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{{Heidelberg/main| | {{Heidelberg/main| | ||
Achievements| | Achievements| | ||
− | + | The essence of our work| | |
− | https://static.igem.org/mediawiki/2017/ | + | https://static.igem.org/mediawiki/2017/2/2e/MS_Libelle_Achievements_Background.png|yellow| |
{{#tag:html| | {{#tag:html| | ||
+ | <div class="content" style="padding-top: 50px;font-size: 25px !important"> | ||
+ | <div style="font-size: 25px !important; font-weight: 700 !important; padding-bottom: 50px !important">We learned a lot, found new friends and had great fun over the summer. In addition, we...</div> | ||
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+ | <div class="heidel-form row"> | ||
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+ | <img src="https://static.igem.org/mediawiki/2017/5/53/T--Heidelberg--2017_PACE_AiGEM.jpg" style="width: 100%; height: auto;"> | ||
+ | </div> | ||
+ | <div class="col-lg-10 col-md-10 col-xs-6" style="vertical-align: center; font-weight: 500 !important"> | ||
+ | Introduced a unique in vivo and <i>in silico</i> directed evolution interface as novel engineering paradigm to synthetic biology.</div> | ||
+ | |||
+ | |||
+ | |||
+ | </div> | ||
+ | |||
+ | |||
+ | |||
+ | <div class="heidel-form row"> | ||
+ | <div class="col-lg-2 col-md-2 col-xs-6"> | ||
+ | <img src="https://static.igem.org/mediawiki/2017/8/85/T--Heidelberg--2017_Pretzel.jpg" style="width: 100%; height: auto;"> | ||
+ | </div> | ||
+ | <div class="col-lg-10 col-md-10 col-xs-6" style="vertical-align: center; font-weight: 500 !important"> | ||
+ | Developed PREDCEL, as simple, cheap and easy-to-implement PACE alternative.</div> | ||
+ | |||
+ | |||
+ | |||
+ | </div> | ||
+ | |||
+ | <div class="heidel-form row"> | ||
+ | <div class="col-lg-2 col-md-2 col-xs-6"> | ||
+ | <img src="https://static.igem.org/mediawiki/2017/3/3c/T--Heidelberg--2017_RiboswitchIcon.jpg" style="width: 100%; height: auto;"> | ||
+ | </div> | ||
+ | <div class="col-lg-10 col-md-10 col-xs-6" style="vertical-align: center; font-weight: 500 !important"> | ||
+ | Outlined a unique workflow for in vivo enzyme evolution based on computationally predicted riboswitches.</div> | ||
+ | |||
+ | </div> | ||
+ | |||
+ | <div class="heidel-form row"> | ||
+ | <div class="col-lg-2 col-md-2 col-xs-6"> | ||
+ | <img src="https://static.igem.org/mediawiki/2017/d/d8/T--Heidelberg--2017.jpeg" style="width: 100%; height: auto;"> | ||
+ | </div> | ||
+ | <div class="col-lg-10 col-md-10 col-xs-6" style="vertical-align: center; font-weight: 500 !important"> | ||
+ | First iGEM team to use an engineered cytochrome to catalyze carbon-silicon bond formation in whole cell extracts.</div> | ||
+ | </div> | ||
+ | |||
+ | <div class="heidel-form row"> | ||
+ | <div class="col-lg-2 col-md-2 col-xs-6"> | ||
+ | <img src="https://static.igem.org/mediawiki/2017/5/5e/T--Heidelberg--2017_Human_Practice2.png" style="width: 100%; height: auto;"> | ||
+ | </div> | ||
+ | <div class="col-lg-10 col-md-10 col-xs-6" style="vertical-align: center; font-weight: 500 !important"> | ||
+ | Successfully integrated the feedback of experts and the broader public into our project design at diverse layers.</div> | ||
+ | </div> | ||
+ | |||
+ | <div class="heidel-form row"> | ||
+ | <div class="col-lg-2 col-md-2 col-xs-6"> | ||
+ | <img src="https://static.igem.org/mediawiki/2017/4/4a/T--Heidelberg--2017_LogoBackgr.jpg" style="width: 100%; height: auto;"> | ||
+ | </div> | ||
+ | <div class="col-lg-10 col-md-10 col-xs-6" style="vertical-align: center; font-weight: 500 !important"> | ||
+ | Frist iGEM team to apply deep learning to protein engineering.</div> | ||
+ | |||
+ | </div> | ||
+ | |||
+ | <div class="heidel-form row"> | ||
+ | <div class="col-lg-2 col-md-2 col-xs-6"> | ||
