Difference between revisions of "Team:William and Mary/Engagement"

 
(43 intermediate revisions by 3 users not shown)
Line 3: Line 3:
 
{{Team:William_and_Mary/SOURCE}}
 
{{Team:William_and_Mary/SOURCE}}
 
{{Team:William_and_Mary/HEADER2}}
 
{{Team:William_and_Mary/HEADER2}}
 +
  
 
<html lang="en">
 
<html lang="en">
 
<cfheader name="X-XSS-Protection" value="1">
 
<cfheader name="X-XSS-Protection" value="1">
  
−
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css">  
+
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css">
 +
<link href="https://fonts.googleapis.com/css?family=PT+Sans" rel="stylesheet">
 +
       
 +
       
  
 +
<style>
 +
      body {
 +
        font-family: 'PT Sans', sans-serif;
 +
        font-size: 13px;
 +
      }
  
−
+
</style>
−
<!----Standard Outreach Stuff---->
+
  
−
<br>
+
</head>
−
</br>
+
−
<center><h1>Outreach</h1></center>
+
  
  
 +
<body>
 +
 
 +
<div style="padding-top: 50px;"></div>
  
−
<div class="row">
 
−
  <div class="col-sm-2" style='margin: 40px; background-color:#E2C4A2;font-size: 18px; position:fixed; top: 25%; height: 5%; '><center>Outreach Navigation </center>
 
−
</div>
 
−
  <div class="col-sm10" ></div>
 
−
</div>
 
  
  
 +
<center><div><img src="https://static.igem.org/mediawiki/2017/7/73/T--William_and_Mary--enagement5t.jpeg" width= 270/></div></center>
 +
<div style="padding-top: 40px;"></div>
 +
<div><center>
 +
<a href="https://2017.igem.org/Team:William_and_Mary/Consult_the_Community"><img src="https://static.igem.org/mediawiki/2017/6/6e/T--William_and_Mary--consult.jpeg" width="17%"/></a>
  
 +
<img src="https://static.igem.org/mediawiki/2017/b/b8/T--William_and_Mary--arrorr.jpeg" width="5%"/>
  
−
  <div style='margin: 30px; background-color:#bcddca;font-size: px; float: left; top: 30.5%;'>
+
<a href="https://2017.igem.org/Team:William_and_Mary/Build_Connections"><img src="https://static.igem.org/mediawiki/2017/d/da/T--William_and_Mary--connections.jpeg" width="17%"/></a>
−
  <ul class="list-unstyled">
+
−
    <li>
+
−
        <div ><a href ="https://2017.igem.org/Team:William_and_Mary/OutreachDatabase"><p style='font-size: 17px;'>Overview</p></a></div>
+
−
    </li>
+
−
    <li>
+
−
        <div ><a href ="https://2017.igem.org/Team:William_and_Mary/OutreachDatabase"><p style='font-size: 17px;'>William & Mary</p></a></div>
+
−
    </li>
+
−
    <li>
+
−
        <div ><a href ="https://2017.igem.org/Team:William_and_Mary/OutreachDatabase"><p style='font-size: 17px;'>iGEM Lab</p></a></div>
+
−
    </li>
+
−
    <li>
+
−
        <div ><a href ="https://2017.igem.org/Team:William_and_Mary/OutreachDatabase"><p style='font-size: 17px;'>Community</p></a></div>
+
−
    </li>
+
−
    <li>
+
−
        <div style='padding-right: 10px;'><a href ="https://2017.igem.org/Team:William_and_Mary/OutreachDatabase"><p style='font-size: 17px;'>Government</p></a></div>
+
−
    </li>
+
−
  </ul>
+
  
 +
<img src="https://static.igem.org/mediawiki/2017/b/b8/T--William_and_Mary--arrorr.jpeg" width="5%" padding-left: 1%/>
  
−
</div>
+
<a href="https://2017.igem.org/Team:William_and_Mary/Sustainable_Impact"><img src="https://static.igem.org/mediawiki/2017/a/af/T--William_and_Mary--impact.jpeg" width="17%"/></a>
 +
</center></div>
  
 +
 
 +
<div style="padding-top: 70px;"></div>
 +
</center>
  
  
  
