Difference between revisions of "Team:IIT Delhi/HP/Gold Integrated"

 
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                                                         <button class="dropbtn1"><a href="https://2017.igem.org/Team:IIT_Delhi">iGEM IIT Delhi</a></button>
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                                                         <button class="dropbtn2"><a href="https://2017.igem.org/Team:IIT_Delhi">iGEM IIT Delhi</a></button>
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<div class = "right_menu">
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        <div class = "right_menu">
 
   <div class="dropdown">
 
   <div class="dropdown">
 
     <button class="dropbtn">Project  
 
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     </button>
 
     </button>
 
     <div class="dropdown-content">
 
     <div class="dropdown-content">
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       <a href="/Team:IIT_Delhi/Description">Description</a>
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       <a href="/Team:IIT_Delhi/Description">Overview</a>
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       <a href="/Team:IIT_Delhi/Results">Results</a>
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       <a href="/Team:IIT_Delhi/Design">Squarewave Generator</a>
  
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       <a href="/Team:IIT_Delhi/Interlab">Interlab</a>
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       <a href="/Team:IIT_Delhi/InterLab">Interlab</a>
 
     </div>
 
     </div>
 
   </div>  
 
   </div>  
 
                                                         <div class="dropdown">
 
                                                         <div class="dropdown">
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    <button class="dropbtn">Results
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    <i class="fa fa-caret-down"></i>
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    </button>
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    <div class="dropdown-content">
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      <a href="/Team:IIT_Delhi/Circuit_Design">Circuit design and construction</a>
 +
      <a href="/Team:IIT_Delhi/Microfluidics">Microfluidics and Fluorescence</a>
 +
      <a href="/Team:IIT_Delhi/Photobleaching">Photobleaching</a>
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      <a href="/Team:IIT_Delhi/Promoter">Promoter strength</a>
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                                                      <a href="/Team:IIT_Delhi/Oscillations">Oscillations</a>
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       <a href="/Team:IIT_Delhi/Improved_Part">Improved Parts</a>
 
       <a href="/Team:IIT_Delhi/Improved_Part">Improved Parts</a>
 
       <a href="/Team:IIT_Delhi/Part_Collection">Part Collection</a>
 
       <a href="/Team:IIT_Delhi/Part_Collection">Part Collection</a>
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       <a href="/Team:IIT_Delhi/Model">Overview</a>
 
       <a href="/Team:IIT_Delhi/Model">Overview</a>
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       <a href="/Team:IIT_Delhi/Database">Simulation Database</a>
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       <a href="/Team:IIT_Delhi/Write_Model">Writing a Model</a>
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                                                        <a href="/Team:IIT_Delhi/Deterministic_Model">Deterministic Model </a>
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                                                        <a href="/Team:IIT_Delhi/Stochastic_Model">Stochastic Model</a>
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                                                        <a href="/Team:IIT_Delhi/Bifurcation">Bifurcation and Squareness</a>
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                                                        <a href="/Team:IIT_Delhi/Resources">Resource sharing</a>
 
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       <a href="/Team:IIT_Delhi/Engagement">Public Engagement</a>
 
       <a href="/Team:IIT_Delhi/Engagement">Public Engagement</a>
 
       <a href="/Team:IIT_Delhi/Collaborations">Collaborations</a>
 
       <a href="/Team:IIT_Delhi/Collaborations">Collaborations</a>
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                                                        <a href="/Team:IIT_Delhi/Safety">Safety</a>
 
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                                                        <a href="/Team:IIT_Delhi/Collaborations">Overview</a>
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      <a href="/Team:IIT_Delhi/GMM_legislation">GMM Legislation</a>
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      <a href="/Team:IIT_Delhi/berlin">iGEM Berlin</a>
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      <a href="/Team:IIT_Delhi/mohali">Mentoring IISER Mohali</a>
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      <a href="/Team:IIT_Delhi/glasgow">iGEM Glasgow</a>
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             <h2 class="h2font">INTEGRATED HUMAN PRACTICES</h2>
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             <h2 class="h2font">Integrated Human Practices</h2>
  
 
             <p> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 
             <p> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 
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<h2 id="pfont">The credits for accomplishment of this project goes to the dedication, commitment and enthusiasm shown by a large number of people and parties from multiple disciplines. It gives us immense pleasure and gratification to acknowledge their support and assistance towards the execution of the project.
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<h2 id="pfont">To get a better idea of how can we improve and move ahead with our project,we first set out to talk to some of the researchers and professors of various departments, both inside our institute and outside. Following is a summary of the talk that we had :
 
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           <button class="accordion back1" style="font-weight: bold;">Wearing Lab Coats</button>
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           <button class="accordion back1" style="font-weight: bold;">Talk With Prof. Shaunak Sen</button>
 
