Difference between revisions of "Team:Heidelberg/Sandbox2"

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                    <a class="navbar-brand" href="https://2017.igem.org/Team:Heidelberg"><div id="circle">
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              <a type="button" data-canvas="body" id="sidebarCollapse" class="navbar-toggle" data-toggle="offcanvas" data-target="#sidebar" style="color: #393939;margin-top: 9px;">NAVIGATION
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                        <li class="dropdown"><a href="https://2017.igem.org/Team:Heidelberg/Team">People <span class="caret"></span></a>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Team">Team</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Attributions">Attributions</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Sponsoring">Sponsoring</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/For_Judges">For Judges</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Description">Overview</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Design">Background &amp; Design </a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Pace">PACE</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Predcel">PREDCEL Toolbox</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Validation">Software Validation</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Organosilicones">Organosilicones</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Parts">Overview</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Model">Overview</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Model/Phage_Titer">Phage Titer</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Model/Mutagenesis_Induction">Mutagenesis Induction</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Software">Overview</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Human_Practices">Overview</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Education">Education</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Notebook">Overview</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Experiments">Methods</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Materials">Materials</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/AwesomeSheet">AwesomeSheet</a></li>
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          <nav id="sidebar" style="background-color: white;border: none;box-shadow:1px 0px 0px #393939;" class="navmenu navmenu-default navmenu-fixed-left offcanvas" role="navigation">
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        <a class="navmenu-brand" href="https://2017.igem.org/Team:Heidelberg"><img src="https://static.igem.org/mediawiki/2017/8/8f/Heidelberg_2017_phage_logo.svg"><br><br> iGEM TEAM HEIDELBERG 2017</a>
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            <li><a data-toggle="collapse" data-target="#People_side">People <i class="fa fa-fw fa-caret-down"></i></a>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Team">Team</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Attributions">Attributions</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Sponsoring">Sponsoring</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/For_Judges">For Judges</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Description">Overview</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Design">Background &amp; Design </a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Pace">PACE</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Predcel">PREDCEL Toolbox</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Validation">Software Validation</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Organosilicones">Organosilicones</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Cytochrome_Engineering">Cytochrome Engineering</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Optogenetics">Optogenetics</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/CRISPR">CRISPR Cas9</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/InterLab">InterLab</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Achievements">Achievements</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Model">Overview</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Model/Phage_Titer">Phage Titer</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Software">Overview</a></li>
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                        <li><a href="https://2017.igem.org/Team:Heidelberg/Software/DeeProtein">DeeProtein</a></li> 
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Human_Practices">Overview</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Integrated">Integrated Human Practices</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Interviews">Expert Interviews</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Safety">Safety &amp; Security</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Education">Education</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Collaborations">Collaborations</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/HP/Silver">HP Silver</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/HP/Gold_Integrated">HP Gold</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Notebook">Overview</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Experiments">Methods</a></li>
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                            <li><a href="https://2017.igem.org/Team:Heidelberg/Materials">Materials</a></li>
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                                                               <div id="Icon1" class="icon"><a href="https://2017.igem.org/Team:Heidelberg/Protein_Interaction"><img src="https://static.igem.org/mediawiki/2017/4/4b/T--Heidelberg--2017_T--Heidelberg--2017_Icon_Protein_Interaction.svg" class="toolbox-icon" style="left: 0px;"></a><div class="icon-text" style="width: 300px;"><a href="https://2017.igem.org/Team:Heidelberg/Protein_Interaction"><h5>Protein Interaction</h5><p>Evolve specific binding</p></a></div></div>
 
                                                               <div id="Icon1" class="icon"><a href="https://2017.igem.org/Team:Heidelberg/Protein_Interaction"><img src="https://static.igem.org/mediawiki/2017/4/4b/T--Heidelberg--2017_T--Heidelberg--2017_Icon_Protein_Interaction.svg" class="toolbox-icon" style="left: 0px;"></a><div class="icon-text" style="width: 300px;"><a href="https://2017.igem.org/Team:Heidelberg/Protein_Interaction"><h5>Protein Interaction</h5><p>Evolve specific binding</p></a></div></div>
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                                                              <div id="Icon4" class="icon"> <a href="https://2017.igem.org/Team:Heidelberg/Cytochrome_Engineering"><img src="https://static.igem.org/mediawiki/2017/9/9c/T--Heidelberg--2017_T--Heidelberg--2017_Icon_Product_Specificity.svg" class="toolbox-icon" style="left: 280px;"></a><div class="icon-text-right"> <a href="https://2017.igem.org/Team:Heidelberg/Cytochrome_Engineering"><h5>Cytochrome Engineering</h5><p>Turning promiscous enzymes into specific biofactories</p></a></div></div>
 
