Gold
We extended the Engineering Cycle for Foundational Advance projects by including sophisticated concepts for safety measures and the responsible use of new technologies.
We improved the function of an existing biobrick by calculated improved beta-lactamase variants in silico and evaluating the superior functionality in the wet lab.
We intensively modeled our PREDCEL experiments and provide web-based interactive tools that enable our users to model their own systems!
We developed PREDCEL to enable phage-assisted directed evolution in batch mode that is much easier to handle and less expensive compared to the original PACE method. We demonstrate the feasibility of our technology on a protein-interaction experiment based on the split T7 polymerase and in evolving the enzyme cytochrome P450 1A2.