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<h2 id="pfont1"><span class="image left"><img src="https://static.igem.org/mediawiki/2017/a/a3/T--IIT_Delhi--Berlin.jpg" alt="" /></span><br> The IIT Delhi iGEM team whole-heartedly collaborated with Berlin team. Berlin team was working on the affordable, practical and effective diagnostic of the widespread third world parasitic disease -Tapeworm Infection. Since India is one of the countries where millions of people are infected by this parasite, IIT Delhi directed Berlin team to a suitable site. It was a hospital in Varanasi, Uttar Pradesh where many cases of tapeworm were reported. After the successful extraction and lysis of the Tapeworm eggs, Berlin team obtained RNA molecules of the T. Solium species of the Tapeworm. IIT Delhi further assisted them by providing our own lab as -20 and -80 degrees centigrade refrigerators and other required lab apparatus were not available in the above-mentioned hospital. Sequencing of the RNA was also done and all the samples were shipped to them.<br>
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<h2 id="pfont1"><br> Dr. Shaunak Sen is a Professor at the Department of Electrical Engineering at our Institute, specialising in Control Theory.  When we started brainstorming over our project, we reached out to him for advice about square wave oscillators that we were planning to design. It was he who suggested to us the idea of using an oscillator feeding into a toggle switch in order to generate Square Waves. He further introduced to us the work Dr. Richard M Murray had done on oscillators with ring topologies. He also told us about trying out relaxation oscillators in order to generate a better Square wave response.
  
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This was not only constricted to iGEM collaboration as we further plan to adopt this technology for affordable diagnostic of tapeworm infection which is otherwise done using fecal inspection using a microscope. This would help in timely detection of infection and thus would save lives of many people. Following this, Berlin team provided us the protease stains without Degradation Tags required by us to generate oscillations in the form of a square. Here is the link to the iGEM Berlin Team.
 
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<a href="https://2017.igem.org/Team:Berlin_diagnostX/Collaborations"> https://2017.igem.org/Team:Berlin_diagnostX/Collaborations </a>
 
 
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           <button class="accordion back2" style="font-weight: bold;">Team: GLASGOW</button>
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           <button class="accordion back2" style="font-weight: bold;">Talk With Prof. James Gomes</button>
 
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<h2 id="pfont1"><span class="image left"><img src="https://static.igem.org/mediawiki/2017/b/bb/T--IIT_Delhi--Glassgow.jpg" alt="" /></span><br> iGEM IIT Delhi assisted team Glasgow in 2016 for filling up survey forms designed for the people of India. This year iGEM Glasgow helped us by providing the biological parts ( pPhlF, RBS+PhlF + T, pSrpR, RBS + SrpR + T) which turned to be of immense use in forming the Oscillator.
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<h2 id="pfont1"><br>Dr. James Gomes is a Professor at the School of Biological Sciences, IIT Delhi. His research mainly revolves around the field of Systems Biology. Once we had decided the topology for our project, we discussed with him at length about possible improvements and also got a lot of help from him in our Square wave Modelling. However, he wasn’t very convinced by our topology and rather suggested to us to use 'build up and fire' kind of oscillators for better generation of Square Waves.
 
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<button class="accordion back3" style="font-weight: bold;">Mentoring IISER Mohali iGEM team (2016-2017)</button>
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<button class="accordion back3" style="font-weight: bold;">Talk With Prof. Vivekananda Perumal</button>
 
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<h2 id="pfont1"><span class="image left"><img src="https://static.igem.org/mediawiki/2017/2/23/T--IIT_Delhi--iGEM_mohali.jpg" alt="" /></span>A PhD student, Mr. Mahendra Sahare, doing a humanities project under a Supreme Court lawyer, Dr. Naveen Thayyil, has been in collaboration with iGEM IIT Delhi for the past two years. Together, we have worked on the aspect of ‘Ethical Scientific Practices’. Also, on his recent visit to IISER Mohali, he came back with a collaborative offer for iGEM IIT Delhi to mentor IISER Mohali and help in the establishment of iGEM club there. On our return from the Giant Jamboree 2016, our team members gave a presentation scheduled there, and thereafter our
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<h2 id="pfont1"><br>Dr. Perumal is a Molecular Biologist at the School of Biological Sciences, IIT Delhi.
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team mentored the iGEM Mohali team.
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Our talk with him was indeed very helpful to us in the execution of our project. It was he who suggested to us the strain Streptomyces griseus (Orf2) whose biosafety facilities were available at our lab.
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Here is the link for Mohali iGEM Team: <a href="https://2017.igem.org/Team:IISER-Mohali-INDIA"> https://2017.igem.org/Team:IISER-Mohali-INDIA </a>
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<button class="accordion back4" style="font-weight: bold;">Team: MANCHESTER </button>
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<button class="accordion back4" style="font-weight: bold;">Talk With Mr. Mahendra Sahare </button>
 
