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| | + | {{AQA_Unesp_nav}} |
| | + | |
| | <html> | | <html> |
| | + | <body> |
| | | | |
| − | <script> | + | <style> |
| | | | |
| − | // This is the jquery part of your template.
| + | .foto-grande { |
| − | // Try not modify any of this code too much since it makes your menu work.
| + | background: url(https://static.igem.org/mediawiki/2017/6/68/Aqaunesp-main-header.png) no-repeat center center; |
| | + | width: 100%; |
| | + | height: 100vh; |
| | + | overflow:hidden; |
| | + | background-size: cover; |
| | + | padding: 5% 0; |
| | + | } |
| | | | |
| − | $(document).ready(function() {
| + | @font-face { |
| | + | font-family: caviardreams; |
| | + | src: url('https://static.igem.org/mediawiki/2017/4/43/Aqaunesp-caviardreams.ttf'); |
| | + | } |
| | | | |
| − | $("#HQ_page").attr('id','');
| + | .insubiota-text { font:12em caviardreams, sans-serif; text-align: center; color:white } |
| | | | |
| − | // call the functions that control the menu
| + | .insubiota-subtext { font:2em caviardreams, sans-serif; text-align: center; color:white; } |
| − | menu_functionality();
| + | |
| − | hide_show_menu();
| + | |
| | | | |
| | + | #titleinsubiota {padding: 10% 0;} |
| | | | |
| | + | #abstract { font:5em caviardreams, sans-serif; text-align: center; color: white; font-weight:bold; padding-top: 2%} |
| | | | |
| − | //this function controls the expand and collapse buttons of the menu and changes the +/- symbols
| + | #gold-award { float:left; } |
| − | function menu_functionality() {
| + | |
| | | | |
| − | //when clicking on a "menu_button", it will change the "+/-" accordingly and it will show/hide the corresponding submenu
| + | </style> |
| − | $(".menu_button").click(function(){
| + | |
| | | | |
| − | // add or remove the class "open" , this class holds the "-"
| |
| − | $(this).children().toggleClass("open");
| |
| − | // show or hide the submenu
| |
| − | $(this).next('.submenu_wrapper').fadeToggle(400);
| |
| − | });
| |
| | | | |
| − | // when the screen size is smaller than 800px, the display_menu_control button appears and will show/hide the whole menu
| + | <div class="foto-grande"> |
| − | $("#display_menu_control").click(function(){
| + | |
| − | $('#menu_content').fadeToggle(400);
| + | |
| − | });
| + | |
| | | | |
| − | // call the current page highlight function
| + | <div id="titleinsubiota"> |
| − | highlight_current_page();
| + | <div style="width:950px; margin: 0 auto"> |
| − | }
| + | |
| | | | |
| | + | <img src="https://static.igem.org/mediawiki/2017/e/ec/Gold-award-aqaunesp.png" width="200px" id="gold-award"> |
| | + | <div class="insubiota-text">INSUBIOTA</div> |
| | + | <div class="insubiota-subtext">treating diabetes with genetically engineered probiotic</div> |
| | | | |
| − | // call the highlight current page function to show it on the menu with a different background color
| + | </div> |
| − | function highlight_current_page() {
| + | </div> |
| | | | |
| − | // select a page from the menu based on the id assigned to it and the current page name and add the class "current page" to make it change background color
| + | </div> |
| − | $("#"+ wgPageName.substring(wgPageName.lastIndexOf("/")+1, wgPageName.length ) + "_page").addClass("current_page");
| + | |
| | | | |
| − | // now that the current_page class has been added to a menu item, make the submenu fade in
| + | <div style="width:100%; margin: 0 auto; background-color: #44558f"> |
| − | $(".current_page").parents(".submenu_wrapper").fadeIn(400);
| + | |
| − | // change the +/- symbol of the corresponding menu button
