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<h3 class="ar-title">Abstract</h3> | <h3 class="ar-title">Abstract</h3> | ||
<h4><br>FOXP3+ regulatory T cells (Treg) are a class of T lymphocyte subsets that play an immunosuppressive and regulatory function. | <h4><br>FOXP3+ regulatory T cells (Treg) are a class of T lymphocyte subsets that play an immunosuppressive and regulatory function. | ||
− | The dysfunction of FOXP3+ Treg is closely related to the development of autoimmune diseases, | + | The dysfunction of FOXP3+ Treg is closely related to the development of autoimmune diseases, say rheumatoid arthritis. FOXP3, |
a transcription factor in Forkhead family, whose functional stability is regulated by post-translational modification enzymes, is a | a transcription factor in Forkhead family, whose functional stability is regulated by post-translational modification enzymes, is a | ||
key transcription factor for Treg cells’ specific expression. The ubiquitinase USP7 was able to specifically modify the FOXP3 | key transcription factor for Treg cells’ specific expression. The ubiquitinase USP7 was able to specifically modify the FOXP3 |
Revision as of 06:38, 1 November 2017