h < this.settings.items && i === !1 ? (f = g + this._items.length, this.reset(f)) : h >= j - this.settings.items && i === !0 && (f = g - this._items.length, this.reset(f)), b.clearTimeout(this.e._goToLoop), this.e._goToLoop = b.setTimeout(a.proxy(function () {
+
−
                this.speed(this.duration(this.current(), f + e, d)), this.current(f + e), this.update()
+
−
            }, this), 30)
+
−
        } else this.speed(this.duration(this.current(), c, d)), this.current(c), this.update()
+
−
    }, e.prototype.next = function (a) {
+
−
        a = a || !1, this.to(this.relative(this.current()) + 1, a)
+
−
    }, e.prototype.prev = function (a) {
+
−
        a = a || !1, this.to(this.relative(this.current()) - 1, a)
+
−
    }, e.prototype.transitionEnd = function (a) {
+
−
        return a !== d && (a.stopPropagation(), (a.target || a.srcElement || a.originalTarget) !== this.$stage.get(0)) ? !1 : (this.state.inMotion = !1, void this.trigger("translated"))
+
−
    }, e.prototype.viewport = function () {
+
−
        var d;
+
−
        if (this.options.responsiveBaseElement !== b) d = a(this.options.responsiveBaseElement).width();
+
−
        else if (b.innerWidth) d = b.innerWidth;
+
−
        else {
+
−
            if (!c.documentElement || !c.documentElement.clientWidth) throw "Can not detect viewport width.";
+
−
            d = c.documentElement.clientWidth
+
 
         }
 
         }
−
         return d
+
         function playSlideshow() {
−
    }, e.prototype.replace = function (b) {
+
             playing = true;
−
        this.$stage.empty(), this._items = [], b && (b = b instanceof jQuery ? b : a(b)), this.settings.nestedItemSelector && (b = b.find("." + this.settings.nestedItemSelector)), b.filter(function () {
+
             slideInterval = setInterval(nextSlide, 3000);
−
             return 1 === this.nodeType
+
−
        }).each(a.proxy(function (a, b) {
+
−
             b = this.prepare(b), this.$stage.append(b), this._items.push(b), this._mergers.push(1 * b.find("[data-merge]").andSelf("[data-merge]").attr("data-merge") || 1)
+
−
        }, this)), this.reset(a.isNumeric(this.settings.startPosition) ? this.settings.startPosition : 0), this.invalidate("items")
+
−
    }, e.prototype.add = function (a, b) {
+
−
        b = b === d ? this._items.length : this.normalize(b, !0), this.trigger("add", {
+
−
            content: a,
+
−
            position: b
+
−
        }), 0 === this._items.length || b === this._items.length ? (this.$stage.append(a), this._items.push(a), this._mergers.push(1 * a.find("[data-merge]").andSelf("[data-merge]").attr("data-merge") || 1)) : (this._items[b].before(a), this._items.splice(b, 0, a), this._mergers.splice(b, 0, 1 * a.find("[data-merge]").andSelf("[data-merge]").attr("data-merge") || 1)), this.invalidate("items"), this.trigger("added", {
+
−
            content: a,
+
−
            position: b
+
−
        })
+
−
    }, e.prototype.remove = function (a) {
+
−
        a = this.normalize(a, !0), a !== d && (this.trigger("remove", {
+
−
            content: this._items[a],
+
−
            position: a
+
−
        }), this._items[a].remove(), this._items.splice(a, 1), this._mergers.splice(a, 1), this.invalidate("items"), this.trigger("removed", {
+
−
            content: null,
+
−
            position: a
+
−
        }))
+
−
    }, e.prototype.addTriggerableEvents = function () {
+
−
        var b = a.proxy(function (b, c) {
+
−
            return a.proxy(function (a) {
+
−
                a.relatedTarget !== this && (this.suppress([c]), b.apply(this, [].slice.call(arguments, 1)), this.release([c]))
+
−
            }, this)
+
−
        }, this);
+
−
        a.each({
+
−
            next: this.next,
+
−
            prev: this.prev,
+
−
            to: this.to,
+
−
            destroy: this.destroy,
+
−
            refresh: this.refresh,
+
−
            replace: this.replace,
+
−
            add: this.add,
+
−
            remove: this.remove
+
−
        }, a.proxy(function (a, c) {
+
−
            this.$element.on(a + ".owl.carousel", b(c, a + ".owl.carousel"))
+
−
        }, this))
+
−
    }, e.prototype.watchVisibility = function () {
+
−
        function c(a) {
+
−
            return a.offsetWidth > 0 && a.offsetHeight > 0
+
 