| + | |
| − | $(".current_page").parents(".submenu_wrapper").prev().children().toggleClass("open");
| + | |
| − |
| + | |
| − | }
| + | |
| − | | + | |
| − | | + | |
| − | | + | |
| − | // allow button on the black menu bar to show/hide the side menu
| + | |
| − | function hide_show_menu() {
| + | |
| − |
| + | |
| − | // in case you preview mode is selected, the menu is hidden for better visibility
| + | |
| − | if (window.location.href.indexOf("submit") >= 0) {
| + | |
| − | $(".igem_2017_menu_wrapper").hide();
| + | |
| − | }
| + | |
| − | | + | |
| − | // if the black menu bar has been loaded
| + | |
| − | if (document.getElementById('bars_item')) {
| + | |
| − | | + | |
| − | // when the "bars_item" has been clicked
| + | |
| − | $("#bars_item").click(function() {
| + | |
| − | $("#sideMenu").hide();
| + | |
| − | | + | |
| − | // show/hide the menu wrapper
| + | |
| − | $(".igem_2017_menu_wrapper").fadeToggle("100");
| + | |
| − | });
| + | |
| − | }
| + | |
| − | | + | |
| − | // because the black menu bars loads at a different time than the rest of the page, this function is set on a time out so it can run again in case it has not been loaded yet
| + | |
| − | else {
| + | |
| − | setTimeout(hide_show_menu, 15);
| + | |
| − | }
| + | |
| − | }
| + | |
| − | | + | |
| − | | + | |
| − | });
| + | |
| − | | + | |
| − | | + | |
| − | </script>
| + | |
| | | | |
| | + | <div id="abstract">ABSTRACT</div> |
| | | | |
| | + | <div style="max-width:1000px; font-size:1.5em; margin: 2% auto; line-height:1.5; text-align:justify; color: white; padding-top:2%; padding-bottom: 2%"> |
| | + | Our project was inspired on the alarming and increasing number of diabetic people, especially diabetes mellitus type 1 patients, who are insulin dependent. The lack of less invasive treatments has motivated us to develop a new treatment based on the probiotic bacteria <i>Lactococcus lactis</i>, that was engineered to produce a single-chain analog insulin in human diabetic’s microbiota. The bacteria will be able to produce the insulin associated with a secretion signal sequence and cell-penetrating peptides, to ensure its uptake. Moreover, the synthesis of the insulin will be controlled by the natural bacteria system of catabolite repression with regulation by a small RNA. At the presence of glucose, the insulin gene expression will be activated, and then, it will be ready to be secreted and absorbed, reaching the blood and performing its biological function. Also, in order to contain the release of our engineered probiotic to the environment, we built a kill switch based on light exposure that uses the CRISPR/Cas9 system to destroy essential genes for the bacterial survival. The final product could be a fermented milk or a lyophilized that could be easily ingested by patients. |
| | | | |
| | + | </div> |
| | + | </div> |
| | | | |
| | + | <div style="text-align:center"> |
| | + | <video width="1000" controls> |
| | + | <source src="https://static.igem.org/mediawiki/2017/a/a7/Aqaunesp-video-insubiota.mp4" type="video/mp4"> |
| | + | </video> |
| | + | </div> |
| | | | |
| | <style> | | <style> |
| | + | #buttons { max-width:1100px; margin:3% auto; display:table} |
| | | | |
| | + | .botao-link { |
| | + | position: relative; |
| | + | width: 150px; |
| | + | float:left; |
| | + | margin:5px; |
| | + | } |
| | | | |
| | | | |
| − | /***************************************************** DEFAULT WIKI SETTINGS ****************************************************/
| + | .image { |
| − |
| + | display: block; |
| − | /* Clear the default wiki settings */
| + | width: 150px; |