−
<!----End of standard outreach----->
+
<div style='padding-top: 0px;'></div>
  
−
<br>
 
−
</br>
 
  
−
</center>
 
−
<div style='padding-left: 21%;padding-right: 13%; font-size:13px;'>
 
−
A fundamental goal of synthetic biology is to create a modular genetic basis for control over circuit behavior properties. While much progress has been made in achieving this objective for properties such as gene expression strength, where well-characterized ribosome binding sites (RBSs) can be conveniently swapped within a genetic part, there is much to be desired in altering gene expression speed. Currently, no such robust mechanism of speed control exists. We intend to provide a means to tune the speed of gene expression in transcriptional circuits, where a pre-characterized genetic part can be inserted into a gene to alter its expression in a predictable way.
 
  
−
Based on multiple well-cited claims in literature, a strong relationship can be asserted between gene expression speed and the rate of protein degradation. Using a basic mathematical model of gene expression, one can derive that the speed of gene expression, defined as the time it takes for its protein product to reach half of its steady-state concentration, is a function of the protein’s degradation rate. This reveals that tuning protein degradation rate is essential to controlling gene expression, thus amenable to an approach involving protein degradation tags. Degradation tags are used endogenously to identify misfolded proteins, and different tags have unique protease-binding affinities which confer various degradation rates on the tagged proteins.
+
<div style = 'padding-left: 15%; padding-right: 15%;font-size: px; text-indent: 25px;line-height: 26px;' >The most important part of our outreach this year has been the focus on creating a sustainable impact, so for our outreach projects, we devised strategies to extend our direct education and public engagement activities to make our impact on our community long-lasting and sustainable. We grouped these Human Practices projects into the following categories: <a href="https://2017.igem.org/Team:William_and_Mary/Consult_the_Community"><u>Consult the Community</u></a>, <a href="https://2017.igem.org/Team:William_and_Mary/Build_Connections"><u>Building Connections</u></a>, <a href="https://2017.igem.org/Team:William_and_Mary/Sustainable_Impact"><u>Sustainable Impact</u></a>, and <a href="https://2017.igem.org/Team:William_and_Mary/OutreachDatabase"><u>the Outreach Database</u></a>.</div>
  
−
In 2008, the Sauer lab at MIT reported that Mycoplasma florum’s Lon protease system was orthogonal to the endogenous protein degradation machinery in E. coli. As of now, mf-Lon degradation tags exist only as isolated sequences on the BioBrick Registry. We intend to build a suite of BioBrick parts in the form of [mf-Lon tag] - [Stop Codon] - [Double Terminator] that can be swapped in to directly modulate protein degradation rate just as RBS and promoter sequences can be swapped to modify protein production. This would drastically increase the accessibility of mf-Lon tags and enable other teams to easily amplify their desired protein sequence by simply cloning it into our construct. Should the relationship between gene expression speed and protein degradation rate exist robustly, we will be providing the first modular genetic basis of speed control, fulfilling a core aspiration of synthetic biology to have every gene expression and circuit property accessible at the genetic level.</div>
+
<div style='padding-top: 50px;'></div>
  
  
−
<br>
 
−
</br>
 
  
−
<!------4 boxes------->
 
  
 +
<div style = 'padding-left: 120px; padding-bottom: 10px;font-size: 25px' ><b>Consult the Community</b></div>
 +
<div style='background: #808080; margin: 2px 120px 40px 120px; height:1px;></div>
  
−
<div class="row">
+
<div style='padding-top: 30px;'></div>
−
  <div class="col-sm-8" style='padding-top: 5px; padding-left: 320px; font-family: "Optima";'><p style='font-size: 22px;'>Database</p><p>Upcoming</p></div>
+
<div style = 'padding-left: 10%; padding-right: 10%;font-size: px; text-indent: 25px;line-height: 26px;' >We talked to experts and leaders in our community to find ways we could integrate our goal of establishing a dialogue about synthetic biology with the goals of members of our community. These activities represent a collaborative “co-design” of strategies and materials that met the needs of all involved, making projects not only more effective in the short term, but more sustainable in the long term.</div>
−
  <div class="col-sm-4" style='padding-left: 70px;'><IMG SRC="https://static.igem.org/mediawiki/2017/b/ba/T--William_and_Mary--Theresa.jpeg" width=160px></div>
+
−
</div>
+
  