         }
 
         }
 +
        next.onclick = function () {
 +
            playing = true;
 +
            nextSlide();
 +
            pauseSlideshow();
 +
        };
 +
        previous.onclick = function () {
 +
            playing = true;
 +
            previousSlide();
 +
            pauseSlideshow();
 +
        };
  
−
         function d() {
+
          
−
            c(this.$element.get(0)) && (this.$element.removeClass("owl-hidden"), this.refresh(), b.clearInterval(this.e._checkVisibile))
+
−
        }
+
−
        c(this.$element.get(0)) || (this.$element.addClass("owl-hidden"), b.clearInterval(this.e._checkVisibile), this.e._checkVisibile = b.setInterval(a.proxy(d, this), 500))
+
−
    }, e.prototype.preloadAutoWidthImages = function (b) {
+
−
        var c, d, e, f;
+
−
        c = 0, d = this, b.each(function (g, h) {
+
−
            e = a(h), f = new Image, f.onload = function () {
+
−
                c++, e.attr("src", f.src), e.css("opacity", 1), c >= b.length && (d.state.imagesLoaded = !0, d.initialize())
+
−
            }, f.src = e.attr("src") || e.attr("data-src") || e.attr("data-src-retina")
+
−
        })
+
−
    }, e.prototype.destroy = function () {
+
−
        this.$element.hasClass(this.settings.themeClass) && this.$element.removeClass(this.settings.themeClass), this.settings.responsive !== !1 && a(b).off("resize.owl.carousel"), this.transitionEndVendor && this.off(this.$stage.get(0), this.transitionEndVendor, this.e._transitionEnd);
+
−
        for (var d in this._plugins) this._plugins[d].destroy();
+
−
        (this.settings.mouseDrag || this.settings.touchDrag) && (this.$stage.off("mousedown touchstart touchcancel"), a(c).off(".owl.dragEvents"), this.$stage.get(0).onselectstart = function () { }, this.$stage.off("dragstart", function () {
+
−
            return !1
+
−
        })), this.$element.off(".owl"), this.$stage.children(".cloned").remove(), this.e = null, this.$element.removeData("owlCarousel"), this.$stage.children().contents().unwrap(), this.$stage.children().unwrap(), this.$stage.unwrap()
+
−
    }, e.prototype.op = function (a, b, c) {
+
−
        var d = this.settings.rtl;
+
−
        switch (b) {
+
−
            case "<":
+
−
                return d ? a > c : c > a;
+
−
            case ">":
+
−
                return d ? c > a : a > c;
+
−
            case ">=":
+
−
                return d ? c >= a : a >= c;
+
−
            case "<=":
+
−
                return d ? a >= c : c >= a
+
−
        }
+
−
    }, e.prototype.on = function (a, b, c, d) {
+
−
        a.addEventListener ? a.addEventListener(b, c, d) : a.attachEvent && a.attachEvent("on" + b, c)
+
−
    }, e.prototype.off = function (a, b, c, d) {
+
−
        a.removeEventListener ? a.removeEventListener(b, c, d) : a.detachEvent && a.detachEvent("on" + b, c)
+
−
    }, e.prototype.trigger = function (b, c, d) {
+
−
        var e = {
+
−
            item: {
+
−
                count: this._items.length,
+
−
                index: this.current()
+
−
            }
+
−
        },
+
−
            f = a.camelCase(a.grep(["on", b, d], function (a) {
+
−
                return a
+
−
            }).join("-").toLowerCase()),
+
−
            g = a.Event([b, "owl", d || "carousel"].join(".").toLowerCase(), a.extend({
+
−
                relatedTarget: this
+
−
            }, e, c));
+
−
        return this._supress[b] || (a.each(this._plugins, function (a, b) {
+
−
            b.onTrigger && b.onTrigger(g)
+
−
        }), this.$element.trigger(g), this.settings && "function" == typeof this.settings[f] && this.settings[f].apply(this, g)), g
+
−
    }, e.prototype.suppress = function (b) {
+
−
        a.each(b, a.proxy(function (a, b) {
+
−
            this._supress[b] = !0
+
−
        }, this))
+
−
    }, e.prototype.release = function (b) {
+
−
        a.each(b, a.proxy(function (a, b) {
+
−
            delete this._supress[b]
+
−
        }, this))
+
−
    }, e.prototype.browserSupport = function () {
+
−
        if (this.support3d = j(), this.support3d) {
+
−
            this.transformVendor = i();
+
−
            var a = ["transitionend", "webkitTransitionEnd", "transitionend", "oTransitionEnd"];
+
−
            this.transitionEndVendor = a[h()], this.vendorName = this.transformVendor.replace(/Transform/i, ""), this.vendorName = "" !== this.vendorName ? "-" + this.vendorName.toLowerCase() + "-" : ""
+
−
        }
+
−
        this.state.orientation = b.orientation
+
−
    }, a.fn.owlCarousel = function (b) {
+
−
        return this.each(function () {
+
−
            a(this).data("owlCarousel") || a(this).data("owlCarousel", new e(this, b))
+
−
        })
+
