Difference between revisions of "Team:Paris Bettencourt/RNA"

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<h1>New Order</h1>In synthetic biology, we are often introducing new pathways to bacteria that do not naturally express them. The novel pathway will produce exotic enzymes and proteins to the host bacteria which will not necessarily have the internal environment to organise these macromolecular products which could be detrimental to the performance of both the pathway and the organism. Furthermore, depending on the organism used, the activity of the pathway can vary and be difficult to make comparisons. Thus, we are creating a standardized microenvironment in the cell wherein the pathway components are localised and perform in a predictable way.
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<h1>New Order</h1>In synthetic biology, we are often introducing new pathways to bacteria that do not naturally express them. The novel pathway will produce exotic enzymes and proteins which the host bacteria will not necessarily have the internal environment to organise these macromolecular products, this could be detrimental to the performance of both the pathway and the organism itself. Additionally, depending on the organism used, the activity of the pathway can vary and be difficult to characterise against other models used. Thus, we aim to standardize the microenvironmental activity of different pathways within the cell by localising the associated enzymes/proteins in an RNA based structure, leading to the pathway to act in a predictable way, regardless of the organism.
 
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<div class=text2left><img id=img1 src="https://static.igem.org/mediawiki/2017/9/94/RNA_Strand_Repeats.png"><!--An image or you can replace it by text--></div>
 
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<div class=text2right><!--Your text or you can replace it by an image-->RNA is a light cost nucleotide material in the cell,
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We aim to recreate RNA agglomerations as formed
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in mammalian cells with triple repeat disorders,
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which show liquid phase separation, forming a
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organelle-like vesicle, where local concentrations of
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enzymes can be created.
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Revision as of 10:31, 28 October 2017

RNA Organelle

New Order

In synthetic biology, we are often introducing new pathways to bacteria that do not naturally express them. The novel pathway will produce exotic enzymes and proteins which the host bacteria will not necessarily have the internal environment to organise these macromolecular products, this could be detrimental to the performance of both the pathway and the organism itself. Additionally, depending on the organism used, the activity of the pathway can vary and be difficult to characterise against other models used. Thus, we aim to standardize the microenvironmental activity of different pathways within the cell by localising the associated enzymes/proteins in an RNA based structure, leading to the pathway to act in a predictable way, regardless of the organism.
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hello


Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
bettencourt.igem2017@gmail.com