Difference between revisions of "Team:SCU-WestChina/Description"

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<html>
 
<html>
  
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<head>
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    <link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.7/css/bootstrap.min.css">
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    <title>index</title>
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<body>
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    <ul class="nav nav-pills">
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        <img src="https://static.igem.org/mediawiki/2017/b/b9/T--SCU-WestChina--logo.png" alt="" class="logo">
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        <div class="nav-right-wrapper">
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            <li role="presentation">
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                <a href="https://2017.igem.org/Team:SCU-WestChina">Home</a>
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            <li role="presentation">
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                <a href="https://2017.igem.org/Team:SCU-WestChina/Background">Background</a>
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                    Project
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Description">Description</a>
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                    </li>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Demonstrate">Proof</a>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Parts">Parts</a>
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                    </li>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Measurement">Measurement</a>
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                    </li>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Hardware">Hardware</a>
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                </ul>
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            <li role="presentation">
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                <a href="https://2017.igem.org/Team:SCU-WestChina/Model">Modeling</a>
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                <a class="dropdown-toggle" data-toggle="dropdown" href="#" role="button">
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                    Human Practice
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                </a>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/HP/Silver">Silver</a>
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                    </li>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/HP/Gold_Integrated">Gold</a>
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                    </li>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Engagement">Education and Public Engagement</a>
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                    </li>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Collaborations">Collaborations</a>
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                    </li>
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                <a class="dropdown-toggle" data-toggle="dropdown" href="#" role="button">
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                    Notebook
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                </a>
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                <ul class="dropdown-menu">
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Notebook">Notebook</a>
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                    </li>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Protocols">Protocols</a>
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                    </li>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Medals">Medals</a>
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                    </li>
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                </ul>
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            </li>
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            <li role="presentation" class="dropdown">
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                <a class="dropdown-toggle" data-toggle="dropdown" href="#" role="button">
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                    Team
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                </a>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Team">Team</a>
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                    </li>
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                    <li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Attributions">Attributions</a>
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                    </li>
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                        <a href="https://2017.igem.org/Team:SCU-WestChina/Acknowledgement">Acknowledgement</a>
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                    </li>
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                </ul>
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            <li role="presentation">
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                <a href="https://2017.igem.org/Team:SCU-WestChina/InterLab">InterLab</a>
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    <div class="main-wrapper">
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        <div class="primary-wrapper">
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            <div class="primary-title">Description</div>
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            <div class="primary-content">Hyperuricemia and refractory gout are caused by the high urate concentration in the blood. Considering there are still debates on whether the drug should be used in the asymptomatic hyperuricemia patients and the drug resistance of the refractory gout patients, new approaches are eagerly needed. We constructed the urate metabolic pathway in the probiotic E. coli Nissle 1917 and applied it in the gut to reduce the urate concentration in the blood indirectly. In addition, we built a dialysis-like device combined with modified bacteria to utilize the urate directly in the blood. Our solutions provide a suitable, long-term and non-drug treatment for the asymptomatic hyperuricemia patients and an ultimate treatment for the refractory gout patients.
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<h1>Description</h1>
 
  
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
 
  
  
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<h5>Advice on writing your Project Description</h5>
 
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.
 
 
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
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<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
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Revision as of 06:22, 31 October 2017

index

Description
Hyperuricemia and refractory gout are caused by the high urate concentration in the blood. Considering there are still debates on whether the drug should be used in the asymptomatic hyperuricemia patients and the drug resistance of the refractory gout patients, new approaches are eagerly needed. We constructed the urate metabolic pathway in the probiotic E. coli Nissle 1917 and applied it in the gut to reduce the urate concentration in the blood indirectly. In addition, we built a dialysis-like device combined with modified bacteria to utilize the urate directly in the blood. Our solutions provide a suitable, long-term and non-drug treatment for the asymptomatic hyperuricemia patients and an ultimate treatment for the refractory gout patients.

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