| − |
| + | height: 150px; |
| − | #home_logo, #sideMenu { display:none; }
| + | } |
| − | #sideMenu, #top_title, .patrollink {display:none;}
| + | |
| − | #content { width:100%; padding:0px; margin-top:-7px; margin-left:0px;}
| + | |
| − | body {background-color:white; }
| + | |
| − | #bodyContent h1, #bodyContent h2, #bodyContent h3, #bodyContent h4, #bodyContent h5 { margin-bottom: 0px; }
| + | |
| | | | |
| − |
| + | .overlay { |
| − |
| + | position: absolute; |
| − |
| + | top: 0; |
| − | /**************************************************************** MENU ***************************************************************/
| + | bottom: 0; |
| − | /* Wrapper for the menu */
| + | left: 0; |
| − | .igem_2017_menu_wrapper {
| + | right: 0; |
| − | width: 15%;
| + | height: 100%; |
| − | height:100vh;
| + | width: 100%; |
| − | position:fixed;
| + | opacity: 0; |
| − | right:0%;
| + | transition: .5s ease; |
| − | padding:0px;
| + | background-color: #008CBA; |
| − | float:right;
| + | border-radius:50%; |
| − | border-left: 1px solid #d3d3d3;
| + | } |
| − | background-color:#ffffff;
| + | |
| − | text-align:left;
| + | |
| − | font-family:Tahoma, Geneva, sans-serif;
| + | |
| − | overflow-y: auto;
| + | |
| − | overflow-x: hidden;
| + | |
| − | }
| + | |
| | | | |
| − | /* this hides the scrollbar to keep view consistency */
| + | #projectdesc {background-color: RGB(255,208,91)} |
| − | .igem_2017_menu_wrappe::-webkit-scrollbar {
| + | #design {background-color: RGB(159,159,226)} |
| − | display: none;
| + | #hpp {background-color: RGB(50,74,94)} |
| − | }
| + | #team {background-color: RGB(255,76,58)} |
| − |
| + | |
| − |
| + | |
| − | /* styling for links in the menu, removes the line under text */
| + | |
| − | .igem_2017_menu_wrapper a {
| + | |
| − | text-decoration: none;
| + | |
| − | }
| + | |
| | | | |
| | + | .botao-link:hover .overlay { |
| | + | opacity: 1; |
| | + | } |
| | | | |
| − | /* styling for the images in the menu */
| + | .text { |
| − | .igem_2017_menu_wrapper img {
| + | color: white; |
| − | width: 100%;
| + | font-size: 20px; |
| − | }
| + | position: absolute; |
| | + | top: 50%; |
| | + | left: 50%; |
| | + | transform: translate(-50%, -50%); |
| | + | -ms-transform: translate(-50%, -50%); |
| | + | } |
| | | | |
| − | /* styling for the menu buttons */
| |
| − | .igem_2017_menu_wrapper .menu_button {
| |
| − | width: 100%;
| |
| − | padding: 10px 0px 10px 15px;
| |
| − | float:left;
| |
| − | border-bottom: 1px solid #d3d3d3;
| |
| − | font-size: 12px;
| |
| − | font-weight: bold;
| |
| − | color: #5e5f5f;
| |
| − | cursor: pointer;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | .igem_2017_menu_wrapper .menu_bottom_padding {
| |
| − | width: 100%;
| |
| − | height: 30px;
| |
| − | float:left;
| |
| − | }
| |
| − |
| |
| − | .menu_button.direct_to_page {
| |
| − | padding-left: 36px;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | .igem_2017_menu_wrapper .menu_button .expand_collapse_icon {
| |
| − | width:10%;
| |
| − | float:left;
| |
| − | }
| |
| − |
| |
| − | .igem_2017_menu_wrapper .menu_button .expand_collapse_icon::before {
| |
| − | content: "+";
| |
| − | }
| |
| − |
| |
| − | .open::before {
| |
| − | content: "-" !important;
| |
| − | }
| |
| − |
| |
| − |
| |
| − |
| |
| − | /* styling for the menu buttons on hover */
| |
| − | .igem_2017_menu_wrapper .menu_button:hover, .igem_2017_menu_wrapper .submenu_button:hover , .submenu_button.current_page:hover {
| |
| − | background-color: #3399ff;
| |
| − | text-decoration: none;
| |
| − | color:#ffffff;
| |
| − | }
| |
| − |
| |
