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Revision as of 14:52, 1 November 2017

OVERVIEW

Why do we need 3D control?

Life exists in three dimensions but oftentimes, life sciences research remains very flat. Our limitation to control precise behaviour in a 3D space, abstracts what we can do and distances us from in vivo. Having power ful tools in the 3D allows us to both study and control life with more accuracy.

A Bacterial 3D printer

To best demonstrate our 3D control tools, we created a intuitive way to bring our technologies into people’s every day life. We created a bacterial 3D printer, where we developed and characterise optogenetic tools in bacteria to produce a biomaterial when activated. This is a demonstration of our work where we showcase spatial control with a final product. This also allowed us to further characterise biomaterial
production in micro-organisms. We chose to focus on three biomaterials: Calcium Carbonate, Poly-silicate and Poly-hydroalkanoates (PHA). The system also allows us to apply intracellular 3D control, which we achieve thanks to designing synthetic RNA organelles in the cell where local enzyme concentrations are generated. Thus, to perfect our 3D printer we focused on several main axes of research.

Optogenentic Control

RNA is a light cost nucleotide material in the cell, We aim to recreate RNA agglomerations as formed in mammalian cells with triple repeat disorders, which show liquid phase separation, forming a organelle-like vesicle, where local concentrations of enzymes can be created.

Biomaterials

RNA is a light cost nucleotide material in the cell, We aim to recreate RNA agglomerations as formed in mammalian cells with triple repeat disorders, which show liquid phase separation, forming a organelle-like vesicle, where local concentrations of enzymes can be created.

RNA organelle

RNA is a light cost nucleotide material in the cell, We aim to recreate RNA agglomerations as formed in mammalian cells with triple repeat disorders, which show liquid phase separation, forming a organelle-like vesicle, where local concentrations of enzymes can be created.

Applications

The students came up with and developed the idea during brainstorming sessions in the firsts months of the competition, letting the project evolve throughout the summer. All of the designs, constructs and experiments were performed by the students of the 2017 Paris Bettencourt team.
Instructors and Advisors provided support, advice and feedback when needed. The team was hosted by the CRI lab inside of the Paris-Descartes University. If more than one person is listed, we highlighted the main person responsible
The students came up with and developed the idea during brainstorming sessions in the firsts months of the competition, letting the project evolve throughout the summer. All of the designs, constructs and experiments were performed by the students of the 2017 Paris Bettencourt team.
Instructors and Advisors provided support, advice and the CRI lab inside of the Paris-Descartes University. If more than one person is listed, we highlighted the main person responsible
n, letting the project evolve throughout the summer. All of the designs, constructs and experiments were performed by the students of the 2017 Paris Bettencourt team.
Instructors and Advisors provided support, advice and the CRI lab inside of the Paris-Descartes University. If more than one person is listed, we highlighted the main person responsible
The students came up with and developed the idea during brainstorming sessions in the firsts months of the competition, letting the project evolve throughout the summer. All of the designs, constructs and experiments were performed by the students of the 2017 Paris Bettencourt team.
Instructors and Advisors provided support, advice and feedback when needed. The team was hosted by the CRI lab inside of the Paris-Descartes University. If more than one person is listed, we highlighted the main person responsible
The students came up with and developed the idea during brainstorming sessions in the firsts months of the competition, letting the project evolve throughout the summer. All of the designs, constructs and experiments were performed by the students of the 2017 Paris Bettencourt team.
Instructors and Advisors provided support, advice and the CRI lab inside of the Paris-Descartes University. If more than one person is listed, we highlighted the main person responsible
n, letting the project evolve throughout the summer. All of the designs, constructs and experiments were performed by the students of the 2017 Paris Bettencourt team.
Instructors and Advisors provided support, advice and the CRI lab inside of the Paris-Descartes University. If more than one person is listed, we highlighted the main person responsible


Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
bettencourt.igem2017@gmail.com