                                                             </div>
 
                                                             </div>
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                                                                <div id="Icon2" class="icon"><a href="https://2017.igem.org/Team:Heidelberg/Optogenetics"><img src="https://static.igem.org/mediawiki/2017/3/38/T--Heidelberg--2017_T--Heidelberg--2017_Icon_Opto_Genetics.svg" class="toolbox-icon" style="left: 0px;"></a><div class="icon-text" style="width: 300px;"><a href="https://2017.igem.org/Team:Heidelberg/Optogenetics"><h5>Opto-Genetics</h5><p>Adapt selection stringency with light</p></a></div></div>
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                                                                <div id="Icon5" class="icon"><a href="https://2017.igem.org/Team:Heidelberg/Organosilicones"><img src="https://static.igem.org/mediawiki/2017/e/e9/T--Heidelberg--2017_T--Heidelberg--2017_Icon_Carbonsilicones.svg" class="toolbox-icon" style="left: 270px;"></a><div class="icon-text-right"><a href="https://2017.igem.org/Team:Heidelberg/Organosilicones"><h5>Organo silicones</h5><p>Teaching nature carbonsilicon chemistry</p></a></div></div>
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                                                                </div>
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                                                                <div id="Icon3" class="icon"> <a href="https://2017.igem.org/Team:Heidelberg/CRISPR"><img src="https://static.igem.org/mediawiki/2017/c/cd/T--Heidelberg--2017_T--Heidelberg--2017_Icon_DNA_Editing.svg" class="toolbox-icon" style="left: 0px;"></a><div class="icon-text" style="width: 230px;"> <a href="https://2017.igem.org/Team:Heidelberg/CRISPR"><h5>CRISPR Cas9</h5><p>Towards next-generation nucleases</p></a></div></div> 
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                                                                <div id="Icon6" class="icon"><a href="https://2017.igem.org/Team:Heidelberg/RFC"><img src="https://static.igem.org/mediawiki/2017/2/27/T--Heidelberg--2017_Icon_RFC.svg" class="toolbox-icon" style="left: 280px;"></a><div class="icon-text-right"><a href="https://2017.igem.org/Team:Heidelberg/RFC"><h5>RFC</h5><p>Our in vivo Evolution Standard</p></a></div></div>
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WikitemplateA home - 2014.igem.org

 

WikitemplateA home

From 2014.igem.org

Life shows an astonishing diversity and complexity, resulting from millions of years of random mutation and selection.

We, the iGEM Team Heidelberg,

Accelerate Evolution

to drive Innovation for human benefit

Explore our project
Curious how?

To speed up and direct evolution, we use phage-assisted continuous evolution and our newly created & simple method called PREDCEL

No way to be fast enough without

Modeling

Learn how we optimized our experimental parameters using ODE models calibrated with wet lab data.

And the best: Our interactive models run entirely in your browser!

Still too slow? Meet our Artificial Intelligence for Genetic Evolution Mimicking,

AiGEM!

AiGEM comprises a deep neuronal network and accompanying genetic algorithm able to fast-forward directed evolution in silico

Not convinced yet? Check out our fully in silico evolved, optimized Beta-lactamase and reprogrammed Beta-glucuronidase!

To make a difference, we need to consider the whole

Colorful Picture

Our integrated human practice activities helped us to make our technology safer and stimulate its responsible use, ideally to address urgent human needs.

Our Applications:

Evolving novel cytochromes with help of in silico predicted riboswitches, to enable fully biological production of organosilicons. Using T7 polymerase as modular platform, we also showcase the evolution of improved protein-protein interaction.

Now it’s on you. Our toolbox guide and RFC help you to get started.