What can modeling do for our project? After careful consideration, our team thinks that what modeling can do does not merely simulate and verify our system though it is important. We hope that with the agency of our modeling, we can find some solutions to the problems we have met or will meet during the process of our project. Thus, we establish “3S” as goals of modeling:
Model to serve, Model to solve, Model for security
Modeling, with its strictness and precision, can be an excellent tool for us to understand the disease and the biological process, and plays an important role in our project. To satisfy our experimental requirements, we created a model of Th17/iTreg differentiation. This model provides a new framework that can be used to analyze the dynamic characteristics of Th17/iTreg differentiation network. In addition, we created a two-variable model for the interactions between pro-inflammatory and anti-inflammatory cytokines by establishing ordinary differential equations (ODE). This model can be used to investigate the involvement of cytokines in the disease process. We finally explore the feasibility of our project by coupling the model with our project. Finally, aimed at security, we explored the relationships between our system and RA models.
What did our model achieve?
We achieved 3 main aims in our modelling work：
We presented a novel mathematical model of TH17-iTreg differentiation that reveals how the control system generates phenotypic diversity and how its final state can be regulated by various signals.
We created a two-variable model for the interactions between pro-inflammatory and anti-inflammatory cytokines, and demonstrateed that mathematical modeling can be used to investigate the involvement of cytokines in the disease process.
We combined the two-variable model with our project to find the method of solving the kinetic parameters of the system, and the relationship between parameters and system security.
All of our models are available on our Github page.
|Reciprocal Differentiation Model||Cytokine-mediated inflammation in RA||Exploration of models|
|A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cells.
|A two-variable model for the interactions between pro-inflammatory and anti-inflammatory cytokines in rheumatoid arthritis.
|A mathematical representation of our SynNotch CAR-Tregs system and exploration of the previous two models