−
    }, a.fn.owlCarousel.Constructor = e
+
−
}(window.Zepto || window.jQuery, window, document),
+
−
function (a, b) {
+
−
    var c = function (b) {
+
−
        this._core = b, this._loaded = [], this._handlers = {
+
−
            "initialized.owl.carousel change.owl.carousel": a.proxy(function (b) {
+
−
                if (b.namespace && this._core.settings && this._core.settings.lazyLoad && (b.property && "position" == b.property.name || "initialized" == b.type))
+
−
                    for (var c = this._core.settings, d = c.center && Math.ceil(c.items / 2) || c.items, e = c.center && -1 * d || 0, f = (b.property && b.property.value || this._core.current()) + e, g = this._core.clones().length, h = a.proxy(function (a, b) {
+
−
                            this.load(b)
+
−
                    }, this) ; e++ < d;) this.load(g / 2 + this._core.relative(f)), g && a.each(this._core.clones(this._core.relative(f++)), h)
+
−
            }, this)
+
−
        }, this._core.options = a.extend({}, c.Defaults, this._core.options), this._core.$element.on(this._handlers)
+
−
    };
+
−
    c.Defaults = {
+
−
        lazyLoad: !1
+
−
    }, c.prototype.load = function (c) {
+
−
        var d = this._core.$stage.children().eq(c),
+
−
            e = d && d.find(".owl-lazy");
+
−
        !e || a.inArray(d.get(0), this._loaded) > -1 || (e.each(a.proxy(function (c, d) {
+
−
            var e, f = a(d),
+
−
                g = b.devicePixelRatio > 1 && f.attr("data-src-retina") || f.attr("data-src");
+
−
            this._core.trigger("load", {
+
−
                element: f,
+
−
                url: g
+
−
            }, "lazy"), f.is("img") ? f.one("load.owl.lazy", a.proxy(function () {
+
−
                f.css("opacity", 1), this._core.trigger("loaded", {
+
−
                    element: f,
+
−
                    url: g
+
−
                }, "lazy")
+
−
            }, this)).attr("src", g) : (e = new Image, e.onload = a.proxy(function () {
+
−
                f.css({
+
−
                    "background-image": "url(" + g + ")",
+
−
                    opacity: "1"
+
−
                }), this._core.trigger("loaded", {
+
−
                    element: f,
+
−
                    url: g
+
−
                }, "lazy")
+
−
            }, this), e.src = g)
+
−
        }, this)), this._loaded.push(d.get(0)))
+
−
    }, c.prototype.destroy = function () {
+
−
        var a, b;
+
−
        for (a in this.handlers) this._core.$element.off(a, this.handlers[a]);
+
−
        for (b in Object.getOwnPropertyNames(this)) "function" != typeof this[b] && (this[b] = null)
+
−
    }, a.fn.owlCarousel.Constructor.Plugins.Lazy = c
+
−
}(window.Zepto || window.jQuery, window, document),
+
−
function (a) {
+
−
    var b = function (c) {
+
−
        this._core = c, this._handlers = {
+
−
            "initialized.owl.carousel": a.proxy(function () {
+
−
                this._core.settings.autoHeight && this.update()
+
−
            }, this),
+
−
            "changed.owl.carousel": a.proxy(function (a) {
+
−
                this._core.settings.autoHeight && "position" == a.property.name && this.update()
+
−
            }, this),
+
−
            "loaded.owl.lazy": a.proxy(function (a) {
+
−
                this._core.settings.autoHeight && a.element.closest("." + this._core.settings.itemClass) === this._core.$stage.children().eq(this._core.current()) && this.update()
+
−
            }, this)
+
−
        }, this._core.options = a.extend({}, b.Defaults, this._core.options), this._core.$element.on(this._handlers)
+
−
    };
+
−
    b.Defaults = {
+
−
        autoHeight: !1,
+
−
        autoHeightClass: "owl-height"
+
−
    }, b.prototype.update = function () {
+
−
        this._core.$stage.parent().height(this._core.$stage.children().eq(this._core.current()).height()).addClass(this._core.settings.autoHeightClass)
+
−
    }, b.prototype.destroy = function () {
+
−
        var a, b;
+
−
        for (a in this._handlers) this._core.$element.off(a, this._handlers[a]);
+
−
        for (b in Object.getOwnPropertyNames(this)) "function" != typeof this[b] && (this[b] = null)
+
−
    }, a.fn.owlCarousel.Constructor.Plugins.AutoHeight = b
+
−
}(window.Zepto || window.jQuery, window, document),
+
−
function (a, b, c) {
+
−
    var d = function (b) {
+
−
        this._core = b, this._videos = {}, this._playing = null, this._fullscreen = !1, this._handlers = {
+
−
            "resize.owl.carousel": a.proxy(function (a) {
+
−
                this._core.settings.video && !this.isInFullScreen() && a.preventDefault()
+
−
            }, this),
+
−
            "refresh.owl.carousel changed.owl.carousel": a.proxy(function () {