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<h2 id="pfont1"><span class="image left"><img src="https://static.igem.org/mediawiki/2017/3/3e/T--IIT_Delhi--iGEM_Manchester.jpg" alt="" /></span>Have a look at the fruits of the 3 months-long interactions, discussions and meet-ups at <a href="https://2017.igem.org/Team:IIT_Delhi/GMM_legislation"> https://2017.igem.org/Team:IIT_Delhi/GMM_legislation </a>.
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<h2 id="pfont1"><br>Mr. Mahendra Sahare, is a PhD scholar at the Department of Humanities doing a project under a Supreme Court lawyer, Dr. Naveen Thayyil. He has been in collaboration with iGEM IIT Delhi for the past two years. Together, we have worked on the aspect of ‘Ethical Scientific Practices’. Also, on his recent visit to IISER Mohali, he came back with a collaborative offer for iGEM IIT Delhi to mentor IISER Mohali and help in the establishment of an iGEM team there. On our return from the Giant Jamboree 2016, our team members gave a presentation there, and thereafter our team mentored the iGEM Mohali team.
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<h2 id="pfont"><br><br>We also talked to many researchers pursuing their Ph.D here at IIT Delhi, to get to know about various possible uses of Biological Oscillators, before we started our project.
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Here are their views on how Biological Oscillators can be used in various applications.<br><br>
  
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          <h2 id="pfont1"><br> Mr. Venkat is a researcher in the field of Systems Biology. In our discussion with him, he told us that Biological Oscillators can be used as a clock reference analogous to those in electrical engineering used for signal processing, particularly as a bridge between networks for synchronisation and as a "modem" carrying information.
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          <h2 id="pfont1"><br>A researcher by profession, he works in the field of synchronisation of non-linear and linear oscillators. His guidance over the subject of Biological Oscillators allowed us to use gene regulatory networks in circuits similar to the repressilator.
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             <h2 id="pfont1"><br>He is a researcher in the field of convergent systems. He told us about how Biological oscillators can have several applications in his field of research. According to him, if the oscillator is tuned to be convergent, then many interesting phenomena like time-scales and synchronisation can be analysed better.
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Latest revision as of 22:27, 1 November 2017

iGEM IIT Delhi

Overview Squarewave Generator Interlab
Circuit design and construction Microfluidics and Fluorescence Photobleaching Promoter strength Oscillations
Basic Parts Composite Parts Improved Parts Part Collection
Overview Writing a Model Deterministic Model Stochastic Model Bifurcation and Squareness Resource sharing
Human Practices Integrated Practices Public Engagement Collaborations Safety
Overview GMM Legislation iGEM Berlin Mentoring IISER Mohali iGEM Glasgow
Lab Records Protocols Recipes Medal Criteria
The Team Attributions

Integrated Human Practices

                                                                                                                                                                                                                 

To get a better idea of how can we improve and move ahead with our project,we first set out to talk to some of the researchers and professors of various departments, both inside our institute and outside. Following is a summary of the talk that we had :


Dr. Shaunak Sen is a Professor at the Department of Electrical Engineering at our Institute, specialising in Control Theory. When we started brainstorming over our project, we reached out to him for advice about square wave oscillators that we were planning to design. It was he who suggested to us the idea of using an oscillator feeding into a toggle switch in order to generate Square Waves. He further introduced to us the work Dr. Richard M Murray had done on oscillators with ring topologies. He also told us about trying out relaxation oscillators in order to generate a better Square wave response.



Dr. James Gomes is a Professor at the School of Biological Sciences, IIT Delhi. His research mainly revolves around the field of Systems Biology. Once we had decided the topology for our project, we discussed with him at length about possible improvements and also got a lot of help from him in our Square wave Modelling. However, he wasn’t very convinced by our topology and rather suggested to us to use 'build up and fire' kind of oscillators for better generation of Square Waves.



Dr. Perumal is a Molecular Biologist at the School of Biological Sciences, IIT Delhi. Our talk with him was indeed very helpful to us in the execution of our project. It was he who suggested to us the strain Streptomyces griseus (Orf2) whose biosafety facilities were available at our lab.



Mr. Mahendra Sahare, is a PhD scholar at the Department of Humanities doing a project under a Supreme Court lawyer, Dr. Naveen Thayyil. He has been in collaboration with iGEM IIT Delhi for the past two years. Together, we have worked on the aspect of ‘Ethical Scientific Practices’. Also, on his recent visit to IISER Mohali, he came back with a collaborative offer for iGEM IIT Delhi to mentor IISER Mohali and help in the establishment of an iGEM team there. On our return from the Giant Jamboree 2016, our team members gave a presentation there, and thereafter our team mentored the iGEM Mohali team.




We also talked to many researchers pursuing their Ph.D here at IIT Delhi, to get to know about various possible uses of Biological Oscillators, before we started our project. Here are their views on how Biological Oscillators can be used in various applications.


Mr. Venkat is a researcher in the field of Systems Biology. In our discussion with him, he told us that Biological Oscillators can be used as a clock reference analogous to those in electrical engineering used for signal processing, particularly as a bridge between networks for synchronisation and as a "modem" carrying information.



A researcher by profession, he works in the field of synchronisation of non-linear and linear oscillators. His guidance over the subject of Biological Oscillators allowed us to use gene regulatory networks in circuits similar to the repressilator.



He is a researcher in the field of convergent systems. He told us about how Biological oscillators can have several applications in his field of research. According to him, if the oscillator is tuned to be convergent, then many interesting phenomena like time-scales and synchronisation can be analysed better.





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E-mail: iitd.igem@gmail.com
Undergraduate Laboratory
Department of Biotechnology and Biochemical Engineering, IIT Delhi