| − | /* styling for the menu button when it is the current page */
| |
| − | .current_page {
| |
| − | background-color:#7fc1f7 !important;
| |
| − | color:#5e5f5f !important;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /* styling for the submenu buttons */
| |
| − | .igem_2017_menu_wrapper .submenu_button {
| |
| − | width: 100%;
| |
| − | padding: 10px 0px 10px 34px;
| |
| − | float:left;
| |
| − | background-color:#f2f2f2;
| |
| − | border-bottom: 1px solid #d3d3d3;
| |
| − | font-size: 12px;
| |
| − | color: #5e5f5f;
| |
| − | cursor: pointer;
| |
| − | }
| |
| − |
| |
| − | /* wrapper for the submenu items, they are hidden by default*/
| |
| − | .igem_2017_menu_wrapper .submenu_wrapper {
| |
| − | display:none;
| |
| − | }
| |
| − |
| |
| − | /* when the page size is bigger than 800px, this show/hide control is hidden by default */
| |
| − | .igem_2017_menu_wrapper #display_menu_control {
| |
| − | display:none;
| |
| − | text-align:center;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /***************************************************** CONTENT OF THE PAGE ****************************************************/
| |
| − |
| |
| − | /* Wrapper for the content */
| |
| − | .igem_2017_content_wrapper {
| |
| − | width: 81%;
| |
| − | margin: 2%;
| |
| − | display:block;
| |
| − | float:left;
| |
| − | background-color:white;
| |
| − | font-family:Tahoma, Geneva, sans-serif;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /********************************* HTML STYLING *********************************/
| |
| − |
| |
| − | /* styling for the titles h1 h2 */
| |
| − | .igem_2017_content_wrapper h1, .igem_2017_content_wrapper h2 {
| |
| − | padding:5px 15px;
| |
| − | border-bottom: 0px;
| |
| − | color: #3399ff;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /* styling for the titles h3 h4 h5 h6*/
| |
| − | .igem_2017_content_wrapper h3, .igem_2017_content_wrapper h4, .igem_2017_content_wrapper h5, .igem_2017_content_wrapper h6 {
| |
| − | padding:5px 15px;
| |
| − | border-bottom:0px;
| |
| − | color: #000000;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /* font and text */
| |
| − | .igem_2017_content_wrapper p {
| |
| − | padding: 0px 15px;
| |
| − | font-size: 13px;
| |
| − | }
| |
| − |
| |
| − | /* Links */
| |
| − | .igem_2017_content_wrapper a {
| |
| − | font-weight: bold;
| |
| − | text-decoration: underline;
| |
| − | text-decoration-color: #3399ff;
| |
| − | color: #3399ff;
| |
| − | -webkit-transition: all 0.4s ease;
| |
| − | -moz-transition: all 0.4s ease;
| |
| − | -ms-transition: all 0.4s ease;
| |
| − | -o-transition: all 0.4s ease;
| |
| − | transition: all 0.4s ease;
| |
| − | }
| |
| − |
| |
| − | /* hover for the links */
| |
| − | .igem_2017_content_wrapper a:hover {
| |
| − | text-decoration:none;
| |
| − | color:#000000;
| |
| − | }
| |
| − |
| |
| − | /* non numbered lists */
| |
| − | .igem_2017_content_wrapper ul {
| |
| − | padding:0px 20px;
| |
| − | font-size: 13px;
| |
| − | font-family:Tahoma, Geneva, sans-serif;
| |
| − | }
| |
| − |
| |
| − | /* numbered lists */
| |
| − | .igem_2017_content_wrapper ol {
| |
| − | padding:0px;
| |
| − | font-size: 13px;
| |
| − | font-family:Tahoma, Geneva, sans-serif;
| |
| − | }
| |
| − |
| |
| − | /* Table */
| |
| − | .igem_2017_content_wrapper table {
| |
| − | width: 97%;
| |
| − | margin:15px 10px;
| |
| − | border: 1px solid #d3d3d3;
| |
| − | border-collapse: collapse;
| |
| − | }
| |
| − |
| |
| − | /* table cells */
| |
| − | .igem_2017_content_wrapper td {
| |
| − | padding: 10px;
| |
| − | vertical-align: text-top;
| |
| − | border: 1px solid #d3d3d3;
| |