 +
<div style='padding-top: 25px;'></div>
  
−
<div class="row" style='padding-top:18px;'>
+
<div style='padding-left: 12%; padding-right: 12%'>
−
  <div class="col-sm-8" style='padding-top: 5px; padding-left: 320px; font-family: "Optima";'><p style='font-size: 22px;'>Database</p><p>Upcoming</p></div>
+
<ol>
−
  <div class="col-sm-4" style='padding-left: 70px;'><IMG SRC="https://static.igem.org/mediawiki/2017/b/ba/T--William_and_Mary--Theresa.jpeg" width=160px></div>
+
 
−
</div>
+
 
 +
 
 +
<li><div style="text-indent: 5px;line-height: 26px;">We consulted the School of Education on how to work with teachers, update our synthetic biology activities booklet, and plan education events for students.</div></li>
 +
 
 +
<div style='padding-top: 20px;'></div>
 +
<li><div style="text-indent: 5px;line-height: 26px;">We met with the head of the science department from a nearby high school to talk to her about what kinds of resources she wanted for her students and teachers. After, she helped us organize a teacher focus group to find out how we could address our outreach goals and effectively help local teachers.</div></li>
 +
 
 +
<div style='padding-top: 20px;'></div>
 +
<li><div style="text-indent: 5px;line-height: 26px;">We consulted with Virginia State Senator Monty Mason about how to reach educators in our area, and he connected us with the STEM coordinator for a nearby school district that includes about 29,000 students.</div></li>
 +
 
 +
<div style='padding-top: 20px;'></div>
 +
<li><div style="text-indent: 5px;line-height: 26px;">We met with the STEM coordinator and she told us how to structure our outreach in a way that helps fulfill state-mandated learning requirements. She also gave us feedback on what resources would be helpful for schools in her district.</div></li>
  
−
<div class="row" style='padding-top:18px;'>
 
−
  <div class="col-sm-8" style='padding-top: 5px; padding-left: 320px; font-family: "Optima";'><p style='font-size: 22px;'>Database</p><p>Upcoming</p></div>
 
−
  <div class="col-sm-4" style='padding-left: 70px;'><IMG SRC="https://static.igem.org/mediawiki/2017/b/ba/T--William_and_Mary--Theresa.jpeg" width=160px></div>
 
−
</div>
 
  
−
<div class="row" style='padding-top:18px;'>
+
</ol>
−
  <div class="col-sm-8" style='padding-top: 5px; padding-left: 320px; font-family: "Optima";'><p style='font-size: 22px;'>Database</p><p>Upcoming</p></div>
+
</div>
−
  <div class="col-sm-4" style='padding-left: 70px;'><IMG SRC="https://static.igem.org/mediawiki/2017/b/ba/T--William_and_Mary--Theresa.jpeg" width=160px></div>
+
 
</div>
 
</div>
  
 +
<div style='padding-top: 60px;'></div>
  
  
  
  
 +
<div style = 'padding-left: 120px; padding-bottom: 10px;font-size: 25px' ><b>Building Connections</b></div>
 +
<div style='background: #808080; margin: 2px 120px 40px 120px; height:1px;></div>
  
 +
<div style='padding-top: 30px;'></div>
 +
<div style = 'padding-left: 10%; padding-right: 10%;font-size: px; text-indent: 25px;line-height: 26px;' > Based on our consultation with our community, we implemented various outreach activities to work directly with students. Additionally, we had activities for people from our college and the scientific community to help raise awareness of synthetic biology and start dialogues.</div>
  
 +
<div style='padding-top: 25px;'></div>
 +
<div style='padding-left: 12%; padding-right: 12%'>
 +
<ol>
  
−
<br>
 
−
</br>
 
  
  
 +
<li><div style="text-indent: 5px;line-height: 26px;"><b>Working with students:</b> we hosted students from a local STEM summer camp in our lab, presented about synthetic biology at a career fair for middle school students, and taught about 75 Girl Scouts about synthetic biology. </div></li>
  
 +
<div style='padding-top: 20px;'></div>
 +
<li><div style="text-indent: 5px;line-height: 26px;"><b>Working with our university community:</b> We organized a Bioengineering Speaker Series to connect students and professors interested in synthetic biology research. We helped students in the Biology Club get started on synthetic biology research projects. We hosted legislators and others responsible for funding synthetic biology research in Virginia public universities in our lab. Going forward, we are creating a student organization for students who want to be part of our outreach efforts with the local school system.</div></li>
  
