Difference between revisions of "Team:Austin UTexas/Model"

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<p>The goal of our model is to simulate the expected behavior of our transformed Lactobacillus plantarum after consumption.
 
<p>The goal of our model is to simulate the expected behavior of our transformed Lactobacillus plantarum after consumption.
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We first modeled the transcription and translation of the gadB gene, then modeled the binding reaction of glutamate decarboxylate and L. Glutamate, dependent on the cofactor pyridoxal- 5"phosphate (PLP). Plp binds to the C-terminal domain of the GadB. We looked specifically at how our Lactobacillus plantarum would encode the gadB gene and encode glutamate decarboxylate. </p>
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We focused on modeling the binding reaction of glutamate decarboxylate and L. Glutamate, dependent on the cofactor pyridoxal- 5"phosphate (PLP). Plp binds to the C-terminal domain of the GadB. We looked specifically at how our Lactobacillus plantarum would encode the gadB gene and encode glutamate decarboxylate. </p>
  
 
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<h3> Gold Medal Criterion #3</h3>
 
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To complete for the gold medal criterion #3, please describe your work on this page and fill out the description on your <a href="https://2017.igem.org/Judging/Judging_Form">judging form</a>. To achieve this medal criterion, you must convince the judges that your team has gained insight into your project from modeling. You may not convince the judges if your model does not have an effect on your project design or implementation.
 
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Please see the <a href="https://2017.igem.org/Judging/Medals"> 2017 Medals Page</a> for more information.
 
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<h3>Best Model Special Prize</h3>
 
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To compete for the <a href="https://2017.igem.org/Judging/Awards">Best Model prize</a>, please describe your work on this page  and also fill out the description on the <a href="https://2017.igem.org/Judging/Judging_Form">judging form</a>. Please note you can compete for both the gold medal criterion #3 and the best model prize with this page.
 
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You must also delete the message box on the top of this page to be eligible for the Best Model Prize.
 
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<h5> Inspiration </h5>
 
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Here are a few examples from previous teams:
 
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<li><a href="https://2016.igem.org/Team:Manchester/Model">Manchester 2016</a></li>
 
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<li><a href="https://2016.igem.org/Team:TU_Delft/Model">TU Delft 2016  </li>
 
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<li><a href="https://2014.igem.org/Team:ETH_Zurich/modeling/overview">ETH Zurich 2014</a></li>
 
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<li><a href="https://2014.igem.org/Team:Waterloo/Math_Book">Waterloo 2014</a></li>
 
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Revision as of 18:07, 15 October 2017

★ ALERT!

This page is used by the judges to evaluate your team for the medal criterion or award listed above.

Delete this box in order to be evaluated for this medal criterion and/or award. See more information at Instructions for Pages for awards.

Why Model?

Scientific models are mathematical renditions of real-world systems. In synthetic biology, models are often used to define the kinetics of biochemical systems to aid in the visualization of information, and can be used to predict the behavior or outcome of biological systems.

Our Model

The goal of our model is to simulate the expected behavior of our transformed Lactobacillus plantarum after consumption. We focused on modeling the binding reaction of glutamate decarboxylate and L. Glutamate, dependent on the cofactor pyridoxal- 5"phosphate (PLP). Plp binds to the C-terminal domain of the GadB. We looked specifically at how our Lactobacillus plantarum would encode the gadB gene and encode glutamate decarboxylate.