| − | border-collapse: collapse;
| |
| − | }
| |
| − |
| |
| − | /* table headers */
| |
| − | .igem_2017_content_wrapper th {
| |
| − | padding: 10px;
| |
| − | vertical-align: text-top;
| |
| − | border: 1px solid #d3d3d3;
| |
| − | border-collapse: collapse;
| |
| − | background-color:#f2f2f2;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /**********************************LAYOUT CLASSES **********************************/
| |
| − |
| |
| − | /* general class for column divs */
| |
| − | .igem_2017_content_wrapper .column {
| |
| − | padding: 10px 0px;
| |
| − | float:left;
| |
| − | }
| |
| − |
| |
| − | /* class for a full width column */
| |
| − | .column .full_size {
| |
| − | width:100%;
| |
| − | }
| |
| − |
| |
| − | /* styling for images in a full width column*/
| |
| − | .column.full_size img {
| |
| − | width:97%;
| |
| − | padding: 10px 15px;
| |
| − | }
| |
| − |
| |
| − | /* class for a half width column */
| |
| − | .column.half_size {
| |
| − | width: 50%;
| |
| − | }
| |
| − | /* styling for images in a half width column*/
| |
| − | .column.half_size img {
| |
| − | width: 94.5%;
| |
| − | padding: 10px 15px;
| |
| − | }
| |
| − |
| |
| − |
| |
| − |
| |
| − |
| |
| − | /********************************* SUPPORT CLASSES ********************************/
| |
| − |
| |
| − | /* class that clears content below*/
| |
| − | .igem_2017_content_wrapper .clear {
| |
| − | clear:both;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /* adds extra spacing when clearing content */
| |
| − | .igem_2017_content_wrapper .clear.extra_space {
| |
| − | height: 30px;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /* highlight class, makes content slightly smaller */
| |
| − | .igem_2017_content_wrapper .highlight {
| |
| − | margin: 0px 15px;
| |
| − | padding: 15px 0px;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /* highlight class, adds a gray background */
| |
| − | .igem_2017_content_wrapper .highlight.gray {
| |
| − | background-color: #f2f2f2;
| |
| − | }
| |
| − |
| |
| − | /* highlight with decoration blue line on top */
| |
| − | .igem_2017_content_wrapper .highlight.blue_top {
| |
| − | border-top: 4px solid #3399ff;
| |
| − | }
| |
| − |
| |
| − | /* highlight with a full blue border decoration */
| |
| − | .igem_2017_content_wrapper .highlight.blue_border {
| |
| − | border: 4px solid #3399ff;
| |
| − | }
| |
| − |
| |
| − |
| |
| − | /* button class */
| |
| − | .igem_2017_content_wrapper .button{
| |
| − | max-width: 35%;
| |
| − | margin: 30px auto;
| |
| − | padding: 12px 10px;
| |
| − | background-color: #3399ff;
| |
| − | text-align: center;
| |
| − | color: #ffffff;
| |
| − | -webkit-transition: all 0.4s ease;
| |
| − | -moz-transition: all 0.4s ease;
| |
| − | -ms-transition: all 0.4s ease;
| |
| − | -o-transition: all 0.4s ease; transition: all 0.4s ease;
| |
| − | }
| |
| − |
| |
| − | /* styling for button on hover */
| |
| − | .igem_2017_content_wrapper .button:hover{
| |
| − | background-color: #3399ff;
| |
| − | color: #000000;
| |
| − | }
| |
| − |
| |
| − |
| |
| − |
| |
| − |
| |
| − | /***************************************************** RESPONSIVE STYLING ****************************************************/
| |
| − |
| |
| − | /* IF THE SCREEN IS LESS THAN 1200PX */
| |
| − | @media only screen and (max-width: 1200px) {
| |
| − |
| |
| − | #content {width:100%; }
| |
| − | .igem_2017_menu_wrapper {width:15%; right:0;}
| |
| − | .highlight {padding:10px 0px;}
| |
| − | .igem_2017_menu_wrapper #display_menu_control { display:none; }
| |
| − | #menu_content { display:block;}
| |
