Difference between revisions of "Team:AFCM-Egypt"
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| − | + | <a class="navbar-brand" href="https://2017.igem.org/Team:AFCM-Egypt"><span><img src="https://static.igem.org/mediawiki/2017/a/aa/AFCM-Egypt-LOGO.png" style="width:150px; height:150px;"></span></a> | |
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| − | + | <li class="active"><a href="https://2017.igem.org/Team:AFCM-Egypt">HOME</a> </li> | |
| − | + | <li> | |
| − | + | <a>TEAM <span class="caret"></span></a> | |
| − | + | <ul> | |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Meet_the_team">Meet The Team</a></li> | |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Collaborations">Collaborations</a></li> | |
| − | + | </ul> | |
| − | + | </li> | |
| − | + | <li class="dropdown"> | |
| − | + | <a>PROJECT <span class="caret"></span></a> | |
| − | + | <ul> | |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Description">Project Description</a></li> | |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Experiments">Experiment</a></li> | |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Results">Results</a></li> | |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Demonstrate">Proof of concept</a></li> | |
| − | + | </ul> | |
| − | + | </li> | |
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| − | + | <a>PARTS <span class="caret"></span></a> | |
| − | + | <ul> | |
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| − | </ul> | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Basic_Part">Parts</a></li> |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Basic_Part">Basic Parts</a></li> | |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Composite_Part">Composite Parts</a></li> | |
| + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Improve">Improve</a></li> | ||
| + | </ul> | ||
| + | </li> | ||
| + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Design">Design</a></li> | ||
| + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Model">MODELING</a></li> | ||
| + | <li class="SOFTWARE"><a href="https://2017.igem.org/Team:AFCM-Egypt/Software">Software</a></li> | ||
| + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Safety">SAFETY</a></li> | ||
| + | <li class="dropdown"> | ||
| + | <a>HUMAN PRACTICE <span class="caret"></span></a> | ||
| + | <ul> | ||
| + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/HP/Silver">Silver</a></li> | ||
| + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/HP/Gold">Gold</a></li> | ||
| + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/HP/Integrated">Integrated</a></li> | ||
| − | + | </ul> | |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Attributions">ATTRIBUTIONS</a></li> | |
| − | + | <li><a href="https://2017.igem.org/Team:AFCM-Egypt/Medal_criteria">MEDAL CRITERIA</a></li> | |
| + | </ul> | ||
| + | </div> | ||
</div> | </div> | ||
| − | + | </nav> | |
| − | </ | + | </section> |
| − | + | <div class="twitter-feed purple" style="padding-bottom:250px"> | |
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| − | </section> | + | |
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| − | <div class="twitter-feed purple" style="padding-bottom:250px"> | + | |
<div class="container section-wrapper" style="padding-top:0px !important;width:90%"> | <div class="container section-wrapper" style="padding-top:0px !important;width:90%"> | ||
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| − | + | <source src="https://static.igem.org/mediawiki/2017/8/88/Final_vid.mp4" type="video/mp4"> | |
| − | </video> | + | </video> |
| − | + | </div> | |
| − | </div> | + | </div> |
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| − | </div> | + | <section class="price-table"> |
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<div class="container section-wrapper"> | <div class="container section-wrapper"> | ||
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| − | + | <div class="col-md-6 text-center" style="float: none;height: auto ; width: 90%; margin: auto; background-color: rgba(0, 0, 0, 0.4);"> | |
| − | + | <p><img style="float: right;" src="https://static.igem.org/mediawiki/2017/d/d4/CRISPR_PNG.png" alt="" width="679" height="988" /></p> | |
| − | + | <h3 class="text-center" style="text-align: center;"><br /><br /><span style="font-size: 14pt; color: #ffffff;">Abstract</span></h3> | |
| − | + | <p style="text-align: left;"><span style="font-size: 14pt; color: #ffffff;"> </span></p> | |
| − | + | <h3 dir="ltr" style="text-align: left;"><span style="font-size: 14pt; color: #ffffff;">Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma</span><br /><br /><br /><span style="font-size: 14pt; color: #ffffff;">Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers in males and next to breast cancer among females in</span><span style="font-size: 14pt; color: #ffffff;"> Egypt based upon results of National Cancer Registry Program of Egypt. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials. This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.</span><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /><br /></h3> | |
| − | + | </div> | |
| − | + | </div> | |
| − | + | </div> | |
| − | + | </section> | |
| − | + | <div class="twitter-feed purple" style="margin-bottom:50vh;background-color: rgba(0, 0, 0, 0.4);"> | |
| − | + | <div class="container section-wrapper"> | |
| + | <div class='col-md-3'></div> | ||
| + | <div class='col-md-6 text-center'> | ||
| + | <h2 class='text-center' style='margin-bottom:30px'> | ||
| + | AFCM-Egypt</h2> | ||
| + | <h3 class='text-center'> | ||
| + | A Culture of Discipline and Innovation</h3> | ||
| + | <a href="http://www.afcm.ac.eg" class="btn btn-5 btn-sub" target="_blank">click here</a> | ||
| + | </div> | ||
| + | <div class='col-md-3'><img src="https://static.igem.org/mediawiki/2017/7/7b/AFCM_LOGO_PNG.png" alt="logo" style='width: 50%;float: right'></div> | ||
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| − | <div class="slider-wrapper theme-mi-slider"> | + | <div class="slider-wrapper theme-mi-slider"> |
| − | <h3 class='text-center'>OUR SPONSORS</h3> | + | <h3 class='text-center'>OUR SPONSORS</h3> |
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| − | + | <img src="https://static.igem.org/mediawiki/2017/b/bd/3-AFCM-Egypt-sponsers-Pharco_Logo.png" style="width: 180px;padding-right: 18px;"> | |
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Revision as of 20:21, 26 October 2017
Abstract
Competing endogenous RNA network : Potential entrants to gene editing in Hepatocellular Carcinoma
Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers in males and next to breast cancer among females in Egypt based upon results of National Cancer Registry Program of Egypt. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials. This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
