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− | <h1>New Order</h1>In synthetic biology, we are often introducing new | + | <h1>New Order</h1>In synthetic biology, we are often introducing new pathways to bacteria that do not naturally express them. The novel pathway will produce exotic enzymes and proteins to the host bacteria which will not necessarily have the internal environment to organise these macromolecular products which could be detrimental to the performance of both the pathway and the organism. Furthermore, depending on the organism used, the activity of the pathway can vary and be difficult to make comparisons. Thus, we are creating a standardized microenvironment in the cell wherein the pathway components are localised and perform in a predictable way. |
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Revision as of 11:06, 27 October 2017
RNA Organelle
New Order
In synthetic biology, we are often introducing new pathways to bacteria that do not naturally express them. The novel pathway will produce exotic enzymes and proteins to the host bacteria which will not necessarily have the internal environment to organise these macromolecular products which could be detrimental to the performance of both the pathway and the organism. Furthermore, depending on the organism used, the activity of the pathway can vary and be difficult to make comparisons. Thus, we are creating a standardized microenvironment in the cell wherein the pathway components are localised and perform in a predictable way.RNA is a light cost nucleotide material in the cell,
We aim to recreate RNA agglomerations as formed
in mammalian cells with triple repeat disorders,
which show liquid phase separation, forming a
organelle-like vesicle, where local concentrations of
enzymes can be created.