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− | < | + | <p style="font-size: 1.3em;" color ="purple" >What is Parkinson's Disease?</p> |
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− | <p>Parkinson’s disease is a neurodegenerative disorder | + | <p>Parkinson’s disease is a neurodegenerative disorder characterized by the destruction of dopaminergic (dopamine producing) neurons in the substantia nigra in the brain. Dopamine acts as a neurotransmitter, a chemical messenger, between two brain areas, substantia nigra and the corpus striatum, to produce controlled movements. When there is a shortage of dopamine, the communication between the two areas becomes ineffective and the movement becomes impaired. In short, the greater the loss of dopamine, the worst the movement-related symptoms. These motor symptoms include shaking, rigidity, slowness of movement, impaired balance, and difficulty in walking. As symptoms get worse, talking, chewing, speaking, or swallowing may be difficult for an individual. Additionally, non-motor symptoms associated with Parkinson’s Disease include loss of sense of smell, cognitive impairment, and constipation. Emotional symptoms may include depression, apathy, and anxiety. |
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Revision as of 03:45, 1 November 2017
Description
What is Parkinson's Disease?
Parkinson’s disease is a neurodegenerative disorder characterized by the destruction of dopaminergic (dopamine producing) neurons in the substantia nigra in the brain. Dopamine acts as a neurotransmitter, a chemical messenger, between two brain areas, substantia nigra and the corpus striatum, to produce controlled movements. When there is a shortage of dopamine, the communication between the two areas becomes ineffective and the movement becomes impaired. In short, the greater the loss of dopamine, the worst the movement-related symptoms. These motor symptoms include shaking, rigidity, slowness of movement, impaired balance, and difficulty in walking. As symptoms get worse, talking, chewing, speaking, or swallowing may be difficult for an individual. Additionally, non-motor symptoms associated with Parkinson’s Disease include loss of sense of smell, cognitive impairment, and constipation. Emotional symptoms may include depression, apathy, and anxiety.
References
iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.