| − | .menu_button.direct_to_page {padding-left: 17px;}
| |
| − |
| |
| − | }
| |
| − |
| |
| − | /* IF THE SCREEN IS LESS THAN 800PX */
| |
| − | @media only screen and (max-width: 800px) {
| |
| − |
| |
| − | .igem_2017_menu_wrapper { width:100%; height: 15%; position:relative; left:0%;}
| |
| − | .igem_2017_content_wrapper {width:100%; margin-left:0px;}
| |
| − | .column.half_size {width:100%; }
| |
| − | .column.full_size img, .column.half_size img { width: 100%; padding: 10px 0px;}
| |
| − | .highlight {padding:15px 5px;}
| |
| − | .igem_2017_menu_wrapper #display_menu_control { display:block; }
| |
| − | #menu_content { display:none;}
| |
| − | .igem_2017_menu_wrapper .menu_button .expand_collapse_icon { width: 5%; }
| |
| − | .menu_bottom_padding {display:none;}
| |
| − | .menu_button.direct_to_page { padding-left: 36px; }
| |
| − | }
| |
| − |
| |
| − |
| |
| − |
| |
| − |
| |
| − | /* special class that the system uses to make sure the team wants a page to be evaluated */
| |
| − | .judges-will-not-evaluate {
| |
| − | width: 96.6%;
| |
| − | margin: 5px 15px;
| |
| − | display: block;
| |
| − | border: 4px solid #3399ff;
| |
| − | font-weight: bold;
| |
| − | }
| |
| − |
| |
| | </style> | | </style> |
| | | | |
| | + | <div id="buttons"> |
| | | | |
| − | <!--- THIS IS WHERE THE HTML BEGINS ---> | + | <div class="botao-link"> |
| | + | <a href="https://2017.igem.org/Team:AQA_Unesp/Description"> |
| | + | <img src="https://static.igem.org/mediawiki/2017/f/f5/Aqaunesp-projectdescription-icon.png" class="image"> |
| | + | <div class="overlay" id="projectdesc"> |
| | + | <div class="text">project description</div> |
| | + | </div> |
| | + | </a> |
| | + | </div> |
| | | | |
| | + | <div class="botao-link"> |
| | + | <a href="https://2017.igem.org/Team:AQA_Unesp/Applied_Design"> |
| | + | <img src="https://static.igem.org/mediawiki/2017/c/cd/AQAUnesp-design-icon.png" class="image"> |
| | + | <div class="overlay" id="design"> |
| | + | <div class="text">design</div> |
| | + | </div> |
| | + | </a> |
| | + | </div> |
| | | | |
| | + | <div class="botao-link"> |
| | + | <a href="https://2017.igem.org/Team:AQA_Unesp/Results"> |
| | + | <img src="https://static.igem.org/mediawiki/2017/7/7c/Aqaunesp-results-icon.png" class="image"> |
| | + | <div class="overlay" id="projectdesc"> |
| | + | <div class="text">results</div> |
| | + | </div> |
| | + | </a> |
| | + | </div> |
| | | | |
| − | <head> | + | <div class="botao-link"> |
| | + | <a href="https://2017.igem.org/Team:AQA_Unesp/HP/Silver"> |
| | + | <img src="https://static.igem.org/mediawiki/2017/0/0a/AQAUnesp-hp-icon.png" class="image"> |
| | + | <div class="overlay" id="hpp"> |
| | + | <div class="text">human practices</div> |
| | + | </div> |
| | + | </a> |
| | + | </div> |
| | | | |
| | + | <div class="botao-link"> |
| | + | <a href="https://2017.igem.org/Team:AQA_Unesp/Team"> |
| | + | <img src="https://static.igem.org/mediawiki/2017/b/bd/AQAUnesp-team-icon.png" class="image"> |
| | + | <div class="overlay" id="team"> |
| | + | <div class="text">team</div> |
| | + | </div> |
| | + | </a> |
| | </div> | | </div> |
| | | | |
| − |
| |
| − |
| |
| − | <!-- start of content -->
| |
| − | <div class="igem_2017_content_wrapper">
| |
| − | <h1>AQA_Unesp</h1>
| |
| − |
| |
| − |
| |
| − | <html>
| |
| − |
| |
| − |
| |
| − | <div class="column full_size" >
| |
| − | <img src="https://static.igem.org/mediawiki/2017/5/54/T--AQA_Unesp--logoInsubiota.png">
| |
| | </div> | | </div> |
| | | | |
| − | | + | </body> |
| − | | + | |
| − | | + | |
| − | | + | |
| − | | + | |
| | </html> | | </html> |
| | + | {{AQA_Unesp_btm}} |