 +
<div style='padding-top: 20px;'></div>
 +
<li><div style="text-indent: 5px;line-height: 26px;"><b>Working with the scientific community:</b> We presented our research and the field of synthetic biology at a local community lab. We also presented our research at a conference for women in the bioscience field.</div></li>
  
  
  
  
 +
</ol>
 +
</div></div>
  
 +
<div style='padding-top: 60px;'></div>
  
  
  
 +
 +
<div style = 'padding-left: 120px; padding-bottom: 10px;font-size: 25px' ><b>Sustainable Impact</b></div>
 +
<div style='background: #808080; margin: 2px 120px 40px 120px; height:1px;></div>
 +
 +
<div style='padding-top: 30px;'></div>
 +
<div style = 'padding-left: 10%; padding-right: 10%;font-size: px; text-indent: 25px;line-height: 26px;' >The most important part of our outreach this year has been a focus on creating a sustainable impact. Part of ensuring our projects were sustainable was making sure that teachers and stakeholders influenced the paths of our projects. By working to meet their needs, we helped establish a long-term connection that will continue past the length of the 2017 project. Our outreach efforts will continue in the following way:</div>
 +
 +
<div style='padding-top: 25px;'></div>
 +
<div style='padding-left: 12%; padding-right: 12%'>
 +
<ol>
 +
 +
 +
 +
<li><div style="text-indent: 5px;line-height: 26px;">We updated and distributed our synthetic biology activities booklets to teachers, and have posted it publicly on our wiki. </div></li>
 +
 +
<div style='padding-top: 20px;'></div>
 +
<li><div style="text-indent: 5px;line-height: 26px;">We have helped our teacher community partners get their students involved in a long-term synthetic biology research project organized by the Biology Club at William & Mary.</div></li>
 +
 +
<div style='padding-top: 20px;'></div>
 +
<li><div style="text-indent: 5px;line-height: 26px;">We created a searchable and user-friendly outreach database with past iGEM outreach projects that can be used to find a vast array of educational activities.</div></li>
 +
 +
<div style='padding-top: 20px;'></div>
 +
<li><div style="text-indent: 5px;line-height: 26px;">We are in the process of establishing a recognized student organization that will help build long-lasting infrastructure at our school for synthetic biology and STEM outreach.</div></li>
 +
 +
 +
</ol>
 +
</div></div>
 +
 +
<div style='padding-top: 40px;'></div>
 +
 +
 +
<div style = 'padding-left: 120px; padding-bottom: 10px;font-size: 25px' ><b>Outreach Database</b></div>
 +
<div style='background: #808080; margin: 2px 120px 40px 120px; height:1px;></div>
 +
 +
<div style='padding-top: 30px;'></div>
 +
<div style = 'padding-left: 10%; padding-right: 10%;font-size: px; text-indent: 25px;line-height: 26px;' >We aim to expand the infrastructure of sharing and building on past projects in the human practices aspect of iGEM. iGEM has already established such an infrastructure for the scientific research portion of teams’ work to ensure that scientific research is rigorously characterized, accessible, and centralized on the Registry of Standard Biological Parts. We want to help bring some of these same concepts to the Human Practices aspect of iGEM - that is, a strong culture of documentation of activities and their outcomes, and a standard way of characterizing them to facilitate sharing of what has worked and what has presented challenges. We have created a comprehensive database that includes outreach projects done by gold-medal teams in the past two years. The approximately 1,500 entries are in a standardized format that makes it easy to assess and compare projects. Additionally, each entry contains descriptive tags, enabling users to search for specific project categories. We would like to help establish this database as a central part of iGEM. By seeing what has worked well, teams do not need to “re-invent the wheel” and can instead focus on adding improvements. On the other hand, if something did not work well, another team can avoid repeating the mistakes. We feel this will help that iGEM is a continuous force for innovation and progress in outreach. </div>
 +
 +
<div style='padding-top: 15px;'></div>
 +
 +
<div style = 'padding-left: 10%; padding-right: 10%;font-size: px; text-indent: 25px;line-height: 26px;' > <a href="https://2017.igem.org/Team:William_and_Mary/Database" style="text-decoration: underline">Click here to access our Outreach Database!</a></div>
 +
 +
</div>
 +
 +
 +
 +
</body>
  