+
−
                this._playing && this.stop()
+
−
            }, this),
+
−
            "prepared.owl.carousel": a.proxy(function (b) {
+
−
                var c = a(b.content).find(".owl-video");
+
−
                c.length && (c.css("display", "none"), this.fetch(c, a(b.content)))
+
−
            }, this)
+
−
        }, this._core.options = a.extend({}, d.Defaults, this._core.options), this._core.$element.on(this._handlers), this._core.$element.on("click.owl.video", ".owl-video-play-icon", a.proxy(function (a) {
+
−
            this.play(a)
+
−
        }, this))
+
−
    };
+
−
    d.Defaults = {
+
−
        video: !1,
+
−
        videoHeight: !1,
+
−
        videoWidth: !1
+
−
    }, d.prototype.fetch = function (a, b) {
+
−
        var c = a.attr("data-vimeo-id") ? "vimeo" : "youtube",
+
−
            d = a.attr("data-vimeo-id") || a.attr("data-youtube-id"),
+
−
            e = a.attr("data-width") || this._core.settings.videoWidth,
+
−
            f = a.attr("data-height") || this._core.settings.videoHeight,
+
−
            g = a.attr("href");
+
−
        if (!g) throw new Error("Missing video URL.");
+
−
        if (d = g.match(/(http:|https:|)\/\/(player.|www.)?(vimeo\.com|youtu(be\.com|\.be|be\.googleapis\.com))\/(video\/|embed\/|watch\?v=|v\/)?([A-Za-z0-9._%-]*)(\&\S+)?/), d[3].indexOf("youtu") > -1) c = "youtube";
+
−
        else {
+
−
            if (!(d[3].indexOf("vimeo") > -1)) throw new Error("Video URL not supported.");
+
−
            c = "vimeo"
+
−
        }
+
−
        d = d[6], this._videos[g] = {
+
−
            type: c,
+
−
            id: d,
+
−
            width: e,
+
−
            height: f
+
−
        }, b.attr("data-video", g), this.thumbnail(a, this._videos[g])
+
−
    }, d.prototype.thumbnail = function (b, c) {
+
−
        var d, e, f, g = c.width && c.height ? 'style="width:' + c.width + "px;height:" + c.height + 'px;"' : "",
+
−
            h = b.find("img"),
+
−
            i = "src",
+
−
            j = "",
+
−
            k = this._core.settings,
+
−
            l = function (a) {
+
−
                e = '<div class="owl-video-play-icon"></div>', d = k.lazyLoad ? '<div class="owl-video-tn ' + j + '" ' + i + '="' + a + '"></div>' : '<div class="owl-video-tn" style="opacity:1;background-image:url(' + a + ')"></div>', b.after(d), b.after(e)
+
−
            };
+
−
        return b.wrap('<div class="owl-video-wrapper"' + g + "></div>"), this._core.settings.lazyLoad && (i = "data-src", j = "owl-lazy"), h.length ? (l(h.attr(i)), h.remove(), !1) : void ("youtube" === c.type ? (f = "http://img.youtube.com/vi/" + c.id + "/hqdefault.jpg", l(f)) : "vimeo" === c.type && a.ajax({
+
−
            type: "GET",
+
−
            url: "http://vimeo.com/api/v2/video/" + c.id + ".json",
+
−
            jsonp: "callback",
+
−
            dataType: "jsonp",
+
−
            success: function (a) {
+
−
                f = a[0].thumbnail_large, l(f)
+
−
            }
+
−
        }))
+
−
    }, d.prototype.stop = function () {
+
−
        this._core.trigger("stop", null, "video"), this._playing.find(".owl-video-frame").remove(), this._playing.removeClass("owl-video-playing"), this._playing = null
+
−
    }, d.prototype.play = function (b) {
+
−
        this._core.trigger("play", null, "video"), this._playing && this.stop();
+
−
        var c, d, e = a(b.target || b.srcElement),
+
−
            f = e.closest("." + this._core.settings.itemClass),
+
−
            g = this._videos[f.attr("data-video")],
+
−
            h = g.width || "100%",
+
−
            i = g.height || this._core.$stage.height();
+
−
        "youtube" === g.type ? c = '<iframe width="' + h + '" height="' + i + '" src="http://www.youtube.com/embed/' + g.id + "?autoplay=1&v=" + g.id + '" frameborder="0" allowfullscreen></iframe>' : "vimeo" === g.type && (c = '<iframe src="http://player.vimeo.com/video/' + g.id + '?autoplay=1" width="' + h + '" height="' + i + '" frameborder="0" webkitallowfullscreen mozallowfullscreen allowfullscreen></iframe>'), f.addClass("owl-video-playing"), this._playing = f, d = a('<div style="height:' + i + "px; width:" + h + 'px" class="owl-video-frame">' + c + "</div>"), e.after(d)
+
−
    }, d.prototype.isInFullScreen = function () {
+
−
        var d = c.fullscreenElement || c.mozFullScreenElement || c.webkitFullscreenElement;
+
−
        return d && a(d).parent().hasClass("owl-video-frame") && (this._core.speed(0), this._fullscreen = !0), d && this._fullscreen && this._playing ? !1 : this._fullscreen ? (this._fullscreen = !1, !1) : this._playing && this._core.state.orientation !== b.orientation ? (this._core.state.orientation = b.orientation, !1) : !0
