Difference between revisions of "Team:Paris Bettencourt/Transmembrane Proteins"
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Revision as of 18:17, 30 October 2017
.ChrisVoigt img{
width: 10%;
height: auto;
display: block;
margin-left: auto;
margin-right: auto
}
MEMBRANE PHOTORECEPTOR
Introduction
Light is one of the crucial determinants of the environment and as such, many naturally occuring organisms, including microorganisms , have evolved mechanisms to respond to light. This is done through photoreceptor proteins embedded in the cell membrane, that either change conformity or energy state when exposed to specific wavelengths to then induce a singalling cascade within the cell.
With the advent of genetic engineering, more specifically synthetic biology, scientists have been able to harness the power of these membrane photosensors and create powerful optogenetic tools that are used in a range of applications. Additionally, protein engineering have increased the sensitivity and portability of these enzymes, resulting in accurate modular systems.
State of the art and inspiration
These optogenetic tools have become vital in Synthetic biology, and have been used to construct genetic circuits, used for both fundamental and applicative research(Ref). Most recently, these proteins have been used to create logical circuits, allowing for control of expression of cells.
The Chris Voigt Lab published a paper where they incorporate photoreceptor proteins into a circuit which when exposed to different light wavelengths produce a specific pigments (ref).
Their system was used to express, red (gusA), blue (lacZ) and green ((bFMO) , proteins in response to red blue and green light respectively. (figure 1)
Aims
- Create and AND gate using two different light wavelengths
- See production of a biomaterial when activated at the specific location where two lights are shone.
- Create a modular desing that can be used with different biomaterials.
Design
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Pellentesque vel vehicula felis. Aenean non elit magna. Integer tincidunt cursus fringilla. Vestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae; Quisque tempor vitae sem at varius. Donec sed rutrum justo. Cras ut elementum sem. Cras tempus, nunc eget tempor feugiat, quam diam aliquet nisi, id pharetra mauris tortor vitae nibh. Curabitur id turpis eget nibh vehicula cursus nec et sapien. Aenean laoreet aliquam gravida. Donec a ex tempus, varius augue quis, pharetra massa. Proin in gravida urna. Pellentesque dapibus elit quis enim mattis, a porttitor purus rutrum. Donec eget consectetur nisl, sed commodo dui. Suspendisse lobortis justo ac ornare lacinia. Pellentesque quis arcu justo. Praesent pulvinar, lorem ut consequat tincidunt, augue nunc laoreet orci, quis pharetra arcu augue eu ligula. Vestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae; Pellentesque fermentum mattis ipsum, et tincidunt dolor tempus nec. Maecenas ac arcu eu lacus fringilla ornare non ac erat. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Sed vehicula euismod placerat. Ut volutpat felis vitae lorem pulvinar, eget finibus dui molestie. Vestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae; Nulla egestas est vitae odio sagittis condimentum euismod et magna. Vivamus porttitor diam tortor, quis tincidunt dolor pulvinar quis. Suspendisse tincidunt ornare eros. Nullam at lobortis lectus. Integer sit amet bibendum turpis. Suspendisse enim elit, placerat ac iaculis sed, maximus vel lectus. Praesent fermentum facilisis eros. Pellentesque tincidunt, enim vel porta commodo, justo massa laoreet lorem, ac interdum massa augue in turpis. Fusce elit est, rutrum sit amet velit ac, ultrices pellentesque metus. Cras viverra rutrum eros id vestibulum. Donec at luctus neque, a pellentesque diam. Donec vel congue nibh, in auctor tellus. Duis nisi lectus, placerat vel odio et, dapibus pharetra dui. Mauris sagittis purus non ipsum eleifend, ut interdum neque tincidunt.
Sub-title5
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