Difference between revisions of "Team:Paris Bettencourt/RNA"

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<h1>New Order</h1>In synthetic biology, we are often introducing new systems to bacteria that are not designed to use the new pathway. The synthetic pathway will produce new and exotic enzymes and proteins for the host bacteria which will not have necessary internal environment to organise these macromolecular products, this could be detrimental to the system or even the host bacteria itself. So we are creating a standardized microenvironment in the cell wherein the pathway components are trapped and perform in a predictable way
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<h1>New Order</h1>In synthetic biology, we are often introducing new pathways to bacteria that do not naturally express them. The novel pathway will produce exotic enzymes and proteins to the host bacteria which will not necessarily have the internal environment to organise these macromolecular products which could be detrimental to the performance of both the pathway and the organism. Furthermore, depending on the organism used, the activity of the pathway can vary and be difficult to make comparisons. Thus, we are creating a standardized microenvironment in the cell wherein the pathway components are localised and perform in a predictable way.
 
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Revision as of 11:06, 27 October 2017

RNA Organelle

New Order

In synthetic biology, we are often introducing new pathways to bacteria that do not naturally express them. The novel pathway will produce exotic enzymes and proteins to the host bacteria which will not necessarily have the internal environment to organise these macromolecular products which could be detrimental to the performance of both the pathway and the organism. Furthermore, depending on the organism used, the activity of the pathway can vary and be difficult to make comparisons. Thus, we are creating a standardized microenvironment in the cell wherein the pathway components are localised and perform in a predictable way.
RNA is a light cost nucleotide material in the cell, We aim to recreate RNA agglomerations as formed in mammalian cells with triple repeat disorders, which show liquid phase separation, forming a organelle-like vesicle, where local concentrations of enzymes can be created.


Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
bettencourt.igem2017@gmail.com