Difference between revisions of "Team:AFCM-Egypt"

 
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<h1> Welcome to iGEM 2017! </h1>
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<h5>Before you start: </h5>
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<p> Please read the following pages:</p>
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<ul>
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<li>  <a href="https://2017.igem.org/Competition">Competition Hub</a> </li>
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<li> <a href="https://2017.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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<li> <a href="https://2017.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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<h5> Styling your wiki </h5>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<h5> Wiki template information </h5>
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2017.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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<h5> Editing your wiki </h5>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p> <a href="https://2017.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
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<h5>Tips</h5>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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<ul>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2017.igem.org/Calendar">iGEM 2017 calendar</a> </li>
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<li>Have lots of fun! </li>
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</ul>
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</div>
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<div class="column half_size" >
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<h5>Inspiration</h5>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<ul>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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</ul>
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</div>
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<h5> Uploading pictures and files </h5>
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<p> You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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When you upload, set the "Destination Filename" to <br><code>T--YourOfficialTeamName--NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)<br><br>
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<a href="https://2017.igem.org/Special:Upload">
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UPLOAD FILES
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</a>
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</p>
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            <div class="col-md-12 text-center">
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                <video autoplay controls loop style="width:85%;height:85%">
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                    <source src="https://static.igem.org/mediawiki/2017/8/88/Final_vid.mp4" type="video/mp4">
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                </video>
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                    <p><img style="float: right;" src="https://static.igem.org/mediawiki/2017/d/d4/CRISPR_PNG.png" alt="" width="679" height="988" /></p>
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<h3 dir="ltr" style="text-align: left;"><span style="font-size: 20pt; color: #ffffff;">Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma</span><br /><br /><br />               
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  <h3 class="text-center" style="text-align: center;"><br /><br /><span style="font-size: 14pt; color: #ffffff;">Abstract</span></h3>
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                    <p style="text-align: left;"><span style="font-size: 14pt; color: #ffffff;">&nbsp;</span></p>
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                  <span style="font-size: 14pt; color: #ffffff;">Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide &amp; ranked first among cancers in males and next to breast cancer among females in</span><span style="font-size: 14pt; color: #ffffff;"> Egypt based upon results of National Cancer Registry Program of Egypt. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain&nbsp; circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies&nbsp; &nbsp;miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.&nbsp; &nbsp;This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is&nbsp; &nbsp; accomplished by utilizing a&nbsp; &nbsp;synthetic circuit to give rise to a springboard in our battle against cancer.</span><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /></h3>
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                <h2 class='text-center' style='margin-bottom:30px'>
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                    AFCM-Egypt</h2>
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                    <h3 class='text-center'>
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                        A Culture of Discipline and Innovation</h3>
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                        <a href="http://www.afcm.ac.eg/" class="btn btn-primary btn-outline with-arrow" target="_blank"> click here <i class="fa fa-arrow-right"></i></a></div>
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            <h3 class='text-center'>OUR SPONSORS</h3>
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                        <img src="https://static.igem.org/mediawiki/2017/3/37/5-AFCM-Egypt-sponsers-IDT.png" style="width: 150px;padding-right: 15px;">
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Latest revision as of 20:11, 31 October 2017

A F C M

A F C M

Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma




Abstract

 

Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers in males and next to breast cancer among females in Egypt based upon results of National Cancer Registry Program of Egypt. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain  circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies   miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.   This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is    accomplished by utilizing a   synthetic circuit to give rise to a springboard in our battle against cancer.














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