+ | <img src="https://static.igem.org/mediawiki/2017/b/b7/T--Heidelberg--2017_DeeProtein_LOGO.jpg" style="width: 100%; height: auto;"> | ||
+ | </div> | ||
+ | <div class="col-lg-10 col-md-10 col-xs-6" style="vertical-align: center; font-weight: 500 !important"> | ||
+ | Created and validated AiGEM, an intelligent software for generating protein functionality de novo.</div> | ||
+ | |||
+ | </div> | ||
+ | |||
+ | <div class="heidel-form row"> | ||
+ | <div class="col-lg-2 col-md-2 col-xs-6"> | ||
+ | <img src="https://static.igem.org/mediawiki/2017/c/cd/T--Heidelberg--2017_SafetyNetRedIcon.jpg" style="width: 100%; height: auto;"> | ||
+ | </div> | ||
+ | <div class="col-lg-10 col-md-10 col-xs-6" style="vertical-align: center; font-weight: 500 !important"> | ||
+ | Implemented SafetyNET to safeguard directed evolution experiments.</div> | ||
+ | |||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | }} | ||
+ | {{#tag:html| | ||
+ | <div class="content" style="padding-top: 50px"> | ||
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+ | |||
+ | <section class="teaser content equal_height" style="padding-top: 20px;"> | ||
+ | <div class="col-lg-4 col-md-4 col-xs-12"> | ||
+ | <div class="card" style="border-left: 10px solid #CD7F32"> | ||
+ | <img class="card-img-top" src="https://static.igem.org/mediawiki/2017/8/83/T--Heidelberg--2017_Bronze.svg" width="60%" alt="Card image cap"> | ||
<div class="card-body"> | <div class="card-body"> | ||
− | <h4 class="card-title"> | + | <h4 class="card-title">Bronze</h4> |
− | <p class="card-text"> | + | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> Find a comprehensive compilation of sponsors, partners and scientific contributors on our <a href="https://2017.igem.org/Team:Heidelberg/Attributions" style="color: #CD7F32 !important">Attributions page</a></p> |
− | <a href="#" class=" | + | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We submitted <a href="https://2017.igem.org/Team:Heidelberg/Parts#Part_List" style="color: #CD7F32 !important">94 parts</a> as part of our <a href="https://2017.igem.org/Team:Heidelberg/Toolbox" style="color: #CD7F32 !important">PREDCEL/PACE toolbox</a> with the necessary documentation.</p> |
+ | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> Find <a href="https://2017.igem.org/Team:Heidelberg/InterLab" style="color: #CD7F32 !important">our results for the InterLab Measurement Study</a></p> | ||
+ | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We complied with all requirements and regulations set by the iGEM competition</p> | ||
+ | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We had a great summer and are very much looking forward to meet you at the Giant Jamboree</a></p> | ||
</div> | </div> | ||
</div> | </div> | ||
</div> | </div> | ||
− | <div class="col-md-4"> | + | <div class="col-lg-4 col-md-4 col-xs-12"> |
− | <div class="card"> | + | <div class="card" style="border-left: 10px solid #C0C0C0"> |
− | <img class="card-img-top" src="https://static.igem.org/mediawiki/2017/5/5c/T--Heidelberg--2017_Silver.svg" alt="Card image cap"> | + | <img class="card-img-top" src="https://static.igem.org/mediawiki/2017/5/5c/T--Heidelberg--2017_Silver.svg" width="60%" alt="Card image cap"> |
<div class="card-body"> | <div class="card-body"> | ||
− | <h4 class="card-title"> | + | <h4 class="card-title">Silver</h4> |
− | + | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We experimentally validated that our BioBricks (e.g. <a href="http://parts.igem.org/Part:BBa_K2398019" style="color: #C0C0C0 !important">BBa_K2398019</a>, <a href="http://parts.igem.org/Part:BBa_K2398555" style="color: #C0C0C0 !important">BBa_K2398555</a> and <a href="http://parts.igem.org/Part:BBa_K2398557" style="color: #C0C0C0 !important">BBa_K2398557</a>) work as expected! Visit our toolbox collection for more than 90 parts</p> | |
− | < | + | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We collaborated with other iGEM teams from all over the world in a bi-directional and significant way. We initiated our own Heidelberg Interlab Study to validate our Mutagenesis Plasmids.</p> |
+ | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We critically thought about the impact of our project on society, environment and safety. To this end, we engaged with the public, experts and pupils. </p> | ||
</div> | </div> | ||
</div> | </div> | ||
</div> | </div> | ||
− | <div class="col-md-4"> | + | <div class="col-lg-4 col-md-4 col-xs-12"> |
− | <div class="card"> | + | <div class="card" style="border-left: 10px solid #ffd700"> |
− | <img class="card-img-top" src="https://static.igem.org/mediawiki/2017/2/2b/T--Heidelberg--2017_Gold.svg" alt="Card image cap"> | + | <img class="card-img-top" src="https://static.igem.org/mediawiki/2017/2/2b/T--Heidelberg--2017_Gold.svg" width="60%" alt="Card image cap"> |
<div class="card-body"> | <div class="card-body"> | ||
− | <h4 class="card-title"> | + | <h4 class="card-title">Gold</h4> |
− | <p class="card-text"> | + | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We extended the Engineering Cycle for Foundational Advance projects by including sophisticated concepts for safety measures and the responsible use of new technologies. </p> |
− | + | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We improved the function of an existing biobrick by calculated improved beta-lactamase variants in silico and evaluating the superior functionality in the wet lab. </p> | |
+ | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We intensively modeled our PREDCEL experiments and provide web-based interactive tools that enable our users to model their own systems! </p> | ||
+ | <p class="card-text content"><i class="fa fa-check" aria-hidden="true"></i> We developed PREDCEL as easy-to-handle and cheap PACE alternative. We demonstrate the feasibility of our technology by several applications including CYP1A2. </p> | ||
</div> | </div> | ||
</div> | </div> | ||
</div> | </div> | ||
− | |||
− | |||
− | |||
</section> | </section> | ||
Latest revision as of 03:32, 2 November 2017
Achievements
The essence of our work
We learned a lot, found new friends and had great fun over the summer. In addition, we...
![](https://static.igem.org/mediawiki/2017/5/53/T--Heidelberg--2017_PACE_AiGEM.jpg)
Introduced a unique in vivo and in silico directed evolution interface as novel engineering paradigm to synthetic biology.
![](https://static.igem.org/mediawiki/2017/8/85/T--Heidelberg--2017_Pretzel.jpg)
Developed PREDCEL, as simple, cheap and easy-to-implement PACE alternative.
![](https://static.igem.org/mediawiki/2017/3/3c/T--Heidelberg--2017_RiboswitchIcon.jpg)
Outlined a unique workflow for in vivo enzyme evolution based on computationally predicted riboswitches.
![](https://static.igem.org/mediawiki/2017/d/d8/T--Heidelberg--2017.jpeg)
First iGEM team to use an engineered cytochrome to catalyze carbon-silicon bond formation in whole cell extracts.
![](https://static.igem.org/mediawiki/2017/5/5e/T--Heidelberg--2017_Human_Practice2.png)
Successfully integrated the feedback of experts and the broader public into our project design at diverse layers.
![](https://static.igem.org/mediawiki/2017/4/4a/T--Heidelberg--2017_LogoBackgr.jpg)
Frist iGEM team to apply deep learning to protein engineering.
![](https://static.igem.org/mediawiki/2017/b/b7/T--Heidelberg--2017_DeeProtein_LOGO.jpg)
Created and validated AiGEM, an intelligent software for generating protein functionality de novo.
![](https://static.igem.org/mediawiki/2017/c/cd/T--Heidelberg--2017_SafetyNetRedIcon.jpg)
Implemented SafetyNET to safeguard directed evolution experiments.
.