Difference between revisions of "Team:Hong Kong HKU"
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<h2>Introduction</h2> | <h2>Introduction</h2> | ||
<p id="para-1">Our project this year continues the work of last year’s HKU iGEM 2016 Team. By focusing on the intriguing world of diagnostic probes, we aim to improve on last year’s design and increase the effectiveness of disease detection. Contrary to last year’s design, we have come up with an alternative tetrahedron structure, in which the 3D tetrahedron is only formed upon binding to the target sequence. Our ultimate goal is to enable our functional DNA nanostructure to be synthesized and self-assembled inside E. coli. They will detect specific biomarkers expressed in the diseased cells. This website will guide you on our journey throughout the iGEM Competition 2017. Click to explore and enjoy!</p> | <p id="para-1">Our project this year continues the work of last year’s HKU iGEM 2016 Team. By focusing on the intriguing world of diagnostic probes, we aim to improve on last year’s design and increase the effectiveness of disease detection. Contrary to last year’s design, we have come up with an alternative tetrahedron structure, in which the 3D tetrahedron is only formed upon binding to the target sequence. Our ultimate goal is to enable our functional DNA nanostructure to be synthesized and self-assembled inside E. coli. They will detect specific biomarkers expressed in the diseased cells. This website will guide you on our journey throughout the iGEM Competition 2017. Click to explore and enjoy!</p> | ||
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| + | <h3>Inspiration</h3> | ||
| + | <h4>Early Diagnosis of Huntington’s Disease</h4> | ||
| + | <p>Huntington’s disease (HD) is an inherited neurodegenerative disorder that results in the death of brain cells. Though the disease is incurable, early diagnosis can help to better relieve symptoms by allowing treatments to start sooner. In the early stages of HD, only subtle changes in personality, cognitive and physical abilities can be identified. Diagnosis of HD (in cases where the parents do not have HD) is usually carried out only after symptoms are identified and the patient approaches the medical professionals. As the early symptoms are generally not severe enough to be recognized as HD symptoms on their own, the treatment is usually delayed. We hope to allow prompt treatment with our non-invasive and highly accessible diagnostic method. | ||
| + | Genetic mutations, namely the trinucleotide repeats in the Huntingtin gene (HTT) located on Chromosome 4, lead to the development of HD.</p> | ||
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Revision as of 13:20, 9 October 2017
Introduction
Our project this year continues the work of last year’s HKU iGEM 2016 Team. By focusing on the intriguing world of diagnostic probes, we aim to improve on last year’s design and increase the effectiveness of disease detection. Contrary to last year’s design, we have come up with an alternative tetrahedron structure, in which the 3D tetrahedron is only formed upon binding to the target sequence. Our ultimate goal is to enable our functional DNA nanostructure to be synthesized and self-assembled inside E. coli. They will detect specific biomarkers expressed in the diseased cells. This website will guide you on our journey throughout the iGEM Competition 2017. Click to explore and enjoy!
Inspiration
Early Diagnosis of Huntington’s Disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder that results in the death of brain cells. Though the disease is incurable, early diagnosis can help to better relieve symptoms by allowing treatments to start sooner. In the early stages of HD, only subtle changes in personality, cognitive and physical abilities can be identified. Diagnosis of HD (in cases where the parents do not have HD) is usually carried out only after symptoms are identified and the patient approaches the medical professionals. As the early symptoms are generally not severe enough to be recognized as HD symptoms on their own, the treatment is usually delayed. We hope to allow prompt treatment with our non-invasive and highly accessible diagnostic method. Genetic mutations, namely the trinucleotide repeats in the Huntingtin gene (HTT) located on Chromosome 4, lead to the development of HD.