  
 
</html>
 
</html>
 +
  
  

Latest revision as of 03:18, 15 December 2017


The most important part of our outreach this year has been the focus on creating a sustainable impact, so for our outreach projects, we devised strategies to extend our direct education and public engagement activities to make our impact on our community long-lasting and sustainable. We grouped these Human Practices projects into the following categories: Consult the Community, Building Connections, Sustainable Impact, and the Outreach Database.
Consult the Community
We talked to experts and leaders in our community to find ways we could integrate our goal of establishing a dialogue about synthetic biology with the goals of members of our community. These activities represent a collaborative “co-design” of strategies and materials that met the needs of all involved, making projects not only more effective in the short term, but more sustainable in the long term.
  1. We consulted the School of Education on how to work with teachers, update our synthetic biology activities booklet, and plan education events for students.
  2. We met with the head of the science department from a nearby high school to talk to her about what kinds of resources she wanted for her students and teachers. After, she helped us organize a teacher focus group to find out how we could address our outreach goals and effectively help local teachers.
  3. We consulted with Virginia State Senator Monty Mason about how to reach educators in our area, and he connected us with the STEM coordinator for a nearby school district that includes about 29,000 students.
  4. We met with the STEM coordinator and she told us how to structure our outreach in a way that helps fulfill state-mandated learning requirements. She also gave us feedback on what resources would be helpful for schools in her district.
Building Connections
Based on our consultation with our community, we implemented various outreach activities to work directly with students. Additionally, we had activities for people from our college and the scientific community to help raise awareness of synthetic biology and start dialogues.
  1. Working with students: we hosted students from a local STEM summer camp in our lab, presented about synthetic biology at a career fair for middle school students, and taught about 75 Girl Scouts about synthetic biology.
  2. Working with our university community: We organized a Bioengineering Speaker Series to connect students and professors interested in synthetic biology research. We helped students in the Biology Club get started on synthetic biology research projects. We hosted legislators and others responsible for funding synthetic biology research in Virginia public universities in our lab. Going forward, we are creating a student organization for students who want to be part of our outreach efforts with the local school system.
  3. Working with the scientific community: We presented our research and the field of synthetic biology at a local community lab. We also presented our research at a conference for women in the bioscience field.
Sustainable Impact
The most important part of our outreach this year has been a focus on creating a sustainable impact. Part of ensuring our projects were sustainable was making sure that teachers and stakeholders influenced the paths of our projects. By working to meet their needs, we helped establish a long-term connection that will continue past the length of the 2017 project. Our outreach efforts will continue in the following way:
  1. We updated and distributed our synthetic biology activities booklets to teachers, and have posted it publicly on our wiki.
  2. We have helped our teacher community partners get their students involved in a long-term synthetic biology research project organized by the Biology Club at William & Mary.
  3. We created a searchable and user-friendly outreach database with past iGEM outreach projects that can be used to find a vast array of educational activities.
  4. We are in the process of establishing a recognized student organization that will help build long-lasting infrastructure at our school for synthetic biology and STEM outreach.
Outreach Database
We aim to expand the infrastructure of sharing and building on past projects in the human practices aspect of iGEM. iGEM has already established such an infrastructure for the scientific research portion of teams’ work to ensure that scientific research is rigorously characterized, accessible, and centralized on the Registry of Standard Biological Parts. We want to help bring some of these same concepts to the Human Practices aspect of iGEM - that is, a strong culture of documentation of activities and their outcomes, and a standard way of characterizing them to facilitate sharing of what has worked and what has presented challenges. We have created a comprehensive database that includes outreach projects done by gold-medal teams in the past two years. The approximately 1,500 entries are in a standardized format that makes it easy to assess and compare projects. Additionally, each entry contains descriptive tags, enabling users to search for specific project categories. We would like to help establish this database as a central part of iGEM. By seeing what has worked well, teams do not need to “re-invent the wheel” and can instead focus on adding improvements. On the other hand, if something did not work well, another team can avoid repeating the mistakes. We feel this will help that iGEM is a continuous force for innovation and progress in outreach.
Click here to access our Outreach Database!