+
−
    }, d.prototype.destroy = function () {
+
−
        var a, b;
+
−
        this._core.$element.off("click.owl.video");
+
−
        for (a in this._handlers) this._core.$element.off(a, this._handlers[a]);
+
−
        for (b in Object.getOwnPropertyNames(this)) "function" != typeof this[b] && (this[b] = null)
+
−
    }, a.fn.owlCarousel.Constructor.Plugins.Video = d
+
−
}(window.Zepto || window.jQuery, window, document),
+
−
function (a, b, c, d) {
+
−
    var e = function (b) {
+
−
        this.core = b, this.core.options = a.extend({}, e.Defaults, this.core.options), this.swapping = !0, this.previous = d, this.next = d, this.handlers = {
+
−
            "change.owl.carousel": a.proxy(function (a) {
+
−
                "position" == a.property.name && (this.previous = this.core.current(), this.next = a.property.value)
+
−
            }, this),
+
−
            "drag.owl.carousel dragged.owl.carousel translated.owl.carousel": a.proxy(function (a) {
+
−
                this.swapping = "translated" == a.type
+
−
            }, this),
+
−
            "translate.owl.carousel": a.proxy(function () {
+
−
                this.swapping && (this.core.options.animateOut || this.core.options.animateIn) && this.swap()
+
−
            }, this)
+
−
        }, this.core.$element.on(this.handlers)
+
−
    };
+
−
    e.Defaults = {
+
−
        animateOut: !1,
+
−
        animateIn: !1
+
−
    }, e.prototype.swap = function () {
+
−
        if (1 === this.core.settings.items && this.core.support3d) {
+
−
            this.core.speed(0);
+
−
            var b, c = a.proxy(this.clear, this),
+
−
                d = this.core.$stage.children().eq(this.previous),
+
−
                e = this.core.$stage.children().eq(this.next),
+
−
                f = this.core.settings.animateIn,
+
−
                g = this.core.settings.animateOut;
+
−
            this.core.current() !== this.previous && (g && (b = this.core.coordinates(this.previous) - this.core.coordinates(this.next), d.css({
+
−
                left: b + "px"
+
−
            }).addClass("animated owl-animated-out").addClass(g).one("webkitAnimationEnd mozAnimationEnd MSAnimationEnd oanimationend animationend", c)), f && e.addClass("animated owl-animated-in").addClass(f).one("webkitAnimationEnd mozAnimationEnd MSAnimationEnd oanimationend animationend", c))
+
−
        }
+
−
    }, e.prototype.clear = function (b) {
+
−
        a(b.target).css({
+
−
            left: ""
+
−
        }).removeClass("animated owl-animated-out owl-animated-in").removeClass(this.core.settings.animateIn).removeClass(this.core.settings.animateOut), this.core.transitionEnd()
+
−
    }, e.prototype.destroy = function () {
+
−
        var a, b;
+
−
        for (a in this.handlers) this.core.$element.off(a, this.handlers[a]);
+
−
        for (b in Object.getOwnPropertyNames(this)) "function" != typeof this[b] && (this[b] = null)
+
−
    }, a.fn.owlCarousel.Constructor.Plugins.Animate = e
+
−
}(window.Zepto || window.jQuery, window, document),
+
−
function (a, b, c) {
+
−
    var d = function (b) {
+
−
        this.core = b, this.core.options = a.extend({}, d.Defaults, this.core.options), this.handlers = {
+
−
            "translated.owl.carousel refreshed.owl.carousel": a.proxy(function () {
+
−
                this.autoplay()
+
−
            }, this),
+
−
            "play.owl.autoplay": a.proxy(function (a, b, c) {
+
−
                this.play(b, c)
+
−
            }, this),
+
−
            "stop.owl.autoplay": a.proxy(function () {
+
−
                this.stop()
+
−
            }, this),
+
−
            "mouseover.owl.autoplay": a.proxy(function () {
+
−
                this.core.settings.autoplayHoverPause && this.pause()
+
−
            }, this),
+
−
            "mouseleave.owl.autoplay": a.proxy(function () {
+
−
                this.core.settings.autoplayHoverPause && this.autoplay()
+
−
            }, this)
+
−
        }, this.core.$element.on(this.handlers)
+
−
    };
+
−
    d.Defaults = {
+
−
        autoplay: !1,
+
−
        autoplayTimeout: 5e3,
+
−
        autoplayHoverPause: !1,
+
−
        autoplaySpeed: !1
+
−
    }, d.prototype.autoplay = function () {
+
−
        this.core.settings.autoplay && !this.core.state.videoPlay ? (b.clearInterval(this.interval), this.interval = b.setInterval(a.proxy(function () {
+
−
            this.play()
+
−
        }, this), this.core.settings.autoplayTimeout)) : b.clearInterval(this.interval)
+
−
    }, d.prototype.play = function () {
+
−
