Difference between revisions of "Team:Hong Kong HKU/Description"

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<h1>Description</h1>
 
<h1>Description</h1>
  
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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The field of DNA nanotechnology has proved to be one of the fastest growing fields in synthetic biology. Recent advances have focused on the development of DNA origami, tweezer structures and various other two and three dimensional structures, with the aim of applying such structures into areas such as diagnostics, drug delivery, detection and more.
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<h5>What should this page contain?</h5>
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<b>Hypothesis:</b>
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<li> A clear and concise description of your project.</li>
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Through our project, we expect to follow in the footsteps of such advancements, however taking them a step further to develop a three dimensional DNA nanostructure that can undergo an induced structural change in the presence of its specific nucleic acid targets (RNA or DNA) not solely in vitro but also in living cells after expression.  
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<li>A detailed explanation of why your team chose to work on this particular project.</li>
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<b>Objectives:</b>
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Our objectives would be to first prove the efficiency and accuracy of our structure in detecting its respective target in vitro with the application of various laboratory techniques, for example gel electrophoresis and colorimetric assays, followed by the expression of our DNA nanostructure in organisms, namely <i>E.coli</i>, after which the structure can be extracted and tested as well again.
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In brief, we will aim to construct a three dimensional DNA nanostructure that can be used for the detection of nucleic acid markers and explore its functionality, both in vitro and in living cells.
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<h5>Advice on writing your Project Description</h5>
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.
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Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
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<h5>References</h5>
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
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<h5>Inspiration</h5>
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<p>See how other teams have described and presented their projects: </p>
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
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<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
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Revision as of 02:53, 1 July 2017

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Description

The field of DNA nanotechnology has proved to be one of the fastest growing fields in synthetic biology. Recent advances have focused on the development of DNA origami, tweezer structures and various other two and three dimensional structures, with the aim of applying such structures into areas such as diagnostics, drug delivery, detection and more.

Hypothesis:
Through our project, we expect to follow in the footsteps of such advancements, however taking them a step further to develop a three dimensional DNA nanostructure that can undergo an induced structural change in the presence of its specific nucleic acid targets (RNA or DNA) not solely in vitro but also in living cells after expression.

Objectives:
Our objectives would be to first prove the efficiency and accuracy of our structure in detecting its respective target in vitro with the application of various laboratory techniques, for example gel electrophoresis and colorimetric assays, followed by the expression of our DNA nanostructure in organisms, namely E.coli, after which the structure can be extracted and tested as well again.
In brief, we will aim to construct a three dimensional DNA nanostructure that can be used for the detection of nucleic acid markers and explore its functionality, both in vitro and in living cells.