Revision as of 15:09, 31 August 2017

Synthetic biology wants to go beyond the pure biological by integrating concepts from chemistry or physics into the living world. At this interphase, our project wants to introduce Peptidosomes as a new fundamental approach for generating and applying encapsulated bacteria. These spheres possess advantageous properties like stability in different media and a mesh-like structure that allows for the selective exchange of compounds via diffusion. Therefore, we are able to benefit from the entrapped cells’ abilities, while ensuring that they are not released into their surroundings. Using the powerful genetics of Bacillus subtilis and its secretory capabilities we demonstrate communication and cooperation between separately encapsulated bacterial populations as well as the environment. Peptidosomes can be further enhanced by incorporating magnetic or biological beads – which can be functionalized with proteins – into their peptide-based shell. With this unique setup, we provide a whole new universe of applications to the iGEM community.

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-<h2>Our Project</h2>
+<h2>EncaBcillus – It’s a trap! </h2>
-<p>The fundamental idea of our project is to use the vast abilities of microorganisms in a controlled environment and manner. To do so, we intent to entrap microbes in a particular type of spherical cage, called a Peptidosome. In doing so, we will be able take advantage of the entrapped cell’s abilities, while making sure they won´t be released into their surrounding environments. These cages consist of peptides (protein components) which will form large filaments under the right circumstances. They also possess several unique properties: being stable in different media, capable of entrapping particles inside, and allowing for selective exchange of fluids and substances through pores. Because of these characteristics, we intend to investigate the applications of Peptidosomes for use in bio-sensor systems, magnetic particles for moving Peptidosomes, the study of microbial cooperation, and their use in the elimination of biofilms</p>
+<p>Synthetic biology wants to go beyond the pure biological by integrating concepts from chemistry or physics into the living world. At this interphase, our project wants to introduce Peptidosomes as a new fundamental approach for generating and applying encapsulated bacteria.
+These spheres possess advantageous properties like stability in different media and a mesh-like structure that allows for the selective exchange of compounds via diffusion. Therefore, we are able to benefit from the entrapped cells’ abilities, while ensuring that they are not released into their surroundings.
+Using the powerful genetics of Bacillus subtilis and its secretory capabilities we demonstrate communication and cooperation between separately encapsulated bacterial populations as well as the environment. Peptidosomes can be further enhanced by incorporating magnetic or biological beads – which can be functionalized with proteins – into their peptide-based shell.
+With this unique setup, we provide a whole new universe of applications to the iGEM community.</p>
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Difference between revisions of "Team:TU Dresden"

Revision as of 15:09, 31 August 2017

TU_Dresden

EncaBcillus – It’s a trap!

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