        return c.hidden === !0 || this.core.state.isTouch || this.core.state.isScrolling || this.core.state.isSwiping || this.core.state.inMotion ? void 0 : this.core.settings.autoplay === !1 ? void b.clearInterval(this.interval) : void this.core.next(this.core.settings.autoplaySpeed)
+
−
    }, d.prototype.stop = function () {
+
−
        b.clearInterval(this.interval)
+
−
    }, d.prototype.pause = function () {
+
−
        b.clearInterval(this.interval)
+
−
    }, d.prototype.destroy = function () {
+
−
        var a, c;
+
−
        b.clearInterval(this.interval);
+
−
        for (a in this.handlers) this.core.$element.off(a, this.handlers[a]);
+
−
        for (c in Object.getOwnPropertyNames(this)) "function" != typeof this[c] && (this[c] = null)
+
−
    }, a.fn.owlCarousel.Constructor.Plugins.autoplay = d
+
−
}(window.Zepto || window.jQuery, window, document),
+
−
function (a) {
+
−
    "use strict";
+
−
    var b = function (c) {
+
−
        this._core = c, this._initialized = !1, this._pages = [], this._controls = {}, this._templates = [], this.$element = this._core.$element, this._overrides = {
+
−
            next: this._core.next,
+
−
            prev: this._core.prev,
+
−
            to: this._core.to
+
−
        }, this._handlers = {
+
−
            "prepared.owl.carousel": a.proxy(function (b) {
+
−
                this._core.settings.dotsData && this._templates.push(a(b.content).find("[data-dot]").andSelf("[data-dot]").attr("data-dot"))
+
−
            }, this),
+
−
            "add.owl.carousel": a.proxy(function (b) {
+
−
                this._core.settings.dotsData && this._templates.splice(b.position, 0, a(b.content).find("[data-dot]").andSelf("[data-dot]").attr("data-dot"))
+
−
            }, this),
+
−
            "remove.owl.carousel prepared.owl.carousel": a.proxy(function (a) {
+
−
                this._core.settings.dotsData && this._templates.splice(a.position, 1)
+
−
            }, this),
+
−
            "change.owl.carousel": a.proxy(function (a) {
+
−
                if ("position" == a.property.name && !this._core.state.revert && !this._core.settings.loop && this._core.settings.navRewind) {
+
−
                    var b = this._core.current(),
+
−
                        c = this._core.maximum(),
+
−
                        d = this._core.minimum();
+
−
                    a.data = a.property.value > c ? b >= c ? d : c : a.property.value < d ? c : a.property.value
+
−
                }
+
−
            }, this),
+
−
            "changed.owl.carousel": a.proxy(function (a) {
+
−
                "position" == a.property.name && this.draw()
+
−
            }, this),
+
−
            "refreshed.owl.carousel": a.proxy(function () {
+
−
                this._initialized || (this.initialize(), this._initialized = !0), this._core.trigger("refresh", null, "navigation"), this.update(), this.draw(), this._core.trigger("refreshed", null, "navigation")
+
−
            }, this)
+
−
        }, this._core.options = a.extend({}, b.Defaults, this._core.options), this.$element.on(this._handlers)
+
−
    };
+
−
    b.Defaults = {
+
−
        nav: !1,
+
−
        navRewind: !0,
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−
        navText: ["prev", "next"],
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−
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        navClass: ["owl-prev", "owl-next"],
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        slideBy: 1,
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        dotClass: "owl-dot",
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        dotsContainer: !1,
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        controlsClass: "owl-controls"
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    }, b.prototype.initialize = function () {
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        var b, c, d = this._core.settings;
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        d.dotsData || (this._templates = [a("<div>").addClass(d.dotClass).append(a("<span>")).prop("outerHTML")]), d.navContainer && d.dotsContainer || (this._controls.$container = a("<div>").addClass(d.controlsClass).appendTo(this.$element)), this._controls.$indicators = d.dotsContainer ? a(d.dotsContainer) : a("<div>").hide().addClass(d.dotsClass).appendTo(this._controls.$container), this._controls.$indicators.on("click", "div", a.proxy(function (b) {
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            var c = a(b.target).parent().is(this._controls.$indicators) ? a(b.target).index() : a(b.target).parent().index();
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            b.preventDefault(), this.to(c, d.dotsSpeed)
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        }, this)), b = d.navContainer ? a(d.navContainer) : a("<div>").addClass(d.navContainerClass).prependTo(this._controls.$container), this._controls.$next = a("<" + d.navElement + ">"), this._controls.$previous = this._controls.$next.clone(), this._controls.$previous.addClass(d.navClass[0]).html(d.navText[0]).hide().prependTo(b).on("click", a.proxy(function () {
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            this.prev(d.navSpeed)
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        }, this)), this._controls.$next.addClass(d.navClass[1]).html(d.navText[1]).hide().appendTo(b).on("click", a.proxy(function () {
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            this.next(d.navSpeed)
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        }, this));
+
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        for (c in this._overrides) this._core[c] = a.proxy(this[c], this)
+
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    }, b.prototype.destroy = function () {
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        var a, b, c, d;
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        for (a in this._handlers) this.$element.off(a, this._handlers[a]);
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        for (b in this._controls) this._controls[b].remove();
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        for (d in this.overides) this._core[d] = this._overrides[d];
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        for (c in Object.getOwnPropertyNames(this)) "function" != typeof this[c] && (this[c] = null)
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    }, b.prototype.update = function () {
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            g = d.center || d.autoWidth || d.dotData ? 1 : d.dotsEach || d.items;
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        if ("page" !== d.slideBy && (d.slideBy = Math.min(d.slideBy, d.items)), d.dots || "page" == d.slideBy)
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    }, b.prototype.draw = function () {
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        var b, c, d = "",
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            e = this._core.settings,
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            f = (this._core.$stage.children(), this._core.relative(this._core.current()));
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            if (b = this._pages.length - this._controls.$indicators.children().length, e.dotData && 0 !== b) {
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                for (c = 0; c < this._controls.$indicators.children().length; c++) d += this._templates[this._core.relative(c)];
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                this._controls.$indicators.html(d)
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            } else b > 0 ? (d = new Array(b + 1).join(this._templates[0]), this._controls.$indicators.append(d)) : 0 > b && this._controls.$indicators.children().slice(b).remove();
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            this._controls.$indicators.find(".active").removeClass("active"), this._controls.$indicators.children().eq(a.inArray(this.current(), this._pages)).addClass("active")
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        }
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        this._controls.$indicators.toggle(e.dots)
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    }, b.prototype.onTrigger = function (b) {
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        var c = this._core.settings;
+
−
        b.page = {
+
−
            index: a.inArray(this.current(), this._pages),
+
−
            count: this._pages.length,
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            size: c && (c.center || c.autoWidth || c.dotData ? 1 : c.dotsEach || c.items)
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        }
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    }, b.prototype.current = function () {
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        var b = this._core.relative(this._core.current());
+
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        return a.grep(this._pages, function (a) {
+
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            return a.start <= b && a.end >= b
+
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        }).pop()
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    }, b.prototype.getPosition = function (b) {
+
−
        var c, d, e = this._core.settings;
+
−
        return "page" == e.slideBy ? (c = a.inArray(this.current(), this._pages), d = this._pages.length, b ? ++c : --c, c = this._pages[(c % d + d) % d].start) : (c = this._core.relative(this._core.current()), d = this._core.items().length, b ? c += e.slideBy : c -= e.slideBy), c
+
−
    }, b.prototype.next = function (b) {
+
−
        a.proxy(this._overrides.to, this._core)(this.getPosition(!0), b)
+
−
    }, b.prototype.prev = function (b) {
+
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        a.proxy(this._overrides.to, this._core)(this.getPosition(!1), b)
+
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    }, b.prototype.to = function (b, c, d) {
+
−
        var e;
+
−
        d ? a.proxy(this._overrides.to, this._core)(b, c) : (e = this._pages.length, a.proxy(this._overrides.to, this._core)(this._pages[(b % e + e) % e].start, c))
+
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    }, a.fn.owlCarousel.Constructor.Plugins.Navigation = b
+
−
}(window.Zepto || window.jQuery, window, document),
+
−
function (a, b) {
+
−
    "use strict";
+
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    var c = function (d) {
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        this._core = d, this._hashes = {}, this.$element = this._core.$element, this._handlers = {
+
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            "initialized.owl.carousel": a.proxy(function () {
+
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                "URLHash" == this._core.settings.startPosition && a(b).trigger("hashchange.owl.navigation")
+
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            }, this),
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            "prepared.owl.carousel": a.proxy(function (b) {
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                var c = a(b.content).find("[data-hash]").andSelf("[data-hash]").attr("data-hash");
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                this._hashes[c] = b.content
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            }, this)
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        }, this._core.options = a.extend({}, c.Defaults, this._core.options), this.$element.on(this._handlers), a(b).on("hashchange.owl.navigation", a.proxy(function () {
+
−
            var a = b.location.hash.substring(1),
+
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                c = this._core.$stage.children(),
+
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                d = this._hashes[a] && c.index(this._hashes[a]) || 0;
+
−
            return a ? void this._core.to(d, !1, !0) : !1
+
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        }, this))
+
−
    };
+
−
    c.Defaults = {
+
−
        URLhashListener: !1
+
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    }, c.prototype.destroy = function () {
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        var c, d;
+
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        a(b).off("hashchange.owl.navigation");
+
−
        for (c in this._handlers) this._core.$element.off(c, this._handlers[c]);
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        for (d in Object.getOwnPropertyNames(this)) "function" != typeof this[d] && (this[d] = null)
+
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    }, a.fn.owlCarousel.Constructor.Plugins.Hash = c
+
−
}(window.Zepto || window.jQuery, window, document);
+
−
</script>
+
−
<script type="text/javascript"/>
+
−
$(document).ready(function() {
+
−
$('.add-owl').owlCarousel({
+
−
        items: 4,
+
−
        nav: true,
+
−
        navText: false,
+
−
        dots: false,
+
−
        loop: true
+
−
    });
+
 
});
 
});
−
</script>
+
    </script>
 +
</body>
 
</html>
 
</html>
 
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Latest revision as of 20:11, 31 October 2017

A F C M

A F C M

Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma




Abstract

 

Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers in males and next to breast cancer among females in Egypt based upon results of National Cancer Registry Program of Egypt. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain  circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies   miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.   This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is    accomplished by utilizing a   synthetic circuit to give rise to a springboard in our battle against cancer.














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